This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to f... See more...

Aliases for TAFA3 Gene

Aliases for TAFA3 Gene

  • TAFA Chemokine Like Family Member 3 2 3 5
  • Family With Sequence Similarity 19 Member A3, C-C Motif Chemokine Like 2 3
  • Chemokine-Like Protein TAFA-3 3 4
  • FAM19A3 3 4
  • TAFA-3 2 3
  • Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A3 3
  • Protein FAM19A3 3
  • TAFA3 5

External Ids for TAFA3 Gene

Previous HGNC Symbols for TAFA3 Gene

  • FAM19A3

Previous GeneCards Identifiers for TAFA3 Gene

  • GC01P112547
  • GC01P112975

Summaries for TAFA3 Gene

Entrez Gene Summary for TAFA3 Gene

  • This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for TAFA3 Gene

TAFA3 (TAFA Chemokine Like Family Member 3) is a Protein Coding gene. An important paralog of this gene is TAFA4.

UniProtKB/Swiss-Prot Summary for TAFA3 Gene

Additional gene information for TAFA3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAFA3 Gene

Genomics for TAFA3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TAFA3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J112718 Promoter 1 EPDnew 600.7 0.0 -24 0.1 HNRNPL CTCF PRDM10 BACH1 JUND LARP7 ZNF143 ZNF24 REST RAD21 TAFA3 ENSG00000225075 MOV10 ENSG00000238761 LOC105378910 PPM1J
GH01J112794 Enhancer 0.9 Ensembl ENCODE 12.2 +75.9 75940 3.4 LEF1 NR2C1 HDAC1 FOXJ2 MGA ZNF316 USF1 NR2C2 ZNF318 NR2F1 PPM1J TAFA3 RHOC LRIG2 piR-41245-017 RF00017-295 lnc-FAM19A3-6 SLC16A1
GH01J112722 Enhancer 0.8 ENCODE CraniofacialAtlas 0.7 +4.0 3959 1.9 HNRNPL ZNF600 SCRT2 ZNF205 ZFHX2 POLR2A BHLHE40 GABPB1 SPI1 REST PPM1J TAFA3 piR-49423-011 SLC16A1
GH01J112735 Enhancer 0.7 Ensembl ENCODE 0.4 +16.9 16922 1.5 JUND JUN FOS FOSL1 FOSL2 MAFK ATF3 SLC16A1 piR-49423-011 NUTF2P4 TAFA3
GH01J112849 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.1 +132.4 132440 4.8 PRDM10 RFX1 ZNF692 FOXA1 ZIC2 PATZ1 ZNF501 POLR2A ZNF341 SCRT2 LINC01357 LINC01356 piR-35674-032 piR-33422-019 SLC16A1 TAFA3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAFA3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAFA3

Genomic Locations for TAFA3 Gene

Genomic Locations for TAFA3 Gene
chr1:112,718,961-112,727,235
(GRCh38/hg38)
Size:
8,275 bases
Orientation:
Plus strand
chr1:113,263,041-113,269,857
(GRCh37/hg19)
Size:
6,817 bases
Orientation:
Plus strand

Genomic View for TAFA3 Gene

Genes around TAFA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAFA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAFA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAFA3 Gene

Proteins for TAFA3 Gene

  • Protein details for TAFA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5A8-TAFA3_HUMAN
    Recommended name:
    Chemokine-like protein TAFA-3
    Protein Accession:
    Q7Z5A8
    Secondary Accessions:
    • B7ZLU0
    • Q2M1P9
    • Q7Z5A6

    Protein attributes for TAFA3 Gene

    Size:
    133 amino acids
    Molecular mass:
    14776 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TAFA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAFA3 Gene

Post-translational modifications for TAFA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAFA3 Gene

No data available for DME Specific Peptides for TAFA3 Gene

Domains & Families for TAFA3 Gene

Gene Families for TAFA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for TAFA3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAFA3 Gene

GenScript: Design optimal peptide antigens:
  • Chemokine-like protein TAFA-3 (F19A3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z5A8

UniProtKB/Swiss-Prot:

TAFA3_HUMAN :
  • Belongs to the TAFA family.
Family:
  • Belongs to the TAFA family.
genes like me logo Genes that share domains with TAFA3: view

Function for TAFA3 Gene

Molecular function for TAFA3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of microglia polarization.

Phenotypes From GWAS Catalog for TAFA3 Gene

Gene Ontology (GO) - Molecular Function for TAFA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048018 receptor ligand activity IBA 21873635
genes like me logo Genes that share ontologies with TAFA3: view
genes like me logo Genes that share phenotypes with TAFA3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TAFA3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAFA3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAFA3 Gene

Localization for TAFA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAFA3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAFA3 gene
Compartment Confidence
extracellular 5
nucleus 0

Gene Ontology (GO) - Cellular Components for TAFA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 25595455
genes like me logo Genes that share ontologies with TAFA3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAFA3 Gene

Pathways & Interactions for TAFA3 Gene

PathCards logo

SuperPathways for TAFA3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TAFA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0014016 neuroblast differentiation IBA 21873635
GO:1902692 regulation of neuroblast proliferation IBA 21873635
GO:1903979 negative regulation of microglial cell activation IBA,ISS --
GO:1903980 positive regulation of microglial cell activation IBA,ISS --
genes like me logo Genes that share ontologies with TAFA3: view

No data available for Pathways by source and SIGNOR curated interactions for TAFA3 Gene

Drugs & Compounds for TAFA3 Gene

No Compound Related Data Available

Transcripts for TAFA3 Gene

mRNA/cDNA for TAFA3 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAFA3

Alternative Splicing Database (ASD) splice patterns (SP) for TAFA3 Gene

No ASD Table

Relevant External Links for TAFA3 Gene

GeneLoc Exon Structure for
TAFA3

Expression for TAFA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAFA3

SOURCE GeneReport for Unigene cluster for TAFA3 Gene:

Hs.439116

mRNA Expression by UniProt/SwissProt for TAFA3 Gene:

Q7Z5A8-TAFA3_HUMAN
Tissue specificity: Brain-specific.

Evidence on tissue expression from TISSUES for TAFA3 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TAFA3: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAFA3 Gene

Orthologs for TAFA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAFA3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM19A3 30 31
  • 99.75 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FAM19A3 30
  • 87.97 (n)
Mouse
(Mus musculus)
Mammalia Fam19a3 30 31
  • 87.28 (n)
OneToOne
Tafa3 17
Rat
(Rattus norvegicus)
Mammalia Fam19a3 30
  • 85.96 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia FAM19A3 31
  • 51 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia FAM19A3 31
  • 50 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FAM19A3 31
  • 24 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FAM19A3 30 31
  • 76.95 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 26 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fam19a3 30
  • 66.98 (n)
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-254n4.3 30
  • 72.98 (n)
si:dkey-238f9.1 31
  • 44 (a)
ManyToMany
Species where no ortholog for TAFA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TAFA3 Gene

ENSEMBL:
Gene Tree for TAFA3 (if available)
TreeFam:
Gene Tree for TAFA3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAFA3: view image

Paralogs for TAFA3 Gene

Paralogs for TAFA3 Gene

genes like me logo Genes that share paralogs with TAFA3: view

Variants for TAFA3 Gene

Additional dbSNP identifiers (rs#s) for TAFA3 Gene

Structural Variations from Database of Genomic Variants (DGV) for TAFA3 Gene

Variant ID Type Subtype PubMed ID
esv27598 CNV loss 19812545
nsv547566 CNV gain 21841781
nsv818378 CNV gain 17921354
nsv998794 CNV gain 25217958

Variation tolerance for TAFA3 Gene

Residual Variation Intolerance Score: 78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAFA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAFA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAFA3 Gene

Disorders for TAFA3 Gene

No disorders were found for TAFA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAFA3 Gene

Publications for TAFA3 Gene

  1. FAM19A3, a novel secreted protein, modulates the microglia/macrophage polarization dynamics and ameliorates cerebral ischemia. (PMID: 25595455) Shao Y … Wang Y (FEBS letters 2015) 2 3 4
  2. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. (PMID: 15028294) Tom Tang Y … Rupp F (Genomics 2004) 2 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for TAFA3 Gene

Sources for TAFA3 Gene