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This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
TAFA4 (TAFA Chemokine Like Family Member 4) is a Protein Coding gene. Diseases associated with TAFA4 include Osteogenesis Imperfecta, Type Xiii and Inflammatory Bowel Disease 9. An important paralog of this gene is TAFA2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH03J068932 | Promoter/Enhancer | 1.4 | EPDnew Ensembl ENCODE | 600.4 | +20.8 | 20796 | 1 | CTCF POLR2A EZH2 ZNF561 SOX13 RAD21 RNF2 USF1 ZBTB26 MAX | TAFA4 RNA5SP135 TAFA1 | |
GH03J068894 | Promoter | 0.4 | EPDnew | 610.8 | +58.6 | 58605 | 0.1 | ZFP36 | TAFA4 RNA5SP135 TAFA1 | |
GH03J068950 | Enhancer | 0.3 | Ensembl | 600.7 | -0.9 | -904 | 0.8 | SPI1 | TAFA4 lnc-ARL6IP5-2 lnc-FAM19A4-3 EOGT | |
GH03J068972 | Enhancer | 0.6 | Ensembl | 5.6 | -20.8 | -20765 | 3.5 | CTCF TEAD4 ZNF143 REST RAD21 SMC3 MYC ZNF654 GLIS1 YY1 | TAFA4 lnc-FAM19A4-3 lnc-ARL6IP5-2 EOGT | |
GH03J068943 | Enhancer | 0.4 | Ensembl | 6.4 | +9.4 | 9396 | 1 | ZNF316 MAFF ZNF384 MAFK | TAFA4 RNA5SP135 TAFA1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 25416956 |
GO:0048018 | receptor ligand activity | IBA,ISS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IBA,ISS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006909 | phagocytosis | IBA,ISS | -- |
GO:0007165 | signal transduction | IEA | -- |
GO:0010469 | regulation of signaling receptor activity | ISS | -- |
GO:0042391 | regulation of membrane potential | IEA | -- |
GO:0042554 | superoxide anion generation | ISS | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FAM19A4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FAM19A4 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FAM19A4 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Fam19a4 30 31 |
|
OneToOne | |
Tafa4 17 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Fam19a4 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | FAM19A4 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | FAM19A4 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FAM19A4 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FAM19A4 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fam19a4 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | fam19a4b 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
719249 | Benign: not provided | 68,733,148(-) | C/T | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
osteogenesis imperfecta, type xiii |
|
|
inflammatory bowel disease 9 |
|
|
prostatic adenoma |
|
|
neuropathy, hereditary sensory and autonomic, type v |
|
|
cervix uteri carcinoma in situ |
|
|