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Aliases for TBC1D3C Gene

Aliases for TBC1D3C Gene

  • TBC1 Domain Family Member 3C 2 3 5
  • TBC1D3D 3 4
  • TBC1 Domain Family Member 3C-Like Protein ENSP00000341742 3
  • Rab GTPase-Activating Protein PRC17 3
  • TBC1 Domain Family Member 3C/3D 3
  • TBC1 Domain Family, Member 3C 2

External Ids for TBC1D3C Gene

Previous GeneCards Identifiers for TBC1D3C Gene

  • GC17M031606
  • GC17M034580
  • GC17M037981

Summaries for TBC1D3C Gene

Entrez Gene Summary for TBC1D3C Gene

  • This gene represents one of a cluster of related genes found on chromosome 17. The proteins encoded by this gene family contain a TBC (Tre-2, Bub2p, and Cdc16p) domain and may be involved in GTPase signaling and vesicle trafficking. [provided by RefSeq, Apr 2014]

GeneCards Summary for TBC1D3C Gene

TBC1D3C (TBC1 Domain Family Member 3C) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is TBC1D3.

UniProtKB/Swiss-Prot for TBC1D3C Gene

  • Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).

Additional gene information for TBC1D3C Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D3C Gene

Genomics for TBC1D3C Gene

GeneHancer (GH) Regulatory Elements for TBC1D3C Gene

Top Transcription factor binding sites by QIAGEN in the TBC1D3C gene promoter:

Genomic Locations for TBC1D3C Gene

Genomic Locations for TBC1D3C Gene
10,942 bases
Minus strand

Genomic View for TBC1D3C Gene

Genes around TBC1D3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D3C Gene

Proteins for TBC1D3C Gene

  • Protein details for TBC1D3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TBC1 domain family member 3C
    Protein Accession:

    Protein attributes for TBC1D3C Gene

    549 amino acids
    Molecular mass:
    62187 Da
    Quaternary structure:
    No Data Available
    • TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog, some human genomes encoding well over 50 copies depending on ethnic origin of the donor.

neXtProt entry for TBC1D3C Gene

Post-translational modifications for TBC1D3C Gene

  • Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination.
  • Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation.

No data available for DME Specific Peptides for TBC1D3C Gene

Domains & Families for TBC1D3C Gene

Gene Families for TBC1D3C Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TBC1D3C Gene

Suggested Antigen Peptide Sequences for TBC1D3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TBC1D3C: view

No data available for UniProtKB/Swiss-Prot for TBC1D3C Gene

Function for TBC1D3C Gene

Molecular function for TBC1D3C Gene

UniProtKB/Swiss-Prot Function:
Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).

Gene Ontology (GO) - Molecular Function for TBC1D3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0017137 Rab GTPase binding IBA --
genes like me logo Genes that share ontologies with TBC1D3C: view

Phenotypes for TBC1D3C Gene

GenomeRNAi human phenotypes for TBC1D3C:
genes like me logo Genes that share phenotypes with TBC1D3C: view

Animal Model Products

miRNA for TBC1D3C Gene

miRTarBase miRNAs that target TBC1D3C

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBC1D3C Gene

Localization for TBC1D3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBC1D3C Gene

Cell membrane; Lipid-anchor. Note=Associated with lipid rafts. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBC1D3C gene
Compartment Confidence
plasma membrane 3
cytosol 3
nucleus 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TBC1D3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005886 plasma membrane IEA --
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TBC1D3C: view

Pathways & Interactions for TBC1D3C Gene

SuperPathways for TBC1D3C Gene

No Data Available

Interacting Proteins for TBC1D3C Gene

Selected Interacting proteins: Q6IPX1-TBC3C_HUMAN for TBC1D3C Gene via IID

Gene Ontology (GO) - Biological Process for TBC1D3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0031338 regulation of vesicle fusion IBA --
GO:0090630 activation of GTPase activity IBA --
genes like me logo Genes that share ontologies with TBC1D3C: view

No data available for Pathways by source and SIGNOR curated interactions for TBC1D3C Gene

Drugs & Compounds for TBC1D3C Gene

No Compound Related Data Available

Transcripts for TBC1D3C Gene

Unigene Clusters for TBC1D3C Gene

TBC1 domain family, member 3C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D3C Gene

No ASD Table

Relevant External Links for TBC1D3C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBC1D3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TBC1D3C Gene

mRNA differential expression in normal tissues according to GTEx for TBC1D3C Gene

This gene is overexpressed in Testis (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of TBC1D3C Gene:


SOURCE GeneReport for Unigene cluster for TBC1D3C Gene:


mRNA Expression by UniProt/SwissProt for TBC1D3C Gene:

Tissue specificity: Expressed in pancreas, thymus and testis.

Evidence on tissue expression from TISSUES for TBC1D3C Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TBC1D3C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TBC1D3C Gene

Orthologs for TBC1D3C Gene

Evolution for TBC1D3C Gene

Gene Tree for TBC1D3C (if available)
Gene Tree for TBC1D3C (if available)

No data available for Orthologs for TBC1D3C Gene

Paralogs for TBC1D3C Gene

Variants for TBC1D3C Gene

Sequence variations from dbSNP and Humsavar for TBC1D3C Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs111848730 -- 38,068,539(-) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs199492283 -- 38,067,640(-) A/G 5_prime_UTR_variant, intron_variant
rs199492284 -- 38,068,227(-) G/T 5_prime_UTR_variant, intron_variant
rs199888436 -- 38,064,802(-) C/A intron_variant
rs201195987 -- 38,064,786(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TBC1D3C Gene

Variant ID Type Subtype PubMed ID
nsv953891 CNV duplication 24416366
nsv833435 CNV gain+loss 17160897
nsv820624 CNV duplication 20802225
nsv471507 CNV gain 19718026
nsv471398 CNV gain 19718026
nsv428341 CNV gain+loss 18775914
nsv1153123 CNV duplication 26484159
nsv1078415 CNV duplication 25765185
esv3582629 CNV loss 25503493
esv3582628 CNV loss 25503493
esv3573020 CNV gain 25503493
esv3572853 CNV gain 25503493
esv3383710 CNV duplication 20981092
esv3357566 CNV duplication 20981092
esv28567 CNV gain+loss 19812545
esv2758688 CNV gain+loss 17122850
dgv916e212 CNV loss 25503493
dgv915e212 CNV gain 25503493
dgv914e212 CNV gain 25503493
dgv913e212 CNV loss 25503493
dgv912e212 CNV loss 25503493
dgv911e212 CNV gain 25503493
dgv1755e59 CNV duplication 20981092
dgv1754e59 CNV duplication 20981092
dgv1753e59 CNV duplication 20981092
dgv1463n106 CNV duplication 24896259

Variation tolerance for TBC1D3C Gene

Gene Damage Index Score: 1.94; 36.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TBC1D3C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D3C Gene

Disorders for TBC1D3C Gene

Additional Disease Information for TBC1D3C

No disorders were found for TBC1D3C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D3C Gene

Publications for TBC1D3C Gene

  1. TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12. (PMID: 16863688) Hodzic D … Stahl PD (Genomics 2006) 2 3 4 58
  2. PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer. (PMID: 12359748) Pei L … Li J (Cancer research 2002) 2 3 58
  3. Diversity of human copy number variation and multicopy genes. (PMID: 21030649) Sudmant PH … Eichler EE (Science (New York, N.Y.) 2010) 4 58
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for TBC1D3C Gene

Sources for TBC1D3C Gene

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