This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustere... See more...

Aliases for TAS2R3 Gene

Aliases for TAS2R3 Gene

  • Taste 2 Receptor Member 3 2 3 5
  • Taste Receptor, Type 2, Member 3 2 3
  • Taste Receptor Type 2 Member 3 3 4
  • T2R3 3 4
  • Candidate Taste Receptor T2R3 3

External Ids for TAS2R3 Gene

Previous GeneCards Identifiers for TAS2R3 Gene

  • GC07P139734
  • GC07P140795
  • GC07P140871
  • GC07P140918
  • GC07P141110
  • GC07P141463
  • GC07P135760
  • GC07P142609
  • GC07P142903
  • GC07P144286
  • GC07P144420
  • GC07P144637
  • GC07P143065
  • GC07P143210
  • GC07P143410
  • GC07P143561
  • GC07P143711
  • GC07P143833
  • GC07P143977
  • GC07P144138

Summaries for TAS2R3 Gene

Entrez Gene Summary for TAS2R3 Gene

  • This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R3 Gene

TAS2R3 (Taste 2 Receptor Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Taste transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R7.

UniProtKB/Swiss-Prot Summary for TAS2R3 Gene

  • Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Gene Wiki entry for TAS2R3 Gene

Additional gene information for TAS2R3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAS2R3 Gene

Genomics for TAS2R3 Gene

GeneHancer (GH) Regulatory Elements for TAS2R3 Gene

Promoters and enhancers for TAS2R3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J141736 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 0.3 -25.4 -25404 3.8 RXRA EP300 FOXK2 ZBTB40 ZNF217 CTCF SIN3A NRF1 TCF12 USF1 WEE2-AS1 SSBP1 NONHSAG048978.2 TAS2R6P TAS2R5 PRSS37 WEE2 TAS2R4 AGK TAS2R3
GH07J141792 Enhancer 0.2 FANTOM5 2.4 +28.4 28393 0.3 WEE2-AS1 TAS2R4 OR9A4 TAS2R5 TAS2R38 TAS2R3 MTCO1P55 lnc-PRSS37-2
GH07J141634 Enhancer 0.2 FANTOM5 1.8 -129.3 -129255 0 TAS2R3 ENSG00000244701 RF00017-6708 AGK
GH07J141316 Enhancer 0.2 FANTOM5 1.4 -447.6 -447554 0.1 TAS2R3 WEE2 NDUFB10P2 lnc-AGK-4 RF00017-6704 lnc-TMEM178B-1 TMEM178B
GH07J141760 Enhancer 0.2 Ensembl 0.7 -2.7 -2696 0.4 WEE2-AS1 TAS2R5 TAS2R3 NONHSAG048978.2 SSBP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAS2R3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAS2R3

Top Transcription factor binding sites by QIAGEN in the TAS2R3 gene promoter:
  • AhR
  • AREB6
  • Arnt
  • Bach2
  • Evi-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • Gfi-1

Genomic Locations for TAS2R3 Gene

Genomic Locations for TAS2R3 Gene
chr7:141,764,097-141,765,197
(GRCh38/hg38)
Size:
1,101 bases
Orientation:
Plus strand
chr7:141,463,897-141,464,997
(GRCh37/hg19)
Size:
1,101 bases
Orientation:
Plus strand

Genomic View for TAS2R3 Gene

Genes around TAS2R3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R3 Gene

Proteins for TAS2R3 Gene

  • Protein details for TAS2R3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW6-TA2R3_HUMAN
    Recommended name:
    Taste receptor type 2 member 3
    Protein Accession:
    Q9NYW6
    Secondary Accessions:
    • A4D1U2
    • Q645W2
    • Q75MV6

    Protein attributes for TAS2R3 Gene

    Size:
    316 amino acids
    Molecular mass:
    35915 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Several bitter taste receptors are expressed in a single taste receptor cell.
    SequenceCaution:
    • Sequence=AAU21157.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TAS2R3 Gene

Post-translational modifications for TAS2R3 Gene

  • Glycosylation at Asn166
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R3 Gene

Domains & Families for TAS2R3 Gene

Gene Families for TAS2R3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for TAS2R3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R3 Gene

GenScript: Design optimal peptide antigens:
  • Taste receptor type 2 member 3 (TA2R3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NYW6

UniProtKB/Swiss-Prot:

TA2R3_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R3: view

Function for TAS2R3 Gene

Molecular function for TAS2R3 Gene

UniProtKB/Swiss-Prot Function:
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Phenotypes From GWAS Catalog for TAS2R3 Gene

Gene Ontology (GO) - Molecular Function for TAS2R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0008527 taste receptor activity TAS 10761934
GO:0033038 bitter taste receptor activity IDA,IBA 20022913
genes like me logo Genes that share ontologies with TAS2R3: view
genes like me logo Genes that share phenotypes with TAS2R3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAS2R3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R3 Gene

Localization for TAS2R3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS2R3 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TAS2R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IC 20022913
genes like me logo Genes that share ontologies with TAS2R3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAS2R3 Gene

Pathways & Interactions for TAS2R3 Gene

genes like me logo Genes that share pathways with TAS2R3: view

Pathways by source for TAS2R3 Gene

1 Qiagen pathway for TAS2R3 Gene
  • Bitter Taste Signaling

Gene Ontology (GO) - Biological Process for TAS2R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0050896 response to stimulus IEA --
GO:0050909 sensory perception of taste IEA --
genes like me logo Genes that share ontologies with TAS2R3: view

No data available for SIGNOR curated interactions for TAS2R3 Gene

Drugs & Compounds for TAS2R3 Gene

(2) Drugs for TAS2R3 Gene - From: BitterDB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
chloroquine Approved, Investigational, Vet_approved Pharma Agonist 164
Calcium Approved Nutra 7884
genes like me logo Genes that share compounds with TAS2R3: view

Transcripts for TAS2R3 Gene

mRNA/cDNA for TAS2R3 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAS2R3

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R3 Gene

No ASD Table

Relevant External Links for TAS2R3 Gene

GeneLoc Exon Structure for
TAS2R3

Expression for TAS2R3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAS2R3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAS2R3

SOURCE GeneReport for Unigene cluster for TAS2R3 Gene:

Hs.676011

mRNA Expression by UniProt/SwissProt for TAS2R3 Gene:

Q9NYW6-TA2R3_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in the antrum and fundus (part of the stomach), duodenum and in gastric endocrine cells.
genes like me logo Genes that share expression patterns with TAS2R3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAS2R3 Gene

Orthologs for TAS2R3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R3 31 30
  • 99.79 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TAS2R3 31 30
  • 80.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TAS2R3 31 30
  • 79.26 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tas2r137 17 31 30
  • 77.85 (n)
rat
(Rattus norvegicus)
Mammalia Tas2r137 30
  • 77.6 (n)
oppossum
(Monodelphis domestica)
Mammalia TAS2R3 31
  • 51 (a)
OneToOne
Species where no ortholog for TAS2R3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R3 Gene

ENSEMBL:
Gene Tree for TAS2R3 (if available)
TreeFam:
Gene Tree for TAS2R3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAS2R3: view image

Paralogs for TAS2R3 Gene

genes like me logo Genes that share paralogs with TAS2R3: view

Variants for TAS2R3 Gene

Additional dbSNP identifiers (rs#s) for TAS2R3 Gene

Structural Variations from Database of Genomic Variants (DGV) for TAS2R3 Gene

Variant ID Type Subtype PubMed ID
esv34135 CNV loss 18971310

Variation tolerance for TAS2R3 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAS2R3 Gene

Human Gene Mutation Database (HGMD)
TAS2R3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAS2R3 Gene

Disorders for TAS2R3 Gene

Additional Disease Information for TAS2R3

No disorders were found for TAS2R3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R3 Gene

Publications for TAS2R3 Gene

  1. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A … Pääbo S (Molecular biology and evolution 2005) 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 54
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 54
  5. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y … Ryba NJ (Cell 2003) 3 4 54

Products for TAS2R3 Gene

Sources for TAS2R3 Gene