Aliases for TAFA4 Gene
External Ids for TAFA4 Gene
Previous HGNC Symbols for TAFA4 Gene
Previous GeneCards Identifiers for TAFA4 Gene
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for TAFA4 Gene
TAFA4 (TAFA Chemokine Like Family Member 4) is a Protein Coding gene. Diseases associated with TAFA4 include Osteogenesis Imperfecta, Type Xiii and Inflammatory Bowel Disease 9. An important paralog of this gene is TAFA2.
UniProtKB/Swiss-Prot Summary for TAFA4 Gene
Modulates injury-induced and chemical pain hypersensitivity (By similarity). Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release (PubMed:25109685).