Aliases for TBC1D31 Gene

Aliases for TBC1D31 Gene

  • TBC1 Domain Family Member 31 2 3 4 5
  • WD Repeat-Containing Protein 67 3 4
  • WD Repeat Domain 67 2 3
  • WDR67 3 4
  • TBC1 Domain Family, Member 31 2
  • Gm85 3

External Ids for TBC1D31 Gene

Previous HGNC Symbols for TBC1D31 Gene

  • WDR67

Previous GeneCards Identifiers for TBC1D31 Gene

  • GC08P124055

Summaries for TBC1D31 Gene

GeneCards Summary for TBC1D31 Gene

TBC1D31 (TBC1 Domain Family Member 31) is a Protein Coding gene. An important paralog of this gene is WDR3.

Additional gene information for TBC1D31 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TBC1D31 Gene

Genomics for TBC1D31 Gene

GeneHancer (GH) Regulatory Elements for TBC1D31 Gene

Promoters and enhancers for TBC1D31 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TBC1D31 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TBC1D31

Genomic Locations for TBC1D31 Gene

Genomic Locations for TBC1D31 Gene
123,206 bases
Plus strand
110,186 bases
Plus strand

Genomic View for TBC1D31 Gene

Genes around TBC1D31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D31 Gene

Proteins for TBC1D31 Gene

  • Protein details for TBC1D31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TBC1 domain family member 31
    Protein Accession:
    Secondary Accessions:
    • B7ZL19
    • Q2M2J9
    • Q3MIR6
    • Q8TBP9

    Protein attributes for TBC1D31 Gene

    1066 amino acids
    Molecular mass:
    124189 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH27237.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TBC1D31 Gene


neXtProt entry for TBC1D31 Gene

Post-translational modifications for TBC1D31 Gene

  • Ubiquitination at Lys41, Lys682, Lys729, Lys782, Lys844, Lys833, Lys866, and Lys877
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TBC1D31 Gene

Domains & Families for TBC1D31 Gene

Gene Families for TBC1D31 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TBC1D31 Gene

GenScript: Design optimal peptide antigens:
  • WDR67 protein (B7ZL19_HUMAN)
  • WDR67 protein (Q3KRB0_HUMAN)
  • WDR67 protein (Q8TAK7_HUMAN)
  • WD repeat-containing protein 67 (WDR67_HUMAN)
genes like me logo Genes that share domains with TBC1D31: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TBC1D31 Gene

Function for TBC1D31 Gene

Phenotypes From GWAS Catalog for TBC1D31 Gene

genes like me logo Genes that share phenotypes with TBC1D31: view

Animal Model Products

CRISPR Products

miRNA for TBC1D31 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBC1D31

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBC1D31 Gene

Localization for TBC1D31 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBC1D31 gene
Compartment Confidence
cytoskeleton 5
nucleus 2
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TBC1D31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IBA,IDA 21399614
genes like me logo Genes that share ontologies with TBC1D31: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TBC1D31 Gene

Pathways & Interactions for TBC1D31 Gene

PathCards logo

SuperPathways for TBC1D31 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TBC1D31 Gene


No data available for Pathways by source and SIGNOR curated interactions for TBC1D31 Gene

Drugs & Compounds for TBC1D31 Gene

No Compound Related Data Available

Transcripts for TBC1D31 Gene

mRNA/cDNA for TBC1D31 Gene

15 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBC1D31

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D31 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: -
SP5: - - - -
SP6: - -
SP7: -
SP8: -
SP9: - - - - - - - - - - - - - -
SP11: - -

ExUns: 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
SP2: -
SP3: - -
SP4: -

Relevant External Links for TBC1D31 Gene

GeneLoc Exon Structure for

Expression for TBC1D31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TBC1D31 Gene

Protein differential expression in normal tissues from HIPED for TBC1D31 Gene

This gene is overexpressed in Platelet (50.5), Plasma (8.6), and Fetal Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TBC1D31 Gene

Protein tissue co-expression partners for TBC1D31 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TBC1D31

Evidence on tissue expression from TISSUES for TBC1D31 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with TBC1D31: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TBC1D31 Gene

Orthologs for TBC1D31 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBC1D31 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR67 31 30
  • 99.62 (n)
(Canis familiaris)
Mammalia TBC1D31 31 30
  • 88.9 (n)
(Bos Taurus)
Mammalia TBC1D31 31 30
  • 88.79 (n)
(Rattus norvegicus)
Mammalia Tbc1d31 30
  • 83.07 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 83 (a)
-- 31
  • 78 (a)
-- 31
  • 63 (a)
(Mus musculus)
Mammalia Tbc1d31 17 31 30
  • 82.7 (n)
(Monodelphis domestica)
Mammalia TBC1D31 31
  • 66 (a)
(Gallus gallus)
Aves WDR67 30
  • 71.62 (n)
TBC1D31 31
  • 67 (a)
(Anolis carolinensis)
Reptilia TBC1D31 31
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tbc1d31 30
  • 65.88 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7579 30
(Danio rerio)
Actinopterygii tbc1d31 31 30
  • 60.9 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG16896 31
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 50 (a)
Cin.4658 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4658 30
Species where no ortholog for TBC1D31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBC1D31 Gene

Gene Tree for TBC1D31 (if available)
Gene Tree for TBC1D31 (if available)
Evolutionary constrained regions (ECRs) for TBC1D31: view image

Paralogs for TBC1D31 Gene

Paralogs for TBC1D31 Gene

(1) SIMAP similar genes for TBC1D31 Gene using alignment to 12 proteins:

  • E5RG45_HUMAN
  • E5RI27_HUMAN
  • E5RI94_HUMAN
genes like me logo Genes that share paralogs with TBC1D31: view

Variants for TBC1D31 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TBC1D31 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs16897967 - p.Arg414His
rs16898023 - p.Val709Phe
rs34994118 - p.Ala1065Thr

Additional dbSNP identifiers (rs#s) for TBC1D31 Gene

Structural Variations from Database of Genomic Variants (DGV) for TBC1D31 Gene

Variant ID Type Subtype PubMed ID
esv3572973 CNV loss 25503493
nsv1015490 CNV loss 25217958
nsv1028933 CNV gain 25217958
nsv1032827 CNV gain 25217958

Variation tolerance for TBC1D31 Gene

Residual Variation Intolerance Score: 46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.73; 89.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TBC1D31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D31 Gene

Disorders for TBC1D31 Gene

Additional Disease Information for TBC1D31

No disorders were found for TBC1D31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D31 Gene

Publications for TBC1D31 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  4. Mapping the Genetic Landscape of Human Cells. (PMID: 30033366) Horlbeck MA … Gilbert LA (Cell 2018) 3 54
  5. A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway. (PMID: 30561431) Van Quickelberghe E … Gevaert K (Scientific data 2018) 3 54

Products for TBC1D31 Gene

  • Biorbyt antibodies for TBC1D31

Sources for TBC1D31 Gene