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Aliases for TAS2R14 Gene

Aliases for TAS2R14 Gene

  • Taste 2 Receptor Member 14 2 3 5
  • Taste Receptor, Type 2, Member 14 2 3
  • T2R14 3 4
  • TRB1 3 4
  • Taste Receptor, Family B, Member 1 3
  • Taste Receptor Family B Member 1 4
  • Taste Receptor Type 2 Member 14 3

External Ids for TAS2R14 Gene

Previous GeneCards Identifiers for TAS2R14 Gene

  • GC12M010794
  • GC12M011235
  • GC12M010991
  • GC12M010982
  • GC12M011090

Summaries for TAS2R14 Gene

Entrez Gene Summary for TAS2R14 Gene

  • This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R14 Gene

TAS2R14 (Taste 2 Receptor Member 14) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Taste transduction. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R13.

UniProtKB/Swiss-Prot for TAS2R14 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Wiki entry for TAS2R14 Gene

Additional gene information for TAS2R14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R14 Gene

Genomics for TAS2R14 Gene

GeneHancer (GH) Regulatory Elements for TAS2R14 Gene

Promoters and enhancers for TAS2R14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I011169 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 580.6 +0.1 132 3 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 POLR2B PRR4 TAS2R14 ENSG00000256712 ENSG00000275778 PRH1 PRH1-PRR4 SMIM10L1 LINC01252 TAS2R64P TAS2R15P
GH12I010940 Promoter 0.5 EPDnew 550.1 +232.3 232300 0.1 TAS2R14 GC12M012113 GC12P010929 GC12M012105 ENSG00000275778 PRH1 PRH1-PRR4 PRR4
GH12I010384 Promoter/Enhancer 1.7 EPDnew FANTOM5 ENCODE dbSUPER 45.4 +784.1 784135 5.1 FOXA2 ZSCAN4 FEZF1 ZEB1 GTF3C2 FOS ZNF362 YY2 CEBPB ZNF662 KLRK1 GC12P010386 TAS2R19 TAS2R31 TAS2R14 TAS2R10 KLRA1P TAS2R15P MAGOHB TAS2R20
GH12I010715 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.8 +451.5 451479 8.8 CLOCK FOXA2 SMAD1 MLX ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 YBX3 KLRA1P TAS2R20 TAS2R31 TAS2R43 MAGOHB TAS2R14 TAS2R50 TAS2R15P TAS2R10
GH12I010211 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.6 +957.7 957739 5.3 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GABARAPL1 ENSG00000255958 KLRA1P TAS2R31 TAS2R20 TAS2R19 TAS2R14 TAS2R10 KLRD1 CLEC7A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TAS2R14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TAS2R14 gene promoter:

Genomic Locations for TAS2R14 Gene

Genomic Locations for TAS2R14 Gene
chr12:10,937,406-11,171,573
(GRCh38/hg38)
Size:
234,168 bases
Orientation:
Minus strand
chr12:11,090,005-11,324,172
(GRCh37/hg19)

Genomic View for TAS2R14 Gene

Genes around TAS2R14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R14 Gene

Proteins for TAS2R14 Gene

  • Protein details for TAS2R14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYV8-T2R14_HUMAN
    Recommended name:
    Taste receptor type 2 member 14
    Protein Accession:
    Q9NYV8
    Secondary Accessions:
    • Q645X3

    Protein attributes for TAS2R14 Gene

    Size:
    317 amino acids
    Molecular mass:
    36160 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

neXtProt entry for TAS2R14 Gene

Post-translational modifications for TAS2R14 Gene

  • Glycosylation at posLast=153153, posLast=162162, and isoforms=171
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R14 Gene

Domains & Families for TAS2R14 Gene

Gene Families for TAS2R14 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for TAS2R14 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R14 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYV8

UniProtKB/Swiss-Prot:

T2R14_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R14: view

Function for TAS2R14 Gene

Molecular function for TAS2R14 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Gene Ontology (GO) - Molecular Function for TAS2R14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0008527 taste receptor activity TAS 10761934
GO:0033038 bitter taste receptor activity IDA 16720576
genes like me logo Genes that share ontologies with TAS2R14: view
genes like me logo Genes that share phenotypes with TAS2R14: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAS2R14 Gene

Localization for TAS2R14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R14 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS2R14 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TAS2R14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IC 16720576
genes like me logo Genes that share ontologies with TAS2R14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAS2R14 Gene

Pathways & Interactions for TAS2R14 Gene

genes like me logo Genes that share pathways with TAS2R14: view

Pathways by source for TAS2R14 Gene

Gene Ontology (GO) - Biological Process for TAS2R14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 16720576
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0050896 response to stimulus IEA --
GO:0050909 sensory perception of taste IEA --
genes like me logo Genes that share ontologies with TAS2R14: view

No data available for SIGNOR curated interactions for TAS2R14 Gene

Drugs & Compounds for TAS2R14 Gene

(20) Drugs for TAS2R14 Gene - From: BitterDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Azathioprine Approved Pharma 190
Benzoin Approved Pharma 0
Carisoprodol Approved Pharma 4
Chlorhexidine Approved, Vet_approved Pharma 545
chloroquine Approved, Investigational, Vet_approved Pharma Agonist 154

(26) Additional Compounds for TAS2R14 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(-)-alpha Thujone
(+/-) Equol
Absinthin
  • (+)-absinthin
  • Absinthin (van)
  • Absinthin (VAN) (8CI)
  • Absynthin
1362-42-1
Adlupulone
28374-71-2
Arborescin
genes like me logo Genes that share compounds with TAS2R14: view

Transcripts for TAS2R14 Gene

mRNA/cDNA for TAS2R14 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R14 Gene

Taste receptor, type 2, member 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R14 Gene

No ASD Table

Relevant External Links for TAS2R14 Gene

GeneLoc Exon Structure for
TAS2R14
ECgene alternative splicing isoforms for
TAS2R14

Expression for TAS2R14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAS2R14 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAS2R14 Gene



Protein tissue co-expression partners for TAS2R14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAS2R14 Gene:

TAS2R14

SOURCE GeneReport for Unigene cluster for TAS2R14 Gene:

Hs.679406

mRNA Expression by UniProt/SwissProt for TAS2R14 Gene:

Q9NYV8-T2R14_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in testis (PubMed:16720576).

Evidence on tissue expression from TISSUES for TAS2R14 Gene

  • Bone marrow(4)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with TAS2R14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAS2R14 Gene

Orthologs for TAS2R14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R14 33 34
  • 99.16 (n)
rat
(Rattus norvegicus)
Mammalia Tas2r140 33
  • 67.64 (n)
mouse
(Mus musculus)
Mammalia Tas2r140 33 16 34
  • 66.56 (n)
Tas2r116 34
  • 51 (a)
OneToMany
Tas2r113 34
  • 50 (a)
OneToMany
Tas2r125 34
  • 50 (a)
OneToMany
Tas2r103 34
  • 49 (a)
OneToMany
Tas2r115 34
  • 47 (a)
OneToMany
Tas2r109 34
  • 45 (a)
OneToMany
Tas2r110 34
  • 45 (a)
OneToMany
Tas2r123 34
  • 44 (a)
OneToMany
Tas2r129 34
  • 43 (a)
OneToMany
Tas2r117 34
  • 42 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CAFA-T2R67 34
  • 40 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia T2R24 34
  • 35 (a)
ManyToMany
T2R25 34
  • 34 (a)
ManyToMany
T2R23 34
  • 30 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia T2R65A 34
  • 32 (a)
ManyToMany
Species where no ortholog for TAS2R14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R14 Gene

ENSEMBL:
Gene Tree for TAS2R14 (if available)
TreeFam:
Gene Tree for TAS2R14 (if available)

Paralogs for TAS2R14 Gene

genes like me logo Genes that share paralogs with TAS2R14: view

Variants for TAS2R14 Gene

Sequence variations from dbSNP and Humsavar for TAS2R14 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000493235 -- 10,939,423(-) C/T upstream_transcript_variant
rs1001964815 -- 10,941,139(-) G/A upstream_transcript_variant
rs1004678250 -- 10,940,199(-) A/C/G upstream_transcript_variant
rs1005544393 -- 10,940,228(-) A/G upstream_transcript_variant
rs1008843475 -- 10,940,227(-) C/A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TAS2R14 Gene

Variant ID Type Subtype PubMed ID
esv2759879 CNV loss 17122850
esv3628550 CNV loss 21293372
nsv1038277 CNV loss 25217958
nsv428272 CNV gain+loss 18775914
nsv832330 CNV gain 17160897

Variation tolerance for TAS2R14 Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAS2R14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R14 Gene

Disorders for TAS2R14 Gene

Additional Disease Information for TAS2R14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TAS2R14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R14 Gene

Publications for TAS2R14 Gene

  1. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E … Zuker CS (Cell 2000) 2 3 4 58
  2. A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer. (PMID: 20534144) Campa D … Canzian F (BMC medical genetics 2010) 3 44 58
  3. Members of RTP and REEP gene families influence functional bitter taste receptor expression. (PMID: 16720576) Behrens M … Meyerhof W (The Journal of biological chemistry 2006) 3 4 58
  4. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A … Pääbo S (Molecular biology and evolution 2005) 3 4 58
  5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 58

Products for TAS2R14 Gene

Sources for TAS2R14 Gene

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