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Aliases for TANGO6 Gene

Aliases for TANGO6 Gene

  • Transport And Golgi Organization 6 Homolog 2 3 5
  • Transmembrane And Coiled-Coil Domain-Containing Protein 7 3 4
  • Transmembrane And Coiled-Coil Domains 7 2 3
  • TMCO7 3 4
  • Transport And Golgi Organization 6 Homolog (Drosophila) 2
  • Transport And Golgi Organization Protein 6 Homolog 3
  • KIAA1746 4

External Ids for TANGO6 Gene

Previous HGNC Symbols for TANGO6 Gene

  • TMCO7

Previous GeneCards Identifiers for TANGO6 Gene

  • GC16P068878

Summaries for TANGO6 Gene

GeneCards Summary for TANGO6 Gene

TANGO6 (Transport And Golgi Organization 6 Homolog) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.

Additional gene information for TANGO6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TANGO6 Gene

Genomics for TANGO6 Gene

GeneHancer (GH) Regulatory Elements for TANGO6 Gene

Promoters and enhancers for TANGO6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I068842 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 555.7 +0.3 344 1.9 FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 POLR2B TANGO6 EDC4 CHTF8 CENPT NONOP1 ZFP90 NFAT5 SNTB2 ENSG00000263276 PRMT7
GH16I068785 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.9 -56.7 -56741 1.8 ELF3 FOXA2 ARID4B DMAP1 DNMT3B ZSCAN9 RAD21 RARA ETS1 YY1 ZFP90 TANGO6 CDH1 RNU4-36P ENSG00000252040 ENSG00000252640 FTLP14 RNA5SP429 GC16P068743
GH16I068759 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 4.7 -81.0 -80956 7 HDGF PKNOX1 FOXA2 ARID4B SIN3A IRF4 GATA2 ZNF143 ATF7 FOS ZFP90 CDH1 PRMT7 TANGO6 THAP11 CYB5B RNA5SP429 GC16P068743 FTLP14
GH16I068846 Enhancer 1 Ensembl ENCODE 5.9 +3.8 3826 0.8 HDGF ELF3 RAD21 RARA ZNF143 IKZF2 MIXL1 ZNF654 YY2 MXD4 FTLP14 TANGO6 GC16P068850
GH16I068797 Enhancer 1.2 Ensembl ENCODE dbSUPER 4.7 -43.0 -43000 5.2 ELF3 ARID4B DNMT3B RAD21 RFX5 ZNF335 ARID2 ZNF143 ATF7 BCLAF1 UTP4 ZFP90 RNU4-36P ENSG00000252640 ENSG00000252040 CDH3 TANGO6 PRMT7 FTLP14 RNA5SP429
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TANGO6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TANGO6 Gene

Genomic Locations for TANGO6 Gene
241,630 bases
Plus strand

Genomic View for TANGO6 Gene

Genes around TANGO6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TANGO6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TANGO6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TANGO6 Gene

Proteins for TANGO6 Gene

  • Protein details for TANGO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transport and Golgi organization protein 6 homolog
    Protein Accession:
    Secondary Accessions:
    • Q569F9
    • Q9H9K1

    Protein attributes for TANGO6 Gene

    1094 amino acids
    Molecular mass:
    120748 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14224.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB21837.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TANGO6 Gene

Post-translational modifications for TANGO6 Gene

  • Ubiquitination at isoforms=387
  • Modification sites at PhosphoSitePlus

Other Protein References for TANGO6 Gene

No data available for DME Specific Peptides for TANGO6 Gene

Domains & Families for TANGO6 Gene

Gene Families for TANGO6 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TANGO6 Gene

Suggested Antigen Peptide Sequences for TANGO6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Tango6 family.
  • Belongs to the Tango6 family.
genes like me logo Genes that share domains with TANGO6: view

Function for TANGO6 Gene

Phenotypes From GWAS Catalog for TANGO6 Gene

Phenotypes for TANGO6 Gene

genes like me logo Genes that share phenotypes with TANGO6: view

Animal Models for TANGO6 Gene

MGI Knock Outs for TANGO6:

Animal Model Products

miRNA for TANGO6 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TANGO6 Gene

Localization for TANGO6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TANGO6 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TANGO6 gene
Compartment Confidence
plasma membrane 2
cytosol 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TANGO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TANGO6: view

Pathways & Interactions for TANGO6 Gene

SuperPathways for TANGO6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TANGO6 Gene


No data available for Pathways by source and SIGNOR curated interactions for TANGO6 Gene

Drugs & Compounds for TANGO6 Gene

No Compound Related Data Available

Transcripts for TANGO6 Gene

mRNA/cDNA for TANGO6 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TANGO6 Gene

Transport and golgi organization 6 homolog (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TANGO6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^
SP1: - - - - -
SP3: -

ExUns: 18 ^ 19a · 19b · 19c

Relevant External Links for TANGO6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TANGO6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TANGO6 Gene

Protein differential expression in normal tissues from HIPED for TANGO6 Gene

This gene is overexpressed in Pancreas (39.9) and Lung (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TANGO6 Gene

Protein tissue co-expression partners for TANGO6 Gene

NURSA nuclear receptor signaling pathways regulating expression of TANGO6 Gene:


SOURCE GeneReport for Unigene cluster for TANGO6 Gene:


Evidence on tissue expression from TISSUES for TANGO6 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TANGO6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TANGO6 Gene

Orthologs for TANGO6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TANGO6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMCO7 33
  • 99.42 (n)
  • 99 (a)
(Canis familiaris)
Mammalia TANGO6 33 34
  • 86.93 (n)
(Bos Taurus)
Mammalia TANGO6 33 34
  • 86.7 (n)
(Rattus norvegicus)
Mammalia Tango6 33
  • 83.95 (n)
(Mus musculus)
Mammalia Tango6 33 16 34
  • 83.6 (n)
(Monodelphis domestica)
Mammalia TANGO6 34
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia TANGO6 34
  • 67 (a)
(Gallus gallus)
Aves -- 34
  • 73 (a)
  • 67.01 (n)
-- 34
  • 60 (a)
(Anolis carolinensis)
Reptilia TANGO6 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tango6 33
  • 59.67 (n)
(Danio rerio)
Actinopterygii tango6 33 34
  • 54.9 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tango6 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea ekl-6 34
  • 16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 17 (a)
RTP1 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
Species where no ortholog for TANGO6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TANGO6 Gene

Gene Tree for TANGO6 (if available)
Gene Tree for TANGO6 (if available)

Paralogs for TANGO6 Gene

No data available for Paralogs for TANGO6 Gene

Variants for TANGO6 Gene

Sequence variations from dbSNP and Humsavar for TANGO6 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000005278 -- 68,971,956(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000007416 -- 68,991,196(+) A/T genic_downstream_transcript_variant, intron_variant
rs1000010981 -- 68,968,572(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000040963 -- 68,852,932(+) T/C intron_variant
rs1000051683 -- 68,893,304(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TANGO6 Gene

Variant ID Type Subtype PubMed ID
esv2595638 CNV deletion 19546169
esv2657396 CNV deletion 23128226
esv2714659 CNV deletion 23290073
esv2714660 CNV deletion 23290073
esv2751611 CNV loss 17911159
esv3433094 CNV insertion 20981092
esv3638913 CNV gain 21293372
esv3638916 CNV loss 21293372
esv3638917 CNV loss 21293372
esv3638919 CNV loss 21293372
esv3638920 CNV loss 21293372
nsv1113818 CNV deletion 24896259
nsv457515 CNV gain 19166990
nsv474806 CNV novel sequence insertion 20440878
nsv475449 CNV novel sequence insertion 20440878
nsv572908 CNV gain 21841781
nsv572910 CNV loss 21841781
nsv827713 CNV loss 20364138
nsv827714 CNV loss 20364138
nsv833268 CNV loss 17160897

Variation tolerance for TANGO6 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.47; 64.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TANGO6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TANGO6 Gene

Disorders for TANGO6 Gene

Additional Disease Information for TANGO6

No disorders were found for TANGO6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TANGO6 Gene

Publications for TANGO6 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana PC … Emili A (Cell 2012) 3 58

Products for TANGO6 Gene

Sources for TANGO6 Gene

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