This intronless gene encodes a helix-loop-helix protein. Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-cell acute lymphoblastic leukemia. [provided by RefSeq, Mar 2009] See more...

Aliases for TAL2 Gene

Aliases for TAL2 Gene

  • TAL BHLH Transcription Factor 2 2 3 5
  • T-Cell Acute Lymphocytic Leukemia Protein 2 3 4
  • Class A Basic Helix-Loop-Helix Protein 19 3 4
  • T-Cell Acute Lymphocytic Leukemia 2 2 3
  • BHLHa19 2 4
  • TAL-2 3 4
  • BHLHA19 4
  • TAL2 5

External Ids for TAL2 Gene

Previous GeneCards Identifiers for TAL2 Gene

  • GC09P099225
  • GC09P100168
  • GC09P101882
  • GC09P103804
  • GC09P105504
  • GC09P107464
  • GC09P108424
  • GC09P078026

Summaries for TAL2 Gene

Entrez Gene Summary for TAL2 Gene

  • This intronless gene encodes a helix-loop-helix protein. Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-cell acute lymphoblastic leukemia. [provided by RefSeq, Mar 2009]

GeneCards Summary for TAL2 Gene

TAL2 (TAL BHLH Transcription Factor 2) is a Protein Coding gene. Diseases associated with TAL2 include T-Cell Acute Lymphoblastic Leukemia and Leukemia. Among its related pathways are MAPK Erk Pathway. Gene Ontology (GO) annotations related to this gene include protein dimerization activity. An important paralog of this gene is TAL1.

Gene Wiki entry for TAL2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAL2 Gene

Genomics for TAL2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TAL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J105661 Enhancer 0.5 Ensembl 600.7 -0.2 -156 1.4 FOXA1 ZNF341 CTBP1 GATA3 TBX21 FOXK2 ZNF687 SPI1 RAD51 TAL2 TMEM38B ENSG00000279609 lnc-TAL2-1 lnc-TAL2-2 FKTN
GH09J105609 Enhancer 0.6 ENCODE 11.6 -53.3 -53282 0.2 CTCF REST RAD21 TRIM22 ZNF592 SMC3 ZNF654 MEIS2 ARID3A DACH1 TAL2 lnc-ABCA1-6 piR-46256-055 FKTN lnc-FKTN-1
GH09J106054 Enhancer 0.2 FANTOM5 18.3 +392.2 392239 0.2 TAL2 ENSG00000225002 piR-50357-158 LINC01505 TMEM38B ZNF462
GH09J105860 Enhancer 0.3 FANTOM5 6.4 +198.4 198416 0.3 MEIS2 TAL2 FSD1L SLC25A6P5 piR-55985-204 lnc-TMEM38B-2 TMEM38B ZNF462
GH09J105683 Enhancer 0.2 ENCODE 12.1 +21.6 21599 1.2 TMEM38B TAL2 lnc-TAL2-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAL2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAL2

Top Transcription factor binding sites by QIAGEN in the TAL2 gene promoter:
  • Bach2
  • FOXO1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • POU2F1
  • POU2F1a
  • RORalpha1

Genomic Locations for TAL2 Gene

Genomic Locations for TAL2 Gene
chr9:105,662,457-105,663,124
(GRCh38/hg38)
Size:
668 bases
Orientation:
Plus strand
chr9:108,424,738-108,425,393
(GRCh37/hg19)
Size:
656 bases
Orientation:
Plus strand

Genomic View for TAL2 Gene

Genes around TAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAL2 Gene

Proteins for TAL2 Gene

  • Protein details for TAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16559-TAL2_HUMAN
    Recommended name:
    T-cell acute lymphocytic leukemia protein 2
    Protein Accession:
    Q16559
    Secondary Accessions:
    • A0AVI7

    Protein attributes for TAL2 Gene

    Size:
    108 amino acids
    Molecular mass:
    12291 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TAL2 Gene

Post-translational modifications for TAL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for TAL2
  • Santa Cruz Biotechnology (SCBT) Antibodies for TAL2

No data available for DME Specific Peptides for TAL2 Gene

Domains & Families for TAL2 Gene

Gene Families for TAL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TAL2 Gene

InterPro:
Blocks:
  • Basic helix-loop-helix dimerization domain bHLH
ProtoNet:

Suggested Antigen Peptide Sequences for TAL2 Gene

GenScript: Design optimal peptide antigens:
  • Class A basic helix-loop-helix protein 19 (TAL2_HUMAN)
genes like me logo Genes that share domains with TAL2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TAL2 Gene

Function for TAL2 Gene

Molecular function for TAL2 Gene

GENATLAS Biochemistry:
helix loop helix protein,homologous to TAL1,involved in T cell acute lymphoblastic leukemia,with translocation t(7;9)(q35;q34)

Phenotypes From GWAS Catalog for TAL2 Gene

Gene Ontology (GO) - Molecular Function for TAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding TAS 1763056
GO:0005515 protein binding IPI 25416956
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with TAL2: view
genes like me logo Genes that share phenotypes with TAL2: view

Human Phenotype Ontology for TAL2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TAL2 Gene

MGI Knock Outs for TAL2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAL2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TAL2 Gene

Localization for TAL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAL2 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with TAL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAL2 Gene

Pathways & Interactions for TAL2 Gene

PathCards logo

SuperPathways for TAL2 Gene

SuperPathway Contained pathways
1 MAPK Erk Pathway
genes like me logo Genes that share pathways with TAL2: view

Pathways by source for TAL2 Gene

1 Sino Biological pathway for TAL2 Gene

SIGNOR curated interactions for TAL2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0009791 post-embryonic development IEA --
GO:0021794 thalamus development IEA --
GO:0030901 midbrain development IEA --
GO:0035264 multicellular organism growth IEA --
genes like me logo Genes that share ontologies with TAL2: view

Drugs & Compounds for TAL2 Gene

No Compound Related Data Available

Transcripts for TAL2 Gene

mRNA/cDNA for TAL2 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAL2

Alternative Splicing Database (ASD) splice patterns (SP) for TAL2 Gene

No ASD Table

Relevant External Links for TAL2 Gene

GeneLoc Exon Structure for
TAL2

Expression for TAL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAL2 Gene

This gene is overexpressed in Muscle - Skeletal (x8.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAL2

SOURCE GeneReport for Unigene cluster for TAL2 Gene:

Hs.247978

Phenotype-based relationships between genes and organs from Gene ORGANizer for TAL2 Gene

Germ Layers:
  • mesoderm
Systems:
  • immune
Regions:
General:
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with TAL2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for TAL2 Gene

Orthologs for TAL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAL2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TAL2 30 31
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TAL2 30 31
  • 91.75 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TAL2 30 31
  • 90.16 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tal2 30 17 31
  • 86.11 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tal2 30
  • 85.19 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia TAL2 31
  • 80 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TAL2 31
  • 73 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TAL2 31
  • 70 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TAL2 31
  • 78 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii tal2 30 31
  • 60.78 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta HLH3B 31
  • 14 (a)
OneToMany
Species where no ortholog for TAL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TAL2 Gene

ENSEMBL:
Gene Tree for TAL2 (if available)
TreeFam:
Gene Tree for TAL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAL2: view image

Paralogs for TAL2 Gene

Paralogs for TAL2 Gene

(23) SIMAP similar genes for TAL2 Gene using alignment to 1 proteins:

  • TAL2_HUMAN
genes like me logo Genes that share paralogs with TAL2: view

Variants for TAL2 Gene

Additional dbSNP identifiers (rs#s) for TAL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TAL2 Gene

Variant ID Type Subtype PubMed ID
esv3891705 CNV loss 25118596
esv3891707 CNV gain 25118596
nsv519023 CNV gain 19592680

Variation tolerance for TAL2 Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAL2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAL2 Gene

Disorders for TAL2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TAL2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
t-cell acute lymphoblastic leukemia
  • acute t cell leukaemia
leukemia
  • leukemias
- elite association - COSMIC cancer census association via MalaCards
Search TAL2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TAL2_HUMAN
  • Note=A chromosomal aberration involving TAL2 may be a cause of some T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;9)(q34;q32) with TCRB. {ECO:0000269 PubMed:1763056}.

Genatlas disease for TAL2 Gene

acute lymphoblastic leukemia (T cell) with breakpoint in t(7;9)(q35;q34) translocation

Additional Disease Information for TAL2

genes like me logo Genes that share disorders with TAL2: view

Publications for TAL2 Gene

  1. TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. (PMID: 1763056) Xia Y … Baer RJ (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 23
  2. Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity. (PMID: 8152805) Xia Y … Baer R (Oncogene 1994) 3 4 23
  3. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli ET … Goldstein DB (European journal of human genetics : EJHG 2010) 3 41
  4. Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. (PMID: 19448620) Perry JR … Murabito JM (Nature genetics 2009) 3 41
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4

Products for TAL2 Gene

  • Signalway ELISA kits for TAL2

Sources for TAL2 Gene