This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In funct... See more...

Aliases for TAS2R8 Gene

Aliases for TAS2R8 Gene

  • Taste 2 Receptor Member 8 2 3 5
  • T2R8 2 3 4
  • TRB5 2 3 4
  • Taste Receptor, Type 2, Member 8 2 3
  • Taste Receptor Type 2 Member 8 3 4
  • Taste Receptor, Family B, Member 5 3
  • Taste Receptor Family B Member 5 4
  • TAS2R8 5

External Ids for TAS2R8 Gene

Previous GeneCards Identifiers for TAS2R8 Gene

  • GC12M010662
  • GC12M011102
  • GC12M010858
  • GC12M010849
  • GC12M010971
  • GC12M010807
  • GC12M012423
  • GC12M012642
  • GC12M012797
  • GC12M013383
  • GC12M010946
  • GC12M011031
  • GC12M011331
  • GC12M011548
  • GC12M011739
  • GC12M011926
  • GC12M012112
  • GC12M012292

Summaries for TAS2R8 Gene

Entrez Gene Summary for TAS2R8 Gene

  • This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R8 Gene

TAS2R8 (Taste 2 Receptor Member 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Taste transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R7.

UniProtKB/Swiss-Prot Summary for TAS2R8 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Gene Wiki entry for TAS2R8 Gene

Additional gene information for TAS2R8 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAS2R8 Gene

Genomics for TAS2R8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TAS2R8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J010808 Enhancer 0.2 Ensembl 600.7 -1.2 -1208 0.6 TAS2R8 TAS2R9 LINC01252 TAS2R15P
GH12J010891 Enhancer 1.1 Ensembl ENCODE 10.5 -84.9 -84876 1.2 GATAD2A REST TFE3 SOX13 NFKBIZ RCOR2 ZNF7 RXRB IRF2 SP1 PRR4 LINC01252 TAS2R8 TAS2R7 TAS2R12P TAS2R13 MN297132 ENSG00000275778 PRH1 PRH1-PRR4
GH12J010849 Promoter/Enhancer 0.5 EPDnew Ensembl 11 -42.5 -42508 1.2 PRR4 TAS2R15P TAS2R7 TAS2R8 ENSG00000256682 TAS2R13 TAS2R18P MN297132 ENSG00000275778 PRH1
GH12J010853 Enhancer 0.3 Ensembl 11 -46.5 -46508 1.2 CTCF POLR2A MN297132 PRR4 TAS2R7 TAS2R8 ENSG00000256682 TAS2R13 TAS2R18P ENSG00000256651 TAS2R12P ENSG00000275778
GH12J010936 Enhancer 0.3 Ensembl 9.1 -129.2 -129207 1 EGR2 PRR4 TAS2R13 ENSG00000256682 TAS2R50 TAS2R8 TAS2R7 TAS2R14 PRH2 lnc-TAS2R50-1 ENSG00000275778
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAS2R8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAS2R8

Top Transcription factor binding sites by QIAGEN in the TAS2R8 gene promoter:
  • C/EBPalpha
  • Chx10
  • E47
  • GCNF
  • GCNF-1
  • GCNF-2
  • MRF-2
  • Nkx6-1
  • p53
  • STAT5B

Genomic Locations for TAS2R8 Gene

Genomic Locations for TAS2R8 Gene
chr12:10,806,051-10,807,293
(GRCh38/hg38)
Size:
1,243 bases
Orientation:
Minus strand
chr12:10,958,650-10,959,892
(GRCh37/hg19)
Size:
1,243 bases
Orientation:
Minus strand

Genomic View for TAS2R8 Gene

Genes around TAS2R8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R8 Gene

Proteins for TAS2R8 Gene

  • Protein details for TAS2R8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW2-TA2R8_HUMAN
    Recommended name:
    Taste receptor type 2 member 8
    Protein Accession:
    Q9NYW2
    Secondary Accessions:
    • Q4KN29
    • Q645Y2

    Protein attributes for TAS2R8 Gene

    Size:
    309 amino acids
    Molecular mass:
    35877 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R8 Gene

Post-translational modifications for TAS2R8 Gene

  • Glycosylation at Asn167
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R8 Gene

Domains & Families for TAS2R8 Gene

Gene Families for TAS2R8 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for TAS2R8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R8 Gene

GenScript: Design optimal peptide antigens:
  • Taste receptor type 2 (Q4KN04_HUMAN)
  • Taste receptor family B member 5 (TA2R8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NYW2

UniProtKB/Swiss-Prot:

TA2R8_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R8: view

Function for TAS2R8 Gene

Molecular function for TAS2R8 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Gene Ontology (GO) - Molecular Function for TAS2R8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0008527 taste receptor activity TAS 10761934
GO:0033038 bitter taste receptor activity IBA,IDA 20022913
genes like me logo Genes that share ontologies with TAS2R8: view
genes like me logo Genes that share phenotypes with TAS2R8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAS2R8

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R8 Gene

Localization for TAS2R8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R8 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS2R8 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TAS2R8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IC 20022913
genes like me logo Genes that share ontologies with TAS2R8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAS2R8 Gene

Pathways & Interactions for TAS2R8 Gene

genes like me logo Genes that share pathways with TAS2R8: view

Pathways by source for TAS2R8 Gene

1 Qiagen pathway for TAS2R8 Gene
  • Bitter Taste Signaling

Gene Ontology (GO) - Biological Process for TAS2R8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IBA,IDA 20022913
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0050896 response to stimulus IEA --
GO:0050909 sensory perception of taste IEA --
genes like me logo Genes that share ontologies with TAS2R8: view

No data available for SIGNOR curated interactions for TAS2R8 Gene

Drugs & Compounds for TAS2R8 Gene

(2) Drugs for TAS2R8 Gene - From: BitterDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chloramphenicol Approved, Vet_approved Pharma 11
Parthenolide Approved, Investigational Pharma 4

(1) Additional Compounds for TAS2R8 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
denatonium benzoate
genes like me logo Genes that share compounds with TAS2R8: view

Transcripts for TAS2R8 Gene

mRNA/cDNA for TAS2R8 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAS2R8

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R8 Gene

No ASD Table

Relevant External Links for TAS2R8 Gene

GeneLoc Exon Structure for
TAS2R8

Expression for TAS2R8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAS2R8 Gene

mRNA differential expression in normal tissues according to GTEx for TAS2R8 Gene

This gene is overexpressed in Brain - Cerebellum (x5.9), Brain - Cortex (x5.2), and Brain - Cerebellar Hemisphere (x4.6).

Protein differential expression in normal tissues from HIPED for TAS2R8 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TAS2R8 Gene



Protein tissue co-expression partners for TAS2R8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAS2R8

SOURCE GeneReport for Unigene cluster for TAS2R8 Gene:

Hs.533755

mRNA Expression by UniProt/SwissProt for TAS2R8 Gene:

Q9NYW2-TA2R8_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
genes like me logo Genes that share expression patterns with TAS2R8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAS2R8 Gene

Orthologs for TAS2R8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TAS2R8 30 31
  • 99.57 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TAS2R8 30
  • 77.7 (n)
Oppossum
(Monodelphis domestica)
Mammalia T2R7B 31
  • 50 (a)
ManyToMany
-- 31
  • 47 (a)
ManyToMany
T2R7A 31
  • 45 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Tas2r122 31
  • 34 (a)
ManyToMany
Species where no ortholog for TAS2R8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TAS2R8 Gene

ENSEMBL:
Gene Tree for TAS2R8 (if available)
TreeFam:
Gene Tree for TAS2R8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAS2R8: view image

Paralogs for TAS2R8 Gene

Pseudogenes.org Pseudogenes for TAS2R8 Gene

genes like me logo Genes that share paralogs with TAS2R8: view

Variants for TAS2R8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAS2R8 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
786222 Benign: not provided 10,806,935(-) C/A NONSENSE
rs2537817 - p.Met308Val

Additional dbSNP identifiers (rs#s) for TAS2R8 Gene

Structural Variations from Database of Genomic Variants (DGV) for TAS2R8 Gene

Variant ID Type Subtype PubMed ID
esv3628543 CNV gain 21293372

Variation tolerance for TAS2R8 Gene

Residual Variation Intolerance Score: 73.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.67; 45.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAS2R8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R8 Gene

Disorders for TAS2R8 Gene

No disorders were found for TAS2R8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R8 Gene

Publications for TAS2R8 Gene

  1. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E … Zuker CS (Cell 2000) 2 3 4
  2. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A … Pääbo S (Molecular biology and evolution 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y … Ryba NJ (Cell 2003) 3 4
  5. Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee RF (The Journal of biological chemistry 2002) 3 4

Products for TAS2R8 Gene

Sources for TAS2R8 Gene