Aliases for TATDN3 Gene

Aliases for TATDN3 Gene

  • TatD DNase Domain Containing 3 2 3 5
  • Putative Deoxyribonuclease TATDN3 3 4
  • EC 3.1.21.- 4
  • EC 3.1.21 51
  • TATDN3 5

External Ids for TATDN3 Gene

Previous GeneCards Identifiers for TATDN3 Gene

  • GC01P209354
  • GC01P211031
  • GC01P212965
  • GC01P183641

Summaries for TATDN3 Gene

GeneCards Summary for TATDN3 Gene

TATDN3 (TatD DNase Domain Containing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include deoxyribonuclease activity and endodeoxyribonuclease activity, producing 5'-phosphomonoesters. An important paralog of this gene is TATDN2.

UniProtKB/Swiss-Prot Summary for TATDN3 Gene

Additional gene information for TATDN3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TATDN3 Gene

Genomics for TATDN3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TATDN3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TATDN3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TATDN3

Top Transcription factor binding sites by QIAGEN in the TATDN3 gene promoter:
  • AML1a
  • Cart-1
  • FOXO3
  • FOXO3a
  • FOXO3b
  • FOXO4
  • POU2F1
  • POU2F1a
  • RORalpha1
  • XBP-1

Genomic Locations for TATDN3 Gene

Genomic Locations for TATDN3 Gene
chr1:212,791,828-212,816,830
(GRCh38/hg38)
Size:
25,003 bases
Orientation:
Plus strand
chr1:212,965,170-212,990,167
(GRCh37/hg19)
Size:
24,998 bases
Orientation:
Plus strand

Genomic View for TATDN3 Gene

Genes around TATDN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TATDN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TATDN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TATDN3 Gene

Proteins for TATDN3 Gene

  • Protein details for TATDN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17R31-TATD3_HUMAN
    Recommended name:
    Putative deoxyribonuclease TATDN3
    Protein Accession:
    Q17R31
    Secondary Accessions:
    • A6NGS3
    • B7Z1C1
    • B7Z978
    • B7ZLQ6
    • E9PJE5
    • E9PNH3
    • G3V151
    • Q4G0L1

    Protein attributes for TATDN3 Gene

    Size:
    274 amino acids
    Molecular mass:
    30333 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH48115.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TATDN3 Gene

    Alternative splice isoforms for TATDN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TATDN3 Gene

Selected DME Specific Peptides for TATDN3 Gene

Q17R31:
  • AIGEVGL
  • PSVAMEGV

Post-translational modifications for TATDN3 Gene

  • Ubiquitination at Lys123
  • Modification sites at PhosphoSitePlus

Domains & Families for TATDN3 Gene

Gene Families for TATDN3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TATDN3 Gene

InterPro:
Blocks:
  • TatD-related deoxyribonuclease
ProtoNet:

Suggested Antigen Peptide Sequences for TATDN3 Gene

GenScript: Design optimal peptide antigens:
  • Putative deoxyribonuclease TATDN3 (TATD3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q17R31

UniProtKB/Swiss-Prot:

TATD3_HUMAN :
  • Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
Family:
  • Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
genes like me logo Genes that share domains with TATDN3: view

Function for TATDN3 Gene

Molecular function for TATDN3 Gene

UniProtKB/Swiss-Prot Function:
Putative deoxyribonuclease.

Enzyme Numbers (IUBMB) for TATDN3 Gene

Phenotypes From GWAS Catalog for TATDN3 Gene

Gene Ontology (GO) - Molecular Function for TATDN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004518 nuclease activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016788 hydrolase activity, acting on ester bonds IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TATDN3: view
genes like me logo Genes that share phenotypes with TATDN3: view

Animal Models for TATDN3 Gene

MGI Knock Outs for TATDN3:
  • Tatdn3 Tatdn3<tm1a(EUCOMM)Wtsi>
  • Tatdn3 Tatdn3<tm1b(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for TATDN3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TATDN3

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TATDN3 Gene

Localization for TATDN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TATDN3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TATDN3 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
mitochondrion 2
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TATDN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TATDN3: view

Pathways & Interactions for TATDN3 Gene

PathCards logo

SuperPathways for TATDN3 Gene

No Data Available

Interacting Proteins for TATDN3 Gene

Gene Ontology (GO) - Biological Process for TATDN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with TATDN3: view

No data available for Pathways by source and SIGNOR curated interactions for TATDN3 Gene

Drugs & Compounds for TATDN3 Gene

No Compound Related Data Available

Transcripts for TATDN3 Gene

mRNA/cDNA for TATDN3 Gene

7 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TATDN3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TATDN3 Gene

No ASD Table

Relevant External Links for TATDN3 Gene

GeneLoc Exon Structure for
TATDN3

Expression for TATDN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TATDN3 Gene

Protein differential expression in normal tissues from HIPED for TATDN3 Gene

This gene is overexpressed in Heart (27.5) and Cervix (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TATDN3 Gene



Protein tissue co-expression partners for TATDN3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TATDN3

SOURCE GeneReport for Unigene cluster for TATDN3 Gene:

Hs.530538

Evidence on tissue expression from TISSUES for TATDN3 Gene

  • Nervous system(4.6)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with TATDN3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TATDN3 Gene

Orthologs for TATDN3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TATDN3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TATDN3 30 31
  • 99.64 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TATDN3 30 31
  • 91.12 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TATDN3 30 31
  • 90.96 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TATDN3 31
  • 86 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tatdn3 30
  • 85.68 (n)
Mouse
(Mus musculus)
Mammalia Tatdn3 30 17 31
  • 85.19 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TATDN3 31
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TATDN3 30 31
  • 73.73 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TATDN3 31
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tatdn3 30
  • 70.16 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC571912 30
  • 67.05 (n)
TATDN3 31
  • 67 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea B0432.8 30 31
  • 48.69 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT3G03500 30
  • 45.34 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 59 (a)
OneToOne
Species where no ortholog for TATDN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TATDN3 Gene

ENSEMBL:
Gene Tree for TATDN3 (if available)
TreeFam:
Gene Tree for TATDN3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TATDN3: view image

Paralogs for TATDN3 Gene

Paralogs for TATDN3 Gene

genes like me logo Genes that share paralogs with TATDN3: view

Variants for TATDN3 Gene

Additional dbSNP identifiers (rs#s) for TATDN3 Gene

Structural Variations from Database of Genomic Variants (DGV) for TATDN3 Gene

Variant ID Type Subtype PubMed ID
esv2758997 CNV loss 17122850
nsv1010003 CNV gain 25217958

Variation tolerance for TATDN3 Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TATDN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TATDN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TATDN3 Gene

Disorders for TATDN3 Gene

Additional Disease Information for TATDN3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for TATDN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TATDN3 Gene

Publications for TATDN3 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
  2. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard TR … Colinge J (BMC systems biology 2011) 4

Products for TATDN3 Gene

Sources for TATDN3 Gene