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This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization. [provided by RefSeq, Aug 2017]
TAGLN (Transgelin) is a Protein Coding gene. Diseases associated with TAGLN include Werner Syndrome and Laryngeal Small Cell Carcinoma. Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is TAGLN3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003779 | actin binding | IEA | -- |
GO:0005515 | protein binding | IEA,IPI | 21044950 |
GO:0051015 | actin filament binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007517 | muscle organ development | TAS | 9615232 |
GO:0030855 | epithelial cell differentiation | IDA | 21492153 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | · | 11e | · | 11f |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP10: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TAGLN 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TAGLN 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TAGLN 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TAGLN 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tagln 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Tagln 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TAGLN 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TAGLN 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tagln 30 |
|
||
Str.5784 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | MGC68550 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tagln 30 31 |
|
OneToMany | |
tagln2 31 |
|
OneToMany | |||
Dr.20602 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5023 31 |
|
ManyToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | cpn-2 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SCP1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
CSA.10356 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
779318 | Benign: not provided | 117,203,888(+) | T/C | INTRON_VARIANT | |
779375 | Benign: not provided | 117,204,298(+) | A/G | MISSENSE_VARIANT | |
787098 | Benign: not provided | 117,204,332(+) | C/T | SYNONYMOUS_VARIANT | |
790849 | Benign: not provided | 117,206,025(+) | G/A | MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT | |
791178 | Benign: not provided | 117,203,355(+) | G/C | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2186n54 | CNV | loss | 21841781 |
dgv730n106 | OTHER | inversion | 24896259 |
nsv1078301 | OTHER | inversion | 25765185 |
nsv524270 | CNV | loss | 19592680 |
nsv7223 | OTHER | inversion | 18451855 |
Disorder | Aliases | PubMed IDs |
---|---|---|
werner syndrome |
|
|
laryngeal small cell carcinoma |
|
|
barrett's adenocarcinoma |
|
|
paranasal sinus lymphoma |
|
|
lung oat cell carcinoma |
|
|