This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided ... See more...

Aliases for TAGAP Gene

Aliases for TAGAP Gene

  • T Cell Activation RhoGTPase Activating Protein 2 3 5
  • T-Cell Activation Rho GTPase-Activating Protein 3 4
  • TAGAP1 3 4
  • T-Cell Activation RhoGTPase Activating Protein 2
  • T-Cell Activation GTPase-Activating Protein 4
  • T-Cell Activation GTPase Activating Protein 2
  • ARHGAP47 3
  • FKSG15 3
  • IDDM21 3

External Ids for TAGAP Gene

Previous GeneCards Identifiers for TAGAP Gene

  • GC06M158897
  • GC06M159329
  • GC06M159365
  • GC06M159426
  • GC06M159375
  • GC06M159457
  • GC06M156926

Summaries for TAGAP Gene

Entrez Gene Summary for TAGAP Gene

  • This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for TAGAP Gene

TAGAP (T Cell Activation RhoGTPase Activating Protein) is a Protein Coding gene. Diseases associated with TAGAP include Diabetes Mellitus, Insulin-Dependent, 21 and Auditory Agnosia. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGAP20.

UniProtKB/Swiss-Prot Summary for TAGAP Gene

  • May function as a GTPase-activating protein and may play important roles during T-cell activation.

Additional gene information for TAGAP Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAGAP Gene

Genomics for TAGAP Gene

GeneHancer (GH) Regulatory Elements for TAGAP Gene

Promoters and enhancers for TAGAP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J159035 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 518.4 +4.2 4154 10.1 ZBTB40 CTCF SIN3A SP1 EP300 GABPA TRIM28 JUND REST RFX1 TAGAP RSPH3 LOC105378083 SYTL3 DYNLT1 lnc-FNDC1-10-002 ENSG00000226032
GH06J159046 Enhancer 0.2 Ensembl 500.7 -1.7 -1749 0.2 TAGAP lnc-FNDC1-8 ENSG00000226032 LOC105378083
GH06J159098 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 41.3 -53.9 -53903 1.8 ZBTB40 PRPF4 ATF2 CREB1 ZNF384 SRF ARNT MEF2B NBN ELF1 TAGAP RSPH3 SYTL3 DYNLT1 ENSG00000226032 ENSG00000224478 LOC112267968
GH06J159060 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 26.4 -17.9 -17864 4.8 SPI1 SCRT1 MITF POLR2A NFIC MAX CREM ZNF548 PKNOX1 RUNX3 lnc-FNDC1-8 TAGAP DYNLT1 SYTL3 piR-52916-031 ENSG00000226032 LOC112267968 LOC105378083
GH06J159103 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.4 -62.0 -61951 6.5 ZBTB40 CTCF NRF1 SP1 ZIC2 FOS TARDBP REST RAD21 CTBP1 TAGAP RSPH3 EZR LOC112267968 ENSG00000224478 ENSG00000226032
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAGAP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAGAP

Top Transcription factor binding sites by QIAGEN in the TAGAP gene promoter:
  • AML1a
  • E2F
  • E2F-1
  • GATA-1
  • NF-E2
  • S8
  • Sox5

Genomic Locations for TAGAP Gene

Genomic Locations for TAGAP Gene
chr6:159,034,468-159,045,152
(GRCh38/hg38)
Size:
10,685 bases
Orientation:
Minus strand
chr6:159,455,500-159,466,184
(GRCh37/hg19)
Size:
10,685 bases
Orientation:
Minus strand

Genomic View for TAGAP Gene

Genes around TAGAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAGAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAGAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAGAP Gene

Proteins for TAGAP Gene

  • Protein details for TAGAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N103-TAGAP_HUMAN
    Recommended name:
    T-cell activation Rho GTPase-activating protein
    Protein Accession:
    Q8N103
    Secondary Accessions:
    • Q2NKM8
    • Q8NI40
    • Q96KZ2
    • Q96QA2

    Protein attributes for TAGAP Gene

    Size:
    731 amino acids
    Molecular mass:
    80703 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 3]: Dubious isoform. The N-terminus appears to be derived from exons of the FGFR1OP locus which is located on the opposing strand of chromosome 6 at a distance of several Mb.

    Alternative splice isoforms for TAGAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAGAP Gene

Post-translational modifications for TAGAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAGAP Gene

No data available for DME Specific Peptides for TAGAP Gene

Domains & Families for TAGAP Gene

Gene Families for TAGAP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TAGAP Gene

Blocks:
  • RhoGAP domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAGAP Gene

GenScript: Design optimal peptide antigens:
  • T-cell activation GTPase-activating protein (TAGAP_HUMAN)
genes like me logo Genes that share domains with TAGAP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TAGAP Gene

Function for TAGAP Gene

Molecular function for TAGAP Gene

UniProtKB/Swiss-Prot Function:
May function as a GTPase-activating protein and may play important roles during T-cell activation.

Phenotypes From GWAS Catalog for TAGAP Gene

Gene Ontology (GO) - Molecular Function for TAGAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005096 GTPase activator activity IBA 21873635
genes like me logo Genes that share ontologies with TAGAP: view
genes like me logo Genes that share phenotypes with TAGAP: view

Animal Models for TAGAP Gene

MGI Knock Outs for TAGAP:

Animal Model Products

CRISPR Products

miRNA for TAGAP Gene

miRTarBase miRNAs that target TAGAP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAGAP Gene

Localization for TAGAP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAGAP gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TAGAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TAGAP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAGAP Gene

Pathways & Interactions for TAGAP Gene

genes like me logo Genes that share pathways with TAGAP: view

Pathways by source for TAGAP Gene

Interacting Proteins for TAGAP Gene

;

Gene Ontology (GO) - Biological Process for TAGAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with TAGAP: view

No data available for SIGNOR curated interactions for TAGAP Gene

Drugs & Compounds for TAGAP Gene

No Compound Related Data Available

Transcripts for TAGAP Gene

mRNA/cDNA for TAGAP Gene

4 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAGAP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: -
SP8:
SP9:

Relevant External Links for TAGAP Gene

GeneLoc Exon Structure for
TAGAP

Expression for TAGAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAGAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAGAP Gene

This gene is overexpressed in Whole Blood (x27.2) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for TAGAP Gene

This gene is overexpressed in Heart (30.8), Peripheral blood mononuclear cells (21.3), Blymphocyte (6.6), and Platelet (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TAGAP Gene



Protein tissue co-expression partners for TAGAP Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAGAP

SOURCE GeneReport for Unigene cluster for TAGAP Gene:

Hs.529984

Evidence on tissue expression from TISSUES for TAGAP Gene

  • Lung(4.2)
  • Spleen(4.2)
  • Liver(4.1)
  • Blood(3.8)
genes like me logo Genes that share expression patterns with TAGAP: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAGAP Gene

Orthologs for TAGAP Gene

This gene was present in the common ancestor of animals.

Orthologs for TAGAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAGAP 31 30
  • 99.45 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TAGAP 31 30
  • 79.35 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tagap 17 31 30
  • 75.94 (n)
Tagap1 31
  • 53 (a)
OneToMany
1700006A11Rik 31
  • 22 (a)
OneToMany
Gm1527 31
  • 15 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tagap 30
  • 75.94 (n)
cow
(Bos Taurus)
Mammalia TAGAP 31 30
  • 73.82 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAGAP 31
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAGAP 31
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAGAP 31 30
  • 59.21 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAGAP 31
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tagap 30
  • 54.29 (n)
zebrafish
(Danio rerio)
Actinopterygii tagapb 31 30
  • 46.09 (n)
OneToMany
tagapa 31
  • 28 (a)
OneToMany
arhgap20 31
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rga-2 31
  • 8 (a)
OneToMany
Species where no ortholog for TAGAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAGAP Gene

ENSEMBL:
Gene Tree for TAGAP (if available)
TreeFam:
Gene Tree for TAGAP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAGAP: view image

Paralogs for TAGAP Gene

Paralogs for TAGAP Gene

(1) SIMAP similar genes for TAGAP Gene using alignment to 1 proteins:

  • TAGAP_HUMAN
genes like me logo Genes that share paralogs with TAGAP: view

Variants for TAGAP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAGAP Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
727285 Benign: not provided 159,036,984(-) G/T MISSENSE_VARIANT
727286 Benign: not provided 159,038,162(-) G/A MISSENSE_VARIANT
735880 Benign: not provided 159,036,992(-) C/T MISSENSE_VARIANT
776179 Benign: not provided 159,036,986(-) C/T MISSENSE_VARIANT
rs35263580 - p.Gly346Asp

Additional dbSNP identifiers (rs#s) for TAGAP Gene

Variation tolerance for TAGAP Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAGAP Gene

Human Gene Mutation Database (HGMD)
TAGAP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAGAP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TAGAP Gene

Disorders for TAGAP Gene

MalaCards: The human disease database

(7) MalaCards diseases for TAGAP Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, insulin-dependent, 21
  • iddm21
auditory agnosia
candidal paronychia
  • candidiasis of skin
multiple sclerosis
  • multiple sclerosis, susceptibility to
rheumatoid arthritis
  • ra
- elite association - COSMIC cancer census association via MalaCards
Search TAGAP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TAGAP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TAGAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAGAP Gene

Publications for TAGAP Gene

  1. Newly identified genetic risk variants for celiac disease related to the immune response. (PMID: 18311140) Hunt KA … van Heel DA (Nature genetics 2008) 2 3 41 54
  2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 41 54
  3. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. (PMID: 22190364) Patsopoulos NA … de Bakker PI (Annals of neurology 2011) 3 41 54
  4. A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease. (PMID: 21298027) Festen EA … Rioux JD (PLoS genetics 2011) 3 41 54
  5. Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois PC … van Heel DA (Nature genetics 2010) 3 41 54

Products for TAGAP Gene

Sources for TAGAP Gene