Aliases for TANC1 Gene

Aliases for TANC1 Gene

  • Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 1 2 3 5
  • Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Domain-Containing Protein 1 3 4
  • Protein TANC1 3 4
  • TPR Domain, Ankyrin-Repeat And Coiled-Coil-Containing 3
  • Rolling Pebbles Homolog B (Drosophila) 2
  • Rolling Pebbles Homolog B 3
  • KIAA1728 4
  • ROLSB 3
  • TANC 3

External Ids for TANC1 Gene

Previous GeneCards Identifiers for TANC1 Gene

  • GC02P159739
  • GC02P159533
  • GC02P151714
  • GC02P159825

Summaries for TANC1 Gene

GeneCards Summary for TANC1 Gene

TANC1 (Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 1) is a Protein Coding gene. Diseases associated with TANC1 include Space Motion Sickness and Chicken Egg Allergy. An important paralog of this gene is TANC2.

UniProtKB/Swiss-Prot Summary for TANC1 Gene

Additional gene information for TANC1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TANC1 Gene

Genomics for TANC1 Gene

GeneHancer (GH) Regulatory Elements for TANC1 Gene

Promoters and enhancers for TANC1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J158966 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 506.1 +0.4 425 5.5 ZSCAN5C NRF1 POLR2G PHF8 ZFX ZIC2 POLR2A ZBTB10 CLOCK ZNF423 MARCHF7 TANC1 AB372702 ENSG00000226266 BAZ2B ENSG00000230783 OR7E28P BTF3L4P2
GH02J159224 Promoter/Enhancer 0.7 EPDnew dbSUPER 500.1 +255.7 255713 0.1 ZBTB33 AGO2 TANC1 LOC105373716 MIR6888
GH02J159029 Enhancer 1.5 VISTA ENCODE CraniofacialAtlas dbSUPER 18.4 +62.4 62354 3 JUND CTBP1 MXI1 LEF1 NR2F2 ZNF316 NFIC MAFF FOSL2 PBX2 TANC1 OR7E89P RF00026-590 RNU6-580P GSTM3P2
GH02J159042 Enhancer 1.1 Ensembl ENCODE dbSUPER 21.8 +76.6 76567 6.4 JUND ZIC2 MYNN WT1 ZNF316 ZBTB17 MAFF ZNF263 BMI1 POLR2A TANC1 RNU2-21P OR7E89P OR7E28P GSTM3P2 RF00026-590 RNU6-580P
GH02J159088 Enhancer 0.9 ENCODE dbSUPER 24.3 +123.4 123440 6.5 ZSCAN5C JUND FOS ZIC2 TRIM28 EP300 WT1 POLR2A NR3C1 CEBPB TANC1 OR7E89P OR7E28P GSTM3P2 HSALNG0019901
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TANC1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TANC1

Top Transcription factor binding sites by QIAGEN in the TANC1 gene promoter:
  • AP-2gamma
  • C/EBPalpha
  • Cart-1
  • FOXO3
  • FOXO3a
  • FOXO3b
  • GCNF
  • GCNF-1
  • GCNF-2
  • Sox9

Genomic Locations for TANC1 Gene

Genomic Locations for TANC1 Gene
264,030 bases
Plus strand
264,025 bases
Plus strand

Genomic View for TANC1 Gene

Genes around TANC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TANC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TANC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TANC1 Gene

Proteins for TANC1 Gene

  • Protein details for TANC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein TANC1
    Protein Accession:
    Secondary Accessions:
    • C9JD88
    • Q49AI8

    Protein attributes for TANC1 Gene

    1861 amino acids
    Molecular mass:
    202219 Da
    Quaternary structure:
    • Interacts probably directly with DLG1, DLG4, HOMER1. Interacts with DLGAP1, INA, CAMK2A, GRIN2B and GRIA1 (By similarity). Interacts with TNIK. Interacts with MINK1 (By similarity).
    • [Isoform 2]: Incomplete sequence.
    • Sequence=AAH37329.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH37329.1; Type=Miscellaneous discrepancy; Note=The cDNA sequence appears to be not correctly spliced at its 3'-end.; Evidence={ECO:0000305};

    Alternative splice isoforms for TANC1 Gene


neXtProt entry for TANC1 Gene

Post-translational modifications for TANC1 Gene

  • Phosphorylated; by MINK1 and TNIK upon stimulation by RAP2A.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TANC1 Gene

Domains & Families for TANC1 Gene

Suggested Antigen Peptide Sequences for TANC1 Gene

GenScript: Design optimal peptide antigens:
  • TANC1 protein (B9EK39_HUMAN)
  • Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1 (TANC1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TANC family.
  • Belongs to the TANC family.
genes like me logo Genes that share domains with TANC1: view

Function for TANC1 Gene

Molecular function for TANC1 Gene

UniProtKB/Swiss-Prot Function:
May be a scaffold component in the postsynaptic density.

Phenotypes From GWAS Catalog for TANC1 Gene

Gene Ontology (GO) - Molecular Function for TANC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 30126976
genes like me logo Genes that share ontologies with TANC1: view
genes like me logo Genes that share phenotypes with TANC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TANC1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TANC1 Gene

Localization for TANC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TANC1 Gene

Cell junction, synapse, postsynaptic density.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TANC1 gene
Compartment Confidence
plasma membrane 3
nucleus 3
cytosol 3
extracellular 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TANC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with TANC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TANC1 Gene

Pathways & Interactions for TANC1 Gene

PathCards logo

SuperPathways for TANC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TANC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007520 myoblast fusion IEA --
GO:0008542 visual learning IEA --
GO:0097062 dendritic spine maintenance IEA --
genes like me logo Genes that share ontologies with TANC1: view

No data available for Pathways by source and SIGNOR curated interactions for TANC1 Gene

Drugs & Compounds for TANC1 Gene

(1) Drugs for TANC1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
radiotherapy Pharma 0
genes like me logo Genes that share compounds with TANC1: view

Transcripts for TANC1 Gene

mRNA/cDNA for TANC1 Gene

15 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TANC1

Alternative Splicing Database (ASD) splice patterns (SP) for TANC1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a ·
SP1: - - - -
SP2: - - - - - - - - - - - - - - - -
SP3: -

ExUns: 21b · 21c ^ 22 ^ 23
SP1: -
SP2: -

Relevant External Links for TANC1 Gene

GeneLoc Exon Structure for

Expression for TANC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TANC1 Gene

Protein differential expression in normal tissues from HIPED for TANC1 Gene

This gene is overexpressed in Serum (16.6), Retina (11.6), Heart (9.5), and Testis (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TANC1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TANC1

SOURCE GeneReport for Unigene cluster for TANC1 Gene:


Evidence on tissue expression from TISSUES for TANC1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TANC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TANC1 Gene

Orthologs for TANC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TANC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TANC1 31 30
  • 99.49 (n)
(Canis familiaris)
Mammalia TANC1 31 30
  • 90.51 (n)
(Bos Taurus)
Mammalia TANC1 31 30
  • 87.35 (n)
(Mus musculus)
Mammalia Tanc1 17 31 30
  • 86.17 (n)
(Rattus norvegicus)
Mammalia Tanc1 30
  • 85.54 (n)
(Monodelphis domestica)
Mammalia TANC1 31
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia TANC1 31
  • 78 (a)
(Gallus gallus)
Aves TANC1 31 30
  • 71.41 (n)
(Anolis carolinensis)
Reptilia TANC1 31
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tanc1 30
  • 66.8 (n)
(Danio rerio)
Actinopterygii LOC100334650 30
  • 66.05 (n)
TANC1 (2 of 2) 31
  • 65 (a)
tanc1a 31
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta rols 31
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1817 31
  • 43 (a)
-- 31
  • 39 (a)
-- 31
  • 34 (a)
Species where no ortholog for TANC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TANC1 Gene

Gene Tree for TANC1 (if available)
Gene Tree for TANC1 (if available)
Evolutionary constrained regions (ECRs) for TANC1: view image

Paralogs for TANC1 Gene

Paralogs for TANC1 Gene

(5) SIMAP similar genes for TANC1 Gene using alignment to 2 proteins:

  • B9EK39_HUMAN
genes like me logo Genes that share paralogs with TANC1: view

Variants for TANC1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TANC1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
775763 Benign: not provided 159,097,783(+) C/A MISSENSE_VARIANT
775764 Benign: not provided 159,163,390(+) C/T MISSENSE_VARIANT,INTRON_VARIANT
775765 Benign: not provided 159,230,129(+) G/T MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT
808835 Uncertain Significance: not provided 159,169,321(+) A/G MISSENSE_VARIANT
808836 Uncertain Significance: not provided 159,225,755(+) G/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TANC1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TANC1 Gene

Variant ID Type Subtype PubMed ID
dgv1173e212 CNV loss 25503493
dgv1174e212 CNV loss 25503493
dgv1175e212 CNV gain 25503493
dgv28n50 CNV loss 21212237
dgv4096n100 CNV gain 25217958
dgv478n27 CNV gain 19166990
dgv671n67 CNV gain+loss 20364138
esv1007408 CNV deletion 20482838
esv1033253 CNV deletion 17803354
esv2675252 CNV deletion 23128226
esv2721030 CNV deletion 23290073
esv29829 CNV gain 19812545
esv3302850 CNV tandem duplication 20981092
esv3344311 CNV insertion 20981092
esv33791 CNV gain 17666407
esv3584120 CNV loss 25503493
esv3584127 CNV loss 25503493
esv3584130 CNV loss 25503493
esv3593094 CNV loss 21293372
esv3593095 CNV gain 21293372
esv3593100 CNV gain 21293372
esv3593101 CNV loss 21293372
esv3593102 CNV gain 21293372
esv3593103 CNV loss 21293372
esv3593104 CNV loss 21293372
esv3593105 CNV gain 21293372
esv3593107 CNV loss 21293372
esv3593109 CNV gain 21293372
esv3593110 CNV loss 21293372
nsv1001024 CNV gain 25217958
nsv1006676 CNV gain 25217958
nsv1008665 CNV gain 25217958
nsv1010774 CNV gain 25217958
nsv1011598 CNV gain 25217958
nsv1072039 CNV deletion 25765185
nsv1118073 CNV deletion 24896259
nsv1122012 CNV deletion 24896259
nsv1123403 CNV deletion 24896259
nsv1150125 CNV deletion 26484159
nsv2993 CNV insertion 18451855
nsv433277 CNV loss 18776910
nsv475263 CNV novel sequence insertion 20440878
nsv475568 CNV novel sequence insertion 20440878
nsv475834 CNV novel sequence insertion 20440878
nsv514100 CNV loss 21397061
nsv518893 CNV gain 19592680
nsv524373 CNV loss 19592680
nsv583449 CNV gain 21841781
nsv583472 CNV loss 21841781
nsv583473 CNV loss 21841781
nsv583474 CNV loss 21841781
nsv583475 CNV loss 21841781
nsv819030 CNV gain 19587683
nsv820838 CNV deletion 20802225
nsv821769 CNV loss 20364138
nsv955271 CNV deletion 24416366
nsv961902 CNV duplication 23825009

Variation tolerance for TANC1 Gene

Residual Variation Intolerance Score: 4.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.74; 78.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TANC1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TANC1 Gene

Disorders for TANC1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for TANC1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
space motion sickness
chicken egg allergy
  • gallus gallus egg allergy
malignant otitis externa
rectosigmoid junction neoplasm
  • neoplasm of rectosigmoid junction
complex chromosomal rearrangement
- elite association - COSMIC cancer census association via MalaCards
Search TANC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TANC1

genes like me logo Genes that share disorders with TANC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TANC1 Gene

Publications for TANC1 Gene

  1. Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma. (PMID: 22182840) Avirneni-Vadlamudi U … Galindo RL (The Journal of clinical investigation 2012) 2 3 54
  2. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat BE … Tseng ZH (BMC cardiovascular disorders 2011) 3 41 54
  3. A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins. (PMID: 15673434) Suzuki T … Endo S (The European journal of neuroscience 2005) 2 3 54
  4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 54
  5. BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion. (PMID: 31519766) Chan CJ … Melançon P (Molecular & cellular proteomics : MCP 2019) 3 54

Products for TANC1 Gene

Sources for TANC1 Gene