Aliases for TAS2R38 Gene
External Ids for TAS2R38 Gene
Previous HGNC Symbols for TAS2R38 Gene
Previous GeneCards Identifiers for TAS2R38 Gene
This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]
GeneCards Summary for TAS2R38 Gene
TAS2R38 (Taste 2 Receptor Member 38) is a Protein Coding gene. Diseases associated with TAS2R38 include Thiourea Tasting and Alexithymia. Among its related pathways are Signaling by GPCR and Taste transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and bitter taste receptor activity. An important paralog of this gene is TAS2R3.
UniProtKB/Swiss-Prot Summary for TAS2R38 Gene
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).