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This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
TAOK2 (TAO Kinase 2) is a Protein Coding gene. Diseases associated with TAOK2 include Wilson-Turner X-Linked Mental Retardation Syndrome and Myeloproliferative Syndrome, Transient. Among its related pathways are MAPK signaling pathway and P38 MAPK Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TAOK1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | NAS | 22683681 |
GO:0004709 | MAP kinase kinase kinase activity | NAS | 22683681 |
GO:0005524 | ATP binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005730 | nucleolus | IDA | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MAPK signaling pathway | ||
2 | P38 MAPK Signaling Pathway (sino) | ||
3 | p38 MAPK signaling pathway (Pathway Interaction Database) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000186 | activation of MAPKK activity | IBA,IDA | 10660600 |
GO:0000187 | activation of MAPK activity | TAS | 22683681 |
GO:0001558 | regulation of cell growth | NAS | 10660600 |
GO:0006468 | protein phosphorylation | IEA | -- |
GO:0006612 | protein targeting to membrane | NAS | 10660600 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
phosphoserine | Experimental | Pharma | Target | 0 | ||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | TAOK2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TAOK2 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TAOK2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Taok2 30 17 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | TAOK2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TAOK2 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TAOK2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | taok2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | taok2b 30 31 31 |
|
OneToMany | |
taok2a 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Tao 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | kin-18 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
709295 | Benign: not provided | 29,985,269(+) | C/T | SYNONYMOUS_VARIANT | |
710084 | Likely Benign: not provided | 29,987,949(+) | G/A | MISSENSE_VARIANT,INTRON_VARIANT | |
714698 | Benign: not provided | 29,978,323(+) | G/A | SYNONYMOUS_VARIANT | |
720874 | Likely Benign: not provided | 29,977,817(+) | G/A | SYNONYMOUS_VARIANT | |
724915 | Benign: not provided | 29,987,599(+) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3638378 | CNV | loss | 21293372 |
esv997840 | CNV | deletion | 20482838 |
Disorder | Aliases | PubMed IDs |
---|---|---|
wilson-turner x-linked mental retardation syndrome |
|
|
myeloproliferative syndrome, transient |
|
|
syndromic x-linked intellectual disability |
|
|
autism spectrum disorder |
|
|
autism |
|
|