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Aliases for TATDN1 Gene

Aliases for TATDN1 Gene

  • TatD DNase Domain Containing 1 2 3 5
  • Hepatocarcinoma High Expression Protein 3 4
  • Putative Deoxyribonuclease TATDN1 3 4
  • EC 3.1.21.- 4
  • EC 3.1.21 56
  • CDA11 3

External Ids for TATDN1 Gene

Previous GeneCards Identifiers for TATDN1 Gene

  • GC08M125458
  • GC08M125569
  • GC08M125500
  • GC08M120826

Summaries for TATDN1 Gene

GeneCards Summary for TATDN1 Gene

TATDN1 (TatD DNase Domain Containing 1) is a Protein Coding gene. Diseases associated with TATDN1 include Lung Cancer and Sporadic Pheochromocytoma. Gene Ontology (GO) annotations related to this gene include deoxyribonuclease activity and endodeoxyribonuclease activity, producing 5'-phosphomonoesters. An important paralog of this gene is TATDN2.

UniProtKB/Swiss-Prot for TATDN1 Gene

Additional gene information for TATDN1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TATDN1 Gene

Genomics for TATDN1 Gene

GeneHancer (GH) Regulatory Elements for TATDN1 Gene

Promoters and enhancers for TATDN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J124537 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 611.1 +0.2 157 4.2 MTA3 ZNF652 CTCF ZFX ELF3 MNT NKRF POLR2A MLLT1 ZNF121 TATDN1 NDUFB9 TRMT12 WASHC5-AS1 RNF139-AS1 FAM91A1 NSMCE2 WASHC5 ENSG00000253106 RNF139
GH08J124724 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 18.7 -187.8 -187767 4.8 MNT POLR2A SP1 GLIS2 ZBTB8A ZBTB33 PRDM10 ZIC2 GATAD2A CTCF MTSS1 LOC105375741 TATDN1 NSMCE2 GC08P124718
GH08J125270 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 22.8 -733.1 -733143 4.3 ZNF121 CEBPG ZNF384 ZSCAN21 NCOA3 BACH1 MAFK TRIM24 SP7 PPARG RN7SL329P TRIB1 TATDN1 RNF139-AS1 ENSG00000253106 WASHC5-AS1 NSMCE2 ENSG00000254431 TRMT12 WASHC5
GH08J125090 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.6 -552.3 -552343 3.2 SP1 ZNF652 CC2D1A ZFX ELF3 MNT SIX5 CBFA2T2 NKRF POLR2A NSMCE2 WASHC5 ENSG00000253106 TATDN1 TRMT12 WASHC5-AS1 RNF139-AS1 LINC00964
GH08J124471 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.7 +65.2 65189 5.9 MTA3 SP1 ZFX ELF3 CBFA2T2 NKRF POLR2A MLLT1 CEBPG CSDE1 RNF139-AS1 RNF139 TRMT12 WASHC5-AS1 FAM91A1 NSMCE2 WASHC5 ENSG00000253106 TATDN1 GC08M124446
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TATDN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TATDN1 gene promoter:
  • C/EBPalpha
  • IRF-2
  • Lmo2
  • NF-kappaB
  • NF-kappaB1
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • TBP

Genomic Locations for TATDN1 Gene

Genomic Locations for TATDN1 Gene
chr8:124,488,485-124,539,458
(GRCh38/hg38)
Size:
50,974 bases
Orientation:
Minus strand
chr8:125,500,726-125,551,699
(GRCh37/hg19)
Size:
50,974 bases
Orientation:
Minus strand

Genomic View for TATDN1 Gene

Genes around TATDN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TATDN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TATDN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TATDN1 Gene

Proteins for TATDN1 Gene

  • Protein details for TATDN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1N9-TATD1_HUMAN
    Recommended name:
    Putative deoxyribonuclease TATDN1
    Protein Accession:
    Q6P1N9
    Secondary Accessions:
    • B2R5J0
    • Q8TD02
    • Q9BY40

    Protein attributes for TATDN1 Gene

    Size:
    297 amino acids
    Molecular mass:
    33602 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TATDN1 Gene

    Alternative splice isoforms for TATDN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TATDN1 Gene

Selected DME Specific Peptides for TATDN1 Gene

Q6P1N9:
  • NLTDPMF
  • STVGCHPTRC
  • TQLKYFEKQF
  • VLKSIPSE
  • KDRNEPCHIIQ
  • FPTKKKWE
  • ETDAPWC
  • LPMFLHCRN

Post-translational modifications for TATDN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for TATDN1 Gene

Gene Families for TATDN1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TATDN1 Gene

Suggested Antigen Peptide Sequences for TATDN1 Gene

GenScript: Design optimal peptide antigens:
  • Hepatocarcinoma high expression protein (TATD1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6P1N9

UniProtKB/Swiss-Prot:

TATD1_HUMAN :
  • Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
Family:
  • Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
genes like me logo Genes that share domains with TATDN1: view

Function for TATDN1 Gene

Molecular function for TATDN1 Gene

UniProtKB/Swiss-Prot Function:
Putative deoxyribonuclease.

Enzyme Numbers (IUBMB) for TATDN1 Gene

Phenotypes From GWAS Catalog for TATDN1 Gene

Gene Ontology (GO) - Molecular Function for TATDN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15846844
GO:0008296 3'-5'-exodeoxyribonuclease activity IBA 21873635
GO:0016787 hydrolase activity IEA --
GO:0016788 hydrolase activity, acting on ester bonds IEA --
GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters IEA --
genes like me logo Genes that share ontologies with TATDN1: view
genes like me logo Genes that share phenotypes with TATDN1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TATDN1

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TATDN1 - Now 50% OFF >
  • * TATDN1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TATDN1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TATDN1 Gene

Localization for TATDN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TATDN1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TATDN1 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TATDN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with TATDN1: view

Pathways & Interactions for TATDN1 Gene

PathCards logo

SuperPathways for TATDN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TATDN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006259 DNA metabolic process IEA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with TATDN1: view

No data available for Pathways by source and SIGNOR curated interactions for TATDN1 Gene

Drugs & Compounds for TATDN1 Gene

No Compound Related Data Available

Transcripts for TATDN1 Gene

Unigene Clusters for TATDN1 Gene

TatD DNase domain containing 1:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TATDN1 - Now 50% OFF >
  • * TATDN1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TATDN1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TATDN1 Gene

No ASD Table

Relevant External Links for TATDN1 Gene

GeneLoc Exon Structure for
TATDN1
ECgene alternative splicing isoforms for
TATDN1

Expression for TATDN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TATDN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TATDN1 Gene

This gene is overexpressed in Skin (8.2) and Lymph node (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TATDN1 Gene



Protein tissue co-expression partners for TATDN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TATDN1 Gene:

TATDN1

SOURCE GeneReport for Unigene cluster for TATDN1 Gene:

Hs.170568

Evidence on tissue expression from TISSUES for TATDN1 Gene

  • Liver(4.3)
  • Muscle(4.3)
  • Eye(4.2)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with TATDN1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TATDN1 Gene

Orthologs for TATDN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TATDN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TATDN1 34
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia TATDN1 35 34
  • 92.52 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TATDN1 35 34
  • 92.37 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tatdn1 17 35 34
  • 89.02 (n)
oppossum
(Monodelphis domestica)
Mammalia TATDN1 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TATDN1 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves TATDN1 35 34
  • 78.56 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TATDN1 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tatdn1 34
  • 69.37 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13646 34
zebrafish
(Danio rerio)
Actinopterygii TATDN1 35
  • 67 (a)
OneToOne
tatdn1 34
  • 65.99 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.862 34
fruit fly
(Drosophila melanogaster)
Insecta CG3358 35 34
  • 53.07 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006162 34
  • 52.4 (n)
worm
(Caenorhabditis elegans)
Secernentea crn-2 35
  • 29 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YBL055C 34
  • 53.2 (n)
-- 35
  • 28 (a)
OneToMany
-- 37
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E19955g 34
  • 49.03 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G52390 34
  • 55.14 (n)
rice
(Oryza sativa)
Liliopsida Os07g0158200 34
  • 56.7 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.11927 34
corn
(Zea mays)
Liliopsida Zm.2802 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 58 (a)
OneToOne
Cin.10795 34
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC17A3.08 34
  • 54.48 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03538 34
  • 48.58 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10795 34
Species where no ortholog for TATDN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TATDN1 Gene

ENSEMBL:
Gene Tree for TATDN1 (if available)
TreeFam:
Gene Tree for TATDN1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TATDN1: view image

Paralogs for TATDN1 Gene

Paralogs for TATDN1 Gene

Pseudogenes.org Pseudogenes for TATDN1 Gene

genes like me logo Genes that share paralogs with TATDN1: view

Variants for TATDN1 Gene

Sequence variations from dbSNP and Humsavar for TATDN1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs369824948 pathogenic, not provided 124,539,187(-) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs199613912 likely-benign, not specified 124,539,169(-) G/C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs534646199 likely-benign, not specified 124,539,156(-) C/G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs754423576 likely-benign, not specified 124,539,161(-) C/G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs755557988 likely-benign, not specified 124,539,209(-) C/A/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TATDN1 Gene

Variant ID Type Subtype PubMed ID
esv3310111 CNV mobile element insertion 20981092
esv3335107 CNV insertion 20981092
nsv951466 CNV duplication 24416366

Variation tolerance for TATDN1 Gene

Residual Variation Intolerance Score: 51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TATDN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TATDN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TATDN1 Gene

Disorders for TATDN1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TATDN1 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • adenocarcinoma of lung
sporadic pheochromocytoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TATDN1

genes like me logo Genes that share disorders with TATDN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TATDN1 Gene

Publications for TATDN1 Gene

  1. The DNase domain-containing protein TATDN1 plays an important role in chromosomal segregation and cell cycle progression during zebrafish eye development. (PMID: 23187801) Yang H … Shen B (Cell cycle (Georgetown, Tex.) 2012) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 58
  5. The role and potential mechanisms of LncRNA-TATDN1 on metastasis and invasion of non-small cell lung cancer. (PMID: 26943769) Zequn N … Shuanying Y (Oncotarget 2016) 3 58

Products for TATDN1 Gene

Sources for TATDN1 Gene

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