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Aliases for TATDN3 Gene

Aliases for TATDN3 Gene

  • TatD DNase Domain Containing 3 2 3 5
  • EC 3.1.21.- 4
  • EC 3.1.21 56

External Ids for TATDN3 Gene

Previous GeneCards Identifiers for TATDN3 Gene

  • GC01P209354
  • GC01P211031
  • GC01P212965
  • GC01P183641

Summaries for TATDN3 Gene

GeneCards Summary for TATDN3 Gene

TATDN3 (TatD DNase Domain Containing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include deoxyribonuclease activity and endodeoxyribonuclease activity, producing 5-phosphomonoesters.

UniProtKB/Swiss-Prot for TATDN3 Gene

  • Putative deoxyribonuclease.

Additional gene information for TATDN3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TATDN3 Gene

Genomics for TATDN3 Gene

GeneHancer (GH) Regulatory Elements for TATDN3 Gene

Promoters and enhancers for TATDN3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I212789 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 575.9 -0.2 -231 4.4 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 TATDN3 NSL1 FLVCR1 FLVCR1-AS1 ANGEL2 RPL21P28 RPS28P2 ENSG00000235182 VASH2 BATF3
GH01I212856 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11 +67.2 67191 4.5 CLOCK FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC FLVCR1-AS1 FLVCR1 ANGEL2 TATDN3 SPATA45 GC01M212767 GC01P212844
GH01I212793 Enhancer 1.2 Ensembl ENCODE 18.9 +2.7 2701 1.4 HDGF PKNOX1 SMAD1 FOXA2 ARNT IRF4 YY1 ZNF766 E2F8 ZNF143 FLVCR1-AS1 TATDN3 FLVCR1 SPATA45 RPS5P4 GC01M212767
GH01I212749 Enhancer 1 Ensembl ENCODE 20.5 -41.7 -41709 1.4 YBX3 ELF3 HDGF ARNT MZF1 YBX1 IRF4 RAD21 RFX5 ZNF143 TATDN3 SNORA16B BATF3 ANGEL2 FLVCR1 PIR52879 NSL1
GH01I212727 Enhancer 1 ENCODE dbSUPER 20.4 -63.5 -63502 2.4 ELF3 FOXA2 ARID4B RAD21 ZNF48 RARA RUNX3 THAP11 MIXL1 KLF11 PIR52879 TATDN3 FLVCR1-AS1 BATF3 SPATA45 NSL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TATDN3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TATDN3 gene promoter:

Genomic Locations for TATDN3 Gene

Genomic Locations for TATDN3 Gene
24,998 bases
Plus strand

Genomic View for TATDN3 Gene

Genes around TATDN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TATDN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TATDN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TATDN3 Gene

Proteins for TATDN3 Gene

  • Protein details for TATDN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative deoxyribonuclease TATDN3
    Protein Accession:
    Secondary Accessions:
    • A6NGS3
    • B7Z1C1
    • B7Z978
    • B7ZLQ6
    • E9PJE5
    • E9PNH3
    • G3V151
    • Q4G0L1

    Protein attributes for TATDN3 Gene

    274 amino acids
    Molecular mass:
    30333 Da
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available
    • Sequence=AAH48115.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TATDN3 Gene

    Alternative splice isoforms for TATDN3 Gene


neXtProt entry for TATDN3 Gene

Selected DME Specific Peptides for TATDN3 Gene


Post-translational modifications for TATDN3 Gene

  • Ubiquitination at posLast=123123
  • Modification sites at PhosphoSitePlus

Domains & Families for TATDN3 Gene

Gene Families for TATDN3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TATDN3 Gene

Suggested Antigen Peptide Sequences for TATDN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
  • Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
genes like me logo Genes that share domains with TATDN3: view

Function for TATDN3 Gene

Molecular function for TATDN3 Gene

UniProtKB/Swiss-Prot Function:
Putative deoxyribonuclease.

Enzyme Numbers (IUBMB) for TATDN3 Gene

Phenotypes From GWAS Catalog for TATDN3 Gene

Gene Ontology (GO) - Molecular Function for TATDN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004518 nuclease activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016788 hydrolase activity, acting on ester bonds IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TATDN3: view
genes like me logo Genes that share phenotypes with TATDN3: view

Animal Models for TATDN3 Gene

MGI Knock Outs for TATDN3:

Animal Model Products

  • Taconic Biosciences Mouse Models for TATDN3

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TATDN3 Gene

Localization for TATDN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TATDN3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TATDN3 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 3
mitochondrion 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TATDN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TATDN3: view

Pathways & Interactions for TATDN3 Gene

SuperPathways for TATDN3 Gene

No Data Available

Interacting Proteins for TATDN3 Gene

Gene Ontology (GO) - Biological Process for TATDN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with TATDN3: view

No data available for Pathways by source and SIGNOR curated interactions for TATDN3 Gene

Drugs & Compounds for TATDN3 Gene

No Compound Related Data Available

Transcripts for TATDN3 Gene

Unigene Clusters for TATDN3 Gene

TatD DNase domain containing 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TATDN3 Gene

No ASD Table

Relevant External Links for TATDN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TATDN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TATDN3 Gene

Protein differential expression in normal tissues from HIPED for TATDN3 Gene

This gene is overexpressed in Heart (27.5) and Cervix (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TATDN3 Gene

Protein tissue co-expression partners for TATDN3 Gene

NURSA nuclear receptor signaling pathways regulating expression of TATDN3 Gene:


SOURCE GeneReport for Unigene cluster for TATDN3 Gene:


Evidence on tissue expression from TISSUES for TATDN3 Gene

  • Nervous system(4.6)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with TATDN3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TATDN3 Gene

Orthologs for TATDN3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TATDN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TATDN3 33 34
  • 99.64 (n)
(Canis familiaris)
Mammalia TATDN3 33 34
  • 91.12 (n)
(Bos Taurus)
Mammalia TATDN3 33 34
  • 90.96 (n)
(Monodelphis domestica)
Mammalia TATDN3 34
  • 86 (a)
(Rattus norvegicus)
Mammalia Tatdn3 33
  • 85.68 (n)
(Mus musculus)
Mammalia Tatdn3 33 16 34
  • 85.19 (n)
(Ornithorhynchus anatinus)
Mammalia TATDN3 34
  • 80 (a)
(Gallus gallus)
Aves TATDN3 33 34
  • 73.73 (n)
(Anolis carolinensis)
Reptilia TATDN3 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tatdn3 33
  • 70.16 (n)
(Danio rerio)
Actinopterygii LOC571912 33
  • 67.05 (n)
  • 67 (a)
(Caenorhabditis elegans)
Secernentea B0432.8 33 34
  • 48.69 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G03500 33
  • 45.34 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 59 (a)
Species where no ortholog for TATDN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TATDN3 Gene

Gene Tree for TATDN3 (if available)
Gene Tree for TATDN3 (if available)

Paralogs for TATDN3 Gene

No data available for Paralogs for TATDN3 Gene

Variants for TATDN3 Gene

Sequence variations from dbSNP and Humsavar for TATDN3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000018291 -- 212,795,385(+) C/G intron_variant
rs1000023862 -- 212,790,040(+) G/C upstream_transcript_variant
rs1000527446 -- 212,799,928(+) C/A intron_variant
rs1000619424 -- 212,813,831(+) CTC/C intron_variant
rs1000671881 -- 212,813,488(+) TAT/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TATDN3 Gene

Variant ID Type Subtype PubMed ID
esv2758997 CNV loss 17122850
nsv1010003 CNV gain 25217958

Variation tolerance for TATDN3 Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TATDN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TATDN3 Gene

Disorders for TATDN3 Gene

Additional Disease Information for TATDN3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TATDN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TATDN3 Gene

Publications for TATDN3 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard TR … Colinge J (BMC systems biology 2011) 4 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for TATDN3 Gene

Sources for TATDN3 Gene

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