Aliases for TAOK3 Gene
External Ids for TAOK3 Gene
Previous GeneCards Identifiers for TAOK3 Gene
The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]
GeneCards Summary for TAOK3 Gene
TAOK3 (TAO Kinase 3) is a Protein Coding gene. Diseases associated with TAOK3 include Cutaneous T Cell Lymphoma and Cardiomyopathy, Familial Hypertrophic, 9. Among its related pathways are MAPK signaling pathway and P38 MAPK Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TAOK1.
UniProtKB/Swiss-Prot Summary for TAOK3 Gene
Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).