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Aliases for TBC1D3F Gene

Aliases for TBC1D3F Gene

  • TBC1 Domain Family Member 3F 2 3 3 5
  • Prostate Cancer Gene 17 Protein 3
  • TBC1 Domain Family, Member 3F 2
  • TBC1 Domain Family Member 3 3
  • Protein TRE17-Alpha 3
  • TBC1D3E 4
  • TBC1D3 3

External Ids for TBC1D3F Gene

Previous GeneCards Identifiers for TBC1D3F Gene

  • GC17M031607
  • GC17U900818
  • GC17P033363
  • GC17M033595
  • GC17P036283
  • GC17M030678
  • GC17M036377

Summaries for TBC1D3F Gene

GeneCards Summary for TBC1D3F Gene

TBC1D3F (TBC1 Domain Family Member 3F) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is TBC1D3D.

UniProtKB/Swiss-Prot for TBC1D3F Gene

  • Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).

Gene Wiki entry for TBC1D3F Gene

Additional gene information for TBC1D3F Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D3F Gene

Genomics for TBC1D3F Gene

GeneHancer (GH) Regulatory Elements for TBC1D3F Gene

Top Transcription factor binding sites by QIAGEN in the TBC1D3F gene promoter:
  • NF-1
  • NF-1/L
  • Egr-4
  • HTF
  • ATF
  • Lmo2

Genomic Locations for TBC1D3F Gene

Genomic Locations for TBC1D3F Gene
10,955 bases
Minus strand
10,956 bases
Plus strand

Genomic View for TBC1D3F Gene

Genes around TBC1D3F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D3F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D3F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D3F Gene

Proteins for TBC1D3F Gene

  • Protein details for TBC1D3F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TBC1 domain family member 3F
    Protein Accession:

    Protein attributes for TBC1D3F Gene

    549 amino acids
    Molecular mass:
    62185 Da
    Quaternary structure:
    No Data Available
    • TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog, some human genomes encoding well over 50 copies depending on ethnic origin of the donor.

neXtProt entry for TBC1D3F Gene

Post-translational modifications for TBC1D3F Gene

  • Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation.
  • Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBC1D3F Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for TBC1D3F

No data available for DME Specific Peptides for TBC1D3F Gene

Domains & Families for TBC1D3F Gene

Gene Families for TBC1D3F Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TBC1D3F Gene

Suggested Antigen Peptide Sequences for TBC1D3F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TBC1D3F: view

No data available for UniProtKB/Swiss-Prot for TBC1D3F Gene

Function for TBC1D3F Gene

Molecular function for TBC1D3F Gene

UniProtKB/Swiss-Prot Function:
Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).

Phenotypes From GWAS Catalog for TBC1D3F Gene

Gene Ontology (GO) - Molecular Function for TBC1D3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0017137 Rab GTPase binding IBA --
genes like me logo Genes that share ontologies with TBC1D3F: view

Phenotypes for TBC1D3F Gene

genes like me logo Genes that share phenotypes with TBC1D3F: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TBC1D3F Gene

Localization for TBC1D3F Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBC1D3F Gene

Cell membrane; Lipid-anchor. Note=Associated with lipid rafts. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBC1D3F gene
Compartment Confidence
endosome 4
plasma membrane 3
nucleus 2
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TBC1D3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005886 plasma membrane IEA --
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with TBC1D3F: view

Pathways & Interactions for TBC1D3F Gene

SuperPathways for TBC1D3F Gene

No Data Available

Interacting Proteins for TBC1D3F Gene

Gene Ontology (GO) - Biological Process for TBC1D3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0031338 regulation of vesicle fusion IBA --
GO:0090630 activation of GTPase activity IBA --
genes like me logo Genes that share ontologies with TBC1D3F: view

No data available for Pathways by source and SIGNOR curated interactions for TBC1D3F Gene

Drugs & Compounds for TBC1D3F Gene

No Compound Related Data Available

Transcripts for TBC1D3F Gene

mRNA/cDNA for TBC1D3F Gene

(1) REFSEQ mRNAs :
(52) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D3F Gene

No ASD Table

Relevant External Links for TBC1D3F Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBC1D3F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TBC1D3F Gene

NURSA nuclear receptor signaling pathways regulating expression of TBC1D3F Gene:


mRNA Expression by UniProt/SwissProt for TBC1D3F Gene:

Tissue specificity: Expressed in most tissues including pancreas, thymus and testis.

Evidence on tissue expression from TISSUES for TBC1D3F Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TBC1D3F: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TBC1D3F Gene

Orthologs for TBC1D3F Gene

Evolution for TBC1D3F Gene

Gene Tree for TBC1D3F (if available)
Gene Tree for TBC1D3F (if available)

No data available for Orthologs for TBC1D3F Gene

Paralogs for TBC1D3F Gene

(15) SIMAP similar genes for TBC1D3F Gene using alignment to 3 proteins:

  • F5GZ95_HUMAN
genes like me logo Genes that share paralogs with TBC1D3F: view

Variants for TBC1D3F Gene

Sequence variations from dbSNP and Humsavar for TBC1D3F Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1001261758 -- 36,439,580(-) C/G upstream_transcript_variant
rs1009912272 -- 36,428,207(-) T/A downstream_transcript_variant
rs1010418967 -- 36,434,799(-) G/A/T coding_sequence_variant, stop_gained, synonymous_variant
rs1019860821 -- 36,428,119(-) T/C downstream_transcript_variant
rs1021204406 -- 36,428,377(-) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TBC1D3F Gene

Variant ID Type Subtype PubMed ID
dgv1463n106 CNV duplication 24896259
dgv1745e59 CNV duplication 20981092
dgv911e212 CNV gain 25503493
dgv912e212 CNV loss 25503493
dgv913e212 CNV loss 25503493
dgv914e212 CNV gain 25503493
dgv915e212 CNV gain 25503493
dgv916e212 CNV loss 25503493
esv2758688 CNV gain+loss 17122850
esv27635 CNV gain+loss 19812545
esv28567 CNV gain+loss 19812545
esv3416493 CNV duplication 20981092
esv3572853 CNV gain 25503493
esv3573020 CNV gain 25503493
esv3582628 CNV loss 25503493
esv3582629 CNV loss 25503493
nsv1077842 CNV duplication 25765185
nsv1078415 CNV duplication 25765185
nsv1124756 CNV duplication 24896259
nsv1132452 CNV duplication 24896259
nsv1147590 CNV duplication 26484159
nsv1153123 CNV duplication 26484159
nsv428341 CNV gain+loss 18775914
nsv469738 CNV gain+loss 16826518
nsv469796 CNV gain+loss 16826518
nsv469853 CNV gain+loss 16826518
nsv471328 CNV gain 19718026
nsv471507 CNV gain 19718026
nsv471697 CNV gain 15918152
nsv509654 CNV insertion 20534489
nsv953886 CNV duplication 24416366
nsv953891 CNV duplication 24416366
nsv962313 CNV duplication 23825009

Variation tolerance for TBC1D3F Gene

Gene Damage Index Score: 0.25; 5.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TBC1D3F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D3F Gene

Disorders for TBC1D3F Gene

Additional Disease Information for TBC1D3F

No disorders were found for TBC1D3F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D3F Gene

Publications for TBC1D3F Gene

  1. TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12. (PMID: 16863688) Hodzic D … Stahl PD (Genomics 2006) 2 3 4 58
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PMID: 23535730) Pharoah PD … Sellers TA (Nature genetics 2013) 3 58

Products for TBC1D3F Gene

Sources for TBC1D3F Gene

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