The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For ex... See more...

Aliases for TANK Gene

Aliases for TANK Gene

  • TRAF Family Member Associated NFKB Activator 2 3 5
  • TRAF Family Member-Associated NF-Kappa-B Activator 3 4
  • TRAF-Interacting Protein 3 4
  • I-TRAF 3 4
  • TRAF2 3 4
  • ITRAF 3 4
  • TRAF Family Member-Associated NFKB Activator 2

External Ids for TANK Gene

Previous HGNC Symbols for TANK Gene

  • TRAF2

Previous GeneCards Identifiers for TANK Gene

  • GC02P160047
  • GC02P160521
  • GC02P161957
  • GC02P162196
  • GC02P161818
  • GC02P161701
  • GC02P153878

Summaries for TANK Gene

Entrez Gene Summary for TANK Gene

  • The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for TANK Gene

TANK (TRAF Family Member Associated NFKB Activator) is a Protein Coding gene. Diseases associated with TANK include Vaccinia and Excessive Tearing. Among its related pathways are NOD-like receptor signaling pathway and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot Summary for TANK Gene

  • Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.

Gene Wiki entry for TANK Gene

Additional gene information for TANK Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TANK Gene

Genomics for TANK Gene

GeneHancer (GH) Regulatory Elements for TANK Gene

Promoters and enhancers for TANK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J161158 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 761.8 +26.8 26801 9.6 SIN3A ZNF24 SP1 ZBTB40 FOXA1 MLX SMARCE1 RBPJ POLR2A NR2F1 TANK LINC01806 ENSG00000226121 RBMS1 ENSG00000235724 ENSG00000224467 HSALNG0019989 LOC105373719 piR-31199-182
GH02J161133 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 777.6 +0.6 631 7.3 FOXA1 ELF1 RELA HLF NKRF ELF3 POLR2A MAFK MLLT1 ZNF687 TANK LINC01806 ENSG00000224467 LOC105373719
GH02J161179 Promoter 0.3 EPDnew 750.3 +42.8 42755 0.1 piR-31199-182 TANK HSALNG0019989
GH02J161076 Enhancer 1.1 FANTOM5 ENCODE 33 -59.1 -59078 2.3 ZNF24 ETV6 RELA SP1 MLLT1 CREM ZBED1 IKZF1 TRIM22 IKZF2 TANK ENSG00000224467 LINC01806 lnc-TANK-2 RF00017-3341 LOC105373719
GH02J161307 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10.2 +172.1 172093 3.6 ZNF24 ZBTB40 ZBTB6 LCORL RBPJ SMARCE1 POLR2A ATF1 CREB1 HCFC1 ENSG00000235724 PSMD14 LINC01806 ENSG00000226121 RBMS1 TANK lnc-DPP4-9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TANK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TANK gene promoter:
  • deltaCREB
  • IRF-7A
  • NF-kappaB
  • NF-kappaB1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for TANK Gene

Genomic Locations for TANK Gene
chr2:161,136,908-161,236,221
(GRCh38/hg38)
Size:
99,314 bases
Orientation:
Plus strand
chr2:161,993,419-162,092,732
(GRCh37/hg19)
Size:
99,314 bases
Orientation:
Plus strand

Genomic View for TANK Gene

Genes around TANK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TANK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TANK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TANK Gene

Proteins for TANK Gene

  • Protein details for TANK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92844-TANK_HUMAN
    Recommended name:
    TRAF family member-associated NF-kappa-B activator
    Protein Accession:
    Q92844
    Secondary Accessions:
    • D3DPB5
    • Q7Z4J6
    • Q92885

    Protein attributes for TANK Gene

    Size:
    425 amino acids
    Molecular mass:
    47816 Da
    Quaternary structure:
    • Homodimer. Found in a deubiquitination complex with TANK, USP10 and ZC3H12A; this complex inhibits genotoxic stress- or interleukin-1-beta-mediated NF-kappaB activation by promoting IKBKG or TRAF6 deubiquitination (PubMed:25861989). Interacts with IKBKG; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with TRAF6; this interaction increases in response to DNA damage and recruits USP10 to the ubiquitinated TRAF6 (PubMed:25861989). Interacts with USP10; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with ZC3H12A; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with TBK1 (PubMed:10581243, PubMed:21931631). Interacts with IKBKE (PubMed:17568778). Interacts also with TRAF1, TRAF2, and TRAF3 by binding to their TRAF-C domains; the interaction with TRAF2 is disrupted by the phosphorylation of TANK by IKBKE (PubMed:10759890, PubMed:12005438). Interacts more strongly with TRAF1 and TRAF2 than TRAF3 (PubMed:10759890, PubMed:12005438). Interacts with IKBKG; the interaction is enhanced by IKBKE and TBK1 (PubMed:12133833). Part of a ternary complex consisting of TANK, IKBKB and IKBKG (PubMed:12133833).
    • (Microbial infection) Interacts with vaccinia virus protein C6 (PubMed:21931555).
    • (Microbial infection) Interacts with Seneca Valley virus protease 3C; this interaction allows the cleavage of TANK and subsequent suppression of host innate immunity.

    Three dimensional structures from OCA and Proteopedia for TANK Gene

    Alternative splice isoforms for TANK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TANK Gene

Post-translational modifications for TANK Gene

  • Phosphorylated by IKBKE.
  • (Microbial infection) Cleaved by encephalomyocarditis virus (EMCV) protease 3C (PubMed:26363073). This cleavage allows the virus to disrupt the TANK-TBK1-IKKepsilon-IRF3 complex, thereby inhibiting the induction of the IFN-beta signal pathway (PubMed:28487378).
  • (Microbial infection) Cleaved by Seneca Valley virus protease 3C allowing the virus to suppress interferon type-I through both RIG-I and Toll-like receptor-dependent pathways.
  • Ubiquitination at Lys86, Lys231, and Lys371
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TANK Gene

Domains & Families for TANK Gene

Gene Families for TANK Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TANK Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TANK Gene

GenScript: Design optimal peptide antigens:
  • TANK protein (Q6NW12_HUMAN)
  • TRAF-interacting protein (TANK_HUMAN)
genes like me logo Genes that share domains with TANK: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TANK Gene

Function for TANK Gene

Molecular function for TANK Gene

UniProtKB/Swiss-Prot Function:
Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.
GENATLAS Biochemistry:
tumor necrosis receptor-associated factor ,TRAF-interacting protein,mediator of NFKB activation after induction by TRAF2

Phenotypes From GWAS Catalog for TANK Gene

Gene Ontology (GO) - Molecular Function for TANK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 contributes_to thiol-dependent ubiquitin-specific protease activity IMP 25861989
GO:0005515 protein binding IPI 12005438
GO:0031625 ubiquitin protein ligase binding IPI 11279055
GO:0035800 deubiquitinase activator activity IMP 25861989
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TANK: view
genes like me logo Genes that share phenotypes with TANK: view

Animal Models for TANK Gene

MGI Knock Outs for TANK:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TANK Gene

Localization for TANK Gene

Subcellular locations from UniProtKB/Swiss-Prot for TANK Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TANK gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TANK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0032991 protein-containing complex IDA 25861989
genes like me logo Genes that share ontologies with TANK: view

Pathways & Interactions for TANK Gene

genes like me logo Genes that share pathways with TANK: view

Pathways by source for TANK Gene

5 Qiagen pathways for TANK Gene
  • TNF Signaling
  • TNFR1 Pathway
  • TNFR2 Pathway
  • Toll-Like Receptors Pathway
  • TRAF Pathway
2 Cell Signaling Technology pathways for TANK Gene
1 GeneTex pathway for TANK Gene

Gene Ontology (GO) - Biological Process for TANK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006974 cellular response to DNA damage stimulus IMP 25861989
GO:0007165 signal transduction TAS 8710854
GO:0007249 I-kappaB kinase/NF-kappaB signaling IBA,IEA 21873635
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with TANK: view

No data available for SIGNOR curated interactions for TANK Gene

Drugs & Compounds for TANK Gene

(1) Drugs for TANK Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TANK: view

Transcripts for TANK Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TANK Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - -
SP8:
SP9:
SP10:
SP11: - - - - - - - - -

ExUns: 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TANK Gene

GeneLoc Exon Structure for
TANK
ECgene alternative splicing isoforms for
TANK

Expression for TANK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TANK Gene

Protein differential expression in normal tissues from HIPED for TANK Gene

This gene is overexpressed in Breast (56.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TANK Gene



Protein tissue co-expression partners for TANK Gene

NURSA nuclear receptor signaling pathways regulating expression of TANK Gene:

TANK

SOURCE GeneReport for Unigene cluster for TANK Gene:

Hs.132257

mRNA Expression by UniProt/SwissProt for TANK Gene:

Q92844-TANK_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TANK Gene

  • Spleen(4.4)
  • Liver(4.3)
  • Nervous system(2.7)
  • Blood(2.5)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with TANK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TANK Gene

Orthologs for TANK Gene

This gene was present in the common ancestor of chordates.

Orthologs for TANK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TANK 33 32
  • 99.53 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TANK 33 32
  • 91.55 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TANK 33 32
  • 90.12 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tank 32
  • 87.01 (n)
mouse
(Mus musculus)
Mammalia Tank 17 33 32
  • 86.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 63 (a)
OneToMany
-- 33
  • 52 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TANK 33
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves TANK 33 32
  • 67.13 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TANK 33
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tank 32
  • 53.43 (n)
zebrafish
(Danio rerio)
Actinopterygii tank 33 32
  • 48.38 (n)
OneToOne
Species where no ortholog for TANK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TANK Gene

ENSEMBL:
Gene Tree for TANK (if available)
TreeFam:
Gene Tree for TANK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TANK: view image

Paralogs for TANK Gene

No data available for Paralogs for TANK Gene

Variants for TANK Gene

Sequence variations from dbSNP and Humsavar for TANK Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000000781 -- 161,154,844(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000017619 -- 161,177,462(+) A/G intron_variant
rs1000024096 -- 161,175,221(+) A/G intron_variant
rs1000049075 -- 161,160,859(+) C/G intron_variant
rs1000096892 -- 161,167,135(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TANK Gene

Variant ID Type Subtype PubMed ID
dgv7140n54 CNV loss 21841781
esv2670224 CNV deletion 23128226
esv3302641 CNV tandem duplication 20981092
esv3306260 CNV mobile element insertion 20981092
esv3323881 CNV duplication 20981092
esv3378589 CNV insertion 20981092
esv3446273 CNV insertion 20981092
esv3593151 CNV loss 21293372
nsv1117263 CNV tandem duplication 24896259
nsv3004 CNV insertion 18451855
nsv437557 CNV loss 16327808
nsv459934 CNV loss 19166990
nsv475536 CNV novel sequence insertion 20440878
nsv478156 CNV novel sequence insertion 20440878
nsv478892 CNV novel sequence insertion 20440878
nsv507044 OTHER sequence alteration 20534489
nsv583500 CNV loss 21841781
nsv834437 CNV gain 17160897
nsv955276 CNV duplication 24416366

Variation tolerance for TANK Gene

Residual Variation Intolerance Score: 89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TANK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TANK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TANK Gene

Disorders for TANK Gene

MalaCards: The human disease database

(2) MalaCards diseases for TANK Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
vaccinia
excessive tearing
  • epiphora
- elite association - COSMIC cancer census association via MalaCards
Search TANK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TANK

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TANK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TANK Gene

Publications for TANK Gene

  1. I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. (PMID: 8710854) Rothe M … Goeddel DV (Proceedings of the National Academy of Sciences of the United States of America 1996) 2 3 4 23 56
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 23 43 56
  3. Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. (PMID: 19262425) Bowes JD … BRAGGSS (Pharmacogenetics and genomics 2009) 3 23 43 56
  4. Downstream regulator TANK binds to the CD40 recognition site on TRAF3. (PMID: 12005438) Li C … Ely KR (Structure (London, England : 1993) 2002) 3 4 23 56
  5. NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. (PMID: 10581243) Pomerantz JL … Baltimore D (The EMBO journal 1999) 3 4 23 56

Products for TANK Gene

Sources for TANK Gene