Aliases for TAS1R2 Gene

Aliases for TAS1R2 Gene

  • Taste 1 Receptor Member 2 2 3 5
  • T1R2 2 3 4
  • TR2 2 3 4
  • Taste Receptor, Type 1, Member 2 2 3
  • Taste Receptor Type 1 Member 2 3 4
  • G-Protein Coupled Receptor 71 3 4
  • Sweet Taste Receptor T1R2 3 4
  • GPR71 3 4
  • G Protein-Coupled Receptor 71 2
  • TAS1R2 5

External Ids for TAS1R2 Gene

Previous HGNC Symbols for TAS1R2 Gene

  • GPR71

Previous GeneCards Identifiers for TAS1R2 Gene

  • GC00U990928
  • GC01M018208
  • GC01M018599
  • GC01M018911
  • GC01M019038
  • GC01M019166
  • GC01M017412

Summaries for TAS1R2 Gene

GeneCards Summary for TAS1R2 Gene

TAS1R2 (Taste 1 Receptor Member 2) is a Protein Coding gene. Diseases associated with TAS1R2 include Dental Caries and Kagami-Ogata Syndrome. Among its related pathways are Signaling by GPCR and Taste transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS1R1.

UniProtKB/Swiss-Prot Summary for TAS1R2 Gene

  • Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.

Gene Wiki entry for TAS1R2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAS1R2 Gene

Genomics for TAS1R2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TAS1R2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J019079 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 10.5 -221.4 -221361 3.1 MYC IKZF1 ZNF592 CEBPA ATF3 YY1 CEBPB BHLHE40 MNT FOXA2 ENSG00000272084 lnc-MRTO4-3 TAS1R2 EMC1 UBR4 MRTO4 HSALNG0001357 IFFO2
GH01J018802 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.3 +54.0 53974 5.8 MYC NCOR1 IKZF1 SIX5 ZNF592 NFIC MNT IRF2 NBN RUNX1 TAS1R2 PAX7 HSALNG0001338 piR-38352-002
GH01J019013 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.6 -155.2 -155218 2.2 YY1 MAFF FOXA2 SMAD4 RXRA SAP130 MIER3 RARA DMAP1 TEAD3 TAS1R2 AKR7A3 EMC1 IFFO2 HSALNG0001346 HSALNG0001351 LOC105376815 lnc-IFFO2-1 UBR4
GH01J018998 Enhancer 0.8 FANTOM5 Ensembl ENCODE dbSUPER 13.9 -139.2 -139231 1.8 ZNF513 IFFO2 TAS1R2 EMC1 HSALNG0001348 HSALNG0001346 piR-42491-002 lnc-IFFO2-1 LOC105376815 UBR4
GH01J019045 Enhancer 1 Ensembl ENCODE 11 -186.3 -186319 2 CEBPA ATF3 YY1 FOXA2 SMAD4 RXRA SAP130 RARA GABPB1 TEAD3 ALDH4A1 MIR1290 TAS1R2 EMC1 lnc-IFFO2-1 LOC105376815 HSALNG0001351 IFFO2 UBR4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAS1R2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAS1R2

Top Transcription factor binding sites by QIAGEN in the TAS1R2 gene promoter:
  • AML1a
  • HNF-4alpha1
  • HNF-4alpha2
  • Ik-1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • USF-1
  • USF1

Genomic Locations for TAS1R2 Gene

Latest Assembly
chr1:18,839,599-18,859,682
(GRCh38/hg38)
Size:
20,084 bases
Orientation:
Minus strand

Previous Assembly
chr1:19,166,093-19,186,154
(GRCh37/hg19 by Entrez Gene)
Size:
20,062 bases
Orientation:
Minus strand

chr1:19,166,093-19,186,176
(GRCh37/hg19 by Ensembl)
Size:
20,084 bases
Orientation:
Minus strand

Genomic View for TAS1R2 Gene

Genes around TAS1R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS1R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS1R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS1R2 Gene

Proteins for TAS1R2 Gene

  • Protein details for TAS1R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE23-TS1R2_HUMAN
    Recommended name:
    Taste receptor type 1 member 2
    Protein Accession:
    Q8TE23
    Secondary Accessions:
    • Q5TZ19

    Protein attributes for TAS1R2 Gene

    Size:
    839 amino acids
    Molecular mass:
    95183 Da
    Quaternary structure:
    • Forms heterodimers with TAS1R3.

neXtProt entry for TAS1R2 Gene

Post-translational modifications for TAS1R2 Gene

  • Glycosylation at Asn84, Asn248, Asn292, Asn312, Asn368, Asn428, Asn487, and Asn527
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS1R2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS1R2 Gene

Domains & Families for TAS1R2 Gene

Gene Families for TAS1R2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for TAS1R2 Gene

Suggested Antigen Peptide Sequences for TAS1R2 Gene

GenScript: Design optimal peptide antigens:
  • Sweet taste receptor T1R2 (TS1R2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TE23

UniProtKB/Swiss-Prot:

TS1R2_HUMAN :
  • Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
Family:
  • Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
genes like me logo Genes that share domains with TAS1R2: view

Function for TAS1R2 Gene

Molecular function for TAS1R2 Gene

UniProtKB/Swiss-Prot Function:
Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.

Phenotypes From GWAS Catalog for TAS1R2 Gene

Gene Ontology (GO) - Molecular Function for TAS1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0008527 taste receptor activity IPI 11917125
GO:0033041 contributes_to sweet taste receptor activity IEA,IDA 16720576
genes like me logo Genes that share ontologies with TAS1R2: view
genes like me logo Genes that share phenotypes with TAS1R2: view

Animal Models for TAS1R2 Gene

MGI Knock Outs for TAS1R2:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAS1R2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TAS1R2 Gene

Localization for TAS1R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS1R2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS1R2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TAS1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IC 11917125
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with TAS1R2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAS1R2 Gene

Pathways & Interactions for TAS1R2 Gene

genes like me logo Genes that share pathways with TAS1R2: view

Pathways by source for TAS1R2 Gene

1 Qiagen pathway for TAS1R2 Gene
  • Sweet Taste Signaling

Gene Ontology (GO) - Biological Process for TAS1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001582 detection of chemical stimulus involved in sensory perception of sweet taste IDA 16720576
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IC,TAS --
GO:0032467 positive regulation of cytokinesis IMP 22888021
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with TAS1R2: view

No data available for SIGNOR curated interactions for TAS1R2 Gene

Drugs & Compounds for TAS1R2 Gene

(3) Drugs for TAS1R2 Gene - From: DrugBank, ClinicalTrials, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sucrose Approved, Experimental, Investigational Pharma Target 0
Aspartame Investigational Nutra Target, agonist 0
Pharmaceutical Solutions Pharma 13050
genes like me logo Genes that share compounds with TAS1R2: view

Transcripts for TAS1R2 Gene

mRNA/cDNA for TAS1R2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAS1R2

Alternative Splicing Database (ASD) splice patterns (SP) for TAS1R2 Gene

No ASD Table

Relevant External Links for TAS1R2 Gene

GeneLoc Exon Structure for
TAS1R2

Expression for TAS1R2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAS1R2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAS1R2

SOURCE GeneReport for Unigene cluster for TAS1R2 Gene:

Hs.553548
genes like me logo Genes that share expression patterns with TAS1R2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAS1R2 Gene

Orthologs for TAS1R2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS1R2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TAS1R2 30
  • 99 (a)
OneToOne
LOC100615078 29
  • 96.86 (n)
Dog
(Canis familiaris)
Mammalia TAS1R2 29
  • 83.21 (n)
Cow
(Bos Taurus)
Mammalia TAS1R2 29 30
  • 82.4 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tas1r2 29
  • 78.4 (n)
Mouse
(Mus musculus)
Mammalia Tas1r2 29 16 30
  • 77.63 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TAS1R2 30
  • 66 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TAS1R2 30
  • 60 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TAS1R2 30
  • 47 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii tas1r2.1 30
  • 33 (a)
OneToMany
tas1r2.2 30
  • 33 (a)
OneToMany
Species where no ortholog for TAS1R2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TAS1R2 Gene

ENSEMBL:
Gene Tree for TAS1R2 (if available)
TreeFam:
Gene Tree for TAS1R2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAS1R2: view image
Alliance of Genome Resources:
Additional Orthologs for TAS1R2

Paralogs for TAS1R2 Gene

Paralogs for TAS1R2 Gene

(4) SIMAP similar genes for TAS1R2 Gene using alignment to 1 proteins:

  • TS1R2_HUMAN
genes like me logo Genes that share paralogs with TAS1R2: view

Variants for TAS1R2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAS1R2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
993832 Uncertain Significance: none provided 18,839,945(-) C/T
NM_152232.4(TAS1R2):c.2174G>A (p.Arg725His)
MISSENSE
rs115820797 Benign: not provided 18,841,860(-) G/A
NM_152232.3(TAS1R2):c.1468-8C>T
INTRON
rs116173086 Benign: not provided 18,839,884(-) G/A
NM_152232.3(TAS1R2):c.2235C>T (p.Phe745=)
SYNONYMOUS
rs145591806 Likely Benign: not provided 18,849,353(-) G/A
NM_152232.3(TAS1R2):c.1455C>T (p.Thr485=)
SYNONYMOUS
rs35775756 Benign: not provided 18,849,479(-) G/A
NM_152232.3(TAS1R2):c.1329C>T (p.Asp443=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TAS1R2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TAS1R2 Gene

Variant ID Type Subtype PubMed ID
dgv59e59 CNV duplication 20981092

Variation tolerance for TAS1R2 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.90; 74.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAS1R2 Gene

Human Gene Mutation Database (HGMD)
TAS1R2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS1R2
Leiden Open Variation Database (LOVD)
TAS1R2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS1R2 Gene

Disorders for TAS1R2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TAS1R2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
dental caries
  • dental caries extending into pulp
kagami-ogata syndrome
  • uniparental disomy, paternal, chromosome 14
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TAS1R2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TAS1R2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAS1R2 Gene

Publications for TAS1R2 Gene

  1. Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor. (PMID: 20302879) Assadi-Porter FM … Max M (Journal of molecular biology 2010) 3 22
  2. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 40
  3. Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. (PMID: 20070850) Edwards TL … Martin ER (Annals of human genetics 2010) 3 40
  4. Taste genes associated with dental caries. (PMID: 20858777) Wendell S … Marazita ML (Journal of dental research 2010) 3 40
  5. Genetic variation in TAS1R2 (Ile191Val) is associated with consumption of sugars in overweight and obese individuals in 2 distinct populations. (PMID: 20943793) Eny KM … El-Sohemy A (The American journal of clinical nutrition 2010) 3 40

Products for TAS1R2 Gene

Sources for TAS1R2 Gene