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Aliases for TATDN2 Gene

Aliases for TATDN2 Gene

  • TatD DNase Domain Containing 2 2 3 5
  • EC 3.1.21.- 4
  • KIAA0218 4

External Ids for TATDN2 Gene

Previous GeneCards Identifiers for TATDN2 Gene

  • GC03P010266
  • GC03P010267
  • GC03P010225
  • GC03P010289

Summaries for TATDN2 Gene

GeneCards Summary for TATDN2 Gene

TATDN2 (TatD DNase Domain Containing 2) is a Protein Coding gene. Among its related pathways are Unfolded Protein Response (UPR) and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include deoxyribonuclease activity and endodeoxyribonuclease activity, producing 5-phosphomonoesters. An important paralog of this gene is ENSG00000272410.

UniProtKB/Swiss-Prot for TATDN2 Gene

  • Putative deoxyribonuclease.

Additional gene information for TATDN2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TATDN2 Gene

Genomics for TATDN2 Gene

GeneHancer (GH) Regulatory Elements for TATDN2 Gene

Promoters and enhancers for TATDN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I010247 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.2 1203 3 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000272410 PIR49172 PIR32642 PIR57492 PIR36484 PIR45247 TATDN2 GHRLOS GHRL IRAK2
GH03I010188 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 26.9 -53.2 -53178 12.1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 POLR2B BRPF1 SETD5 IRAK2 GHRLOS LINC00852 TATDN2 FANCD2 GHRL TTLL3 SEC13
GH03I009394 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.9 -849.0 -849032 9.8 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SETD5 THUMPD3-AS1 GC03P009403 BRPF1 RAD18 GHRLOS TTLL3 FANCD2 JAGN1 SEC13
GH03I010201 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.9 -43.5 -43502 6.7 FOXA2 MLX ZFP64 ARID4B DMAP1 ETS1 YY1 FOS RXRA REST GC03M010202 IRAK2 TATDN2 VHL GHRLOS ARPC4 FANCD2OS GHRL SEC13 CAMK1
GH03I010185 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 14.1 -61.1 -61069 2.5 SMARCE1 HDAC1 RFX1 SOX6 GABPA ZNF766 POLR2A HDAC2 MYNN ZNF239 IRAK2 GHRLOS TATDN2 GHRL FANCD2OS LINC00852 VHL GC03M010202
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TATDN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TATDN2 gene promoter:

Genomic Locations for TATDN2 Gene

Genomic Locations for TATDN2 Gene
chr3:10,248,023-10,281,222
(GRCh38/hg38)
Size:
33,200 bases
Orientation:
Plus strand
chr3:10,289,707-10,322,906
(GRCh37/hg19)

Genomic View for TATDN2 Gene

Genes around TATDN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TATDN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TATDN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TATDN2 Gene

Proteins for TATDN2 Gene

  • Protein details for TATDN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93075-TATD2_HUMAN
    Recommended name:
    Putative deoxyribonuclease TATDN2
    Protein Accession:
    Q93075
    Secondary Accessions:
    • Q3MIL9
    • Q5BKU0

    Protein attributes for TATDN2 Gene

    Size:
    761 amino acids
    Molecular mass:
    85023 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13208.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TATDN2 Gene

Post-translational modifications for TATDN2 Gene

No Post-translational modifications

Other Protein References for TATDN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TATDN2 Gene

Domains & Families for TATDN2 Gene

Gene Families for TATDN2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TATDN2 Gene

Suggested Antigen Peptide Sequences for TATDN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q93075

UniProtKB/Swiss-Prot:

TATD2_HUMAN :
  • Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
Family:
  • Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
genes like me logo Genes that share domains with TATDN2: view

Function for TATDN2 Gene

Molecular function for TATDN2 Gene

UniProtKB/Swiss-Prot Function:
Putative deoxyribonuclease.

Enzyme Numbers (IUBMB) for TATDN2 Gene

Phenotypes From GWAS Catalog for TATDN2 Gene

Gene Ontology (GO) - Molecular Function for TATDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004536 deoxyribonuclease activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0016788 hydrolase activity, acting on ester bonds IEA --
GO:0016888 endodeoxyribonuclease activity, producing 5-phosphomonoesters IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TATDN2: view
genes like me logo Genes that share phenotypes with TATDN2: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TATDN2 Gene

Localization for TATDN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TATDN2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TATDN2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleus (3)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TATDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IDA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with TATDN2: view

Pathways & Interactions for TATDN2 Gene

genes like me logo Genes that share pathways with TATDN2: view

Gene Ontology (GO) - Biological Process for TATDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006259 DNA metabolic process IEA --
GO:0006308 DNA catabolic process IBA --
GO:0036498 IRE1-mediated unfolded protein response TAS --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with TATDN2: view

No data available for SIGNOR curated interactions for TATDN2 Gene

Drugs & Compounds for TATDN2 Gene

No Compound Related Data Available

Transcripts for TATDN2 Gene

Unigene Clusters for TATDN2 Gene

TatD DNase domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TATDN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for TATDN2 Gene

GeneLoc Exon Structure for
TATDN2
ECgene alternative splicing isoforms for
TATDN2

Expression for TATDN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TATDN2 Gene

Protein differential expression in normal tissues from HIPED for TATDN2 Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TATDN2 Gene



Protein tissue co-expression partners for TATDN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TATDN2 Gene:

TATDN2

SOURCE GeneReport for Unigene cluster for TATDN2 Gene:

Hs.475401

Evidence on tissue expression from TISSUES for TATDN2 Gene

  • Nervous system(4.7)
  • Bone marrow(4.2)
genes like me logo Genes that share expression patterns with TATDN2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TATDN2 Gene

Orthologs for TATDN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TATDN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TATDN2 33 34
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia TATDN2 33
  • 87.29 (n)
-- 34
  • 84 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TATDN2 33
  • 81.84 (n)
-- 34
  • 78 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tatdn2 33
  • 78.03 (n)
mouse
(Mus musculus)
Mammalia Tatdn2 33 16 34
  • 77.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 67 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 45 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tatdn2 33
  • 59.27 (n)
zebrafish
(Danio rerio)
Actinopterygii tatdn2 34
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3308 34
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y24F12A.1 34
  • 27 (a)
ManyToMany
Y37H2A.1 34
  • 26 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 15 (a)
OneToMany
Species where no ortholog for TATDN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TATDN2 Gene

ENSEMBL:
Gene Tree for TATDN2 (if available)
TreeFam:
Gene Tree for TATDN2 (if available)

Paralogs for TATDN2 Gene

Paralogs for TATDN2 Gene

Pseudogenes.org Pseudogenes for TATDN2 Gene

genes like me logo Genes that share paralogs with TATDN2: view

Variants for TATDN2 Gene

Sequence variations from dbSNP and Humsavar for TATDN2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000046008 -- 10,267,575(+) G/A intron_variant
rs1000081783 -- 10,266,601(+) A/G intron_variant
rs1000161179 -- 10,248,758(+) G/A 5_prime_UTR_variant
rs1000222636 -- 10,273,438(+) T/C intron_variant
rs1000334155 -- 10,254,023(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TATDN2 Gene

Variant ID Type Subtype PubMed ID
nsv589650 CNV loss 21841781
nsv508903 CNV insertion 20534489
nsv460420 CNV loss 19166990
nsv436869 CNV insertion 17901297
nsv436362 CNV deletion 17901297
nsv236904 CNV deletion 16902084
nsv1121603 CNV deletion 24896259
nsv1073204 CNV deletion 25765185
esv4117 OTHER complex 18987735
dgv762e201 CNV deletion 23290073

Variation tolerance for TATDN2 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.33; 85.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TATDN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TATDN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TATDN2 Gene

Disorders for TATDN2 Gene

Additional Disease Information for TATDN2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TATDN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TATDN2 Gene

Publications for TATDN2 Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 2 3 4 58
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. (PMID: 24129315) Guo A … Comb MJ (Molecular & cellular proteomics : MCP 2014) 4 58

Products for TATDN2 Gene

Sources for TATDN2 Gene

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