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Aliases for TBC1D31 Gene

Aliases for TBC1D31 Gene

  • TBC1 Domain Family Member 31 2 3 4 5
  • WD Repeat-Containing Protein 67 3 4
  • WD Repeat Domain 67 2 3
  • WDR67 3 4
  • TBC1 Domain Family, Member 31 2
  • Gm85 3

External Ids for TBC1D31 Gene

Previous HGNC Symbols for TBC1D31 Gene

  • WDR67

Previous GeneCards Identifiers for TBC1D31 Gene

  • GC08P124055

Summaries for TBC1D31 Gene

GeneCards Summary for TBC1D31 Gene

TBC1D31 (TBC1 Domain Family Member 31) is a Protein Coding gene. An important paralog of this gene is WDR3.

Additional gene information for TBC1D31 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D31 Gene

Genomics for TBC1D31 Gene

GeneHancer (GH) Regulatory Elements for TBC1D31 Gene

Promoters and enhancers for TBC1D31 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J123040 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 600.7 -0.1 -83 3.4 CC2D1A SP1 ZFX ELF3 SIX5 CBFA2T2 NKRF POLR2A MLLT1 RERE TBC1D31 DERL1 ENSG00000253607
GH08J123072 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 612.6 +30.9 30933 3.4 SP1 ZFX ELF3 SIX5 NKRF POLR2A MLLT1 ZNF121 GTF2F1 ZNF687 TBC1D31 DERL1 RNY4P5 HMGB1P19
GH08J122779 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 -260.1 -260092 4.6 MTA3 ZNF652 ELF3 MNT NKRF CEBPG ZNF687 AHR MYC TFE3 ZHX2 ENSG00000272384 ENSG00000272043 TBC1D31 DERL1 C8orf76 PIR52073
GH08J123065 Enhancer 1.1 Ensembl ENCODE 13.2 +23.9 23932 1 CC2D1A CTCF CBFA2T2 BACH1 MAFK SP7 TRIM24 RAD21 EGR1 SMARCA4 TBC1D31 DERL1 ENSG00000238901 ENSG00000253607 FAM83A-AS1 RNY4P5 HMGB1P19
GH08J123074 Promoter/Enhancer 1.2 Ensembl ENCODE 12.1 +32.9 32923 0.2 CEBPG PKNOX1 CTBP1 SOX13 SMARCA5 ESRRA SAP130 ZNF217 FOXP1 FOXA1 TBC1D31 DERL1 RNY4P5 HMGB1P19
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TBC1D31 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TBC1D31 Gene

Genomic Locations for TBC1D31 Gene
chr8:123,041,968-123,165,173
(GRCh38/hg38)
Size:
123,206 bases
Orientation:
Plus strand
chr8:124,054,208-124,164,393
(GRCh37/hg19)
Size:
110,186 bases
Orientation:
Plus strand

Genomic View for TBC1D31 Gene

Genes around TBC1D31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D31 Gene

Proteins for TBC1D31 Gene

  • Protein details for TBC1D31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DN5-TBC31_HUMAN
    Recommended name:
    TBC1 domain family member 31
    Protein Accession:
    Q96DN5
    Secondary Accessions:
    • B7ZL19
    • Q2M2J9
    • Q3MIR6
    • Q8TBP9

    Protein attributes for TBC1D31 Gene

    Size:
    1066 amino acids
    Molecular mass:
    124189 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH27237.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TBC1D31 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBC1D31 Gene

Post-translational modifications for TBC1D31 Gene

  • Ubiquitination at posLast=833833, posLast=844844, posLast=782782, isoforms=2, 3877, posLast=4141, posLast=682682, isoforms=2, 3729, and posLast=866866
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TBC1D31 Gene

Domains & Families for TBC1D31 Gene

Gene Families for TBC1D31 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TBC1D31 Gene

GenScript: Design optimal peptide antigens:
  • WDR67 protein (B7ZL19_HUMAN)
  • WDR67 protein (Q3KRB0_HUMAN)
  • WDR67 protein (Q8TAK7_HUMAN)
  • WD repeat-containing protein 67 (WDR67_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TBC1D31: view

No data available for UniProtKB/Swiss-Prot for TBC1D31 Gene

Function for TBC1D31 Gene

Phenotypes From GWAS Catalog for TBC1D31 Gene

genes like me logo Genes that share phenotypes with TBC1D31: view

Animal Model Products

CRISPR Products

miRNA for TBC1D31 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBC1D31

Clone Products

  • Applied Biological Materials (abm): Clones for TBC1D31 - Now 50% OFF >
  • * TBC1D31 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TBC1D31 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBC1D31 Gene

Localization for TBC1D31 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBC1D31 gene
Compartment Confidence
cytoskeleton 5
nucleus 2
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TBC1D31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA,IBA 21399614
genes like me logo Genes that share ontologies with TBC1D31: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TBC1D31 Gene

Pathways & Interactions for TBC1D31 Gene

PathCards logo

SuperPathways for TBC1D31 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TBC1D31 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TBC1D31 Gene

Drugs & Compounds for TBC1D31 Gene

No Compound Related Data Available

Transcripts for TBC1D31 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBC1D31

Clone Products

  • Applied Biological Materials (abm): Clones for TBC1D31 - Now 50% OFF >
  • * TBC1D31 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TBC1D31 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D31 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4:
SP5: - - - -
SP6: - -
SP7: -
SP8: -
SP9: - - - - - - - - - - - - - -
SP10:
SP11: - -

ExUns: 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1:
SP2: -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TBC1D31 Gene

GeneLoc Exon Structure for
TBC1D31
ECgene alternative splicing isoforms for
TBC1D31

Expression for TBC1D31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TBC1D31 Gene

Protein differential expression in normal tissues from HIPED for TBC1D31 Gene

This gene is overexpressed in Platelet (50.5), Plasma (8.6), and Fetal Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TBC1D31 Gene



Protein tissue co-expression partners for TBC1D31 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TBC1D31 Gene:

TBC1D31

Evidence on tissue expression from TISSUES for TBC1D31 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with TBC1D31: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TBC1D31 Gene

Orthologs for TBC1D31 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBC1D31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR67 35 34
  • 99.62 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TBC1D31 35 34
  • 88.9 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TBC1D31 35 34
  • 88.79 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbc1d31 34
  • 83.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 83 (a)
OneToMany
-- 35
  • 78 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tbc1d31 17 35 34
  • 82.7 (n)
oppossum
(Monodelphis domestica)
Mammalia TBC1D31 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR67 34
  • 71.62 (n)
TBC1D31 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBC1D31 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tbc1d31 34
  • 65.88 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7579 34
zebrafish
(Danio rerio)
Actinopterygii tbc1d31 35 34
  • 60.9 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16896 35
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToOne
Cin.4658 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4658 34
Species where no ortholog for TBC1D31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBC1D31 Gene

ENSEMBL:
Gene Tree for TBC1D31 (if available)
TreeFam:
Gene Tree for TBC1D31 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TBC1D31: view image

Paralogs for TBC1D31 Gene

Paralogs for TBC1D31 Gene

(1) SIMAP similar genes for TBC1D31 Gene using alignment to 12 proteins:

  • TBC31_HUMAN
  • E5RFG6_HUMAN
  • E5RG45_HUMAN
  • E5RHC6_HUMAN
  • E5RI27_HUMAN
  • E5RI94_HUMAN
  • E7ERK7_HUMAN
  • E7ESI5_HUMAN
  • E7EWW7_HUMAN
  • F5GYF1_HUMAN
  • H0YCP2_HUMAN
  • H0YCY3_HUMAN
genes like me logo Genes that share paralogs with TBC1D31: view

Variants for TBC1D31 Gene

Sequence variations from dbSNP and Humsavar for TBC1D31 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000044187 -- 123,102,826(+) T/C intron_variant
rs1000060093 -- 123,126,236(+) T/C intron_variant
rs1000069025 -- 123,061,352(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000093734 -- 123,109,708(+) T/C intron_variant
rs1000116599 -- 123,103,933(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TBC1D31 Gene

Variant ID Type Subtype PubMed ID
esv3572973 CNV loss 25503493
nsv1015490 CNV loss 25217958
nsv1028933 CNV gain 25217958
nsv1032827 CNV gain 25217958

Variation tolerance for TBC1D31 Gene

Residual Variation Intolerance Score: 46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.73; 89.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TBC1D31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TBC1D31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D31 Gene

Disorders for TBC1D31 Gene

Additional Disease Information for TBC1D31

No disorders were found for TBC1D31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D31 Gene

Publications for TBC1D31 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Mapping the Genetic Landscape of Human Cells. (PMID: 30033366) Horlbeck MA … Gilbert LA (Cell 2018) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TBC1D31 Gene

  • Biorbyt antibodies for TBC1D31

Sources for TBC1D31 Gene

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