This gene belongs to the transport and Golgi organization family, whose members are predicted to play roles in secretory protein loading in the endoplasmic reticulum. Depletion of this gene in Drosophila S2 cells causes fusion of the Golgi with the ER. In mouse tissue culture cells, this protein co-localizes with a mitochondrially targeted mCherry protein and displays very low ... See more...

Aliases for TANGO2 Gene

Aliases for TANGO2 Gene

  • Transport And Golgi Organization 2 Homolog 2 3 5
  • Transport And Golgi Organization Protein 2 Homolog 3 4
  • C22orf25 3 4
  • Transport And Golgi Organization 2 Homolog (Drosophila) 2
  • Chromosome 22 Open Reading Frame 25 2
  • DKFZp761P1121 2
  • MECRCN 3
  • TANGO2 5

External Ids for TANGO2 Gene

Previous HGNC Symbols for TANGO2 Gene

  • C22orf25

Previous GeneCards Identifiers for TANGO2 Gene

  • GC22P020005

Summaries for TANGO2 Gene

Entrez Gene Summary for TANGO2 Gene

  • This gene belongs to the transport and Golgi organization family, whose members are predicted to play roles in secretory protein loading in the endoplasmic reticulum. Depletion of this gene in Drosophila S2 cells causes fusion of the Golgi with the ER. In mouse tissue culture cells, this protein co-localizes with a mitochondrially targeted mCherry protein and displays very low levels of co-localization with Golgi and peroxisomes. Allelic variants of this gene are associated with rhabdomyolysis, metabolic crises with encephalopathy, and cardiac arrhythmia. [provided by RefSeq, Apr 2016]

GeneCards Summary for TANGO2 Gene

TANGO2 (Transport And Golgi Organization 2 Homolog) is a Protein Coding gene. Diseases associated with TANGO2 include Metabolic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration and Cardiac Arrhythmia.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TANGO2 Gene

Genomics for TANGO2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TANGO2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TANGO2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TANGO2

Genomic Locations for TANGO2 Gene

Genomic Locations for TANGO2 Gene
chr22:20,017,000-20,067,164
(GRCh38/hg38)
Size:
50,165 bases
Orientation:
Plus strand
chr22:20,004,537-20,053,449
(GRCh37/hg19)
Size:
48,913 bases
Orientation:
Plus strand

Genomic View for TANGO2 Gene

Genes around TANGO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TANGO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TANGO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TANGO2 Gene

Proteins for TANGO2 Gene

  • Protein details for TANGO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ICL3-TNG2_HUMAN
    Recommended name:
    Transport and Golgi organization protein 2 homolog
    Protein Accession:
    Q6ICL3
    Secondary Accessions:
    • A8MUE9
    • B7WNV6
    • B7Z583
    • B7Z730
    • D3DX23
    • Q8IW05
    • Q8NAL0
    • Q8TCS0
    • Q96M16

    Protein attributes for TANGO2 Gene

    Size:
    276 amino acids
    Molecular mass:
    30937 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TANGO2 Gene

neXtProt entry for TANGO2 Gene

Post-translational modifications for TANGO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TANGO2 Gene

Domains & Families for TANGO2 Gene

Gene Families for TANGO2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for TANGO2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TANGO2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ78955, highly similar to Ser/Thr-rich protein T10 in DGCR region (B7WNV6_HUMAN)
  • cDNA FLJ50702, moderately similar to Ser/Thr-rich protein T10 in DGCR region (B7Z6W2_HUMAN)
  • cDNA FLJ51964, highly similar to Ser/Thr-rich protein T10 in DGCR region (B7Z730_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ICL3

UniProtKB/Swiss-Prot:

TNG2_HUMAN :
  • Belongs to the Tango2 family.
Family:
  • Belongs to the Tango2 family.
genes like me logo Genes that share domains with TANGO2: view

Function for TANGO2 Gene

Phenotypes From GWAS Catalog for TANGO2 Gene

genes like me logo Genes that share phenotypes with TANGO2: view

Human Phenotype Ontology for TANGO2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for TANGO2 Gene

miRTarBase miRNAs that target TANGO2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TANGO2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TANGO2 Gene

Localization for TANGO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TANGO2 Gene

Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TANGO2 gene
Compartment Confidence
golgi apparatus 5
mitochondrion 2
nucleus 2
cytosol 2
plasma membrane 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TANGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IBA,IDA 26805781
genes like me logo Genes that share ontologies with TANGO2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TANGO2 Gene

Pathways & Interactions for TANGO2 Gene

PathCards logo

SuperPathways for TANGO2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TANGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IBA 21873635
GO:0009306 protein secretion IBA 21873635
genes like me logo Genes that share ontologies with TANGO2: view

No data available for Pathways by source and SIGNOR curated interactions for TANGO2 Gene

Drugs & Compounds for TANGO2 Gene

No Compound Related Data Available

Transcripts for TANGO2 Gene

mRNA/cDNA for TANGO2 Gene

34 REFSEQ mRNAs :
39 NCBI additional mRNA sequence :
26 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TANGO2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TANGO2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - -
SP2: -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: -
SP7: -
SP8:
SP9: - - - -

Relevant External Links for TANGO2 Gene

GeneLoc Exon Structure for
TANGO2

Expression for TANGO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TANGO2 Gene

mRNA differential expression in normal tissues according to GTEx for TANGO2 Gene

This gene is overexpressed in Whole Blood (x5.7).

Protein differential expression in normal tissues from HIPED for TANGO2 Gene

This gene is overexpressed in Spleen (9.8), Peripheral blood mononuclear cells (9.4), and Platelet (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TANGO2 Gene



Protein tissue co-expression partners for TANGO2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TANGO2

SOURCE GeneReport for Unigene cluster for TANGO2 Gene:

Hs.474233

Evidence on tissue expression from TISSUES for TANGO2 Gene

  • Nervous system(4.7)
  • Heart(2.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with TANGO2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TANGO2 Gene

Orthologs for TANGO2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TANGO2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TANGO2 31
  • 92 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia TANGO2 30 31
  • 86.59 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TANGO2 30 31 31
  • 85.27 (n)
OneToMany
Mouse
(Mus musculus)
Mammalia Tango2 30 17 31
  • 84.3 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tango2 30
  • 83.57 (n)
Oppossum
(Monodelphis domestica)
Mammalia TANGO2 31
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TANGO2 31
  • 73 (a)
OneToOne
C15H22ORF25 30
  • 68.36 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tango2 30
  • 66.91 (n)
Str.20456 30
African clawed frog
(Xenopus laevis)
Amphibia MGC68627 30
Zebrafish
(Danio rerio)
Actinopterygii tango2 30 31
  • 66.18 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8435 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002962 30
  • 48.76 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Tango2 30 31
  • 46.64 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea R186.1 30 31
  • 41.35 (n)
OneToMany
Y80D3A.9 31
  • 27 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 31
  • 26 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT4G38260 30
  • 44.27 (n)
Rice
(Oryza sativa)
Liliopsida Os09g0323500 30
  • 47.75 (n)
Species where no ortholog for TANGO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TANGO2 Gene

ENSEMBL:
Gene Tree for TANGO2 (if available)
TreeFam:
Gene Tree for TANGO2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TANGO2: view image

Paralogs for TANGO2 Gene

(1) SIMAP similar genes for TANGO2 Gene using alignment to 11 proteins:

  • TNG2_HUMAN
  • A8MWT1_HUMAN
  • B7WNV6_HUMAN
  • B7Z583_HUMAN
  • B7Z6W2_HUMAN
  • B7Z730_HUMAN
  • C9J695_HUMAN
  • C9JC99_HUMAN
  • C9JDT9_HUMAN
  • C9JKN2_HUMAN
  • F8WDT9_HUMAN
genes like me logo Genes that share paralogs with TANGO2: view

No data available for Paralogs for TANGO2 Gene

Variants for TANGO2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TANGO2 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
672143 Benign: not provided 20,043,226(+) C/A INTRON_VARIANT
672144 Benign: not provided 20,043,493(+) G/C INTRON_VARIANT
672145 Benign: not provided 20,043,579(+) G/A INTRON_VARIANT
672502 Benign: not provided 20,052,697(+) C/T INTRON_VARIANT
673860 Likely Benign: not provided 20,037,002(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for TANGO2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TANGO2 Gene

Variant ID Type Subtype PubMed ID
dgv4479n100 CNV loss 25217958
dgv72n68 CNV loss 17160897
dgv7983n54 CNV gain 21841781
dgv7985n54 CNV loss 21841781
esv2658430 CNV deletion 23128226
esv2758825 CNV loss 17122850
esv3647284 CNV gain 21293372
esv3647285 CNV loss 21293372
esv3647286 CNV loss 21293372
esv3893434 CNV gain 25118596
nsv1056768 CNV loss 25217958
nsv3560 CNV insertion 18451855
nsv433325 CNV loss 18776910
nsv469641 CNV loss 16826518
nsv471183 CNV loss 18288195
nsv473218 CNV novel sequence insertion 20440878
nsv521042 CNV loss 19592680
nsv588243 CNV loss 21841781
nsv588246 CNV loss 21841781
nsv588247 CNV loss 21841781
nsv828938 CNV gain 20364138
nsv828939 CNV loss 20364138
nsv834133 CNV loss 17160897
nsv953026 CNV deletion 24416366

Variation tolerance for TANGO2 Gene

Residual Variation Intolerance Score: 72.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TANGO2 Gene

Human Gene Mutation Database (HGMD)
TANGO2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TANGO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TANGO2 Gene

Disorders for TANGO2 Gene

MalaCards: The human disease database

(11) MalaCards diseases for TANGO2 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TNG2_HUMAN
  • Metabolic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration (MECRCN) [MIM:616878]: An autosomal recessive disorder characterized by metabolic encephalomyopathic crises, hypoglycemia, hyperammonemia, episodic rhabdomyolysis, susceptibility to life-threatening cardiac tachyarrhythmias, developmental delay, mental retardation, and mild diffuse cerebral atrophy. {ECO:0000269 PubMed:26805781, ECO:0000269 PubMed:26805782}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with TANGO2: view

No data available for Genatlas for TANGO2 Gene

Publications for TANGO2 Gene

  1. Recurrent Muscle Weakness with Rhabdomyolysis, Metabolic Crises, and Cardiac Arrhythmia Due to Bi-allelic TANGO2 Mutations. (PMID: 26805781) Lalani SR … Yang Y (American journal of human genetics 2016) 2 3 4
  2. Bi-allelic Truncating Mutations in TANGO2 Cause Infancy-Onset Recurrent Metabolic Crises with Encephalocardiomyopathy. (PMID: 26805782) Kremer LS … Haack TB (American journal of human genetics 2016) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4

Products for TANGO2 Gene

Sources for TANGO2 Gene