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This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
TAFA3 (TAFA Chemokine Like Family Member 3) is a Protein Coding gene. An important paralog of this gene is TAFA4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0048018 | receptor ligand activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IDA | 25595455 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0014016 | neuroblast differentiation | IBA | 21873635 |
GO:1902692 | regulation of neuroblast proliferation | IBA | 21873635 |
GO:1903979 | negative regulation of microglial cell activation | IBA,ISS | -- |
GO:1903980 | positive regulation of microglial cell activation | IBA,ISS | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FAM19A3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FAM19A3 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Fam19a3 30 31 |
|
OneToOne | |
Tafa3 17 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Fam19a3 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | FAM19A3 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FAM19A3 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | FAM19A3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FAM19A3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fam19a3 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-254n4.3 30 |
|
||
si:dkey-238f9.1 31 |
|
ManyToMany |
No disorders were found for TAFA3 Gene.