Aliases for TAGLN Gene
External Ids for TAGLN Gene
Previous GeneCards Identifiers for TAGLN Gene
This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization. [provided by RefSeq, Aug 2017]
GeneCards Summary for TAGLN Gene
TAGLN (Transgelin) is a Protein Coding gene. Diseases associated with TAGLN include Werner Syndrome and Peyronie Disease. Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is TAGLN3.
UniProtKB/Swiss-Prot Summary for TAGLN Gene
Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.