Aliases for TARBP2 Gene
- TARBP2 Subunit Of RISC Loading Complex 2 3 5
- TARBP2, RISC Loading Complex RNA Binding Subunit 2 3
- RISC-Loading Complex Subunit TARBP2 3 4
- TAR (HIV-1) RNA Binding Protein 2 2 3
- TRBP 3 4
- Trans-Activation Responsive RNA-Binding Protein 3
- Trans-Activation-Responsive RNA-Binding Protein 4
- TAR (HIV) RNA-Binding Protein TRBP1 3
External Ids for TARBP2 Gene
Previous GeneCards Identifiers for TARBP2 Gene
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TARBP2 Gene
TARBP2 (TARBP2 Subunit Of RISC Loading Complex) is a Protein Coding gene. Diseases associated with TARBP2 include Pleuropulmonary Blastoma and Ewing Sarcoma. Among its related pathways are Tat-mediated elongation of the HIV-1 transcript and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and double-stranded RNA binding. An important paralog of this gene is PRKRA.
UniProtKB/Swiss-Prot Summary for TARBP2 Gene
Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
(Microbial infection) Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs (PubMed:2011739, PubMed:11438532, PubMed:12475984). This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha (PubMed:11438532). May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR (PubMed:12475984). Mediates recruitment of FTSJ3 methyltransferase to HIV-1 RNA, leading to 2'-O-methylation of the viral genome, allowing HIV-1 to escape the innate immune system (PubMed:30626973).