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Aliases for TBC1D26 Gene

Aliases for TBC1D26 Gene

  • TBC1 Domain Family Member 26 2 3 5
  • TBC1 Domain Family, Member 26 2

External Ids for TBC1D26 Gene

Previous GeneCards Identifiers for TBC1D26 Gene

  • GC17P015577
  • GC17P015580
  • GC17P015635
  • GC17P015510

Summaries for TBC1D26 Gene

GeneCards Summary for TBC1D26 Gene

TBC1D26 (TBC1 Domain Family Member 26) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is TBC1D28.

UniProtKB/Swiss-Prot for TBC1D26 Gene

  • May act as a GTPase-activating protein for Rab family protein(s).

Additional gene information for TBC1D26 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D26 Gene

Genomics for TBC1D26 Gene

GeneHancer (GH) Regulatory Elements for TBC1D26 Gene

Promoters and enhancers for TBC1D26 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I015732 Promoter 0.6 EPDnew 550.8 +0.0 17 0.1 MNT TBC1D26 ENSG00000233002 ENSG00000255104
GH17I015699 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.4 -32.5 -32546 1.4 HDGF PKNOX1 CLOCK ATF1 ARID4B SIN3A BRCA1 ETS1 ZNF121 POLR2B ENSG00000255104 ZNF286A TBC1D26 GC17P015704
GH17I016406 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +675.5 675464 2.2 HDGF SMAD1 ZFP64 SIN3A FEZF1 YBX1 IRF4 ZNF213 ZNF207 ZNF548 PIGL PPIAP53 ENSG00000266538 NCOR1 TVP23C MPRIP-AS1 ZNF286A LOC644422 UPF3AP1 MPRIP
GH17I016385 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.3 +654.6 654627 2.7 FOXA2 ARID4B SIN3A DMAP1 ZNF2 POLR2B ZNF213 ZNF143 ZNF548 SP3 GC17M016375 PIGL ENSG00000266538 LOC644422 TVP23C PPIAP53 NCOR1 RPL13P12 ACTG1P24 TBC1D26
GH17I015683 Promoter/Enhancer 1.3 Ensembl ENCODE 10.1 -48.0 -47967 1 HDAC1 PKNOX1 ZNF133 ARID4B SIN3A ZNF76 DMAP1 ZBTB40 ETS1 ZNF335 TRIM16 TBC1D26 ZNF29P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TBC1D26 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TBC1D26 gene promoter:

Genomic Locations for TBC1D26 Gene

Genomic Locations for TBC1D26 Gene
16,946 bases
Plus strand

Genomic View for TBC1D26 Gene

Genes around TBC1D26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D26 Gene

Proteins for TBC1D26 Gene

  • Protein details for TBC1D26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TBC1 domain family member 26
    Protein Accession:
    Secondary Accessions:
    • A8K929
    • Q4G172

    Protein attributes for TBC1D26 Gene

    250 amino acids
    Molecular mass:
    28839 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TBC1D26 Gene


neXtProt entry for TBC1D26 Gene

Post-translational modifications for TBC1D26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TBC1D26 Gene

Domains & Families for TBC1D26 Gene

Gene Families for TBC1D26 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TBC1D26 Gene

Suggested Antigen Peptide Sequences for TBC1D26 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TBC1D26: view

No data available for UniProtKB/Swiss-Prot for TBC1D26 Gene

Function for TBC1D26 Gene

Molecular function for TBC1D26 Gene

UniProtKB/Swiss-Prot Function:
May act as a GTPase-activating protein for Rab family protein(s).

Gene Ontology (GO) - Molecular Function for TBC1D26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0017137 Rab GTPase binding IBA --
genes like me logo Genes that share ontologies with TBC1D26: view

Phenotypes for TBC1D26 Gene

GenomeRNAi human phenotypes for TBC1D26:
genes like me logo Genes that share phenotypes with TBC1D26: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TBC1D26 Gene

Localization for TBC1D26 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBC1D26 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TBC1D26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with TBC1D26: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TBC1D26 Gene

Pathways & Interactions for TBC1D26 Gene

SuperPathways for TBC1D26 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TBC1D26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0031338 regulation of vesicle fusion IBA --
GO:0090630 activation of GTPase activity IBA --
genes like me logo Genes that share ontologies with TBC1D26: view

No data available for Pathways by source and SIGNOR curated interactions for TBC1D26 Gene

Drugs & Compounds for TBC1D26 Gene

No Compound Related Data Available

Transcripts for TBC1D26 Gene

mRNA/cDNA for TBC1D26 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TBC1D26 Gene

TBC1 domain family, member 26:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D26 Gene

No ASD Table

Relevant External Links for TBC1D26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBC1D26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TBC1D26 Gene

mRNA differential expression in normal tissues according to GTEx for TBC1D26 Gene

This gene is overexpressed in Testis (x24.1) and Brain - Nucleus accumbens (basal ganglia) (x6.2).

NURSA nuclear receptor signaling pathways regulating expression of TBC1D26 Gene:


SOURCE GeneReport for Unigene cluster for TBC1D26 Gene:


Evidence on tissue expression from TISSUES for TBC1D26 Gene

  • Kidney(3.2)
genes like me logo Genes that share expression patterns with TBC1D26: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TBC1D26 Gene

Orthologs for TBC1D26 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBC1D26 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TBC1D26 33
  • 98 (n)
-- 34
  • 24 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 29 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 25 (a)
(Canis familiaris)
Mammalia -- 34
  • 22 (a)
-- 34
  • 22 (a)
-- 34
  • 21 (a)
-- 34
  • 21 (a)
-- 34
  • 19 (a)
-- 34
  • 19 (a)
-- 34
  • 17 (a)
-- 34
  • 15 (a)
-- 34
  • 2 (a)
(Bos Taurus)
Mammalia -- 34
  • 21 (a)
(Gallus gallus)
Aves -- 34
  • 22 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 27 (a)
(Danio rerio)
Actinopterygii TBC1D3G 34
  • 8 (a)
fruit fly
(Drosophila melanogaster)
Insecta RN-tre 34
  • 13 (a)
(Caenorhabditis elegans)
Secernentea tbc-17 34
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
Species where no ortholog for TBC1D26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TBC1D26 Gene

Gene Tree for TBC1D26 (if available)
Gene Tree for TBC1D26 (if available)

Paralogs for TBC1D26 Gene

(8) SIMAP similar genes for TBC1D26 Gene using alignment to 6 proteins: Pseudogenes for TBC1D26 Gene

genes like me logo Genes that share paralogs with TBC1D26: view

Variants for TBC1D26 Gene

Sequence variations from dbSNP and Humsavar for TBC1D26 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000015741 -- 15,734,789(+) A/G intron_variant
rs1000067971 -- 15,735,035(+) C/G 5_prime_UTR_variant
rs1000084231 -- 15,741,731(+) G/T intron_variant
rs1001190518 -- 15,734,587(+) G/T intron_variant
rs1002136316 -- 15,730,480(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TBC1D26 Gene

Variant ID Type Subtype PubMed ID
dgv3107n100 CNV gain 25217958
dgv562e214 CNV loss 21293372
esv2421582 CNV duplication 20811451
esv2715701 CNV deletion 23290073
esv29820 CNV gain+loss 19812545
esv3640083 CNV gain 21293372
esv3892969 CNV loss 25118596
esv3892972 CNV loss 25118596
nsv1149017 CNV duplication 26484159
nsv436847 CNV insertion 17901297
nsv516755 CNV loss 19592680
nsv518765 CNV loss 19592680
nsv520426 CNV loss 19592680
nsv524553 CNV loss 19592680
nsv960060 CNV duplication 23825009

Variation tolerance for TBC1D26 Gene

Residual Variation Intolerance Score: 92.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.46; 94.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TBC1D26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D26 Gene

Disorders for TBC1D26 Gene

Additional Disease Information for TBC1D26

No disorders were found for TBC1D26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D26 Gene

Publications for TBC1D26 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 58
  2. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. (PMID: 21244100) Virok DP … Fülöp L (Journal of proteome research 2011) 3 58
  3. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K … Fukuda M (Genes to cells : devoted to molecular & cellular mechanisms 2009) 3 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 58

Products for TBC1D26 Gene

Sources for TBC1D26 Gene

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