Aliases for TAX1BP3 Gene
External Ids for TAX1BP3 Gene
Previous GeneCards Identifiers for TAX1BP3 Gene
This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]
GeneCards Summary for TAX1BP3 Gene
TAX1BP3 (Tax1 Binding Protein 3) is a Protein Coding gene. Diseases associated with TAX1BP3 include Cholesterol Embolism and Intracranial Embolism. Among its related pathways are RHO GTPases Activate Rhotekin and Rhophilins and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include protein C-terminus binding and beta-catenin binding.
UniProtKB/Swiss-Prot for TAX1BP3 Gene
May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.