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TBC1D10A (TBC1 Domain Family Member 10A) is a Protein Coding gene. Diseases associated with TBC1D10A include Hyperhidrosis, Gustatory. Among its related pathways are Vesicle-mediated transport and Deregulation of Rab and Rab Effector Genes in Bladder Cancer. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and PDZ domain binding. An important paralog of this gene is TBC1D10B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005085 | guanyl-nucleotide exchange factor activity | IEA | -- |
GO:0005096 | GTPase activator activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 11285285 |
GO:0030165 | PDZ domain binding | IPI | 11285285 |
GO:0031267 | small GTPase binding | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | IEA | -- |
GO:0005886 | plasma membrane | IDA | 17562788 |
GO:0005902 | microvillus | TAS | 11285285 |
GO:0042995 | cell projection | IEA | -- |
GO:0070062 | extracellular exosome | HDA | 19056867 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Vesicle-mediated transport | ||
2 | TBC/RABGAPs | ||
3 | Deregulation of Rab and Rab Effector Genes in Bladder Cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006886 | intracellular protein transport | IBA | 21873635 |
GO:0042147 | retrograde transport, endosome to Golgi | IMP | 17562788 |
GO:0045862 | positive regulation of proteolysis | IDA | 18387192 |
GO:0090630 | activation of GTPase activity | IBA | 21873635 |
GO:0097202 | activation of cysteine-type endopeptidase activity | IDA | 18387192 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||||||||||||||||
SP9: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TBC1D10A 30 |
|
||
Dog (Canis familiaris) |
Mammalia | TBC1D10A 30 |
|
||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | TBC1D10A 30 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Tbc1d10a 30 17 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Tbc1d10a 30 |
|
||
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
TBC1D10A 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tbc1d10a 30 |
|
||
Str.17286 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.10297 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tbc1d10a 30 31 |
|
ManyToMany | |
si:ch211-87l2.1 31 |
|
ManyToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | wkd 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | tbc-10 30 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MSB4 31 |
|
ManyToMany | |
MSB3 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6221 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs4823086 | - |
p.Arg411His |
Disorder | Aliases | PubMed IDs |
---|---|---|
hyperhidrosis, gustatory |
|
|