Aliases for TARS2 Gene
External Ids for TARS2 Gene
Previous HGNC Symbols for TARS2 Gene
Previous GeneCards Identifiers for TARS2 Gene
This gene encodes a member of the class-II aminoacyl-tRNA synthetase family. The encoded protein is a mitochondrial aminoacyl-tRNA synthetase. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 4. [provided by RefSeq, Dec 2012]
GeneCards Summary for TARS2 Gene
TARS2 (Threonyl-TRNA Synthetase 2, Mitochondrial) is a Protein Coding gene. Diseases associated with TARS2 include Combined Oxidative Phosphorylation Deficiency 21 and Myopathy, Lactic Acidosis, And Sideroblastic Anemia. Among its related pathways are tRNA Aminoacylation and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleotide binding. An important paralog of this gene is TARS3.
UniProtKB/Swiss-Prot Summary for TARS2 Gene
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain.