Aliases for TBC1D25 Gene
External Ids for TBC1D25 Gene
Previous HGNC Symbols for TBC1D25 Gene
Previous GeneCards Identifiers for TBC1D25 Gene
This gene encodes a protein with a TBC domain and functions as a Rab GTPase activating protein. The encoded protein is involved in the fusion of autophagosomes with endosomes and lysosomes. This gene was previously known as ornithine aminotransferase-like 1, but has no similarity to ornithine aminotransferase. [provided by RefSeq, Jan 2017]
GeneCards Summary for TBC1D25 Gene
TBC1D25 (TBC1 Domain Family Member 25) is a Protein Coding gene. Diseases associated with TBC1D25 include Oligospermia and Spindle Cell Synovial Sarcoma. Among its related pathways are Vesicle-mediated transport and TBC/RABGAPs. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is TBC1D16.
UniProtKB/Swiss-Prot Summary for TBC1D25 Gene
Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes.