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Aliases for TAS2R20 Gene

Aliases for TAS2R20 Gene

  • Taste 2 Receptor Member 20 2 3 5
  • Taste Receptor, Type 2, Member 49 2 3
  • Taste Receptor Type 2 Member 56 3 4
  • TAS2R49 3 4
  • T2R49 3 4
  • T2R56 3 4
  • Taste Receptor, Type 2, Member 20 2
  • Taste Receptor Type 2 Member 20 3
  • Taste Receptor Type 2 Member 49 4
  • T2R20 3

External Ids for TAS2R20 Gene

Previous HGNC Symbols for TAS2R20 Gene

  • TAS2R49

Previous GeneCards Identifiers for TAS2R20 Gene

  • GC00U991282
  • GC12U900764
  • GC12M011039
  • GC12M011148
  • GC12M010876
  • GC12M010996
  • GC12M011000
  • GC12M011192
  • GC12M011340
  • GC12M011555
  • GC12M011745

Summaries for TAS2R20 Gene

Entrez Gene Summary for TAS2R20 Gene

  • This gene encodes a member of the taste receptor two family of class C G-protein coupled receptors. Receptors of this family have a short extracellular N-terminus, seven transmembrane helices, three extracellular loops and three intracellular loops, and an intracellular C-terminus. Members of this family are expressed in a subset of taste receptor cells, where they function in bitter taste reception, as well as in non-gustatory cells including those of the brain, reproductive organs, respiratory system, and gastrointestinal system. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2016]

GeneCards Summary for TAS2R20 Gene

TAS2R20 (Taste 2 Receptor Member 20) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Taste transduction. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is TAS2R46.

UniProtKB/Swiss-Prot for TAS2R20 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Wiki entry for TAS2R20 Gene

Additional gene information for TAS2R20 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R20 Gene

Genomics for TAS2R20 Gene

GeneHancer (GH) Regulatory Elements for TAS2R20 Gene

Promoters and enhancers for TAS2R20 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I010997 Promoter 0.5 EPDnew 550.8 -0.1 -74 0.1 TAS2R20 TAS2R64P TAS2R15P TAS2R19 GC12P010929 ENSG00000275778 PRH1 PRH1-PRR4 PRR4 TAS2R14
GH12I010715 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 33.6 +277.8 277781 8.8 CLOCK FOXA2 SMAD1 MLX ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 YBX3 KLRA1P TAS2R20 TAS2R31 TAS2R43 MAGOHB TAS2R14 TAS2R50 TAS2R15P TAS2R10
GH12I010384 Promoter/Enhancer 1.7 EPDnew FANTOM5 ENCODE dbSUPER 25.5 +610.4 610437 5.1 FOXA2 ZSCAN4 FEZF1 ZEB1 GTF3C2 FOS ZNF362 YY2 CEBPB ZNF662 KLRK1 GC12P010386 TAS2R19 TAS2R31 TAS2R14 TAS2R10 KLRA1P TAS2R15P MAGOHB TAS2R20
GH12I010673 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 14.2 +323.7 323732 1.5 SIN3A ZNF2 TCF12 GLIS2 ZNF207 ZNF143 RUNX3 SP3 YY2 REST STYK1 KLRA1P MAGOHB TAS2R20 TAS2R14 LOC101928100 GC12P010619
GH12I010211 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.9 +784.0 784041 5.3 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GABARAPL1 ENSG00000255958 KLRA1P TAS2R31 TAS2R20 TAS2R19 TAS2R14 TAS2R10 KLRD1 CLEC7A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TAS2R20 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TAS2R20 gene promoter:

Genomic Locations for TAS2R20 Gene

Genomic Locations for TAS2R20 Gene
chr12:10,995,962-10,997,875
(GRCh38/hg38)
Size:
1,914 bases
Orientation:
Minus strand
chr12:11,148,561-11,150,474
(GRCh37/hg19)

Genomic View for TAS2R20 Gene

Genes around TAS2R20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R20 Gene

Proteins for TAS2R20 Gene

  • Protein details for TAS2R20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59543-T2R20_HUMAN
    Recommended name:
    Taste receptor type 2 member 20
    Protein Accession:
    P59543
    Secondary Accessions:
    • P59549
    • Q2HIZ4
    • Q496D8
    • Q645X9

    Protein attributes for TAS2R20 Gene

    Size:
    309 amino acids
    Molecular mass:
    35358 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R20 Gene

Post-translational modifications for TAS2R20 Gene

  • Glycosylation at isoforms=161 and posLast=176176
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R20 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R20 Gene

Domains & Families for TAS2R20 Gene

Gene Families for TAS2R20 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for TAS2R20 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R20 Gene

Graphical View of Domain Structure for InterPro Entry

P59543

UniProtKB/Swiss-Prot:

T2R20_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R20: view

Function for TAS2R20 Gene

Molecular function for TAS2R20 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Ontology (GO) - Molecular Function for TAS2R20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0033038 bitter taste receptor activity IBA --
genes like me logo Genes that share ontologies with TAS2R20: view
genes like me logo Genes that share phenotypes with TAS2R20: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R20 Gene

Localization for TAS2R20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R20 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS2R20 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for TAS2R20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with TAS2R20: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAS2R20 Gene

Pathways & Interactions for TAS2R20 Gene

genes like me logo Genes that share pathways with TAS2R20: view

Pathways by source for TAS2R20 Gene

Gene Ontology (GO) - Biological Process for TAS2R20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IBA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0050896 response to stimulus IEA --
GO:0050909 sensory perception of taste IEA --
genes like me logo Genes that share ontologies with TAS2R20: view

No data available for SIGNOR curated interactions for TAS2R20 Gene

Drugs & Compounds for TAS2R20 Gene

(1) Drugs for TAS2R20 Gene - From: BitterDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diphenidol Approved, Investigational, Withdrawn Pharma 1

(1) Additional Compounds for TAS2R20 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cromolyn
genes like me logo Genes that share compounds with TAS2R20: view

Transcripts for TAS2R20 Gene

mRNA/cDNA for TAS2R20 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R20 Gene

Taste receptor, type 2, member 20:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R20 Gene

No ASD Table

Relevant External Links for TAS2R20 Gene

GeneLoc Exon Structure for
TAS2R20
ECgene alternative splicing isoforms for
TAS2R20

Expression for TAS2R20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAS2R20 Gene

NURSA nuclear receptor signaling pathways regulating expression of TAS2R20 Gene:

TAS2R20

SOURCE GeneReport for Unigene cluster for TAS2R20 Gene:

Hs.686384

mRNA Expression by UniProt/SwissProt for TAS2R20 Gene:

P59543-T2R20_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
genes like me logo Genes that share expression patterns with TAS2R20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAS2R20 Gene

Orthologs for TAS2R20 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R20 33 34
  • 99.57 (n)
cow
(Bos Taurus)
Mammalia TAS2R46 34
  • 57 (a)
ManyToMany
-- 34
  • 56 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CAFA-T2R43 34
  • 52 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tas2r120 34
  • 51 (a)
ManyToMany
Tas2r136 34
  • 42 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia T2R24 34
  • 34 (a)
ManyToMany
T2R25 34
  • 34 (a)
ManyToMany
T2R23 34
  • 30 (a)
ManyToMany
Species where no ortholog for TAS2R20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R20 Gene

ENSEMBL:
Gene Tree for TAS2R20 (if available)
TreeFam:
Gene Tree for TAS2R20 (if available)

Paralogs for TAS2R20 Gene

genes like me logo Genes that share paralogs with TAS2R20: view

Variants for TAS2R20 Gene

Sequence variations from dbSNP and Humsavar for TAS2R20 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs193920802 uncertain-significance, Malignant tumor of prostate 10,997,622(-) G/C coding_sequence_variant, missense_variant
rs1000641588 -- 10,996,167(-) A/C 3_prime_UTR_variant
rs1000946678 -- 10,999,139(-) T/C upstream_transcript_variant
rs1001231818 -- 10,996,771(-) T/A 3_prime_UTR_variant
rs1002575526 -- 10,998,282(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TAS2R20 Gene

Variant ID Type Subtype PubMed ID
esv26197 CNV gain 19812545
esv2664609 CNV deletion 23128226
esv2745546 CNV deletion 23290073
esv2759879 CNV loss 17122850
esv3628556 CNV loss 21293372
esv8289 CNV loss 19470904
nsv1038277 CNV loss 25217958
nsv1159978 CNV duplication 26073780
nsv428272 CNV gain+loss 18775914
nsv832330 CNV gain 17160897
nsv8915 CNV gain 18304495

Variation tolerance for TAS2R20 Gene

Residual Variation Intolerance Score: 93.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.72; 73.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAS2R20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R20 Gene

Disorders for TAS2R20 Gene

Additional Disease Information for TAS2R20

No disorders were found for TAS2R20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R20 Gene

Publications for TAS2R20 Gene

  1. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A … Pääbo S (Molecular biology and evolution 2005) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y … Ryba NJ (Cell 2003) 3 4 58
  4. Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee RF (The Journal of biological chemistry 2002) 3 4 58
  5. Receptors for bitter and sweet taste. (PMID: 12139982) Montmayeur JP … Matsunami H (Current opinion in neurobiology 2002) 3 4 58

Products for TAS2R20 Gene

Sources for TAS2R20 Gene

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