Aliases for TAL1 Gene
Aliases for TAL1 Gene
External Ids for TAL1 Gene
- HGNC: 11556
- Entrez Gene: 6886
- Ensembl: ENSG00000162367
- OMIM: 187040
- UniProtKB: P17542
Previous HGNC Symbols for TAL1 Gene
- TCL5
Previous GeneCards Identifiers for TAL1 Gene
- GC01M047308
- GC01M046571
- GC01M047040
- GC01M047051
- GC01M047393
- GC01M047454
- GC01M047681
- GC01M045798
Summaries for TAL1 Gene
GeneCards Summary for TAL1 Gene
TAL1 (TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor) is a Protein Coding gene. Diseases associated with TAL1 include Precursor T-Cell Acute Lymphoblastic Leukemia and Acute Lymphocytic Leukemia. Among its related pathways are NF-kappaB Signaling and MAPK-Erk Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is LYL1.
UniProtKB/Swiss-Prot for TAL1 Gene
-
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).
Additional gene information for TAL1 Gene
- Monarch Initiative
- Search for TAL1 at DataMed
- Search for TAL1 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAL1 Gene
Genomics for TAL1 Gene
GeneHancer (GH) Regulatory Elements for TAL1 Gene
Promoters and enhancers for TAL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TAL1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TAL1 gene promoter:
-
- AML1a
Regulatory Element Products
Genomic Locations for TAL1 Gene
Genomic Locations for TAL1 Gene
- chr1:47,216,290-47,232,373
- (GRCh38/hg38)
- Size:
- 16,084 bases
- Orientation:
- Minus strand
- chr1:47,681,962-47,697,892
- (GRCh37/hg19)
- Size:
- 15,931 bases
- Orientation:
- Minus strand
Genomic View for TAL1 Gene
Genes around TAL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p33 by Entrez Gene
- 1p33 by HGNC
- 1p33 by Ensembl
TAL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TAL1 Gene
Proteins for TAL1 Gene
-
Protein details for TAL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P17542-TAL1_HUMAN
- Recommended name:
- T-cell acute lymphocytic leukemia protein 1
- Protein Accession:
- P17542
- D3DQ24
Protein attributes for TAL1 Gene
- Size:
- 331 amino acids
- Molecular mass:
- 34271 Da
- Quaternary structure:
-
- Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3. Interacts with SBNO2; this interaction inhibits TAL1 occupancy of the DCSTAMP promoter, leading to the activation of the DCSTAMP promoter by the transcription factor MITF.
Protein Expression for TAL1 Gene
Post-translational modifications for TAL1 Gene
- Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity).
- Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity).
- Ubiquitination at isoforms=3, 2241, posLast=234234, and isoforms=2185
- Modification sites at PhosphoSitePlus
Other Protein References for TAL1 Gene
Antibody Products
- R&D Systems Antibodies for TAL1 (SCL/Tal1)
-
Custom Antibody ServicesOriGene Antibodies for TAL1
- AP12390PU-N
- AP21141PU-N
- AP21393AF-N
- AP21393BT-N
- AP21393PU-N
- AP55831PU-N
- AP55831PU-S
- TA503922S
- TA313028
- TA313029
- TA353478
- TA353479
- TA353480
- TA353481
- TA503896
- CF503896
- TA503897
- CF503897
- TA503898
- CF503898
- TA503899
- CF503899
- TA503900
- CF503900
- TA503901
- CF503901
- TA503919
- CF503919
- TA503921
- CF503921
- TA503922
- CF503922
- TA590662
- Novus Biologicals Antibodies for TAL1
- Invitrogen Antibodies for TAL1
- antibodies-online: Search results for 207 available TAL1 Antibodies ranked by validation data
- Compare Top TAL1 Antibodies
-
Recommended
- 36 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 116 WB Antibodies (anti-human)
- 29 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 DB Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 ChIP Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 17 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 36 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 116 WB Antibodies (anti-human)
- 29 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 DB Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 ChIP Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 17 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- GeneTex TAL1 Antibody for TAL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for TAL1
Protein Products
-
OriGene Purified Proteins for TAL1
- Search Origene for MassSpec and Protein Over-expression Lysates for TAL1
- Origene Custom Protein Services for TAL1
- Search GeneTex for Proteins for TAL1
Assay Products
No data available for DME Specific Peptides for TAL1 Gene
Domains & Families for TAL1 Gene
Gene Families for TAL1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for TAL1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TAL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P17542UniProtKB/Swiss-Prot:
TAL1_HUMAN :- The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.
- Domain:
-
- The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.
Function for TAL1 Gene
Molecular function for TAL1 Gene
- UniProtKB/Swiss-Prot Function:
- Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).
Phenotypes From GWAS Catalog for TAL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IEA | -- |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | -- |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | IEA | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | ISM,IEA | 19274049 |
Phenotypes for TAL1 Gene
- MGI mutant phenotypes for TAL1:
-
inferred from 9 alleles
- cardiovascular system phenotype
- pigmentation phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- integument phenotype
- mortality/aging
- cellular phenotype
- skeleton phenotype
- embryo phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for TAL1:
Animal Models for TAL1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TAL1
-
CRISPR Products
-
OriGene CRISPR knockouts for TAL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TAL1
- genomics-online: gRNA clones - Search results for 101 available TAL1 gene related products
- Overview of 101 available TAL1 gene related products
-
Recommended
- Applied Biological Materials CRISPR for TAL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TAL1
- GenScript: Design CRISPR guide RNA sequences for TAL1
miRNA for TAL1 Gene
- miRTarBase miRNAs that target TAL1
-
- hsa-mir-9-5p (MIRT053370)
- hsa-mir-223-3p (MIRT054047)
- hsa-mir-4780 (MIRT498291)
- hsa-mir-4429 (MIRT498292)
- hsa-mir-320d (MIRT498293)
- hsa-mir-320c (MIRT498294)
- hsa-mir-320b (MIRT498295)
- hsa-mir-320a (MIRT498296)
- hsa-mir-1273e (MIRT516186)
- hsa-mir-6807-5p (MIRT516187)
- hsa-mir-561-5p (MIRT516188)
- hsa-mir-1233-3p (MIRT516189)
- hsa-mir-1225-3p (MIRT516190)
- hsa-mir-3922-5p (MIRT563546)
- hsa-mir-377-3p (MIRT665951)
- hsa-mir-342-3p (MIRT665952)
- hsa-mir-4719 (MIRT665953)
- hsa-mir-577 (MIRT665954)
- hsa-mir-8485 (MIRT665955)
- hsa-mir-3121-3p (MIRT665956)
- hsa-mir-6895-3p (MIRT684336)
- hsa-mir-6827-3p (MIRT698710)
- hsa-mir-340-3p (MIRT698711)
Transcription Factor Targets for TAL1 Gene
Targeted motifs for TAL1 Gene
HOMER Transcription Factor Regulatory Elements motif TAL1
- Consensus sequence: ANCAGCTG Submotif: canonical Cell Type: HPC7 GEO ID: GSE13511
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TAL1
- Browse OriGene Inhibitory RNA Products For TAL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAL1
- genomics-online: shRNA clones - Search results for 101 available TAL1 gene related products
- Overview of 101 available TAL1 gene related products
-
Recommended
Clone Products
- Sino Biological Human cDNA Clone for TAL1
- VectorBuilder custom plasmid, inducible vectors for TAL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TAL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TAL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TAL1
- genomics-online: cdna clones - Search results for 101 available TAL1 gene related products
- Overview of 101 available TAL1 gene related products
-
Recommended
- orf clones - Search results for 101 available TAL1 gene related products
- Overview of 101 available TAL1 gene related products
-
Recommended
- Applied Biological Materials Clones for TAL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TAL1
No data available for Enzyme Numbers (IUBMB) for TAL1 Gene
Localization for TAL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TAL1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
| cytosol | 1 |
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000118 | colocalizes_with histone deacetylase complex | IDA | 19497860 |
| GO:0000790 | nuclear chromatin | IDA | 20855495 |
| GO:0005634 | nucleus | IDA | 19497860 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IEA,IDA | 15920471 |
Pathways & Interactions for TAL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | NF-kappaB Signaling | ||
| 2 | MAPK-Erk Pathway |
.38
|
|
Pathways by source for TAL1 Gene
1 Sino Biological pathway for TAL1 Gene
1 Cell Signaling Technology pathway for TAL1 Gene
Interacting Proteins for TAL1 Gene
Selected Interacting proteins:
P17542-TAL1_HUMAN
ENSP00000294339
for TAL1 Gene via
IID
UniProtKB
MINT
STRING
GPS-Prot Interaction Network for TAL1
SIGNOR curated interactions for TAL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA,ISS | -- |
Transcripts for TAL1 Gene
mRNA/cDNA for TAL1 Gene
- (14) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (61) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000294339 5001 bps (uc001cqx.4)
- ENST00000371884 4642 bps (uc001cqy.3)
- ENST00000459729 1796 bps (uc057ghm.1)
- ENST00000464796 237 bps (uc001cqz.2)
- ENST00000465912 433 bps (uc057ghp.1)
Unigene Clusters for TAL1 Gene
- T-cell acute lymphocytic leukemia 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for TAL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TAL1
- genomics-online: gRNA clones - Search results for 101 available TAL1 gene related products
- Overview of 101 available TAL1 gene related products
-
Recommended
- Applied Biological Materials CRISPR for TAL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TAL1
- GenScript: Design CRISPR guide RNA sequences for TAL1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TAL1
- Browse OriGene Inhibitory RNA Products For TAL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAL1
- genomics-online: shRNA clones - Search results for 101 available TAL1 gene related products
- Overview of 101 available TAL1 gene related products
-
Recommended
Clone Products
- Sino Biological Human cDNA Clone for TAL1
- VectorBuilder custom plasmid, inducible vectors for TAL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TAL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TAL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TAL1
- genomics-online: cdna clones - Search results for 101 available TAL1 gene related products
- Overview of 101 available TAL1 gene related products
-
Recommended
- orf clones - Search results for 101 available TAL1 gene related products
- Overview of 101 available TAL1 gene related products
-
Recommended
- Applied Biological Materials Clones for TAL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||
| SP2: | - | ||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||
| SP4: |
Expression for TAL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Erythroblasts Hematopoietic Bone Marrow
- Primitive Hematopoietic Stem Cells Extraembryonic Blood Islands
- Hemangioblasts Posterior Primitive Streak
- Neural Tube (Nervous System)
-
Endothelium (Cardiovascular System)
- Hemangioblasts Posterior Primitive Streak
- Extraembryonic Angioblasts Extraembryonic Blood Islands
- Angioblasts Embryonic Blood Islands
- Inner Cell Mass (Early Embryonic Tissues)
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Angioblasts Embryonic Blood Islands
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Primitive Hematopoietic Stem Cells Extraembryonic Blood Islands
- Extraembryonic Angioblasts Extraembryonic Blood Islands
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Hematopoietic Stem Cells Liver Bud
- Brain (Nervous System)
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Primitive Streak (Early Embryonic Tissues)
- Hemangioblasts Posterior Primitive Streak
-
Heart (Cardiovascular System)
- Cardiac Crescent Cells Cardiac Crescent
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- NULL (Uncategorized)
-
Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for TAL1 Gene
This gene is overexpressed in Whole Blood (x4.6).
This gene is overexpressed in Liver (62.4) and Fetal Liver (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAL1 Gene
NURSA nuclear receptor signaling pathways regulating expression of TAL1 Gene:
TAL1SOURCE GeneReport for Unigene cluster for TAL1 Gene:
Hs.705618mRNA Expression by UniProt/SwissProt for TAL1 Gene:
P17542-TAL1_HUMAN
Tissue specificity:
Leukemic stem cell.
Evidence on tissue expression from TISSUES for TAL1 Gene
- Bone marrow(4.5)
- Blood(3.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TAL1 Gene
Germ Layers:
- mesoderm
Systems:
- cardiovascular
- immune
- lymphatic
Regions:
General:
- blood
- bone marrow
- white blood cell
Primer Products
-
OriGene qPCR primer pairs and template standards for TAL1
-
OriGene qPCR primer pairs for TAL1
- genomics-online: primer clones - Search results for 101 available TAL1 gene related products
- Overview of 101 available TAL1 gene related products
-
Recommended
Gene Expression Assay Products
Orthologs for TAL1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TAL1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | TAL1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TAL1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Tal1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tal1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TAL1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | TAL1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SCL 34 |
|
OneToOne | |
| TAL1 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | TAL1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tal1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398028 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tal1 34 33 33 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12172 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | HLH3B 34 |
|
OneToMany |
- Species where no ortholog for TAL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for TAL1 Gene
- ENSEMBL:
- Gene Tree for TAL1 (if available)
- TreeFam:
- Gene Tree for TAL1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TAL1: view image
Paralogs for TAL1 Gene
Variants for TAL1 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000051743 | -- | 47,229,029(-) | A/C | intron_variant | |
| rs1000285429 | -- | 47,216,411(-) | C/A/T | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1000346723 | -- | 47,222,290(-) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000718576 | -- | 47,217,591(-) | C/T | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1000947154 | -- | 47,223,946(-) | C/T | genic_downstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.46;
43.23% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TAL1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAL1 Gene
Disorders for TAL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| precursor t-cell acute lymphoblastic leukemia |
|
|
| acute lymphocytic leukemia |
|
|
| lymphoblastic lymphoma |
|
|
| t-cell leukemia |
|
|
| immunodeficiency 18 |
|
|
Search TAL1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TAL1_HUMAN- Note=A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes. {ECO:0000269 PubMed:2303035}.
Genatlas disease for TAL1 Gene
acute lymphoblastic leukemia (T cell) with interstitial deletion 5 to TAL1 (stem-cell leukemia) or with translocations t(1;14)(p32;q11),t(1;7)(p32;p35),t(1;3)(p34;p21),t(1;5)(p32;q31),see SCL,SIL,TCTA
Additional Disease Information for TAL1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Publications for TAL1 Gene
- Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at serine residues. (PMID: 8437851) Cheng JT … Baer R (Oncogene 1993) 3 4 22 58
- The SCL gene product: a positive regulator of erythroid differentiation. (PMID: 1396592) Aplan PD … Kirsch IR (The EMBO journal 1992) 3 4 22 58
- Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia. (PMID: 2230650) Chen Q … Baer R (The Journal of experimental medicine 1990) 3 4 22 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1. (PMID: 20028976) Lausen J … Leutz A (The Journal of biological chemistry 2010) 3 22 58
Products for TAL1 Gene
- R&D Systems Antibodies for TAL1 (SCL/Tal1)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for TAL1
- AP12390PU-N
- AP21141PU-N
- AP21393AF-N
- AP21393BT-N
- AP21393PU-N
- AP55831PU-N
- AP55831PU-S
- TA503922S
- TA313028
- TA313029
- TA353478
- TA353479
- TA353480
- TA353481
- TA503896
- CF503896
- TA503897
- CF503897
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- CF503898
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- CF503899
- TA503900
- CF503900
- TA503901
- CF503901
- TA503919
- CF503919
- TA503921
- CF503921
- TA503922
- CF503922
- TA590662
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TAL1
- Search Origene for MassSpec and Protein Over-expression Lysates for TAL1
- Origene Custom Protein Services for TAL1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TAL1
- Browse OriGene Inhibitory RNA Products For TAL1
- OriGene qPCR primer pairs and template standards for TAL1
- OriGene qPCR primer pairs for TAL1
- OriGene CRISPR knockouts for TAL1
- OriGene ORF clones in human for TAL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TAL1
- GenScript: Next-day shipping of latest version cDNA ORF clones for TAL1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for TAL1
- GenScript Custom Assay Services for TAL1
- GenScript Custom overexpressing Cell Line Services for TAL1
- GenScript: Design CRISPR guide RNA sequences for TAL1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TAL1
- Sino Biological Human cDNA Clone for TAL1
- Browse Sino Biological Recombinant Proteins
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- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TAL1
- Novus Biologicals lysates and proteins for TAL1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- VectorBuilder custom plasmid, inducible vectors for TAL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TAL1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TAL1
- antibodies-online: Search results for 207 available TAL1 Antibodies ranked by validation data
- Compare Top TAL1 Antibodies
- Recommended
- 36 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 116 WB Antibodies (anti-human)
- 29 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 DB Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 ChIP Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 17 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 36 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 116 WB Antibodies (anti-human)
- 29 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 DB Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 ChIP Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 17 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- antibodies-online: Search results for 4 available TAL1 Elisa Kits ranked by validation data
- Compare Top TAL1 Elisa Kits
- antibodies-online: Search results for 6 available TAL1 Proteins ranked by validation data
- Compare Top TAL1 Proteins
- GeneTex TAL1 Antibody for TAL1
- Search GeneTex for Proteins for TAL1
- Santa Cruz Biotechnology (SCBT) Antibodies for TAL1
- Search Santa Cruz Biotechnology (SCBT) for TAL1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TAL1
- Horizon Cell Lines for TAL1
- genomics-online: cdna clones - Search results for 101 available TAL1 gene related products
- Overview of 101 available TAL1 gene related products
- Recommended
- orf clones - Search results for 101 available TAL1 gene related products
- Overview of 101 available TAL1 gene related products
- Recommended
- genomics-online: gRNA clones - Search results for 101 available TAL1 gene related products
- Overview of 101 available TAL1 gene related products
- Recommended
- genomics-online: primer clones - Search results for 101 available TAL1 gene related products
- Overview of 101 available TAL1 gene related products
- Recommended
- genomics-online: shRNA clones - Search results for 101 available TAL1 gene related products
- Overview of 101 available TAL1 gene related products
- Recommended
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TAL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TAL1
- GeneCopoeia miRNA 3'UTR Target clone products for TAL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAL1
Sources for TAL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt