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Aliases for TAS2R4 Gene

Aliases for TAS2R4 Gene

  • Taste 2 Receptor Member 4 2 3 5
  • Taste Receptor, Type 2, Member 4 2 3
  • T2R4 3 4
  • Taste Receptor Type 2 Member 4 3
  • Candidate Taste Receptor T2R4 3

External Ids for TAS2R4 Gene

Previous GeneCards Identifiers for TAS2R4 Gene

  • GC07P139749
  • GC07P140808
  • GC07P140885
  • GC07P140931
  • GC07P141124
  • GC07P141479
  • GC07P135774
  • GC07P142610
  • GC07P142904
  • GC07P143066
  • GC07P143211
  • GC07P143411
  • GC07P143562
  • GC07P143712

Summaries for TAS2R4 Gene

Entrez Gene Summary for TAS2R4 Gene

  • This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R4 Gene

TAS2R4 (Taste 2 Receptor Member 4) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Taste transduction. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R41.

UniProtKB/Swiss-Prot for TAS2R4 Gene

  • Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.

Gene Wiki entry for TAS2R4 Gene

Additional gene information for TAS2R4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R4 Gene

Genomics for TAS2R4 Gene

GeneHancer (GH) Regulatory Elements for TAS2R4 Gene

Promoters and enhancers for TAS2R4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I141778 Promoter 0.5 EPDnew 550.8 +0.0 5 0.1 TAS2R4 TAS2R6P SSBP1
GH07I141736 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 10.2 -40.1 -40100 3.1 MLX ZFP64 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 WEE2-AS1 SSBP1 TAS2R6P TAS2R5 PRSS37 WEE2 KIAA1147 TAS2R4
GH07I141550 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10 -227.0 -227016 2 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 AGK ENSG00000261570 LOC105375538 TAS2R6P WEE2 TAS2R5 TAS2R4 BRAF ENSG00000270157 WEE2-AS1
GH07I142150 Enhancer 0.7 FANTOM5 ENCODE 5.4 +373.4 373423 3.4 CTCF ZNF316 MAFG MAFK EMSY RAD21 WEE2 TAS2R4 OR9A4 TAS2R38 TAS2R5 MGAM2 MOXD2P
GH07I141889 Enhancer 0.3 FANTOM5 9.2 +111.0 111038 0.4 GC07P143910 GC07P143914 CLEC5A TAS2R4 TAS2R38 MGAM OR9A4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TAS2R4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TAS2R4 gene promoter:

Genomic Locations for TAS2R4 Gene

Genomic Locations for TAS2R4 Gene
chr7:141,778,442-141,780,819
(GRCh38/hg38)
Size:
2,378 bases
Orientation:
Plus strand
chr7:141,478,242-141,479,235
(GRCh37/hg19)

Genomic View for TAS2R4 Gene

Genes around TAS2R4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R4 Gene

Proteins for TAS2R4 Gene

  • Protein details for TAS2R4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW5-TA2R4_HUMAN
    Recommended name:
    Taste receptor type 2 member 4
    Protein Accession:
    Q9NYW5
    Secondary Accessions:
    • Q645W5
    • Q75MV8

    Protein attributes for TAS2R4 Gene

    Size:
    299 amino acids
    Molecular mass:
    33841 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Several bitter taste receptors are expressed in a single taste receptor cell.

neXtProt entry for TAS2R4 Gene

Post-translational modifications for TAS2R4 Gene

  • Glycosylation at posLast=164164, posLast=165165, and isoforms=169

Other Protein References for TAS2R4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R4 Gene

Domains & Families for TAS2R4 Gene

Gene Families for TAS2R4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for TAS2R4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYW5

UniProtKB/Swiss-Prot:

TA2R4_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R4: view

Function for TAS2R4 Gene

Molecular function for TAS2R4 Gene

UniProtKB/Swiss-Prot Function:
Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.

Gene Ontology (GO) - Molecular Function for TAS2R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0008527 taste receptor activity TAS 10761934
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R4: view
genes like me logo Genes that share phenotypes with TAS2R4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAS2R4 Gene

Localization for TAS2R4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R4 Gene

Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS2R4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TAS2R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005929 cilium IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IC,IBA 20022913
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with TAS2R4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAS2R4 Gene

Pathways & Interactions for TAS2R4 Gene

genes like me logo Genes that share pathways with TAS2R4: view

Pathways by source for TAS2R4 Gene

Gene Ontology (GO) - Biological Process for TAS2R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007165 signal transduction TAS --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007585 respiratory gaseous exchange IEA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with TAS2R4: view

No data available for SIGNOR curated interactions for TAS2R4 Gene

Drugs & Compounds for TAS2R4 Gene

(10) Drugs for TAS2R4 Gene - From: BitterDB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Azathioprine Approved Pharma 190
Colchicine Approved Pharma Antagonist Tubulin Inhibitor 118
Dapsone Approved, Investigational Pharma 68
Diphenidol Approved, Investigational, Withdrawn Pharma 1
Parthenolide Approved, Investigational Pharma 4

(6) Additional Compounds for TAS2R4 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
amarogentin
21018-84-8
Arborescin
Artemorin
Campher
denatonium benzoate
3734-33-6
genes like me logo Genes that share compounds with TAS2R4: view

Transcripts for TAS2R4 Gene

mRNA/cDNA for TAS2R4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R4 Gene

Taste receptor, type 2, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R4 Gene

No ASD Table

Relevant External Links for TAS2R4 Gene

GeneLoc Exon Structure for
TAS2R4
ECgene alternative splicing isoforms for
TAS2R4

Expression for TAS2R4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAS2R4 Gene

mRNA differential expression in normal tissues according to GTEx for TAS2R4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.4) and Brain - Cerebellum (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of TAS2R4 Gene:

TAS2R4

SOURCE GeneReport for Unigene cluster for TAS2R4 Gene:

Hs.735690

mRNA Expression by UniProt/SwissProt for TAS2R4 Gene:

Q9NYW5-TA2R4_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed on airway ciliated epithelium.
genes like me logo Genes that share expression patterns with TAS2R4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAS2R4 Gene

Orthologs for TAS2R4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R4 33 34
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia TAS2R4 33
  • 82.44 (n)
cow
(Bos Taurus)
Mammalia TAS2R4 33 34
  • 81.87 (n)
mouse
(Mus musculus)
Mammalia Tas2r108 33 16 34
  • 76.66 (n)
rat
(Rattus norvegicus)
Mammalia Tas2r108 33
  • 74.97 (n)
chicken
(Gallus gallus)
Aves TAS2R7 34
  • 23 (a)
OneToMany
Species where no ortholog for TAS2R4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R4 Gene

ENSEMBL:
Gene Tree for TAS2R4 (if available)
TreeFam:
Gene Tree for TAS2R4 (if available)

Paralogs for TAS2R4 Gene

Variants for TAS2R4 Gene

Sequence variations from dbSNP and Humsavar for TAS2R4 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000367134 -- 141,777,657(+) A/G upstream_transcript_variant
rs1000419230 -- 141,778,000(+) A/G upstream_transcript_variant
rs1000781380 -- 141,777,781(+) A/G upstream_transcript_variant
rs1001548850 -- 141,778,131(+) C/G upstream_transcript_variant
rs1001996581 -- 141,778,388(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TAS2R4 Gene

Variant ID Type Subtype PubMed ID
esv34135 CNV loss 18971310

Variation tolerance for TAS2R4 Gene

Residual Variation Intolerance Score: 87.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.58; 72.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAS2R4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R4 Gene

Disorders for TAS2R4 Gene

Additional Disease Information for TAS2R4

No disorders were found for TAS2R4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R4 Gene

Publications for TAS2R4 Gene

  1. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E … Zuker CS (Cell 2000) 2 3 4 58
  2. T2Rs function as bitter taste receptors. (PMID: 10761935) Chandrashekar J … Ryba NJ (Cell 2000) 2 3 4 58
  3. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A … Pääbo S (Molecular biology and evolution 2005) 3 4 58
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y … Ryba NJ (Cell 2003) 3 4 58
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58

Products for TAS2R4 Gene

Sources for TAS2R4 Gene

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