Aliases for TBC1D28 Gene

Aliases for TBC1D28 Gene

  • TBC1 Domain Family Member 28 2 3 4 5
  • TBC1 Domain Family, Member 28 2

External Ids for TBC1D28 Gene

Previous GeneCards Identifiers for TBC1D28 Gene

  • GC17M018480
  • GC17M018482
  • GC17M018538
  • GC17M018146
  • GC17M018635
  • GC17M018636
  • GC17M019038
  • GC17M019097
  • GC17M018687
  • GC17M018725
  • GC17M018764
  • GC17M018806
  • GC17M018850
  • GC17M018895
  • GC17M018938
  • GC17M018984

Summaries for TBC1D28 Gene

GeneCards Summary for TBC1D28 Gene

TBC1D28 (TBC1 Domain Family Member 28) is a Protein Coding gene. An important paralog of this gene is TBC1D26.

Additional gene information for TBC1D28 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TBC1D28 Gene

Genomics for TBC1D28 Gene

GeneHancer (GH) Regulatory Elements for TBC1D28 Gene


Top Transcription factor binding sites by QIAGEN in the TBC1D28 gene promoter:
  • AP-2gamma
  • c-Ets-1
  • CUTL1
  • HFH-1
  • Nkx3-1
  • Nkx3-1 v1
  • Pax-4a
  • Pax-6
  • RSRFC4
  • Spz1

Genomic Locations for TBC1D28 Gene

Genomic Locations for TBC1D28 Gene
chr17:18,634,434-18,644,433
(GRCh38/hg38)
Size:
10,000 bases
Orientation:
Minus strand
chr17:18,538,319-18,565,263
(GRCh37/hg19)
Size:
26,945 bases
Orientation:
Minus strand

Genomic View for TBC1D28 Gene

Genes around TBC1D28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D28 Gene

Proteins for TBC1D28 Gene

  • Protein details for TBC1D28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M2D7-TBC28_HUMAN
    Recommended name:
    TBC1 domain family member 28
    Protein Accession:
    Q2M2D7
    Secondary Accessions:
    • Q2M2E1

    Protein attributes for TBC1D28 Gene

    Size:
    210 amino acids
    Molecular mass:
    24072 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TBC1D28 Gene

Post-translational modifications for TBC1D28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TBC1D28 Gene

Domains & Families for TBC1D28 Gene

Gene Families for TBC1D28 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TBC1D28 Gene

Suggested Antigen Peptide Sequences for TBC1D28 Gene

GenScript: Design optimal peptide antigens:
  • TBC1 domain family member 28 (TBC28_HUMAN)
genes like me logo Genes that share domains with TBC1D28: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TBC1D28 Gene

Function for TBC1D28 Gene

Gene Ontology (GO) - Molecular Function for TBC1D28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA 21873635
GO:0017137 Rab GTPase binding IBA 21873635
genes like me logo Genes that share ontologies with TBC1D28: view

Phenotypes for TBC1D28 Gene

genes like me logo Genes that share phenotypes with TBC1D28: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBC1D28 Gene

Localization for TBC1D28 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBC1D28 gene
Compartment Confidence
cytosol 2
extracellular 1
mitochondrion 0

Gene Ontology (GO) - Cellular Components for TBC1D28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with TBC1D28: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TBC1D28 Gene

Pathways & Interactions for TBC1D28 Gene

PathCards logo

SuperPathways for TBC1D28 Gene

No Data Available

Interacting Proteins for TBC1D28 Gene

Gene Ontology (GO) - Biological Process for TBC1D28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0090630 activation of GTPase activity IBA 21873635
genes like me logo Genes that share ontologies with TBC1D28: view

No data available for Pathways by source and SIGNOR curated interactions for TBC1D28 Gene

Drugs & Compounds for TBC1D28 Gene

No Compound Related Data Available

Transcripts for TBC1D28 Gene

mRNA/cDNA for TBC1D28 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D28 Gene

No ASD Table

Relevant External Links for TBC1D28 Gene

GeneLoc Exon Structure for
TBC1D28
ECgene alternative splicing isoforms for
TBC1D28

Expression for TBC1D28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TBC1D28 Gene

mRNA differential expression in normal tissues according to GTEx for TBC1D28 Gene

This gene is overexpressed in Testis (x48.7).

Protein differential expression in normal tissues from HIPED for TBC1D28 Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TBC1D28 Gene



Protein tissue co-expression partners for TBC1D28 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TBC1D28 Gene:

TBC1D28

SOURCE GeneReport for Unigene cluster for TBC1D28 Gene:

Hs.434123

Evidence on tissue expression from TISSUES for TBC1D28 Gene

  • Kidney(3.2)
genes like me logo Genes that share expression patterns with TBC1D28: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TBC1D28 Gene

Orthologs for TBC1D28 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBC1D28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBC1D28 33
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 23 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 33
  • 20 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 18 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 33
  • 18 (a)
ManyToMany
-- 33
  • 16 (a)
ManyToMany
-- 33
  • 16 (a)
ManyToMany
-- 33
  • 15 (a)
ManyToMany
-- 33
  • 14 (a)
ManyToMany
-- 33
  • 14 (a)
ManyToMany
-- 33
  • 12 (a)
ManyToMany
-- 33
  • 2 (a)
ManyToMany
-- 33
  • 1 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 33
  • 18 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 21 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TBC1D3G 33
  • 6 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta RN-tre 33
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tbc-17 33
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 16 (a)
OneToMany
Species where no ortholog for TBC1D28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TBC1D28 Gene

ENSEMBL:
Gene Tree for TBC1D28 (if available)
TreeFam:
Gene Tree for TBC1D28 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TBC1D28: view image

Paralogs for TBC1D28 Gene

(8) SIMAP similar genes for TBC1D28 Gene using alignment to 5 proteins:

  • TBC28_HUMAN
  • I3L197_HUMAN
  • I3L433_HUMAN
  • I3L4T3_HUMAN
  • I3L502_HUMAN
genes like me logo Genes that share paralogs with TBC1D28: view

Variants for TBC1D28 Gene

Sequence variations from dbSNP and Humsavar for TBC1D28 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000065631 -- 18,642,092(-) G/A intron_variant
rs1000416866 -- 18,642,416(-) C/A intron_variant
rs1001477783 -- 18,640,648(-) C/T intron_variant
rs1001703409 -- 18,634,869(-) C/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1001757140 -- 18,634,194(-) AAAAAAAAAA/AAAAAAAA/AAAAAAAAA/AAAAAAAAAAA/AAAAAAAAAAAA downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TBC1D28 Gene

Variant ID Type Subtype PubMed ID
dgv3111n100 CNV gain 25217958
dgv3115n100 CNV gain 25217958
esv29176 CNV gain 19812545
esv3640158 CNV loss 21293372
esv3640159 CNV gain 21293372
nsv1057803 CNV loss 25217958
nsv1060744 CNV gain 25217958
nsv499818 OTHER inversion 21111241
nsv827913 CNV gain 20364138
nsv9504 CNV gain+loss 18304495
nsv960070 CNV duplication 23825009
nsv978379 CNV duplication 23825009

Variation tolerance for TBC1D28 Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TBC1D28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TBC1D28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D28 Gene

Disorders for TBC1D28 Gene

Additional Disease Information for TBC1D28

No disorders were found for TBC1D28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D28 Gene

Publications for TBC1D28 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 56

Products for TBC1D28 Gene

Sources for TBC1D28 Gene