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Aliases for TANC1 Gene

Aliases for TANC1 Gene

  • Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 1 2 3 5
  • Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Domain-Containing Protein 1 3 4
  • TPR Domain, Ankyrin-Repeat And Coiled-Coil-Containing 3
  • Rolling Pebbles Homolog B (Drosophila) 2
  • Rolling Pebbles Homolog B 3
  • Protein TANC1 3
  • KIAA1728 4
  • ROLSB 3
  • TANC 3

External Ids for TANC1 Gene

Previous GeneCards Identifiers for TANC1 Gene

  • GC02P159739
  • GC02P159533
  • GC02P151714
  • GC02P159825

Summaries for TANC1 Gene

GeneCards Summary for TANC1 Gene

TANC1 (Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 1) is a Protein Coding gene. Diseases associated with TANC1 include Space Motion Sickness and Motion Sickness. An important paralog of this gene is TANC2.

UniProtKB/Swiss-Prot for TANC1 Gene

  • May be a scaffold component in the postsynaptic density.

Additional gene information for TANC1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TANC1 Gene

Genomics for TANC1 Gene

GeneHancer (GH) Regulatory Elements for TANC1 Gene

Promoters and enhancers for TANC1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J158966 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 656.1 +0.4 432 5.5 PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF48 YY1 GLIS2 SP5 TANC1 MARCH7 OR7E28P GC02P158993
GH02J159224 Promoter/Enhancer 0.8 EPDnew dbSUPER 650.1 +255.7 255713 0.1 ZBTB33 TANC1 LOC105373716 MIR6888
GH02J159029 Enhancer 1.6 VISTA Ensembl ENCODE dbSUPER 18.4 +62.4 62354 3 HDAC1 NFIB RCOR1 FOS RXRA NR2F2 SP1 NFIC SMARCA4 IKZF1 TANC1 OR7E89P RNU6-580P GC02M159029 GSTM3P2 GC02P158993
GH02J159088 Enhancer 1.1 Ensembl ENCODE dbSUPER 24.3 +123.4 123440 6.5 CTCF MEIS2 PKNOX1 ZBTB6 JUN ZIC2 ZBTB40 GATA3 ZSCAN5C ZNF600 TANC1 OR7E89P OR7E28P GSTM3P2 MIR6888
GH02J159612 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.5 +646.6 646613 6.2 PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B BAZ2B LOC643072 MARCH7 PLA2R1 TANC1 LY75 ENSG00000226266 ENSG00000207117
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TANC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TANC1 gene promoter:
  • C/EBPalpha
  • FOXO3b
  • FOXO3a
  • FOXO3
  • Cart-1
  • AP-2gamma
  • GCNF
  • GCNF-1
  • GCNF-2
  • Sox9

Genomic Locations for TANC1 Gene

Genomic Locations for TANC1 Gene
264,030 bases
Plus strand
264,025 bases
Plus strand

Genomic View for TANC1 Gene

Genes around TANC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TANC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TANC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TANC1 Gene

Proteins for TANC1 Gene

  • Protein details for TANC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein TANC1
    Protein Accession:
    Secondary Accessions:
    • C9JD88
    • Q49AI8

    Protein attributes for TANC1 Gene

    1861 amino acids
    Molecular mass:
    202219 Da
    Quaternary structure:
    • Interacts probably directly with DLG1, DLG4, HOMER1. Interacts with DLGAP1, INA, CAMK2A, GRIN2B and GRIA1 (By similarity). Interacts with TNIK. Interacts with MINK1 (By similarity).
    • Sequence=AAH37329.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH37329.1; Type=Miscellaneous discrepancy; Note=The cDNA sequence appears to be not correctly spliced at its 3-end.; Evidence={ECO:0000305};

    Alternative splice isoforms for TANC1 Gene


neXtProt entry for TANC1 Gene

Post-translational modifications for TANC1 Gene

  • Phosphorylated; by MINK1 and TNIK upon stimulation by RAP2A.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TANC1 Gene

Domains & Families for TANC1 Gene

Suggested Antigen Peptide Sequences for TANC1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TANC family.
  • Belongs to the TANC family.
genes like me logo Genes that share domains with TANC1: view

Function for TANC1 Gene

Molecular function for TANC1 Gene

UniProtKB/Swiss-Prot Function:
May be a scaffold component in the postsynaptic density.

Phenotypes From GWAS Catalog for TANC1 Gene

genes like me logo Genes that share phenotypes with TANC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TANC1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TANC1 Gene

Localization for TANC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TANC1 Gene

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TANC1 gene
Compartment Confidence
cytosol 4
plasma membrane 3
nucleus 3

Gene Ontology (GO) - Cellular Components for TANC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with TANC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TANC1 Gene

Pathways & Interactions for TANC1 Gene

SuperPathways for TANC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TANC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007520 myoblast fusion IEA --
GO:0008542 visual learning IEA --
GO:0097062 dendritic spine maintenance IEA --
genes like me logo Genes that share ontologies with TANC1: view

No data available for Pathways by source and SIGNOR curated interactions for TANC1 Gene

Drugs & Compounds for TANC1 Gene

(1) Drugs for TANC1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
radiotherapy Pharma 0
genes like me logo Genes that share compounds with TANC1: view

Transcripts for TANC1 Gene

mRNA/cDNA for TANC1 Gene

(32) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TANC1 Gene

Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TANC1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TANC1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a ·
SP1: - - - -
SP2: - - - - - - - - - - - - - - - -
SP3: -

ExUns: 21b · 21c ^ 22 ^ 23
SP1: -
SP2: -

Relevant External Links for TANC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TANC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TANC1 Gene

Protein differential expression in normal tissues from HIPED for TANC1 Gene

This gene is overexpressed in Serum (16.6), Retina (11.6), Heart (9.5), and Testis (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TANC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TANC1 Gene:


SOURCE GeneReport for Unigene cluster for TANC1 Gene:


Evidence on tissue expression from TISSUES for TANC1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TANC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TANC1 Gene

Orthologs for TANC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TANC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TANC1 34 33
  • 99.49 (n)
(Canis familiaris)
Mammalia TANC1 34 33
  • 90.51 (n)
(Bos Taurus)
Mammalia TANC1 34 33
  • 87.35 (n)
(Mus musculus)
Mammalia Tanc1 16 34 33
  • 86.17 (n)
(Rattus norvegicus)
Mammalia Tanc1 33
  • 85.54 (n)
(Monodelphis domestica)
Mammalia TANC1 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia TANC1 34
  • 78 (a)
(Gallus gallus)
Aves TANC1 34 33
  • 71.41 (n)
(Anolis carolinensis)
Reptilia TANC1 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tanc1 33
  • 66.8 (n)
(Danio rerio)
Actinopterygii LOC100334650 33
  • 66.05 (n)
TANC1 (2 of 2) 34
  • 65 (a)
tanc1a 34
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta rols 34
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1817 34
  • 43 (a)
-- 34
  • 39 (a)
-- 34
  • 34 (a)
Species where no ortholog for TANC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TANC1 Gene

Gene Tree for TANC1 (if available)
Gene Tree for TANC1 (if available)
Evolutionary constrained regions (ECRs) for TANC1: view image

Paralogs for TANC1 Gene

(5) SIMAP similar genes for TANC1 Gene using alignment to 2 proteins:

  • B9EK39_HUMAN
genes like me logo Genes that share paralogs with TANC1: view

Variants for TANC1 Gene

Sequence variations from dbSNP and Humsavar for TANC1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs10497203 drug-response, radiotherapy response - Toxicity/ADR 158,994,911(+) A/C genic_upstream_transcript_variant, intron_variant
rs264588 drug-response, radiotherapy response - Toxicity/ADR 159,079,879(+) C/A/T genic_upstream_transcript_variant, intron_variant
rs264631 drug-response, radiotherapy response - Toxicity/ADR 159,094,353(+) C/G genic_upstream_transcript_variant, intron_variant
rs264651 drug-response, radiotherapy response - Toxicity/ADR 159,072,919(+) A/G genic_upstream_transcript_variant, intron_variant
rs6432512 drug-response, radiotherapy response - Toxicity/ADR 159,043,401(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TANC1 Gene

Variant ID Type Subtype PubMed ID
dgv1173e212 CNV loss 25503493
dgv1174e212 CNV loss 25503493
dgv1175e212 CNV gain 25503493
dgv28n50 CNV loss 21212237
dgv4096n100 CNV gain 25217958
dgv478n27 CNV gain 19166990
dgv671n67 CNV gain+loss 20364138
esv1007408 CNV deletion 20482838
esv1033253 CNV deletion 17803354
esv2675252 CNV deletion 23128226
esv2721030 CNV deletion 23290073
esv29829 CNV gain 19812545
esv3302850 CNV tandem duplication 20981092
esv3344311 CNV insertion 20981092
esv33791 CNV gain 17666407
esv3584120 CNV loss 25503493
esv3584127 CNV loss 25503493
esv3584130 CNV loss 25503493
esv3593094 CNV loss 21293372
esv3593095 CNV gain 21293372
esv3593100 CNV gain 21293372
esv3593101 CNV loss 21293372
esv3593102 CNV gain 21293372
esv3593103 CNV loss 21293372
esv3593104 CNV loss 21293372
esv3593105 CNV gain 21293372
esv3593107 CNV loss 21293372
esv3593109 CNV gain 21293372
esv3593110 CNV loss 21293372
nsv1001024 CNV gain 25217958
nsv1006676 CNV gain 25217958
nsv1008665 CNV gain 25217958
nsv1010774 CNV gain 25217958
nsv1011598 CNV gain 25217958
nsv1072039 CNV deletion 25765185
nsv1118073 CNV deletion 24896259
nsv1122012 CNV deletion 24896259
nsv1123403 CNV deletion 24896259
nsv1150125 CNV deletion 26484159
nsv2993 CNV insertion 18451855
nsv433277 CNV loss 18776910
nsv475263 CNV novel sequence insertion 20440878
nsv475568 CNV novel sequence insertion 20440878
nsv475834 CNV novel sequence insertion 20440878
nsv514100 CNV loss 21397061
nsv518893 CNV gain 19592680
nsv524373 CNV loss 19592680
nsv583449 CNV gain 21841781
nsv583472 CNV loss 21841781
nsv583473 CNV loss 21841781
nsv583474 CNV loss 21841781
nsv583475 CNV loss 21841781
nsv819030 CNV gain 19587683
nsv820838 CNV deletion 20802225
nsv821769 CNV loss 20364138
nsv955271 CNV deletion 24416366
nsv961902 CNV duplication 23825009

Variation tolerance for TANC1 Gene

Residual Variation Intolerance Score: 4.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.74; 78.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TANC1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TANC1 Gene

Disorders for TANC1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TANC1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
space motion sickness
motion sickness
  • travel sickness
- elite association - COSMIC cancer census association via MalaCards
Search TANC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TANC1

genes like me logo Genes that share disorders with TANC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TANC1 Gene

Publications for TANC1 Gene

  1. Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma. (PMID: 22182840) Avirneni-Vadlamudi U … Galindo RL (The Journal of clinical investigation 2012) 2 3 58
  2. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat BE … Tseng ZH (BMC cardiovascular disorders 2011) 3 44 58
  3. A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins. (PMID: 15673434) Suzuki T … Endo S (The European journal of neuroscience 2005) 2 3 58
  4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58
  5. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 58

Products for TANC1 Gene

Sources for TANC1 Gene

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