Aliases for TAS2R4 Gene
External Ids for TAS2R4 Gene
Previous GeneCards Identifiers for TAS2R4 Gene
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
GeneCards Summary for TAS2R4 Gene
TAS2R4 (Taste 2 Receptor Member 4) is a Protein Coding gene. Diseases associated with TAS2R4 include Cerebellar Ataxia Type 9. Among its related pathways are Signaling by GPCR and Taste transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R7.
UniProtKB/Swiss-Prot Summary for TAS2R4 Gene
Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.