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This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and t... See more...
Aliases for TAGLN Gene
Aliases for TAGLN Gene
External Ids for TAGLN Gene
- HGNC: 11553
- Entrez Gene: 6876
- Ensembl: ENSG00000149591
- OMIM: 600818
- UniProtKB: Q01995
Previous GeneCards Identifiers for TAGLN Gene
- GC11P119422
- GC11P118581
- GC11P117103
- GC11P116607
- GC11P116575
- GC11P117070
- GC11P113002
Summaries for TAGLN Gene
-
This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization. [provided by RefSeq, Aug 2017]
GeneCards Summary for TAGLN Gene
TAGLN (Transgelin) is a Protein Coding gene. Diseases associated with TAGLN include Werner Syndrome and Laryngeal Small Cell Carcinoma. Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is TAGLN3.
UniProtKB/Swiss-Prot Summary for TAGLN Gene
-
Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
Additional gene information for TAGLN Gene
- HGNC(11553)
- Entrez Gene(6876)
- Ensembl(ENSG00000149591)
- OMIM(600818)
- UniProtKB(Q01995)
- Open Targets Platform(ENSG00000149591)
- Monarch Initiative
- Search for TAGLN at DataMed
- Search for TAGLN at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAGLN Gene
Genomics for TAGLN Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TAGLN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TAGLN on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAGLN
- Top Transcription factor binding sites by QIAGEN in the TAGLN gene promoter:
-
- Nkx2-5
- Sp1
Genomic Locations for TAGLN Gene
Genomic Locations for TAGLN Gene
- chr11:117,199,294-117,207,465
- (GRCh38/hg38)
- Size:
- 8,172 bases
- Orientation:
- Plus strand
- chr11:117,070,037-117,075,508
- (GRCh37/hg19)
- Size:
- 5,472 bases
- Orientation:
- Plus strand
Genomic View for TAGLN Gene
Genes around TAGLN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q23.3 by HGNC
- 11q23.3 by Entrez Gene
- 11q23.3 by Ensembl
TAGLN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TAGLN Gene
Proteins for TAGLN Gene
-
Protein details for TAGLN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q01995-TAGL_HUMAN
- Recommended name:
- Transgelin
- Protein Accession:
- Q01995
- O15542
Protein attributes for TAGLN Gene
- Size:
- 201 amino acids
- Molecular mass:
- 22611 Da
- Quaternary structure:
- No Data Available
Protein Expression for TAGLN Gene
Post-translational modifications for TAGLN Gene
Other Protein References for TAGLN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences TAGLN / Transgelin / SM22 Antibody (LS-B2563) and TAGLN / Transgelin / SM22 Antibody (LS-B6880)
- G Biosciences Immunotag™ SM22 aphla Antibody
- NSJ Bioreagents Transgelin Antibody (Mouse Monoclonal)
-
Custom Antibody ServicesOriGene Antibodies for TAGLN
- Novus Biologicals Antibodies for TAGLN
-
Abcam antibodies for TAGLN
- Invitrogen Antibodies for TAGLN (AFLGC-TAGLN)
-
Boster Bio Antibodies for TAGLN
-
Santa Cruz Biotechnology (SCBT) Antibodies for TAGLN
- Sino Biological Antibodies for TAGLN
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for TAGLN
- Origene Custom Protein Services for TAGLN
- ProSpec Recombinant Proteins for TAGLN
-
Abcam proteins for TAGLN
Assay Products
- G Biosciences Immunotag™ Human TAGLN (Transgelin) ELISA
- antibodies-online: Show 28 available Transgelin Elisa Kits ranked by validation data
- Compare Top Transgelin Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for TAGLN
No data available for DME Specific Peptides for TAGLN Gene
Domains & Families for TAGLN Gene
Gene Families for TAGLN Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for TAGLN Gene
- InterPro:
- Blocks:
-
- Calponin-like actin-binding
- Calponin-like actin-binding subtype
- Smooth muscle protein 22-alpha (transgelin) signature
- ProtoNet:
Suggested Antigen Peptide Sequences for TAGLN Gene
- GenScript: Design optimal peptide antigens:
-
- Transgelin variant 1 (B0YJ58_HUMAN)
- cDNA, FLJ94704, highly similar to Homo sapiens transgelin (TAGLN), mRNA (Q5U0D2_HUMAN)
- TAGLN protein (Q6FI52_HUMAN)
- Smooth muscle protein 22-alpha (TAGL_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q01995- Family:
-
- Belongs to the calponin family.
Function for TAGLN Gene
Molecular function for TAGLN Gene
- UniProtKB/Swiss-Prot Function:
- Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
- UniProtKB/Swiss-Prot Induction:
- Overexpressed in senescent human fibroblasts.
- GENATLAS Biochemistry:
- transgelin,22kDa,cytoplasmic,one of the earliest markers of differentiated smooth muscle cells and adult tissues,murine Sm22 alpha homolog,highly expressed in senescent fibroblasts and in fibroblasts from patients with Werner syndrome
Phenotypes From GWAS Catalog for TAGLN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IEA | -- |
| GO:0005515 | protein binding | IEA,IPI | 21044950 |
| GO:0051015 | actin filament binding | IEA | -- |
Phenotypes for TAGLN Gene
- MGI mutant phenotypes for TAGLN:
-
inferred from 6 alleles
- nervous system phenotype
- immune system phenotype
- normal phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- renal/urinary system phenotype
- neoplasm
- digestive/alimentary phenotype
- reproductive system phenotype
- skeleton phenotype
- GenomeRNAi human phenotypes for TAGLN:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability
- Reduced mammosphere formation
- Inconclusive
- Decreased ionizing radiation sensitivity
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Decreased viability with carboplatin
- Decreased viability (cell death)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TAGLN - Select products 50% OFF >
- * TAGLN CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TAGLN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TAGLN
-
Santa Cruz Biotechnology (SCBT) CRISPR for TAGLN
miRNA for TAGLN Gene
- miRTarBase miRNAs that target TAGLN
-
- rno-let-7e-5p (MIRT002146)
- rno-let-7b-5p (MIRT002147)
- rno-miR-485-5p (MIRT002149)
- rno-miR-382-5p (MIRT002150)
- rno-miR-338-3p (MIRT002151)
- rno-miR-320-3p (MIRT002152)
- rno-miR-290 (MIRT002153)
- rno-miR-204-5p (MIRT002154)
- rno-miR-139-5p (MIRT002155)
- rno-miR-98-5p (MIRT002156)
- rno-miR-34a-5p (MIRT002157)
- rno-let-7a-5p (MIRT003935)
- hsa-miR-9-5p (MIRT021406)
- hsa-miR-128-3p (MIRT022018)
- hsa-miR-7-5p (MIRT025891)
- hsa-miR-26b-5p (MIRT030313)
- hsa-miR-6845-5p (MIRT496586)
- hsa-miR-6762-5p (MIRT496587)
- hsa-miR-486-3p (MIRT496588)
- hsa-miR-6883-5p (MIRT496589)
- hsa-miR-6785-5p (MIRT496590)
- hsa-miR-4728-5p (MIRT496591)
- hsa-miR-149-3p (MIRT496592)
- hsa-miR-6797-5p (MIRT496593)
- hsa-miR-1249-5p (MIRT496594)
- hsa-miR-423-5p (MIRT496595)
- hsa-miR-3184-5p (MIRT496596)
- hsa-miR-6133 (MIRT496597)
- hsa-miR-6130 (MIRT496598)
- hsa-miR-6129 (MIRT496599)
- hsa-miR-6127 (MIRT496600)
- hsa-miR-4510 (MIRT496601)
- hsa-miR-4419a (MIRT496602)
- hsa-miR-4756-5p (MIRT496603)
- hsa-miR-4739 (MIRT496604)
- hsa-miR-1321 (MIRT496605)
- hsa-miR-449c-5p (MIRT496606)
- hsa-miR-34b-5p (MIRT496607)
- hsa-miR-2682-5p (MIRT496608)
- hsa-miR-3714 (MIRT496609)
- rno-miR-133a-5p (MIRT733939)
- hsa-miR-129-5p (MIRT783607)
- hsa-miR-8055 (MIRT789737)
- hsa-miR-8081 (MIRT789819)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TAGLN
- Browse OriGene Inhibitory RNA Products For TAGLN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAGLN
Clone Products
- Applied Biological Materials (abm): Clones for TAGLN - Select products 50% OFF >
- * TAGLN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG202069
- MR202069
- MR202069L3
- MR202069L4
- RC202448
- RC202448L1
- RC202448L2
- RC202448L3
- RC202448L4
- RC215789
- RC215789L1
- RC215789L2
- RC215789L3
- RC215789L4
- RG202448
- RG215789
- RR213687
- RR213687L3
- RR213687L4
- MR202069L3V
- MR202069L4V
- RC202448L1V
- RC202448L2V
- RC202448L3V
- RC202448L4V
- RC215789L1V
- RC215789L2V
- RC215789L3V
- RC215789L4V
- RR213687L3V
- RR213687L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TAGLN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TAGLN
Cell Line Products
- ESI BIO PureStem Z11, Meso Progenitor and PureStem ES-210, Ecto-ntu Progenitor for TAGLN
-
Horizon Cell Lines for TAGLN
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAGLN Gene
Localization for TAGLN Gene
Subcellular locations from UniProtKB/Swiss-Prot for TAGLN Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| extracellular | 3 |
| cytoskeleton | 3 |
| nucleus | 3 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Microtubules (2)
- Mitochondria (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for TAGLN Gene
Interacting Proteins for TAGLN Gene
Selected Interacting proteins:
Q01995-TAGL_HUMAN
ENSP00000432282
for TAGLN Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TAGLN
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007517 | muscle organ development | TAS | 9615232 |
| GO:0030855 | epithelial cell differentiation | IDA | 21492153 |
No data available for Pathways by source for TAGLN Gene
Transcripts for TAGLN Gene
mRNA/cDNA for TAGLN Gene
- 2 REFSEQ mRNAs :
- 23 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000278968 1477 nts (view in UCSC)
- ENST00000392951 3786 nts (view in UCSC)
- ENST00000525531 1048 nts (view in UCSC)
- ENST00000529622 501 nts (view in UCSC)
- ENST00000529792 375 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TAGLN - Select products 50% OFF >
- * TAGLN CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TAGLN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TAGLN
-
Santa Cruz Biotechnology (SCBT) CRISPR for TAGLN
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TAGLN
- Browse OriGene Inhibitory RNA Products For TAGLN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAGLN
Clone Products
- Applied Biological Materials (abm): Clones for TAGLN - Select products 50% OFF >
- * TAGLN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG202069
- MR202069
- MR202069L3
- MR202069L4
- RC202448
- RC202448L1
- RC202448L2
- RC202448L3
- RC202448L4
- RC215789
- RC215789L1
- RC215789L2
- RC215789L3
- RC215789L4
- RG202448
- RG215789
- RR213687
- RR213687L3
- RR213687L4
- MR202069L3V
- MR202069L4V
- RC202448L1V
- RC202448L2V
- RC202448L3V
- RC202448L4V
- RC215789L1V
- RC215789L2V
- RC215789L3V
- RC215789L4V
- RR213687L3V
- RR213687L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TAGLN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TAGLN
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | · | 11e | · | 11f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP10: |
Relevant External Links for TAGLN Gene
- GeneLoc Exon Structure for
- TAGLN
Expression for TAGLN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Smooth Muscle (Muscoskeletal System)
- Smooth Muscle Cells Prechordal Mesenchyme
- Vascular Smooth Muscle Cells Splanchnic Mesoderm
- Mural Cells Splanchnic Mesoderm
- Vascular Smooth Muscle Cells Veins
- Vascular Smooth Muscle Cells Dorsal Aorta
-
Heart (Cardiovascular System)
- Vascular Smooth Muscle Cells Dorsal Aorta
- Vascular Smooth Muscle Cells Coronary Capillary Plexus
- Vascular Smooth Muscle Cells Aortic Arch Arteries
- Heart Tube
- Atrioventricular Node
- Umbilical Cord (Extraembryonic Tissues)
-
Epiblast (Early Embryo)
- Extraembryonic Mural Cells Extraembryonic Mesoderm
- Epiblast Stem Cell line 5
- Epiblast-like cells (Hayashi K et. al. 2011)
- Gut Tube (Gastrointestinal Tract)
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Vascular Smooth Muscle Cells Splanchnic Mesoderm
- Mural Cells Splanchnic Mesoderm
- Inner Cell Mass (Early Embryonic Tissues)
- Blood (Hematopoietic System)
- Mesenchymal Stem Cells
-
Hair (Integumentary System)
- Outer Root Sheath Cells Outer Root Sheath
-
Epithelial Cells
- Outer Root Sheath Cells Outer Root Sheath
-
Head Mesenchyme (Muscoskeletal System)
- Smooth Muscle Cells Prechordal Mesenchyme
- Endothelium (Cardiovascular System)
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Mural Cells Extraembryonic Mesoderm
-
Primitive Streak (Early Embryo)
- Extraembryonic Mural Cells Extraembryonic Mesoderm
-
Somite (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
-
Dermis (Integumentary System)
- Dermal Fibroblasts Dorsal Dermis
-
Fibroblasts
- Dermal Fibroblasts Dorsal Dermis
- Intermediate Mesoderm (Gastrulation Derivatives)
- Kidney (Urinary System)
- Intestine (Gastrointestinal Tract)
- Limb (Muscoskeletal System)
- Brain (Nervous System)
- NULL (Uncategorized)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for TAGLN Gene
This gene is overexpressed in Artery - Tibial (x6.0), Artery - Coronary (x5.5), Artery - Aorta (x5.1), Esophagus - Muscularis (x4.4), and Colon - Sigmoid (x4.4).
This gene is overexpressed in Seminal vesicle (10.8), Cardia (10.3), Colon muscle (7.6), and Prostate (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAGLN Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAGLN
SOURCE GeneReport for Unigene cluster for TAGLN Gene:
Hs.410977Evidence on tissue expression from TISSUES for TAGLN Gene
- Nervous system(4.6)
- Liver(4.6)
- Heart(4.6)
- Lung(4.6)
- Blood(4.5)
- Intestine(4.5)
- Eye(4.3)
- Skin(4.3)
- Muscle(4.2)
- Pancreas(4.2)
- Bone(4.1)
- Stomach(3.9)
- Kidney(3.7)
- Lymph node(3.2)
- Gall bladder(3.2)
- Spleen(3.1)
- Adrenal gland(3)
- Thyroid gland(2.8)
- Bone marrow(2.4)
Primer Products
-
OriGene qPCR primer pairs for TAGLN
-
OriGene qPCR primer pairs and template standards for TAGLN
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAGLN Gene
Orthologs for TAGLN Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TAGLN 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TAGLN 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TAGLN 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TAGLN 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tagln 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Tagln 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TAGLN 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TAGLN 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tagln 30 |
|
||
| Str.5784 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68550 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | tagln 30 31 |
|
OneToMany | |
| tagln2 31 |
|
OneToMany | |||
| Dr.20602 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG5023 31 |
|
ManyToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | cpn-2 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SCP1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| CSA.10356 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany |
- Species where no ortholog for TAGLN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for TAGLN Gene
- ENSEMBL:
- Gene Tree for TAGLN (if available)
- TreeFam:
- Gene Tree for TAGLN (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TAGLN: view image
Paralogs for TAGLN Gene
Variants for TAGLN Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAGLN Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 779318 | Benign: not provided | 117,203,888(+) | T/C | INTRON_VARIANT | |
| 779375 | Benign: not provided | 117,204,298(+) | A/G | MISSENSE_VARIANT | |
| 787098 | Benign: not provided | 117,204,332(+) | C/T | SYNONYMOUS_VARIANT | |
| 790849 | Benign: not provided | 117,206,025(+) | G/A | MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT | |
| 791178 | Benign: not provided | 117,203,355(+) | G/C | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2186n54 | CNV | loss | 21841781 |
| dgv730n106 | OTHER | inversion | 24896259 |
| nsv1078301 | OTHER | inversion | 25765185 |
| nsv524270 | CNV | loss | 19592680 |
| nsv7223 | OTHER | inversion | 18451855 |
Residual Variation Intolerance Score:
57.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.09;
38.13% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TAGLN Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TAGLN
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAGLN Gene
Disorders for TAGLN Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| werner syndrome |
|
|
| laryngeal small cell carcinoma |
|
|
| barrett's adenocarcinoma |
|
|
| paranasal sinus lymphoma |
|
|
| lung oat cell carcinoma |
|
|
Search TAGLN in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TAGLN
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TAGLN Gene
Publications for TAGLN Gene
- A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts. (PMID: 1520290) Thweatt R … Goldstein S (Biochemical and biophysical research communications 1992) 2 3 4 23
- Screening the single nucleotide polymorphisms in patients with internal carotid artery stenosis by oligonucleotide-based custom DNA array. (PMID: 20066125) Nakai K … Ogawa A (Bioinformatics and biology insights 2009) 3 23 41
- Expression and cytogenetic localization of the human SM22 gene (TAGLN). (PMID: 9615232) Camoretti-Mercado B … Solway J (Genomics 1998) 3 4 23
- Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. (PMID: 21943158) Middelberg RP … Whitfield JB (BMC medical genetics 2011) 3 41
- Expression of the actin-associated protein transgelin (SM22) is decreased in prostate cancer. (PMID: 20012321) Prasad PD … Assinder SJ (Cell and tissue research 2010) 3 23
ExternalLinks
Products for TAGLN Gene
- Custom Antibody ServicesOriGene Antibodies for TAGLN
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Browse OriGene Inhibitory RNA Products For TAGLN
- OriGene qPCR primer pairs for TAGLN
- OriGene qPCR primer pairs and template standards for TAGLN
- OriGene CRISPR knockouts for TAGLN
- MG202069
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- RC215789L4V
- RR213687L3V
- RR213687L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TAGLN
- Sino Biological Human cDNA Clone for TAGLN
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- Novus Biologicals proteins and lysates for TAGLN
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- Abcam proteins for TAGLN
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- ProSpec Recombinant Proteins for TAGLN
- ESI BIO PureStem Z11, Meso Progenitor and PureStem ES-210, Ecto-ntu Progenitor for TAGLN
- Invitrogen Antibodies for TAGLN (AFLGC-TAGLN)
- VectorBuilder Custom and pre-made DNA vectors for TAGLN (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TAGLN (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Virus packaging for TAGLN CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TAGLN
- antibodies-online: Show 55 available Transgelin Antibodies ranked by validation data
- Compare Top Transgelin Antibodies
- antibodies-online: Show 28 available Transgelin Elisa Kits ranked by validation data
- Compare Top Transgelin Elisa Kits
- Quality Products:
- antibodies-online: Show 16 available Transgelin Proteins ranked by validation data
- Compare Top Transgelin Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for TAGLN
- Search Santa Cruz Biotechnology (SCBT) for TAGLN siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TAGLN
- Horizon Cell Lines for TAGLN
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TAGLN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TAGLN
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TAGLN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAGLN
- Boster Bio Antibodies for TAGLN
- Browse Boster Bio ELISA Kits
Sources for TAGLN Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
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- (15) ProtoNet
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
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- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
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- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
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- (128) SNPedia
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- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
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- (143) Applied Biosystems
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- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB