This gene encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. The encoded protein contains conserved domains, including a leucine zipper sequence, PDZ domain and a C-terminal PDZ-binding motif. Alternately spliced transcript variants have been observed for this gene.[provided by R... See more...

Aliases for TAMALIN Gene

Aliases for TAMALIN Gene

  • Trafficking Regulator And Scaffold Protein Tamalin 2 3
  • General Receptor For Phosphoinositides 1 Associated Scaffold Protein 2 3 5
  • GRASP 3 4 5
  • GRP1 (General Receptor For Phosphoinositides 1)-Associated Scaffold Protein 2 3
  • General Receptor For Phosphoinositides 1-Associated Scaffold Protein 3 4
  • GRP1-Associated Scaffold Protein 4
  • Protein TAMALIN 4

External Ids for TAMALIN Gene

Previous HGNC Symbols for TAMALIN Gene

  • GRASP

Summaries for TAMALIN Gene

Entrez Gene Summary for TAMALIN Gene

  • This gene encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. The encoded protein contains conserved domains, including a leucine zipper sequence, PDZ domain and a C-terminal PDZ-binding motif. Alternately spliced transcript variants have been observed for this gene.[provided by RefSeq, Dec 2012]

GeneCards Summary for TAMALIN Gene

TAMALIN (Trafficking Regulator And Scaffold Protein Tamalin) is a Protein Coding gene. An important paralog of this gene is CYTIP.

UniProtKB/Swiss-Prot Summary for TAMALIN Gene

  • Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.

Additional gene information for TAMALIN Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAMALIN Gene

Genomics for TAMALIN Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TAMALIN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAMALIN on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAMALIN

Genomic Locations for TAMALIN Gene

Genomic Locations for TAMALIN Gene
chr12:52,006,946-52,015,889
(GRCh38/hg38)
Size:
8,944 bases
Orientation:
Plus strand
chr12:52,400,724-52,409,673
(GRCh37/hg19)
Size:
8,950 bases
Orientation:
Plus strand

Genomic View for TAMALIN Gene

Genes around TAMALIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAMALIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAMALIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAMALIN Gene

Proteins for TAMALIN Gene

  • Protein details for TAMALIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6J2-GRASP_HUMAN
    Recommended name:
    Protein TAMALIN
    Protein Accession:
    Q7Z6J2
    Secondary Accessions:
    • Q6PIF8
    • Q7Z741

    Protein attributes for TAMALIN Gene

    Size:
    395 amino acids
    Molecular mass:
    42623 Da
    Quaternary structure:
    • Heteromer. Composed of TAMALIN, CYTH2 and at least one GRM1. Also interacts with CYTH3, GRM2, GRM3 and GRM5 (By similarity).

    Three dimensional structures from OCA and Proteopedia for TAMALIN Gene

    Alternative splice isoforms for TAMALIN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAMALIN Gene

Post-translational modifications for TAMALIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAMALIN Gene

No data available for DME Specific Peptides for TAMALIN Gene

Domains & Families for TAMALIN Gene

Gene Families for TAMALIN Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TAMALIN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAMALIN Gene

GenScript: Design optimal peptide antigens:
  • General receptor for phosphoinositides 1-associated scaffold protein (GRASP_HUMAN)
genes like me logo Genes that share domains with TAMALIN: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TAMALIN Gene

Function for TAMALIN Gene

Molecular function for TAMALIN Gene

UniProtKB/Swiss-Prot Function:
Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.

Phenotypes From GWAS Catalog for TAMALIN Gene

Gene Ontology (GO) - Molecular Function for TAMALIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0030165 PDZ domain binding IEA --
GO:0030306 ADP-ribosylation factor binding IEA --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with TAMALIN: view
genes like me logo Genes that share phenotypes with TAMALIN: view

Animal Models for TAMALIN Gene

MGI Knock Outs for TAMALIN:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAMALIN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAMALIN Gene

Localization for TAMALIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAMALIN Gene

Cytoplasm, perinuclear region. Cell membrane. Peripheral membrane protein. Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAMALIN gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAMALIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IBA 21873635
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with TAMALIN: view

Pathways & Interactions for TAMALIN Gene

PathCards logo

SuperPathways for TAMALIN Gene

No Data Available

Gene Ontology (GO) - Biological Process for TAMALIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA 21873635
GO:0008104 protein localization IEA --
GO:0099152 regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with TAMALIN: view

No data available for Pathways by source and SIGNOR curated interactions for TAMALIN Gene

Drugs & Compounds for TAMALIN Gene

No Compound Related Data Available

Transcripts for TAMALIN Gene

mRNA/cDNA for TAMALIN Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAMALIN

Alternative Splicing Database (ASD) splice patterns (SP) for TAMALIN Gene

No ASD Table

Relevant External Links for TAMALIN Gene

GeneLoc Exon Structure for
TAMALIN

Expression for TAMALIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAMALIN

SOURCE GeneReport for Unigene cluster for TAMALIN Gene:

Hs.407202

Evidence on tissue expression from TISSUES for TAMALIN Gene

  • Skin(4.5)
  • Nervous system(2.8)
  • Heart(2.3)
  • Intestine(2.3)
  • Blood(2.3)
  • Muscle(2.2)
  • Kidney(2.2)
  • Liver(2.2)
  • Lung(2.1)
  • Thyroid gland(2)
  • Bone marrow(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with TAMALIN: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAMALIN Gene

Orthologs for TAMALIN Gene

This gene was present in the common ancestor of animals.

Orthologs for TAMALIN Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GRASP 30 31
  • 99.54 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GRASP 30 31
  • 88.03 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Grasp 30
  • 86.38 (n)
Mouse
(Mus musculus)
Mammalia Grasp 30 17 31
  • 86.05 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GRASP 31
  • 80 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia GRASP 31
  • 69 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GRASP 31
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia grasp 30
  • 59.48 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC52824 30
Zebrafish
(Danio rerio)
Actinopterygii grasp 30 31
  • 56.67 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG6619 31
  • 7 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea gras-1 31
  • 20 (a)
OneToMany
Species where no ortholog for TAMALIN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TAMALIN Gene

ENSEMBL:
Gene Tree for TAMALIN (if available)
TreeFam:
Gene Tree for TAMALIN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAMALIN: view image

Paralogs for TAMALIN Gene

Paralogs for TAMALIN Gene

genes like me logo Genes that share paralogs with TAMALIN: view

Variants for TAMALIN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAMALIN Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
783034 Benign: not provided 52,009,214(+) C/T MISSENSE_VARIANT
rs200789033 Likely Benign: Anophthalmia - microphthalmia 52,015,095(+) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TAMALIN Gene

Structural Variations from Database of Genomic Variants (DGV) for TAMALIN Gene

Variant ID Type Subtype PubMed ID
dgv2629n54 CNV loss 21841781
nsv469378 CNV loss 19166990
nsv558898 CNV loss 21841781

Variation tolerance for TAMALIN Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAMALIN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAMALIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAMALIN Gene

Disorders for TAMALIN Gene

No disorders were found for TAMALIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAMALIN Gene

Publications for TAMALIN Gene

  1. GRASP and IPCEF promote ARF-to-Rac signaling and cell migration by coordinating the association of ARNO/cytohesin 2 with Dock180. (PMID: 20016009) White DT … Santy LC (Molecular biology of the cell 2010) 3 23
  2. Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation. (PMID: 17396155) Sugi T … Jingami H (The EMBO journal 2007) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors. (PMID: 10828067) Nevrivy DJ … Leid M (The Journal of biological chemistry 2000) 2 3
  5. POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1. (PMID: 30745168) Wang B … Liu Y (EBioMedicine 2019) 3

Products for TAMALIN Gene

Sources for TAMALIN Gene