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Aliases for TAS1R1 Gene

Aliases for TAS1R1 Gene

  • Taste 1 Receptor Member 1 2 3 5
  • Taste Receptor, Type 1, Member 1 2 3
  • G-Protein Coupled Receptor 70 3 4
  • GPR70 3 4
  • T1R1 3 4
  • TR1 3 4
  • Seven Transmembrane Helix Receptor 3
  • Taste Receptor Type 1 Member 1 3
  • G Protein-Coupled Receptor 70 2
  • GM148 3

External Ids for TAS1R1 Gene

Previous HGNC Symbols for TAS1R1 Gene

  • GPR70

Previous GeneCards Identifiers for TAS1R1 Gene

  • GC01P006207
  • GC01P006439
  • GC01P006325
  • GC01P006326
  • GC01P006550
  • GC01P006615
  • GC01P005763

Summaries for TAS1R1 Gene

Entrez Gene Summary for TAS1R1 Gene

  • The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for TAS1R1 Gene

TAS1R1 (Taste 1 Receptor Member 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Taste transduction. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS1R2.

UniProtKB/Swiss-Prot for TAS1R1 Gene

  • Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.

Gene Wiki entry for TAS1R1 Gene

Additional gene information for TAS1R1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS1R1 Gene

Genomics for TAS1R1 Gene

GeneHancer (GH) Regulatory Elements for TAS1R1 Gene

Promoters and enhancers for TAS1R1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I006553 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.7 -741 2.9 CLOCK SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF213 E2F8 ZNF207 TAS1R1 NOL9 THAP3 PLEKHG5 ZBTB48 PHF13 ENSG00000229519
GH01I006589 Enhancer 0.7 ENCODE dbSUPER 12.7 +34.3 34273 0.8 ZFHX2 KLF1 POLR2A SCRT2 ZNF600 ZBTB33 EGR2 GC01M006590 THAP3 PHF13 KLHL21 NOL9 TAS1R1 ENSG00000229519 RNU6-731P DNAJC11 ZBTB48
GH01I006587 Enhancer 0.6 ENCODE dbSUPER 12.7 +33.0 33044 1.5 POLR2A SCRT2 NOL9 TAS1R1 PHF13 KLHL21 ENSG00000229519 RNU6-731P THAP3 DNAJC11 GC01M006590 ZBTB48
GH01I006527 Enhancer 0.3 dbSUPER 11.7 -26.5 -26524 2.6 SPI1 NOL9 PLEKHG5 TAS1R1 KLHL21 PHF13 RNU6-731P
GH01I006578 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 0.3 +25.9 25898 4.2 HDGF PKNOX1 SMAD1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 ZBTB48 THAP3 GC01M006590 TAS1R1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TAS1R1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TAS1R1 gene promoter:

Genomic Locations for TAS1R1 Gene

Genomic Locations for TAS1R1 Gene
chr1:6,555,181-6,579,757
(GRCh38/hg38)
Size:
24,577 bases
Orientation:
Plus strand
chr1:6,615,241-6,639,817
(GRCh37/hg19)

Genomic View for TAS1R1 Gene

Genes around TAS1R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS1R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS1R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS1R1 Gene

Proteins for TAS1R1 Gene

  • Protein details for TAS1R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTX1-TS1R1_HUMAN
    Recommended name:
    Taste receptor type 1 member 1
    Protein Accession:
    Q7RTX1
    Secondary Accessions:
    • B2RMX0
    • Q5SY22
    • Q5SY24
    • Q8NGZ7
    • Q8TDJ7
    • Q8TDJ8
    • Q8TDJ9
    • Q8TDK0

    Protein attributes for TAS1R1 Gene

    Size:
    841 amino acids
    Molecular mass:
    93074 Da
    Quaternary structure:
    • Forms heterodimers with TAS1R3.
    SequenceCaution:
    • Sequence=AAL91359.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL91360.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL91361.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC05845.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TAS1R1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAS1R1 Gene

Post-translational modifications for TAS1R1 Gene

  • Glycosylation at posLast=8787, isoforms=2, 3, 488, isoforms=2, 3, 495, isoforms=291, isoforms=2, 4479, and isoforms=2, 4529

No data available for DME Specific Peptides for TAS1R1 Gene

Domains & Families for TAS1R1 Gene

Gene Families for TAS1R1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry

Q7RTX1

UniProtKB/Swiss-Prot:

TS1R1_HUMAN :
  • Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
Family:
  • Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
genes like me logo Genes that share domains with TAS1R1: view

Function for TAS1R1 Gene

Molecular function for TAS1R1 Gene

UniProtKB/Swiss-Prot Function:
Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.

Phenotypes From GWAS Catalog for TAS1R1 Gene

Gene Ontology (GO) - Molecular Function for TAS1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0008527 taste receptor activity IDA 11917125
GO:0046982 protein heterodimerization activity NAS 11917125
genes like me logo Genes that share ontologies with TAS1R1: view
genes like me logo Genes that share phenotypes with TAS1R1: view

Animal Models for TAS1R1 Gene

MGI Knock Outs for TAS1R1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TAS1R1 Gene

Localization for TAS1R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS1R1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS1R1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TAS1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IC 11917125
genes like me logo Genes that share ontologies with TAS1R1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAS1R1 Gene

Pathways & Interactions for TAS1R1 Gene

genes like me logo Genes that share pathways with TAS1R1: view

Pathways by source for TAS1R1 Gene

Gene Ontology (GO) - Biological Process for TAS1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050896 response to stimulus IEA --
GO:0050909 sensory perception of taste IEA --
GO:0050917 sensory perception of umami taste IDA 11917125
genes like me logo Genes that share ontologies with TAS1R1: view

No data available for SIGNOR curated interactions for TAS1R1 Gene

Drugs & Compounds for TAS1R1 Gene

(1) Additional Compounds for TAS1R1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TAS1R1: view

Transcripts for TAS1R1 Gene

mRNA/cDNA for TAS1R1 Gene

Unigene Clusters for TAS1R1 Gene

Taste receptor, type 1, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS1R1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - -
SP2:
SP3:
SP4: -
SP5: -
SP6: - -
SP7:
SP8: - -
SP9: -
SP10:

ExUns: 18a · 18b ^ 19a · 19b · 19c
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TAS1R1 Gene

GeneLoc Exon Structure for
TAS1R1
ECgene alternative splicing isoforms for
TAS1R1

Expression for TAS1R1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAS1R1 Gene

mRNA differential expression in normal tissues according to GTEx for TAS1R1 Gene

This gene is overexpressed in Testis (x18.4).

Protein differential expression in normal tissues from HIPED for TAS1R1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAS1R1 Gene



Protein tissue co-expression partners for TAS1R1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TAS1R1 Gene:

TAS1R1

SOURCE GeneReport for Unigene cluster for TAS1R1 Gene:

Hs.124574

Evidence on tissue expression from TISSUES for TAS1R1 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with TAS1R1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAS1R1 Gene

Orthologs for TAS1R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS1R1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS1R1 33 34
  • 99.17 (n)
cow
(Bos Taurus)
Mammalia TAS1R1 33 34
  • 81.33 (n)
dog
(Canis familiaris)
Mammalia TAS1R1 34
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tas1r1 33 16 34
  • 79.62 (n)
rat
(Rattus norvegicus)
Mammalia Tas1r1 33
  • 79.13 (n)
oppossum
(Monodelphis domestica)
Mammalia TAS1R1 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAS1R1 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAS1R1 33 34
  • 59.03 (n)
lizard
(Anolis carolinensis)
Reptilia TAS1R1 34
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tas1r1 33 34
  • 51.72 (n)
Species where no ortholog for TAS1R1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAS1R1 Gene

ENSEMBL:
Gene Tree for TAS1R1 (if available)
TreeFam:
Gene Tree for TAS1R1 (if available)

Paralogs for TAS1R1 Gene

Paralogs for TAS1R1 Gene

(6) SIMAP similar genes for TAS1R1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TAS1R1: view

Variants for TAS1R1 Gene

Sequence variations from dbSNP and Humsavar for TAS1R1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000024691 -- 6,579,158(+) G/A coding_sequence_variant, intron_variant, synonymous_variant
rs1000068632 -- 6,577,753(+) G/A intron_variant
rs1000080312 -- 6,573,764(+) G/A intron_variant
rs1000269121 -- 6,568,380(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000368542 -- 6,563,047(+) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TAS1R1 Gene

Variant ID Type Subtype PubMed ID
nsv831647 CNV loss 17160897
nsv831536 CNV loss 17160897
nsv7880 CNV gain+loss 18304495
nsv545269 CNV loss 21841781
nsv545268 CNV loss 21841781
nsv476608 CNV novel sequence insertion 20440878
nsv1078292 OTHER inversion 25765185
esv3585108 CNV loss 21293372
esv3302807 CNV tandem duplication 20981092
esv1249079 CNV insertion 17803354

Variation tolerance for TAS1R1 Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.58; 72.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAS1R1 Gene

Human Gene Mutation Database (HGMD)
TAS1R1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS1R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS1R1 Gene

Disorders for TAS1R1 Gene

Additional Disease Information for TAS1R1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TAS1R1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS1R1 Gene

Publications for TAS1R1 Gene

  1. Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes. (PMID: 19587085) Chen QY … Breslin PA (The American journal of clinical nutrition 2009) 3 22 44 58
  2. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PMID: 21738478) Okada Y … Kamatani N (PLoS genetics 2011) 3 44 58
  3. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
  4. Genetic and molecular basis of individual differences in human umami taste perception. (PMID: 19696921) Shigemura N … Ninomiya Y (PloS one 2009) 3 22 58
  5. Variation in umami perception and in candidate genes for the umami receptor in mice and humans. (PMID: 19625681) Shigemura N … Ninomiya Y (The American journal of clinical nutrition 2009) 3 22 58

Products for TAS1R1 Gene

Sources for TAS1R1 Gene

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