Aliases for TARS1 Gene
External Ids for TARS1 Gene
Previous HGNC Symbols for TARS1 Gene
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]
GeneCards Summary for TARS1 Gene
TARS1 (Threonyl-TRNA Synthetase 1) is a Protein Coding gene. Diseases associated with TARS1 include Trichothiodystrophy 7, Nonphotosensitive and Trichothiodystrophy. Among its related pathways are tRNA Aminoacylation and Gene Expression. An important paralog of this gene is TARS3.
UniProtKB/Swiss-Prot Summary for TARS1 Gene
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity).