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TAOK1 (TAO Kinase 1) is a Protein Coding gene. Diseases associated with TAOK1 include Autosomal Dominant Non-Syndromic Intellectual Disability and Wilson-Turner X-Linked Mental Retardation Syndrome. Among its related pathways are Signaling by GPCR and Mitotic Prometaphase. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TAOK3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | ISS,NAS | 14517247 |
GO:0004674 | protein serine/threonine kinase activity | NAS | 14517247 |
GO:0004709 | MAP kinase kinase kinase activity | IBA | -- |
GO:0005515 | protein binding | IPI | 11733138 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
GO:0015630 | microtubule cytoskeleton | IMP | 12639963 |
GO:0048471 | perinuclear region of cytoplasm | IMP | 12639963 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cell Cycle, Mitotic |
.83
|
.60
|
2 | Mitotic Metaphase and Anaphase |
.94
|
|
3 | Mitotic Prometaphase | ||
4 | MAPK signaling pathway | ||
5 | Signaling by Rho GTPases |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000186 | activation of MAPKK activity | IBA | -- |
GO:0000187 | activation of MAPK activity | TAS | 22683681 |
GO:0000226 | microtubule cytoskeleton organization | IMP | 12639963 |
GO:0006281 | DNA repair | IEA | -- |
GO:0006468 | protein phosphorylation | NAS | 14517247 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - |
ExUns: | 22 |
---|---|
SP1: | |
SP2: | |
SP3: | |
SP4: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TAOK1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TAOK1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TAOK1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TAOK1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TAOK1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Taok1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Taok1 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TAOK1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TAOK1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | taok1 30 |
|
||
Str.6620 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | MGC52943 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | TAOK1 (2 of 3) 31 |
|
OneToMany | |
taok1 31 |
|
OneToMany | |||
CU929119.2 31 |
|
OneToMany | |||
LOC100004576 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Tao 30 31 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003202 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | kin-18 30 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.8830 30 |
|
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
717510 | Benign: not provided | 29,498,311(+) | C/T | INTRON_VARIANT | |
743113 | Benign: not provided | 29,534,252(+) | C/T | SYNONYMOUS_VARIANT | |
777157 | Benign: not provided | 29,489,668(+) | A/G | SYNONYMOUS_VARIANT | |
779365 | Benign: not provided | 29,517,575(+) | A/G | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
871002 | Uncertain Significance: not provided | 29,530,518(+) | A/G | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv22895 | CNV | loss | 19812545 |
esv2335781 | CNV | deletion | 18987734 |
esv2474903 | CNV | deletion | 19546169 |
esv2658989 | CNV | deletion | 23128226 |
esv2673792 | CNV | deletion | 23128226 |
esv2715797 | CNV | deletion | 23290073 |
esv3303028 | CNV | tandem duplication | 20981092 |
esv3405501 | CNV | insertion | 20981092 |
esv3582597 | CNV | loss | 25503493 |
esv3640327 | CNV | loss | 21293372 |
esv994280 | OTHER | inversion | 20482838 |
nsv1077840 | CNV | duplication | 25765185 |
nsv819892 | CNV | loss | 19587683 |
nsv821292 | CNV | duplication | 20802225 |
nsv827940 | CNV | gain | 20364138 |
nsv833409 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
autosomal dominant non-syndromic intellectual disability |
|
|
wilson-turner x-linked mental retardation syndrome |
|
|
syndromic x-linked intellectual disability |
|
|
syndromic intellectual disability |
|
|