This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alterna... See more...

Aliases for TAX1BP1 Gene

Aliases for TAX1BP1 Gene

  • Tax1 Binding Protein 1 2 3 5
  • Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 1 2 3
  • Tax1-Binding Protein 1 3 4
  • TRAF6-Binding Protein 3 4
  • T6BP 3 4
  • CALCOCO3 3
  • TXBP151 3

External Ids for TAX1BP1 Gene

Previous GeneCards Identifiers for TAX1BP1 Gene

  • GC07P027422
  • GC07P027522
  • GC07P027553
  • GC07P027746

Summaries for TAX1BP1 Gene

Entrez Gene Summary for TAX1BP1 Gene

  • This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

GeneCards Summary for TAX1BP1 Gene

TAX1BP1 (Tax1 Binding Protein 1) is a Protein Coding gene. Among its related pathways are TNF signaling (REACTOME) and Apoptosis and Autophagy. Gene Ontology (GO) annotations related to this gene include kinase binding. An important paralog of this gene is CALCOCO1.

UniProtKB/Swiss-Prot Summary for TAX1BP1 Gene

  • Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.

Gene Wiki entry for TAX1BP1 Gene

Additional gene information for TAX1BP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAX1BP1 Gene

Genomics for TAX1BP1 Gene

GeneHancer (GH) Regulatory Elements for TAX1BP1 Gene

Promoters and enhancers for TAX1BP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J027736 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 762.3 +0.7 748 6.2 SIN3A ZBTB40 SP1 SMARCE1 POLR2A CREB1 HCFC1 MIXL1 MYC CC2D1A TAX1BP1 ENSG00000229893 LOC105375210 HIBADH LOC442292 piR-52261-252 piR-49423-245
GH07J027714 Enhancer 0.8 Ensembl ENCODE 18.5 -24.3 -24330 1.6 MAFK ZNF644 HMG20B PRDM10 GATAD2A SOX13 SAP130 TEAD1 TEAD3 HMG20A HIBADH TAX1BP1 ENSG00000229893 LOC442292 piR-57460-603 LOC105375211
GH07J027676 Enhancer 1.2 FANTOM5 Ensembl ENCODE 10.9 -60.9 -60930 3.6 SIN3A SMARCE1 HLF L3MBTL2 MAX MNT SP7 SMARCA4 POLR2A ATF1 HIBADH TAX1BP1 ENSG00000229893 piR-57133-540 LOC105375211
GH07J027606 Enhancer 1.4 UCNEbase Ensembl ENCODE 8.9 -131.7 -131729 4 CTCF ZBTB6 FOXA1 SMARCE1 CTBP1 NR2F6 HLF RAD21 SP1 ZNF384 HIBADH TAX1BP1 TSL piR-61945-451
GH07J027689 Enhancer 0.8 Ensembl ENCODE 11.7 -49.4 -49448 0.6 CTCF MYC MAX RAD21 MAFK REST ZNF585B ZNF316 FOXA2 SMC3 HIBADH TAX1BP1 ENSG00000229893 piR-57133-540 RF00017-6087 LOC105375211
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAX1BP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TAX1BP1 gene promoter:
  • AML1a
  • CREB
  • CUTL1
  • NF-kappaB1
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • POU6F1 (c2)
  • XBP-1

Genomic Locations for TAX1BP1 Gene

Genomic Locations for TAX1BP1 Gene
chr7:27,739,331-27,844,564
(GRCh38/hg38)
Size:
105,234 bases
Orientation:
Plus strand
chr7:27,778,950-27,884,183
(GRCh37/hg19)
Size:
105,234 bases
Orientation:
Plus strand

Genomic View for TAX1BP1 Gene

Genes around TAX1BP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAX1BP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAX1BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAX1BP1 Gene

Proteins for TAX1BP1 Gene

  • Protein details for TAX1BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VP1-TAXB1_HUMAN
    Recommended name:
    Tax1-binding protein 1
    Protein Accession:
    Q86VP1
    Secondary Accessions:
    • A4D196
    • B4DKU7
    • E7ENV2
    • O60398
    • O95770
    • Q13311
    • Q9BQG5
    • Q9UI88

    Protein attributes for TAX1BP1 Gene

    Size:
    789 amino acids
    Molecular mass:
    90877 Da
    Quaternary structure:
    • Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLV-1 protein Tax-1.
    SequenceCaution:
    • Sequence=AAC13359.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAX1BP1 Gene

    Alternative splice isoforms for TAX1BP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAX1BP1 Gene

Post-translational modifications for TAX1BP1 Gene

  • Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation.
  • Ubiquitination at Lys465 and Lys561
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TAX1BP1 Gene

Domains & Families for TAX1BP1 Gene

Gene Families for TAX1BP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TAX1BP1 Gene

Suggested Antigen Peptide Sequences for TAX1BP1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ95049, Homo sapiens Tax1 (human T-cell leukemia virus type I) bindingprotein 1 (TAX1BP1), mRNA (A4D196_HUMAN)
  • TRAF6-binding protein (TAXB1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86VP1

UniProtKB/Swiss-Prot:

TAXB1_HUMAN :
  • The C-terminal UBZ-type zinc fingers function as ubiquitin-binding domains.
Domain:
  • The C-terminal UBZ-type zinc fingers function as ubiquitin-binding domains.
genes like me logo Genes that share domains with TAX1BP1: view

Function for TAX1BP1 Gene

Molecular function for TAX1BP1 Gene

UniProtKB/Swiss-Prot Function:
Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.

Phenotypes From GWAS Catalog for TAX1BP1 Gene

Gene Ontology (GO) - Molecular Function for TAX1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10920205
GO:0019900 kinase binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TAX1BP1: view
genes like me logo Genes that share phenotypes with TAX1BP1: view

Animal Models for TAX1BP1 Gene

MGI Knock Outs for TAX1BP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAX1BP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAX1BP1 Gene

Localization for TAX1BP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAX1BP1 gene
Compartment Confidence
cytosol 5
nucleus 3
cytoskeleton 1
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAX1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 18570454
genes like me logo Genes that share ontologies with TAX1BP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAX1BP1 Gene

Pathways & Interactions for TAX1BP1 Gene

genes like me logo Genes that share pathways with TAX1BP1: view

Pathways by source for TAX1BP1 Gene

2 Cell Signaling Technology pathways for TAX1BP1 Gene

SIGNOR curated interactions for TAX1BP1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TAX1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway TAS --
GO:0032088 negative regulation of NF-kappaB transcription factor activity ISS --
GO:0032480 negative regulation of type I interferon production TAS --
GO:0043066 negative regulation of apoptotic process IEA,TAS --
genes like me logo Genes that share ontologies with TAX1BP1: view

Drugs & Compounds for TAX1BP1 Gene

No Compound Related Data Available

Transcripts for TAX1BP1 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAX1BP1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAX1BP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: - - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6: - - - - -

Relevant External Links for TAX1BP1 Gene

GeneLoc Exon Structure for
TAX1BP1
ECgene alternative splicing isoforms for
TAX1BP1

Expression for TAX1BP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAX1BP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TAX1BP1 Gene

This gene is overexpressed in Uterus (27.8) and Cardia (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAX1BP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of TAX1BP1 Gene:

TAX1BP1

SOURCE GeneReport for Unigene cluster for TAX1BP1 Gene:

Hs.34576

mRNA Expression by UniProt/SwissProt for TAX1BP1 Gene:

Q86VP1-TAXB1_HUMAN
Tissue specificity: Expressed in all tissues tested.

Evidence on tissue expression from TISSUES for TAX1BP1 Gene

  • Nervous system(4.9)
  • Skin(4.6)
  • Liver(4.4)
  • Lung(3.4)
  • Kidney(3)
  • Intestine(2.6)
  • Heart(2.2)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with TAX1BP1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAX1BP1 Gene

Orthologs for TAX1BP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAX1BP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAX1BP1 33 32
  • 99.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TAX1BP1 33 32
  • 92.34 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TAX1BP1 33 32
  • 91.68 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tax1bp1 17 33 32
  • 87.04 (n)
rat
(Rattus norvegicus)
Mammalia Tax1bp1 32
  • 87 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 79 (a)
OneToMany
-- 33
  • 76 (a)
OneToMany
-- 33
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TAX1BP1 33
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAX1BP1 33 32
  • 76.28 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAX1BP1 33
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tax1bp1 32
  • 68.89 (n)
MGC76179 32
zebrafish
(Danio rerio)
Actinopterygii tax1bp1b 33 32
  • 59.41 (n)
OneToMany
tax1bp1a 33
  • 45 (a)
OneToMany
wufc20c12 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10595 32
sea squirt
(Ciona savignyi)
Ascidiacea CSA.823 33
  • 23 (a)
OneToMany
Species where no ortholog for TAX1BP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAX1BP1 Gene

ENSEMBL:
Gene Tree for TAX1BP1 (if available)
TreeFam:
Gene Tree for TAX1BP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAX1BP1: view image

Paralogs for TAX1BP1 Gene

Paralogs for TAX1BP1 Gene

(2) SIMAP similar genes for TAX1BP1 Gene using alignment to 9 proteins:

  • TAXB1_HUMAN
  • A4D196_HUMAN
  • B8ZZD4_HUMAN
  • C9J7J4_HUMAN
  • C9JBZ7_HUMAN
  • F8WBU9_HUMAN
  • H7C3L5_HUMAN
  • L8E7U3_HUMAN
  • V9GZ06_HUMAN
genes like me logo Genes that share paralogs with TAX1BP1: view

Variants for TAX1BP1 Gene

Sequence variations from dbSNP and Humsavar for TAX1BP1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
VAR_035665 A breast cancer sample p.Gln457Arg
rs1000018181 -- 27,792,367(+) A/G intron_variant
rs1000026536 -- 27,750,056(+) G/T intron_variant
rs1000079904 -- 27,741,222(+) C/A intron_variant
rs1000082591 -- 27,770,355(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TAX1BP1 Gene

Variant ID Type Subtype PubMed ID
dgv3517n106 CNV deletion 24896259
esv1133870 CNV deletion 17803354
esv2172029 CNV deletion 18987734
esv2603706 CNV deletion 19546169
esv2734172 CNV deletion 23290073
esv2759520 CNV loss 17122850
esv3449561 CNV insertion 20981092
esv3541379 CNV deletion 23714750
esv3891091 CNV gain 25118596
esv989626 CNV insertion 20482838
esv993269 CNV deletion 20482838
nsv1018550 CNV gain 25217958
nsv1030685 CNV loss 25217958
nsv1075020 CNV deletion 25765185
nsv1153740 CNV deletion 26484159
nsv5677 CNV deletion 18451855
nsv7393 OTHER inversion 18451855
nsv957620 CNV deletion 24416366

Variation tolerance for TAX1BP1 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.32; 63.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAX1BP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAX1BP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAX1BP1 Gene

Disorders for TAX1BP1 Gene

Additional Disease Information for TAX1BP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TAX1BP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAX1BP1 Gene

Publications for TAX1BP1 Gene

  1. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. (PMID: 10435631) De Valck D … Beyaert R (Oncogene 1999) 2 3 4 56
  2. The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1. (PMID: 21765415) Shembade N … Harhaj EW (Nature immunology 2011) 3 4 56
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 43 56
  4. Analysis of the TAX1BP1 gene in head and neck cancer patients. (PMID: 20549079) Ruiz MT … Goloni-Bertollo EM (Brazilian journal of otorhinolaryngology 2010) 3 43 56
  5. NRP/Optineurin Cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein. (PMID: 19609363) Journo C … Weil R (PLoS pathogens 2009) 3 23 56

Products for TAX1BP1 Gene

Sources for TAX1BP1 Gene