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Aliases for TAGLN2 Gene

Aliases for TAGLN2 Gene

  • Transgelin 2 2 3 5
  • SM22-Alpha Homolog 2 3 4
  • Epididymis Tissue Protein Li 7e 3 4
  • Transgelin-2 3
  • KIAA0120 4
  • HA1756 3

External Ids for TAGLN2 Gene

Previous GeneCards Identifiers for TAGLN2 Gene

  • GC01M157680
  • GC01M155620
  • GC01M156665
  • GC01M157104
  • GC01M156700
  • GC01M158108
  • GC01M158154
  • GC01M159887
  • GC01M131244

Summaries for TAGLN2 Gene

Entrez Gene Summary for TAGLN2 Gene

  • The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is thought to be a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

GeneCards Summary for TAGLN2 Gene

TAGLN2 (Transgelin 2) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include actin filament binding. An important paralog of this gene is TAGLN3.

Gene Wiki entry for TAGLN2 Gene

Additional gene information for TAGLN2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAGLN2 Gene

Genomics for TAGLN2 Gene

GeneHancer (GH) Regulatory Elements for TAGLN2 Gene

Promoters and enhancers for TAGLN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I159908 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 559.8 +8.2 8249 18.5 CLOCK FEZF1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ZC3H11A TAGLN2 GC01M159886 GC01M159919 LOC100287049 NCSTN SLAMF8 RAD1P2 ENSG00000272668 SNHG28 VSIG8
GH01I159888 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.8 +35.2 35249 3 HDGF ATF1 SIN3A ZNF2 IRF4 GLIS2 ARID2 ZNF207 ZNF143 ATF7 ENSG00000272668 SLAMF8 SNHG28 FCRL6 VSIG8 ENSG00000212161 IGSF9 DUSP23 PIGM SLAMF9
GH01I159881 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 2 +43.6 43597 1.7 PKNOX1 SMAD1 ATF7 FOS DEK ZNF491 ZNF518A ZNF592 MAFF SMARCA4 RPSAP18 ENSG00000272668 SNHG28 LOC100287049 SLAMF8 PIGM DCAF8 CADM3 CADM3-AS1 COPA
GH01I160346 Enhancer 1.1 FANTOM5 Ensembl ENCODE 2.5 -421.2 -421169 1.8 HDGF ZNF687 MAX ZNF384 EBF1 ELF1 BATF ZBTB40 IKZF1 NBN NCSTN IGSF8 COPA TAGLN2 CD48 SLAMF7 GC01P160354 NHLH1
GH01I159848 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 1.3 +76.2 76205 1.9 CEBPB FOS ENSG00000272668 SLAMF9 SLAMF8 TAGLN2 ENSG00000212161 GC01M159852 GC01M159841 SNHG28
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TAGLN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TAGLN2 gene promoter:

Genomic Locations for TAGLN2 Gene

Genomic Locations for TAGLN2 Gene
chr1:159,918,107-159,925,732
(GRCh38/hg38)
Size:
7,626 bases
Orientation:
Minus strand
chr1:159,887,897-159,895,522
(GRCh37/hg19)

Genomic View for TAGLN2 Gene

Genes around TAGLN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAGLN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAGLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAGLN2 Gene

Proteins for TAGLN2 Gene

  • Protein details for TAGLN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P37802-TAGL2_HUMAN
    Recommended name:
    Transgelin-2
    Protein Accession:
    P37802
    Secondary Accessions:
    • E9KL39
    • Q5JRQ6
    • Q5JRQ7
    • Q6FGI1
    • Q9BUH5
    • Q9H4P0

    Protein attributes for TAGLN2 Gene

    Size:
    199 amino acids
    Molecular mass:
    22391 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA04802.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI14604.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAGLN2 Gene

    Alternative splice isoforms for TAGLN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAGLN2 Gene

Post-translational modifications for TAGLN2 Gene

  • Ubiquitination at posLast=7979 and posLast=120120

Other Protein References for TAGLN2 Gene

No data available for DME Specific Peptides for TAGLN2 Gene

Domains & Families for TAGLN2 Gene

Gene Families for TAGLN2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for TAGLN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P37802

UniProtKB/Swiss-Prot:

TAGL2_HUMAN :
  • Belongs to the calponin family.
Family:
  • Belongs to the calponin family.
genes like me logo Genes that share domains with TAGLN2: view

Function for TAGLN2 Gene

Molecular function for TAGLN2 Gene

GENATLAS Biochemistry:
transgelin 2,one of the earliest markers of differentiated smooth muscle cells and adult tissues,murine 2,Sm22 alpha homolog

Phenotypes From GWAS Catalog for TAGLN2 Gene

Gene Ontology (GO) - Molecular Function for TAGLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21577206
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with TAGLN2: view
genes like me logo Genes that share phenotypes with TAGLN2: view

Animal Model Products

CRISPR Products

miRNA for TAGLN2 Gene

miRTarBase miRNAs that target TAGLN2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAGLN2 Gene

Localization for TAGLN2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAGLN2 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAGLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
GO:0031982 vesicle HDA,IDA 19190083
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with TAGLN2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAGLN2 Gene

Pathways & Interactions for TAGLN2 Gene

genes like me logo Genes that share pathways with TAGLN2: view

Gene Ontology (GO) - Biological Process for TAGLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0030855 epithelial cell differentiation IDA 21492153
genes like me logo Genes that share ontologies with TAGLN2: view

No data available for SIGNOR curated interactions for TAGLN2 Gene

Drugs & Compounds for TAGLN2 Gene

No Compound Related Data Available

Transcripts for TAGLN2 Gene

Unigene Clusters for TAGLN2 Gene

Transgelin 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAGLN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2:
SP3:

Relevant External Links for TAGLN2 Gene

GeneLoc Exon Structure for
TAGLN2
ECgene alternative splicing isoforms for
TAGLN2

Expression for TAGLN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAGLN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAGLN2 Gene

This gene is overexpressed in Whole Blood (x10.5).

Protein differential expression in normal tissues from HIPED for TAGLN2 Gene

This gene is overexpressed in Platelet (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAGLN2 Gene



Protein tissue co-expression partners for TAGLN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAGLN2 Gene:

TAGLN2

SOURCE GeneReport for Unigene cluster for TAGLN2 Gene:

Hs.517168

mRNA Expression by UniProt/SwissProt for TAGLN2 Gene:

P37802-TAGL2_HUMAN
Tissue specificity: Expressed in epididymis (at protein level).

Evidence on tissue expression from TISSUES for TAGLN2 Gene

  • Blood(4.6)
  • Bone marrow(4.4)
  • Skin(4.4)
  • Liver(4.3)
  • Lung(4.2)
  • Nervous system(4.1)
  • Pancreas(3.8)
  • Intestine(3.2)
  • Eye(2.9)
  • Kidney(2.7)
  • Lymph node(2.6)
  • Stomach(2.3)
  • Muscle(2.2)
  • Spleen(2.2)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with TAGLN2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TAGLN2 Gene

Orthologs for TAGLN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAGLN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAGLN2 33 34
  • 99.39 (n)
oppossum
(Monodelphis domestica)
Mammalia TAGLN2 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAGLN2 33 34
  • 93.63 (n)
dog
(Canis familiaris)
Mammalia TAGLN2 33 34
  • 92.63 (n)
rat
(Rattus norvegicus)
Mammalia Tagln2 33
  • 91.29 (n)
mouse
(Mus musculus)
Mammalia Tagln2 33 16 34
  • 90.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TAGLN2 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857291 33
  • 76.38 (n)
TAGLN2 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tagln2 33
  • 69.56 (n)
MGC75598 33
African clawed frog
(Xenopus laevis)
Amphibia tagln2-prov 33
zebrafish
(Danio rerio)
Actinopterygii cnn3a 34
  • 25 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11293 33
fruit fly
(Drosophila melanogaster)
Insecta Chd64 35
  • 42 (a)
Mp20 34
  • 37 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cpn-2 34
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCP1 34 36 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
ManyToMany
CSA.10356 34
  • 41 (a)
ManyToMany
Species where no ortholog for TAGLN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAGLN2 Gene

ENSEMBL:
Gene Tree for TAGLN2 (if available)
TreeFam:
Gene Tree for TAGLN2 (if available)

Paralogs for TAGLN2 Gene

Paralogs for TAGLN2 Gene

(5) SIMAP similar genes for TAGLN2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TAGLN2 Gene

genes like me logo Genes that share paralogs with TAGLN2: view

Variants for TAGLN2 Gene

Sequence variations from dbSNP and Humsavar for TAGLN2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000474536 -- 159,921,560(-) A/C intron_variant
rs1000695898 -- 159,917,796(-) T/C downstream_transcript_variant
rs1000891252 -- 159,924,597(-) CCCCCC/CCCCCCC genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001755834 -- 159,920,958(-) C/T intron_variant
rs1001856821 -- 159,926,129(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TAGLN2 Gene

Variant ID Type Subtype PubMed ID
nsv946451 CNV duplication 23825009
nsv548053 CNV loss 21841781
nsv548052 CNV gain 21841781
nsv524006 CNV gain 19592680
nsv516637 CNV loss 19592680
nsv464150 CNV gain 19166990
nsv1005195 CNV gain 25217958

Variation tolerance for TAGLN2 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAGLN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAGLN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAGLN2 Gene

Disorders for TAGLN2 Gene

Additional Disease Information for TAGLN2

No disorders were found for TAGLN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAGLN2 Gene

Publications for TAGLN2 Gene

  1. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PMID: 20736409) Li J … Liu Y (Molecular & cellular proteomics : MCP 2010) 3 4 58
  2. Tissue proteomics reveals differential and compartment-specific expression of the homologs transgelin and transgelin-2 in lung adenocarcinoma and its stroma. (PMID: 19848416) Rho JH … Wang JY (Journal of proteome research 2009) 3 22 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4 58

Products for TAGLN2 Gene

Sources for TAGLN2 Gene

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