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Aliases for TARSL2 Gene

Aliases for TARSL2 Gene

  • Threonyl-TRNA Synthetase Like 2 2 3 5
  • Threonyl-TRNA Synthetase-Like Protein 2 3 4
  • EC 4 56
  • ThrRS 3 4
  • Probable Threonyl-TRNA Synthetase 2, Cytoplasmic 3
  • Probable Threonine--TRNA Ligase 2, Cytoplasmic 3
  • Threonyl-TRNA Synthetase 4
  • Threonine--TRNA Ligase 3

External Ids for TARSL2 Gene

Previous GeneCards Identifiers for TARSL2 Gene

  • GC15M100013
  • GC15M102193
  • GC15M078317

Summaries for TARSL2 Gene

GeneCards Summary for TARSL2 Gene

TARSL2 (Threonyl-TRNA Synthetase Like 2) is a Protein Coding gene. Among its related pathways are tRNA Aminoacylation. Gene Ontology (GO) annotations related to this gene include nucleotide binding. An important paralog of this gene is TARS.

Additional gene information for TARSL2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TARSL2 Gene

Genomics for TARSL2 Gene

GeneHancer (GH) Regulatory Elements for TARSL2 Gene

Promoters and enhancers for TARSL2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I101723 Promoter/Enhancer 1.5 Ensembl ENCODE 550.8 +0.5 480 2.1 PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 TARSL2 LOC100128108 SELENOS TM2D3 GC15M101723
GH15I101650 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.7 +72.3 72336 2.8 PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 TM2D3 TARSL2 RNU6-807P
GH15I101640 Enhancer 1.2 Ensembl ENCODE dbSUPER 20.1 +82.6 82611 2.7 ELF3 PKNOX1 ARID4B KLF17 ZNF2 RAD21 ARID2 ZNF143 BCLAF1 THAP11 TM2D3 TARSL2 LOC100128108 SNRPA1 SELENOS RNU6-807P LINC02348
GH15I101293 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 3.8 +429.3 429250 4.7 PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B POLR2B SNRPA1 ENSG00000259172 LINS1 LOC100419174 CERS3-AS1 PRKXP1 RNU6-807P WASH3P LRRK1 ENSG00000270127
GH15I101683 Enhancer 0.7 ENCODE 9.8 +40.1 40128 1.2 SIN3A FOSL1 CTBP1 GATA3 POLR2A ATF7 FOS FOSL2 SMARCE1 STAT1 TM2D3 TARSL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TARSL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TARSL2 gene promoter:

Genomic Locations for TARSL2 Gene

Genomic Locations for TARSL2 Gene
71,007 bases
Minus strand

Genomic View for TARSL2 Gene

Genes around TARSL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TARSL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TARSL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TARSL2 Gene

Proteins for TARSL2 Gene

  • Protein details for TARSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable threonine--tRNA ligase 2, cytoplasmic
    Protein Accession:
    Secondary Accessions:
    • B2RMP7
    • Q6B0A1
    • Q6IS76
    • Q96LW3
    • Q96MP4

    Protein attributes for TARSL2 Gene

    802 amino acids
    Molecular mass:
    92646 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71554.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TARSL2 Gene


neXtProt entry for TARSL2 Gene

Selected DME Specific Peptides for TARSL2 Gene


Post-translational modifications for TARSL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TARSL2 Gene

Domains & Families for TARSL2 Gene

Gene Families for TARSL2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TARSL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class-II aminoacyl-tRNA synthetase family.
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with TARSL2: view

Function for TARSL2 Gene

Molecular function for TARSL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

Enzyme Numbers (IUBMB) for TARSL2 Gene

Gene Ontology (GO) - Molecular Function for TARSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0004829 threonine-tRNA ligase activity IEA,IBA --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TARSL2: view

Animal Model Products

miRNA for TARSL2 Gene

miRTarBase miRNAs that target TARSL2

Clone Products

No data available for Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TARSL2 Gene

Localization for TARSL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TARSL2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TARSL2 gene
Compartment Confidence
mitochondrion 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TARSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA,IBA --
genes like me logo Genes that share ontologies with TARSL2: view

Pathways & Interactions for TARSL2 Gene

SuperPathways for TARSL2 Gene

SuperPathway Contained pathways
1 tRNA Aminoacylation
genes like me logo Genes that share pathways with TARSL2: view

Pathways by source for TARSL2 Gene

1 KEGG pathway for TARSL2 Gene

Gene Ontology (GO) - Biological Process for TARSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006418 tRNA aminoacylation for protein translation IEA --
GO:0006435 threonyl-tRNA aminoacylation IBA,IEA --
GO:0008150 biological_process ND --
GO:0043039 tRNA aminoacylation IEA --
genes like me logo Genes that share ontologies with TARSL2: view

No data available for SIGNOR curated interactions for TARSL2 Gene

Drugs & Compounds for TARSL2 Gene

(4) Drugs for TARSL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
L-Threonine Approved Nutra 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for TARSL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
genes like me logo Genes that share compounds with TARSL2: view

Transcripts for TARSL2 Gene

Unigene Clusters for TARSL2 Gene

Threonyl-tRNA synthetase-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TARSL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b
SP1: - - -
SP2: - - - - - - -
SP3: - - -

Relevant External Links for TARSL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TARSL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TARSL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TARSL2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.4) and Rectum (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TARSL2 Gene

Protein tissue co-expression partners for TARSL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TARSL2 Gene:


SOURCE GeneReport for Unigene cluster for TARSL2 Gene:


Evidence on tissue expression from TISSUES for TARSL2 Gene

  • Nervous system(4.6)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with TARSL2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TARSL2 Gene

Orthologs for TARSL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TARSL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TARSL2 33 34
  • 99.42 (n)
(Canis familiaris)
Mammalia TARSL2 33 34
  • 88.61 (n)
(Ornithorhynchus anatinus)
Mammalia TARSL2 34
  • 86 (a)
(Mus musculus)
Mammalia Tarsl2 33 16 34
  • 85.18 (n)
(Bos Taurus)
Mammalia TARSL2 33 34
  • 83.17 (n)
(Rattus norvegicus)
Mammalia Tarsl2 33
  • 82.81 (n)
(Monodelphis domestica)
Mammalia TARSL2 34
  • 78 (a)
(Gallus gallus)
Aves TARSL2 33 34
  • 75.83 (n)
(Anolis carolinensis)
Reptilia TARSL2 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tarsl2 33
  • 71.61 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18083 33
(Danio rerio)
Actinopterygii CABZ01081822.1 34
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta Aats-thr 34
  • 63 (a)
(Caenorhabditis elegans)
Secernentea tars-1 34
  • 57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THS1 34
  • 53 (a)
(Glycine max)
eudicotyledons Gma.2547 33
(Triticum aestivum)
Liliopsida Ta.3509 33
(Zea mays)
Liliopsida Zm.6559 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 62 (a)
Species where no ortholog for TARSL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for TARSL2 Gene

Gene Tree for TARSL2 (if available)
Gene Tree for TARSL2 (if available)

Paralogs for TARSL2 Gene

Paralogs for TARSL2 Gene

(3) SIMAP similar genes for TARSL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TARSL2: view

Variants for TARSL2 Gene

Sequence variations from dbSNP and Humsavar for TARSL2 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000009398 -- 101,726,213(-) A/C upstream_transcript_variant
rs1000023609 -- 101,716,015(-) T/C intron_variant
rs1000034446 -- 101,716,104(-) C/T intron_variant
rs1000072527 -- 101,715,787(-) C/T intron_variant
rs1000122567 -- 101,715,052(-) /G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TARSL2 Gene

Variant ID Type Subtype PubMed ID
dgv113e55 CNV gain 17911159
dgv2675n100 CNV gain 25217958
dgv2677n100 CNV loss 25217958
dgv2679n100 CNV loss 25217958
dgv2680n100 CNV gain 25217958
dgv2681n100 CNV gain 25217958
dgv2682n100 CNV gain 25217958
dgv2683n100 CNV gain 25217958
dgv4792n54 CNV gain 21841781
dgv4800n54 CNV gain 21841781
dgv4801n54 CNV gain 21841781
dgv764e212 CNV gain 25503493
dgv765e212 CNV gain 25503493
esv1005771 CNV deletion 20482838
esv1418059 CNV deletion 17803354
esv2660030 CNV deletion 23128226
esv2667525 CNV deletion 23128226
esv2761688 CNV gain+loss 21179565
esv29627 CNV loss 19812545
esv3057 CNV loss 18987735
esv3581879 CNV loss 25503493
esv3581880 CNV loss 25503493
esv3581886 CNV loss 25503493
esv3637519 CNV gain 21293372
esv3637520 CNV gain 21293372
esv3637521 CNV loss 21293372
esv3637522 CNV gain 21293372
esv3637523 CNV loss 21293372
esv3892746 CNV gain 25118596
esv3892749 CNV gain 25118596
esv3892750 CNV gain 25118596
nsv1041586 CNV gain 25217958
nsv1046557 CNV gain 25217958
nsv1051784 CNV gain 25217958
nsv1140135 CNV insertion 24896259
nsv1693 CNV insertion 18451855
nsv457293 CNV gain 19166990
nsv477753 CNV novel sequence insertion 20440878
nsv521896 CNV gain 19592680
nsv523315 CNV gain 19592680
nsv528761 CNV gain 19592680
nsv570905 CNV gain 21841781
nsv570906 CNV loss 21841781
nsv827470 CNV gain 20364138

Variation tolerance for TARSL2 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.65; 93.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TARSL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TARSL2 Gene

Disorders for TARSL2 Gene

Additional Disease Information for TARSL2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TARSL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TARSL2 Gene

Publications for TARSL2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58

Products for TARSL2 Gene

Sources for TARSL2 Gene

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