TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). See also TAS2R10 (MIM 604791).[supplied by OMIM, Mar 2008] See more...

Aliases for TAS2R50 Gene

Aliases for TAS2R50 Gene

  • Taste 2 Receptor Member 50 2 3 5
  • T2R51 2 3 4
  • Taste Receptor, Type 2, Member 50 2 3
  • Taste Receptor Type 2 Member 50 3 4
  • Taste Receptor Type 2 Member 51 3 4
  • T2R50 3 4
  • TAS2R51 3
  • TAS2R50 5

External Ids for TAS2R50 Gene

Previous GeneCards Identifiers for TAS2R50 Gene

  • GC00U991259
  • GC12M011038
  • GC12M011029
  • GC12M011138
  • GC12M010866

Summaries for TAS2R50 Gene

Entrez Gene Summary for TAS2R50 Gene

  • TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). See also TAS2R10 (MIM 604791).[supplied by OMIM, Mar 2008]

GeneCards Summary for TAS2R50 Gene

TAS2R50 (Taste 2 Receptor Member 50) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Taste transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and bitter taste receptor activity. An important paralog of this gene is TAS2R46.

UniProtKB/Swiss-Prot Summary for TAS2R50 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Wiki entry for TAS2R50 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAS2R50 Gene

Genomics for TAS2R50 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TAS2R50 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAS2R50 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAS2R50

Top Transcription factor binding sites by QIAGEN in the TAS2R50 gene promoter:
  • FOXO3
  • FOXO3a
  • FOXO3b
  • FOXO4
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • POU6F1 (c2)

Genomic Locations for TAS2R50 Gene

Latest Assembly
chr12:10,985,913-10,986,912
(GRCh38/hg38)
Size:
1,000 bases
Orientation:
Minus strand

Previous Assembly
chr12:11,138,512-11,139,511
(GRCh37/hg19 by Entrez Gene)
Size:
1,000 bases
Orientation:
Minus strand

chr12:11,138,512-11,139,511
(GRCh37/hg19 by Ensembl)
Size:
1,000 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr12(ALT_REF_LOCI_1):184,619-185,618 (-)
  • chr12(ALT_REF_LOCI_2):184,606-185,605 (-)

Genomic View for TAS2R50 Gene

Genes around TAS2R50 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R50 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R50 Gene

Proteins for TAS2R50 Gene

  • Protein details for TAS2R50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59544-T2R50_HUMAN
    Recommended name:
    Taste receptor type 2 member 50
    Protein Accession:
    P59544
    Secondary Accessions:
    • P59545
    • Q2M255
    • Q645Y0

    Protein attributes for TAS2R50 Gene

    Size:
    299 amino acids
    Molecular mass:
    34558 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R50 Gene

Post-translational modifications for TAS2R50 Gene

  • Glycosylation at Asn161

Other Protein References for TAS2R50 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R50 Gene

Domains & Families for TAS2R50 Gene

Gene Families for TAS2R50 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for TAS2R50 Gene

InterPro:

Suggested Antigen Peptide Sequences for TAS2R50 Gene

GenScript: Design optimal peptide antigens:
  • Taste receptor type 2 member 51 (T2R50_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P59544

UniProtKB/Swiss-Prot:

T2R50_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R50: view

Function for TAS2R50 Gene

Molecular function for TAS2R50 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Phenotypes From GWAS Catalog for TAS2R50 Gene

Gene Ontology (GO) - Molecular Function for TAS2R50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0033038 bitter taste receptor activity IBA,IDA 20022913
genes like me logo Genes that share ontologies with TAS2R50: view
genes like me logo Genes that share phenotypes with TAS2R50: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAS2R50

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R50 Gene

Localization for TAS2R50 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R50 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS2R50 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for TAS2R50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IC 20022913
genes like me logo Genes that share ontologies with TAS2R50: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAS2R50 Gene

Pathways & Interactions for TAS2R50 Gene

genes like me logo Genes that share pathways with TAS2R50: view

Pathways by source for TAS2R50 Gene

Gene Ontology (GO) - Biological Process for TAS2R50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0050896 response to stimulus IEA --
GO:0050909 sensory perception of taste IEA --
genes like me logo Genes that share ontologies with TAS2R50: view

No data available for SIGNOR curated interactions for TAS2R50 Gene

Drugs & Compounds for TAS2R50 Gene

(1) Drugs for TAS2R50 Gene - From: BitterDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Andrographolide Investigational Pharma NF-κB signaling Inhibitor 15

(1) Additional Compounds for TAS2R50 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
amarogentin
genes like me logo Genes that share compounds with TAS2R50: view

Transcripts for TAS2R50 Gene

mRNA/cDNA for TAS2R50 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAS2R50

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R50 Gene

No ASD Table

Relevant External Links for TAS2R50 Gene

GeneLoc Exon Structure for
TAS2R50

Expression for TAS2R50 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAS2R50 Gene

mRNA differential expression in normal tissues according to GTEx for TAS2R50 Gene

This gene is overexpressed in Brain - Cerebellum (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAS2R50

SOURCE GeneReport for Unigene cluster for TAS2R50 Gene:

Hs.688194

mRNA Expression by UniProt/SwissProt for TAS2R50 Gene:

P59544-T2R50_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Evidence on tissue expression from TISSUES for TAS2R50 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TAS2R50: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAS2R50 Gene

Orthologs for TAS2R50 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R50 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TAS2R50 29 30
  • 99.11 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 30
  • 55 (a)
ManyToMany
TAS2R46 30
  • 55 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia CAFA-T2R43 30
  • 51 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Tas2r120 30
  • 50 (a)
ManyToMany
Tas2r136 30
  • 41 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia T2R24 30
  • 33 (a)
ManyToMany
T2R25 30
  • 32 (a)
ManyToMany
T2R23 30
  • 32 (a)
ManyToMany
Species where no ortholog for TAS2R50 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TAS2R50 Gene

ENSEMBL:
Gene Tree for TAS2R50 (if available)
TreeFam:
Gene Tree for TAS2R50 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAS2R50: view image
Alliance of Genome Resources:
Additional Orthologs for TAS2R50

Paralogs for TAS2R50 Gene

genes like me logo Genes that share paralogs with TAS2R50: view

Variants for TAS2R50 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAS2R50 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs151058158 Benign: not provided 10,986,774(-) C/G
NM_176890.2(TAS2R50):c.87G>C (p.Leu29=)
SYNONYMOUS_VARIANT,INTRON
rs1376251 -- p.Cys203Tyr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TAS2R50 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TAS2R50 Gene

Variant ID Type Subtype PubMed ID
dgv251e214 CNV loss 21293372
esv2745546 CNV deletion 23290073
esv2759879 CNV loss 17122850
esv3628555 CNV gain 21293372
nsv1038277 CNV loss 25217958
nsv428272 CNV gain+loss 18775914
nsv832330 CNV gain 17160897
nsv973026 CNV duplication 23825009

Variation tolerance for TAS2R50 Gene

Residual Variation Intolerance Score: 57.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.33; 85.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAS2R50 Gene

Human Gene Mutation Database (HGMD)
TAS2R50
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R50
Leiden Open Variation Database (LOVD)
TAS2R50

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R50 Gene

Disorders for TAS2R50 Gene

Additional Disease Information for TAS2R50

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for TAS2R50 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R50 Gene

Publications for TAS2R50 Gene

  1. Identification of four gene variants associated with myocardial infarction. (PMID: 16175505) Shiffman D … Kane JP (American journal of human genetics 2005) 2 3 40
  2. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. (PMID: 12379855) Bufe B … Meyerhof W (Nature genetics 2002) 2 3 4
  3. Identification and characterization of human taste receptor genes belonging to the TAS2R family. (PMID: 12584440) Conte C … Andres-Barquin PJ (Cytogenetic and genome research 2002) 2 3 4
  4. Variations of specific non-candidate genes and risk of myocardial infarction: a replication study. (PMID: 19709766) Koch W … Kastrati A (International journal of cardiology 2011) 3 40
  5. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 40

Products for TAS2R50 Gene

Sources for TAS2R50 Gene