Aliases for TARS3 Gene

Aliases for TARS3 Gene

  • Threonyl-TRNA Synthetase 3 2 3 5
  • Threonine--TRNA Ligase 2, Cytoplasmic 3 4
  • Threonyl-TRNA Synthetase Protein 3 3 4
  • Threonyl-TRNA Synthetase Like 2 2 3
  • EC 6.1.1.3 4 50
  • ThrRS-L 2 3
  • TARSL2 3 4
  • ThrRS 3 4
  • Probable Threonyl-TRNA Synthetase 2, Cytoplasmic 3
  • Probable Threonine--TRNA Ligase 2, Cytoplasmic 3
  • Threonyl-TRNA Synthetase-Like Protein 2 3
  • Threonyl-TRNA Synthetase 4
  • FLJ25005 2
  • TARS3 5

External Ids for TARS3 Gene

Previous HGNC Symbols for TARS3 Gene

  • TARSL2

Previous GeneCards Identifiers for TARS3 Gene

  • GC15M102768
  • GC15M103882
  • GC15M105011
  • GC15M106220

Summaries for TARS3 Gene

GeneCards Summary for TARS3 Gene

TARS3 (Threonyl-TRNA Synthetase 3) is a Protein Coding gene. Diseases associated with TARS3 include Antisynthetase Syndrome. Among its related pathways are tRNA Aminoacylation. An important paralog of this gene is TARS1.

UniProtKB/Swiss-Prot Summary for TARS3 Gene

  • Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TARS3 Gene

Genomics for TARS3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TARS3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TARS3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TARS3

Genomic Locations for TARS3 Gene

Latest Assembly
chr15:101,653,596-101,724,473
(GRCh38/hg38)
Size:
70,878 bases
Orientation:
Minus strand

Previous Assembly
chr15:102,193,799-102,264,676
(GRCh37/hg19 by Entrez Gene)
Size:
70,878 bases
Orientation:
Minus strand

chr15:102,193,801-102,264,807
(GRCh37/hg19 by Ensembl)
Size:
71,007 bases
Orientation:
Minus strand

Genomic View for TARS3 Gene

Genes around TARS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TARS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TARS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TARS3 Gene

Proteins for TARS3 Gene

  • Protein details for TARS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RTX5-SYTC2_HUMAN
    Recommended name:
    Threonine--tRNA ligase 2, cytoplasmic
    Protein Accession:
    A2RTX5
    Secondary Accessions:
    • B2RMP7
    • Q6B0A1
    • Q6IS76
    • Q96LW3
    • Q96MP4

    Protein attributes for TARS3 Gene

    Size:
    802 amino acids
    Molecular mass:
    92646 Da
    Quaternary structure:
    • May be a component of the multisynthetase complex (MSC), a large multi-subunit complex which contains at least eight different aminoacyl-tRNA synthetases plus three auxillary subunits AIMP1, AIMP2 and EEF1E1. Interacts with the MSC components EPRS1, AIMP1, AIMP2 and KARS1.
    SequenceCaution:
    • Sequence=BAB71554.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TARS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TARS3 Gene

Selected DME Specific Peptides for TARS3 Gene

A2RTX5:
  • WKTTPYQ
  • IKDAIGR
  • LCYGPPI
  • LKPMNCP
  • QLDFQLP
  • YNSKLWE
  • WEKFQEEAK
  • TIQLDFQ
  • SPGSCFFLP
  • KPMNCPG
  • AFYGPKID
  • KNSSTYWEG
  • RFNLTYV
  • WHSSAHI
  • DGDDKKRPVI
  • HRPRSWRE
  • ENYGGKWP
  • RDHRKIG
  • IENGFYYD
  • GPHVRHTG
  • QDDAHIF
  • FKYNKFKCRIL
  • SGHWQHY
  • GDGAFYGPK
  • DDAHIFC
  • WPFWLSPR
  • RIYGISFP
  • DLCKGPH
  • LLEMFKYN
  • WLSPRQVMV
  • HRAILGS
  • TVYRCGPL
  • ADFGVLHR

Post-translational modifications for TARS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TARS3 Gene

Domains & Families for TARS3 Gene

Gene Families for TARS3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TARS3 Gene

GenScript: Design optimal peptide antigens:
  • Threonyl-tRNA synthetase-like protein 2 (SYTC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A2RTX5

UniProtKB/Swiss-Prot:

SYTC2_HUMAN :
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with TARS3: view

Function for TARS3 Gene

Molecular function for TARS3 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr); Xref=Rhea:RHEA:24624, Rhea:RHEA-COMP:9670, Rhea:RHEA-COMP:9704, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57926, ChEBI:CHEBI:78442, ChEBI:CHEBI:78534, ChEBI:CHEBI:456215; EC=6.1.1.3; Evidence={ECO:0000250|UniProtKB:Q8BLY2};.

Enzyme Numbers (IUBMB) for TARS3 Gene

Gene Ontology (GO) - Molecular Function for TARS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003674 molecular_function ND --
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0004829 threonine-tRNA ligase activity IEA,ISS --
GO:0005515 protein binding IPI 24312579
genes like me logo Genes that share ontologies with TARS3: view

Phenotypes for TARS3 Gene

GenomeRNAi human phenotypes for TARS3:
genes like me logo Genes that share phenotypes with TARS3: view

miRNA for TARS3 Gene

miRTarBase miRNAs that target TARS3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TARS3

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TARS3 Gene

Localization for TARS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TARS3 Gene

Cytoplasm. Nucleus. Note=Primarily cytoplasmic. Also detected at lower levels in the nucleus. {ECO:0000250 UniProtKB:Q8BLY2}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TARS3 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TARS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA,ISS --
genes like me logo Genes that share ontologies with TARS3: view

Pathways & Interactions for TARS3 Gene

PathCards logo

SuperPathways for TARS3 Gene

SuperPathway Contained pathways
1 tRNA Aminoacylation
genes like me logo Genes that share pathways with TARS3: view

Pathways by source for TARS3 Gene

1 KEGG pathway for TARS3 Gene

Gene Ontology (GO) - Biological Process for TARS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006418 tRNA aminoacylation for protein translation IEA --
GO:0006435 threonyl-tRNA aminoacylation IEA,ISS --
GO:0008150 biological_process ND --
GO:0043039 tRNA aminoacylation IEA --
genes like me logo Genes that share ontologies with TARS3: view

No data available for SIGNOR curated interactions for TARS3 Gene

Drugs & Compounds for TARS3 Gene

(4) Drugs for TARS3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved, Investigational Nutra 0
Threonine Approved Nutra 40
Phosphate Experimental Pharma 0
ATP Investigational Nutra 0

(1) Additional Compounds for TARS3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(HO)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • Pyrophosphoric acid
14000-31-8
genes like me logo Genes that share compounds with TARS3: view

Transcripts for TARS3 Gene

mRNA/cDNA for TARS3 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TARS3

Alternative Splicing Database (ASD) splice patterns (SP) for TARS3 Gene

No ASD Table

Relevant External Links for TARS3 Gene

GeneLoc Exon Structure for
TARS3

Expression for TARS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TARS3

SOURCE GeneReport for Unigene cluster for TARS3 Gene:

Hs.657163

Evidence on tissue expression from TISSUES for TARS3 Gene

  • Nervous system(4.7)
  • Lung(4.3)
  • Muscle(2.6)
  • Heart(2.4)
  • Liver(2.2)
  • Intestine(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with TARS3: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TARS3 Gene

Orthologs for TARS3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TARS3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TARSL2 29 30
  • 99.42 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TARSL2 29 30
  • 88.61 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TARSL2 30
  • 86 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Tarsl2 29 16 30
  • 85.18 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TARSL2 29 30
  • 83.17 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tarsl2 29
  • 82.81 (n)
Oppossum
(Monodelphis domestica)
Mammalia TARSL2 30
  • 78 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TARSL2 29 30
  • 75.83 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TARSL2 30
  • 69 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tarsl2 29
  • 71.61 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18083 29
Zebrafish
(Danio rerio)
Actinopterygii CABZ01081822.1 30
  • 33 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Aats-thr 30
  • 63 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea tars-1 30
  • 57 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THS1 30
  • 53 (a)
OneToMany
Soybean
(Glycine max)
eudicotyledons Gma.2547 29
Wheat
(Triticum aestivum)
Liliopsida Ta.3509 29
Corn
(Zea mays)
Liliopsida Zm.6559 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 62 (a)
ManyToMany
Species where no ortholog for TARS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for TARS3 Gene

ENSEMBL:
Gene Tree for TARS3 (if available)
TreeFam:
Gene Tree for TARS3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TARS3: view image
Alliance of Genome Resources:
Additional Orthologs for TARS3

Paralogs for TARS3 Gene

Paralogs for TARS3 Gene

genes like me logo Genes that share paralogs with TARS3: view

Variants for TARS3 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TARS3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TARS3 Gene

Variant ID Type Subtype PubMed ID
dgv113e55 CNV gain 17911159
dgv2675n100 CNV gain 25217958
dgv2677n100 CNV loss 25217958
dgv2679n100 CNV loss 25217958
dgv2680n100 CNV gain 25217958
dgv2681n100 CNV gain 25217958
dgv2682n100 CNV gain 25217958
dgv2683n100 CNV gain 25217958
dgv4792n54 CNV gain 21841781
dgv4800n54 CNV gain 21841781
dgv4801n54 CNV gain 21841781
dgv764e212 CNV gain 25503493
dgv765e212 CNV gain 25503493
esv1005771 CNV deletion 20482838
esv1418059 CNV deletion 17803354
esv2660030 CNV deletion 23128226
esv2667525 CNV deletion 23128226
esv2761688 CNV gain+loss 21179565
esv29627 CNV loss 19812545
esv3057 CNV loss 18987735
esv3581879 CNV loss 25503493
esv3581880 CNV loss 25503493
esv3581886 CNV loss 25503493
esv3637519 CNV gain 21293372
esv3637520 CNV gain 21293372
esv3637521 CNV loss 21293372
esv3637522 CNV gain 21293372
esv3637523 CNV loss 21293372
esv3892746 CNV gain 25118596
esv3892749 CNV gain 25118596
esv3892750 CNV gain 25118596
nsv1041586 CNV gain 25217958
nsv1046557 CNV gain 25217958
nsv1051784 CNV gain 25217958
nsv1140135 CNV insertion 24896259
nsv1693 CNV insertion 18451855
nsv457293 CNV gain 19166990
nsv477753 CNV novel sequence insertion 20440878
nsv521896 CNV gain 19592680
nsv523315 CNV gain 19592680
nsv528761 CNV gain 19592680
nsv570905 CNV gain 21841781
nsv570906 CNV loss 21841781
nsv827470 CNV gain 20364138

Variation tolerance for TARS3 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.65; 93.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TARS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TARS3
Leiden Open Variation Database (LOVD)
TARS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TARS3 Gene

Disorders for TARS3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TARS3 Gene - From: COP

Disorder Aliases PubMed IDs
antisynthetase syndrome
  • anti-jo1 syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TARS3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TARS3

genes like me logo Genes that share disorders with TARS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TARS3 Gene

Publications for TARS3 Gene

  1. Reinvestigation of aminoacyl-tRNA synthetase core complex by affinity purification-mass spectrometry reveals TARSL2 as a potential member of the complex. (PMID: 24312579) Kim K … Lee C (PloS one 2013) 2 3 4
  2. Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex. (PMID: 31287872) Zhou XL … Wang ED (Nucleic acids research 2019) 2 3
  3. A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities. (PMID: 29579307) Chen Y … Wang ED (Nucleic acids research 2018) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for TARS3 Gene

Sources for TARS3 Gene