Aliases for TASOR2 Gene

Aliases for TASOR2 Gene

  • Transcription Activation Suppressor Family Member 2 2 3 5
  • Family With Sequence Similarity 208 Member B 2 3
  • Protein TASOR 2 3 4
  • C10orf18 3 4
  • FAM208B 3 4
  • Family With Sequence Similarity 208, Member B 2
  • Chromosome 10 Open Reading Frame 18 2
  • Protein FAM208B 3
  • BA318E3.2 3
  • KIAA2006 4

External Ids for TASOR2 Gene

Previous HGNC Symbols for TASOR2 Gene

  • C10orf18
  • FAM208B

Summaries for TASOR2 Gene

GeneCards Summary for TASOR2 Gene

TASOR2 (Transcription Activation Suppressor Family Member 2) is a Protein Coding gene. An important paralog of this gene is TASOR.

Additional gene information for TASOR2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TASOR2 Gene

Genomics for TASOR2 Gene

GeneHancer (GH) Regulatory Elements for TASOR2 Gene

Promoters and enhancers for TASOR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TASOR2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TASOR2

Genomic Locations for TASOR2 Gene

Genomic Locations for TASOR2 Gene
chr10:5,684,772-5,765,779
(GRCh38/hg38)
Size:
81,008 bases
Orientation:
Plus strand
chr10:5,726,801-5,805,703
(GRCh37/hg19)
Size:
78,903 bases
Orientation:
Plus strand

Genomic View for TASOR2 Gene

Genes around TASOR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TASOR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TASOR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TASOR2 Gene

Proteins for TASOR2 Gene

  • Protein details for TASOR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VWN6-TASO2_HUMAN
    Recommended name:
    Protein TASOR 2
    Protein Accession:
    Q5VWN6
    Secondary Accessions:
    • Q2YD91
    • Q5VWN5
    • Q6ZRQ8
    • Q8IVG4
    • Q9BUZ7
    • Q9H5J9
    • Q9H7A4
    • Q9H996
    • Q9NXA1

    Protein attributes for TASOR2 Gene

    Size:
    2430 amino acids
    Molecular mass:
    268843 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91115.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14336.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14993.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAC87251.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for TASOR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TASOR2 Gene

Post-translational modifications for TASOR2 Gene

  • Ubiquitination at Lys694 and Lys768
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TASOR2 Gene

Domains & Families for TASOR2 Gene

Gene Families for TASOR2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TASOR2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TASOR2 Gene

GenScript: Design optimal peptide antigens:
  • C10orf18 protein (Q6IPC8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5VWN6

UniProtKB/Swiss-Prot:

TASO2_HUMAN :
  • Belongs to the TASOR family.
Family:
  • Belongs to the TASOR family.
genes like me logo Genes that share domains with TASOR2: view

Function for TASOR2 Gene

Phenotypes From GWAS Catalog for TASOR2 Gene

Gene Ontology (GO) - Molecular Function for TASOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with TASOR2: view

Phenotypes for TASOR2 Gene

genes like me logo Genes that share phenotypes with TASOR2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TASOR2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TASOR2 Gene

Localization for TASOR2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TASOR2 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TASOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with TASOR2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TASOR2 Gene

Pathways & Interactions for TASOR2 Gene

PathCards logo

SuperPathways for TASOR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TASOR2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TASOR2 Gene

Drugs & Compounds for TASOR2 Gene

No Compound Related Data Available

Transcripts for TASOR2 Gene

mRNA/cDNA for TASOR2 Gene

4 REFSEQ mRNAs :
26 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TASOR2

Alternative Splicing Database (ASD) splice patterns (SP) for TASOR2 Gene

No ASD Table

Relevant External Links for TASOR2 Gene

GeneLoc Exon Structure for
TASOR2

Expression for TASOR2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TASOR2

SOURCE GeneReport for Unigene cluster for TASOR2 Gene:

Hs.610717

Evidence on tissue expression from TISSUES for TASOR2 Gene

  • Liver(4.2)
  • Nervous system(4.2)
  • Blood(4.1)
  • Eye(4)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TASOR2 Gene

Orthologs for TASOR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TASOR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM208B 31 30
  • 98.88 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM208B 31 30
  • 77.34 (n)
OneToOne
mouse
(Mus musculus)
Mammalia BC016423 31 30
  • 73.92 (n)
OneToOne
Tasor2 17
rat
(Rattus norvegicus)
Mammalia Fam208b 30
  • 73.92 (n)
cow
(Bos Taurus)
Mammalia FAM208B 31 30
  • 73.01 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM208B 31
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM208B 31
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM208B 31
  • 28 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 42 (a)
OneToMany
-- 31
  • 23 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fam208b 31
  • 13 (a)
OneToOne
Species where no ortholog for TASOR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TASOR2 Gene

ENSEMBL:
Gene Tree for TASOR2 (if available)
TreeFam:
Gene Tree for TASOR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TASOR2: view image

Paralogs for TASOR2 Gene

Paralogs for TASOR2 Gene

genes like me logo Genes that share paralogs with TASOR2: view

Variants for TASOR2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TASOR2 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs11593253 - p.Thr1782Ile
rs17143175 - p.Pro1578Ser
rs2254067 - p.Cys499Gly
rs2275774 - p.Lys2288Arg
rs2669142 - p.Val1679Ala

Additional dbSNP identifiers (rs#s) for TASOR2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TASOR2 Gene

Variant ID Type Subtype PubMed ID
dgv1e49 CNV loss 18971310
dgv36n21 CNV loss 19592680
esv1004136 CNV insertion 20482838
esv2759729 CNV gain 17122850
nsv1050663 CNV loss 25217958
nsv522415 CNV gain 19592680
nsv528504 CNV gain 19592680
nsv549895 CNV loss 21841781
nsv831775 CNV loss 17160897
nsv8600 CNV gain 18304495

Variation tolerance for TASOR2 Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.70; 93.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TASOR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TASOR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TASOR2 Gene

Disorders for TASOR2 Gene

No disorders were found for TASOR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TASOR2 Gene

Publications for TASOR2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  3. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 54
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for TASOR2 Gene

Sources for TASOR2 Gene