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TAL1 (TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor) is a Protein Coding gene. Diseases associated with TAL1 include Precursor T-Cell Acute Lymphoblastic Leukemia and Childhood T-Cell Acute Lymphoblastic Leukemia. Among its related pathways are MAPK Erk Pathway and NF-kappaB Signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is LYL1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IEA,ISS | -- |
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | 21873635 |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IEA,ISM | 19274049 |
GO:0001085 | RNA polymerase II transcription factor binding | IPI | 15920471 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000118 | colocalizes_with histone deacetylase complex | IDA | 19497860 |
GO:0000790 | nuclear chromatin | IDA,ISA | -- |
GO:0005634 | nucleus | IBA,IDA | 19497860 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005667 | transcription factor complex | IEA,IDA | 15920471 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | NF-kappaB Signaling | ||
2 | MAPK Erk Pathway |
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
GO:0001525 | angiogenesis | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA,ISS | -- |
GO:0006366 | transcription by RNA polymerase II | IEA | -- |
GO:0007275 | multicellular organism development | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||
SP2: | - | ||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||
SP4: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TAL1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TAL1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TAL1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tal1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tal1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | TAL1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TAL1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SCL 31 |
|
OneToOne | |
TAL1 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | TAL1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tal1 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | LOC398028 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tal1 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12172 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | HLH3B 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
precursor t-cell acute lymphoblastic leukemia |
|
|
childhood t-cell acute lymphoblastic leukemia |
|
|
lymphoblastic lymphoma |
|
|
acute leukemia |
|
|
leukemia |
|