This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another ... See more...

Aliases for TAS2R4 Gene

Aliases for TAS2R4 Gene

  • Taste 2 Receptor Member 4 2 3 5
  • T2R4 2 3 4
  • Taste Receptor, Type 2, Member 4 2 3
  • Taste Receptor Type 2 Member 4 3 4
  • Candidate Taste Receptor T2R4 3
  • TAS2R4 5

External Ids for TAS2R4 Gene

Previous GeneCards Identifiers for TAS2R4 Gene

  • GC07P139749
  • GC07P140808
  • GC07P140885
  • GC07P140931
  • GC07P141124
  • GC07P141479
  • GC07P135774
  • GC07P142610
  • GC07P142904
  • GC07P144287
  • GC07P144421
  • GC07P144638
  • GC07P144878
  • GC07P143066
  • GC07P143211
  • GC07P143411
  • GC07P143562
  • GC07P143712
  • GC07P143834
  • GC07P143978
  • GC07P144139

Summaries for TAS2R4 Gene

Entrez Gene Summary for TAS2R4 Gene

  • This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R4 Gene

TAS2R4 (Taste 2 Receptor Member 4) is a Protein Coding gene. Diseases associated with TAS2R4 include Cerebellar Ataxia Type 9. Among its related pathways are Signaling by GPCR and Taste transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R7.

UniProtKB/Swiss-Prot Summary for TAS2R4 Gene

  • Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.

Gene Wiki entry for TAS2R4 Gene

Additional gene information for TAS2R4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAS2R4 Gene

Genomics for TAS2R4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TAS2R4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J141736 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10.2 -38.0 -37981 3.8 ZNF221 RNF2 SP1 CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 ZNF629 WEE2-AS1 SSBP1 NONHSAG048978.2 TAS2R6P TAS2R5 PRSS37 BRAF WEE2 TAS2R4 AGK
GH07J141550 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10 -225.1 -225073 2.4 ZNF221 SP1 GATAD2A HNRNPL TEAD4 PRDM10 ZNF629 SIX5 NFKBIZ KDM1A AGK ENSG00000261570 LOC105375538 TAS2R6P TAS2R5 BRAF WEE2-AS1 WEE2 TAS2R4 ENSG00000270157
GH07J141071 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas 11 -702.7 -702673 5.6 CREB1 CTCF PRDM10 ZNF629 REST RFX1 ZNF692 PRDM1 ZIC2 ZSCAN4 TMEM178B lnc-MRPS33-1 AGK TAS2R5 MRPS33 RNU4-74P WEE2-AS1 TAS2R4 PRSS37 TAS2R6P
GH07J141889 Enhancer 0.6 FANTOM5 Ensembl 9.2 +113.6 113627 3.8 SPI1 GABPA WEE2-AS1 CLEC5A OR9N1P TAS2R4 TAS2R38 lnc-CLEC5A-1 lnc-MGAM-1 MGAM PRSS37
GH07J141928 Enhancer 0.6 FANTOM5 Ensembl 8.6 +152.8 152827 4.6 USF1 SPI1 POLR2A WEE2-AS1 OR9A4 CLEC5A TAS2R38 TAS2R4 MG828668-118 lnc-TAS2R38-1 MGAM
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAS2R4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAS2R4

Top Transcription factor binding sites by QIAGEN in the TAS2R4 gene promoter:
  • Bach2
  • c-Rel
  • Cart-1
  • GR
  • GR-alpha
  • LCR-F1
  • Msx-1
  • Nkx2-5
  • TBP

Genomic Locations for TAS2R4 Gene

Genomic Locations for TAS2R4 Gene
chr7:141,776,674-141,781,691
(GRCh38/hg38)
Size:
5,018 bases
Orientation:
Plus strand
chr7:141,478,242-141,479,235
(GRCh37/hg19)
Size:
994 bases
Orientation:
Plus strand

Genomic View for TAS2R4 Gene

Genes around TAS2R4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R4 Gene

Proteins for TAS2R4 Gene

  • Protein details for TAS2R4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW5-TA2R4_HUMAN
    Recommended name:
    Taste receptor type 2 member 4
    Protein Accession:
    Q9NYW5
    Secondary Accessions:
    • Q645W5
    • Q75MV8

    Protein attributes for TAS2R4 Gene

    Size:
    299 amino acids
    Molecular mass:
    33841 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Several bitter taste receptors are expressed in a single taste receptor cell.

neXtProt entry for TAS2R4 Gene

Post-translational modifications for TAS2R4 Gene

  • Glycosylation at Asn164, Asn165, and Asn169

Other Protein References for TAS2R4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R4 Gene

Domains & Families for TAS2R4 Gene

Gene Families for TAS2R4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for TAS2R4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R4 Gene

GenScript: Design optimal peptide antigens:
  • Taste receptor type 2 (A1L485_HUMAN)
  • Taste receptor type 2 (A4D1U1_HUMAN)
  • Taste receptor type 2 member 4 (TA2R4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NYW5

UniProtKB/Swiss-Prot:

TA2R4_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R4: view

Function for TAS2R4 Gene

Molecular function for TAS2R4 Gene

UniProtKB/Swiss-Prot Function:
Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.

Phenotypes From GWAS Catalog for TAS2R4 Gene

Gene Ontology (GO) - Molecular Function for TAS2R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0008527 taste receptor activity TAS 10761934
GO:0033038 bitter taste receptor activity IBA,IDA 20022913
genes like me logo Genes that share ontologies with TAS2R4: view
genes like me logo Genes that share phenotypes with TAS2R4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAS2R4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAS2R4 Gene

Localization for TAS2R4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R4 Gene

Membrane. Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS2R4 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TAS2R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005929 cilium IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IC 20022913
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with TAS2R4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAS2R4 Gene

Pathways & Interactions for TAS2R4 Gene

genes like me logo Genes that share pathways with TAS2R4: view

Pathways by source for TAS2R4 Gene

1 Qiagen pathway for TAS2R4 Gene
  • Bitter Taste Signaling

Gene Ontology (GO) - Biological Process for TAS2R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IBA,IDA 20022913
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007585 respiratory gaseous exchange IEA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with TAS2R4: view

No data available for SIGNOR curated interactions for TAS2R4 Gene

Drugs & Compounds for TAS2R4 Gene

(10) Drugs for TAS2R4 Gene - From: BitterDB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Azathioprine Approved Pharma 227
Chlorpheniramine Approved Pharma 70
Colchicine Approved Pharma Antagonist Tubulin Inhibitor 157
Dapsone Approved, Investigational Pharma 69
Diphenidol Approved, Investigational, Withdrawn Pharma 1

(6) Additional Compounds for TAS2R4 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
amarogentin
Arborescin
Artemorin
Campher
denatonium benzoate
genes like me logo Genes that share compounds with TAS2R4: view

Transcripts for TAS2R4 Gene

mRNA/cDNA for TAS2R4 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAS2R4

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R4 Gene

No ASD Table

Relevant External Links for TAS2R4 Gene

GeneLoc Exon Structure for
TAS2R4

Expression for TAS2R4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAS2R4 Gene

mRNA differential expression in normal tissues according to GTEx for TAS2R4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.4) and Brain - Cerebellum (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAS2R4

SOURCE GeneReport for Unigene cluster for TAS2R4 Gene:

Hs.735690

mRNA Expression by UniProt/SwissProt for TAS2R4 Gene:

Q9NYW5-TA2R4_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed on airway ciliated epithelium.
genes like me logo Genes that share expression patterns with TAS2R4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAS2R4 Gene

Orthologs for TAS2R4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TAS2R4 30 31
  • 99.78 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TAS2R4 30
  • 82.44 (n)
Cow
(Bos Taurus)
Mammalia TAS2R4 30 31
  • 81.87 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tas2r108 30 17 31
  • 76.66 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tas2r108 30
  • 74.97 (n)
Chicken
(Gallus gallus)
Aves TAS2R7 31
  • 23 (a)
OneToMany
Species where no ortholog for TAS2R4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TAS2R4 Gene

ENSEMBL:
Gene Tree for TAS2R4 (if available)
TreeFam:
Gene Tree for TAS2R4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAS2R4: view image

Paralogs for TAS2R4 Gene

Variants for TAS2R4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAS2R4 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
720426 Benign: not provided 141,778,505(+) A/C MISSENSE_VARIANT
771417 Benign: not provided 141,778,497(+) G/C SYNONYMOUS_VARIANT
774457 Likely Benign: not provided 141,779,153(+) C/T MISSENSE_VARIANT
rs2233995 - p.Arg3Gln
rs2233998 - p.Phe7Ser

Additional dbSNP identifiers (rs#s) for TAS2R4 Gene

Structural Variations from Database of Genomic Variants (DGV) for TAS2R4 Gene

Variant ID Type Subtype PubMed ID
esv34135 CNV loss 18971310

Variation tolerance for TAS2R4 Gene

Residual Variation Intolerance Score: 87.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.58; 72.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAS2R4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R4 Gene

Disorders for TAS2R4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TAS2R4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cerebellar ataxia type 9
  • sca9
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with TAS2R4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAS2R4 Gene

Publications for TAS2R4 Gene

  1. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E … Zuker CS (Cell 2000) 2 3 4
  2. T2Rs function as bitter taste receptors. (PMID: 10761935) Chandrashekar J … Ryba NJ (Cell 2000) 2 3 4
  3. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A … Pääbo S (Molecular biology and evolution 2005) 3 4
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4
  5. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y … Ryba NJ (Cell 2003) 3 4

Products for TAS2R4 Gene

  • Signalway ELISA kits for TAS2R4

Sources for TAS2R4 Gene