TAL1 Gene (Protein Coding)

TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor

GC01M047216
GIFtS:
45
See more...

Aliases for TAL1 Gene

Aliases for TAL1 Gene

  • TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor 2 3 5
  • BHLHa17 2 3 4
  • SCL 2 3 4
  • T-Cell Acute Lymphocytic Leukemia Protein 1 3 4
  • Class A Basic Helix-Loop-Helix Protein 17 3 4
  • T-Cell Acute Lymphocytic Leukemia 1 2 3
  • T-Cell Leukemia/Lymphoma Protein 5 3 4
  • Stem Cell Protein 3 4
  • TCL5 3 4
  • Tal-1 Product 3
  • BHLHA17 4
  • Tal-1 3
  • TAL-1 4
  • TAL1 5

External Ids for TAL1 Gene

Previous HGNC Symbols for TAL1 Gene

  • TCL5

Previous GeneCards Identifiers for TAL1 Gene

  • GC01M047308
  • GC01M046571
  • GC01M047040
  • GC01M047051
  • GC01M047393
  • GC01M047454
  • GC01M047681
  • GC01M045798

Summaries for TAL1 Gene

GeneCards Summary for TAL1 Gene

TAL1 (TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor) is a Protein Coding gene. Diseases associated with TAL1 include Precursor T-Cell Acute Lymphoblastic Leukemia and Childhood T-Cell Acute Lymphoblastic Leukemia. Among its related pathways are MAPK Erk Pathway and NF-kappaB Signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is LYL1.

UniProtKB/Swiss-Prot Summary for TAL1 Gene

  • Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).

Gene Wiki entry for TAL1 Gene

Additional gene information for TAL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAL1 Gene

Genomics for TAL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for TAL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAL1

Top Transcription factor binding sites by QIAGEN in the TAL1 gene promoter:
  • AML1a

Genomic Locations for TAL1 Gene

Genomic Locations for TAL1 Gene
chr1:47,216,290-47,232,389
(GRCh38/hg38)
Size:
16,100 bases
Orientation:
Minus strand
chr1:47,681,962-47,697,892
(GRCh37/hg19)
Size:
15,931 bases
Orientation:
Minus strand

Genomic View for TAL1 Gene

Genes around TAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAL1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TAL1 Gene

Proteins for TAL1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17542-TAL1_HUMAN
    Recommended name:
    T-cell acute lymphocytic leukemia protein 1
    Protein Accession:
    P17542
    Secondary Accessions:
    • D3DQ24

    Protein attributes for TAL1 Gene

    Size:
    331 amino acids
    Molecular mass:
    34271 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3. Interacts with SBNO2; this interaction inhibits TAL1 occupancy of the DCSTAMP promoter, leading to the activation of the DCSTAMP promoter by the transcription factor MITF.

    Three dimensional structures from OCA and Proteopedia for TAL1 Gene

    Alternative splice isoforms for TAL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAL1 Gene

Protein Expression for TAL1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TAL1 Gene

  • Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity).
  • Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity).
  • Ubiquitination at Lys234, Lys241, and Lys185
  • Modification sites at PhosphoSitePlus

Other Protein References for TAL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for TAL1

No data available for DME Specific Peptides for TAL1 Gene

Domains & Families for TAL1 Gene

Gene Families for TAL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TAL1 Gene

InterPro:
Blocks:
  • Basic helix-loop-helix dimerization domain bHLH
ProtoNet:

Suggested Antigen Peptide Sequences for TAL1 Gene

GenScript: Design optimal peptide antigens:
  • TAL-1 (Q16509_HUMAN)
  • Tal-1 product (Q9UE36_HUMAN)
  • T-cell leukemia/lymphoma protein 5 (TAL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17542

UniProtKB/Swiss-Prot:

TAL1_HUMAN :
  • The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.
Domain:
  • The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.
genes like me logo Genes that share domains with TAL1: view

Function for TAL1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for TAL1 Gene

UniProtKB/Swiss-Prot Function:
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).

Phenotypes From GWAS Catalog for TAL1 Gene

Gene Ontology (GO) - Molecular Function for TAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IEA,ISS --
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IEA,ISM 19274049
GO:0001085 RNA polymerase II transcription factor binding IPI 15920471
genes like me logo Genes that share ontologies with TAL1: view
genes like me logo Genes that share phenotypes with TAL1: view

Human Phenotype Ontology for TAL1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TAL1 Gene

MGI Knock Outs for TAL1:

Animal Model Products

CRISPR Products

Transcription Factor Targets for TAL1 Gene

Selected GeneGlobe predicted Target genes for TAL1
Targeted motifs for TAL1 Gene
HOMER Transcription Factor Regulatory Elements motif TAL1
  • Consensus sequence: ANCAGCTG Submotif: canonical Cell Type: HPC7 GEO ID: GSE13511

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAL1

No data available for Enzyme Numbers (IUBMB) for TAL1 Gene

Localization for TAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAL1 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAL1 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 colocalizes_with histone deacetylase complex IDA 19497860
GO:0000790 nuclear chromatin IDA,ISA --
GO:0005634 nucleus IBA,IDA 19497860
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA,IDA 15920471
genes like me logo Genes that share ontologies with TAL1: view

Pathways & Interactions for TAL1 Gene

PathCards logo

SuperPathways for TAL1 Gene

SuperPathway Contained pathways
1 NF-kappaB Signaling
NF-kappaB Signaling
-
2 MAPK Erk Pathway
MAPK Erk Pathway
.32
genes like me logo Genes that share pathways with TAL1: view

Pathways by source for TAL1 Gene

1 Sino Biological pathway for TAL1 Gene
1 Cell Signaling Technology pathway for TAL1 Gene

SIGNOR curated interactions for TAL1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001525 angiogenesis IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA,ISS --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with TAL1: view

Drugs & Compounds for TAL1 Gene

Products:

  1. Drug

(2) Drugs for TAL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for TAL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TAL1: view

Transcripts for TAL1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TAL1 Gene

6 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAL1

Alternative Splicing Database (ASD) splice patterns (SP) for TAL1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: - -
SP2: -
SP3: - - - - -
SP4:

Relevant External Links for TAL1 Gene

GeneLoc Exon Structure for
TAL1

Expression for TAL1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAL1 Gene

mRNA expression in normal human tissues for TAL1 Gene
mRNA expression by GTEx for TAL1 GenemRNA expression by BioGPS for TAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAL1 Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for TAL1 Gene

This gene is overexpressed in Liver (62.4) and Fetal Liver (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAL1 Gene



Protein tissue co-expression partners for TAL1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAL1

SOURCE GeneReport for Unigene cluster for TAL1 Gene:

Hs.705618

mRNA Expression by UniProt/SwissProt for TAL1 Gene:

P17542-TAL1_HUMAN
Tissue specificity: Leukemic stem cell.

Evidence on tissue expression from TISSUES for TAL1 Gene

  • Bone marrow(4.6)
  • Blood(3.3)
  • Heart(2.3)
  • Nervous system(2.3)
  • Liver(2.3)
  • Spleen(2.2)
  • Skin(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TAL1 Gene

Germ Layers:
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • lymphatic
Regions:
General:
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with TAL1: view

Orthologs for TAL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAL1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia TAL1 30 31
  • 99.9 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia TAL1 30 31
  • 90.52 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia TAL1 30 31
  • 90.42 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Tal1 30 17 31
  • 88.75 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Tal1 30
  • 88.05 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia TAL1 31
  • 76 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia TAL1 31
  • 72 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves SCL 31
  • 82 (a)
 OneToOne
TAL1 30
  • 72.46 (n)
Lizard
(Anolis carolinensis)
 Reptilia TAL1 31
  • 79 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia tal1 30
  • 68.45 (n)
African clawed frog
(Xenopus laevis)
 Amphibia LOC398028 30
Zebrafish
(Danio rerio)
 Actinopterygii tal1 30 31
  • 68.73 (n)
 OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.12172 30
Fruit Fly
(Drosophila melanogaster)
 Insecta HLH3B 31
  • 19 (a)
 OneToMany
Species where no ortholog for TAL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TAL1 Gene

ENSEMBL:
Gene Tree for TAL1 (if available)
TreeFam:
Gene Tree for TAL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAL1: view image

Paralogs for TAL1 Gene

Paralogs for TAL1 Gene

(4) SIMAP similar genes for TAL1 Gene using alignment to 3 proteins:

  • TAL1_HUMAN
  • E7EVM2_HUMAN
  • L8E8Z6_HUMAN
genes like me logo Genes that share paralogs with TAL1: view

Variants for TAL1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAL1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
754520 Likely Benign: not provided 47,224,026(-) G/A SYNONYMOUS_VARIANT
786986 Likely Benign: not provided 47,225,448(-) G/C SYNONYMOUS_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for TAL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TAL1 Gene

Variant ID Type Subtype PubMed ID
nsv475889 CNV novel sequence insertion 20440878
nsv475925 CNV novel sequence insertion 20440878

Variation tolerance for TAL1 Gene

Residual Variation Intolerance Score: 64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAL1 Gene

Human Gene Mutation Database (HGMD)
TAL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAL1 Gene

Disorders for TAL1 Gene

MalaCards: The human disease database

(14) MalaCards diseases for TAL1 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
childhood t-cell acute lymphoblastic leukemia
  • childhood precursor t-lymphoblastic lymphoma/leukemia
lymphoblastic lymphoma
  • lymphoma, lymphoblastic
acute leukemia
  • stem cell leukaemia
leukemia
  • leukemias
- elite association - COSMIC cancer census association via MalaCards
Search TAL1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TAL1_HUMAN
  • Note=A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes. {ECO:0000269 PubMed:2303035}.

Genatlas disease for TAL1 Gene

acute lymphoblastic leukemia (T cell) with interstitial deletion 5' to TAL1 (stem-cell leukemia) or with translocations t(1;14)(p32;q11),t(1;7)(p32;p35),t(1;3)(p34;p21),t(1;5)(p32;q31),see SCL,SIL,TCTA

Additional Disease Information for TAL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TAL1: view

Publications for TAL1 Gene

  1. Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at serine residues. (PMID: 8437851) Cheng JT … Baer R (Oncogene 1993) 3 4 23
  2. The SCL gene product: a positive regulator of erythroid differentiation. (PMID: 1396592) Aplan PD … Kirsch IR (The EMBO journal 1992) 3 4 23
  3. Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia. (PMID: 2230650) Chen Q … Baer R (The Journal of experimental medicine 1990) 3 4 23
  4. Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1. (PMID: 20028976) Lausen J … Leutz A (The Journal of biological chemistry 2010) 3 23
  5. Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus. (PMID: 20140202) Dhami P … Vetrie D (PloS one 2010) 3 23

ExternalLinks

View latest publications for TAL1 gene in Mastermind

Products for TAL1 Gene

  • Addgene plasmids for TAL1
  • Signalway ELISA kits for TAL1

Sources for TAL1 Gene