This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to f... See more...

Aliases for TAFA1 Gene

Aliases for TAFA1 Gene

  • TAFA Chemokine Like Family Member 1 2 3 5
  • Family With Sequence Similarity 19 Member A1, C-C Motif Chemokine Like 2 3
  • Chemokine-Like Protein TAFA-1 3 4
  • FAM19A1 3 4
  • TAFA-1 2 3
  • Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A1 3
  • Protein FAM19A1 3
  • TAFA1 5

External Ids for TAFA1 Gene

Previous HGNC Symbols for TAFA1 Gene

  • FAM19A1

Previous GeneCards Identifiers for TAFA1 Gene

  • GC03U900528
  • GC03P068138

Summaries for TAFA1 Gene

Entrez Gene Summary for TAFA1 Gene

  • This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAFA1 Gene

TAFA1 (TAFA Chemokine Like Family Member 1) is a Protein Coding gene. An important paralog of this gene is TAFA2.

UniProtKB/Swiss-Prot Summary for TAFA1 Gene

  • Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation.

Gene Wiki entry for TAFA1 Gene

Additional gene information for TAFA1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAFA1 Gene

Genomics for TAFA1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TAFA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J067652 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600 -337.1 -337106 4.3 SP1 HNRNPL REST TFE3 ZNF692 POLR2A NFRKB ZNF7 LARP7 ZIC2 SUCLG2-AS1 SUCLG2 piR-33730-055 TAFA1 LOC105377148 KBTBD8
GH03J068004 Promoter/Enhancer 0.5 EPDnew Ensembl 600.4 +13.3 13309 1.8 TAFA1 piR-61532-188 TAFA4
GH03J068006 Promoter 0.3 EPDnew 600.4 +14.6 14619 0.1 TAFA1 piR-61532-188 TAFA4
GH03J068061 Enhancer 0.4 FANTOM5 17.8 +70.3 70329 0.3 ATF7 ATF2 JUND TAFA1 piR-61532-188 TAFA4
GH03J067939 Enhancer 0.5 Ensembl 10.6 -50.8 -50848 2.3 SP1 CTCF YY1 JUND NR2F2 RAD21 HNF4A RXRA ATF3 TAFA1 HSALNG0026676 piR-50200 SUCLG2 SUCLG2-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAFA1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAFA1

Genomic Locations for TAFA1 Gene

Genomic Locations for TAFA1 Gene
chr3:67,991,592-68,546,056
(GRCh38/hg38)
Size:
554,465 bases
Orientation:
Plus strand
chr3:68,053,359-68,594,776
(GRCh37/hg19)
Size:
541,418 bases
Orientation:
Plus strand

Genomic View for TAFA1 Gene

Genes around TAFA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAFA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAFA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAFA1 Gene

Proteins for TAFA1 Gene

  • Protein details for TAFA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5A9-TAFA1_HUMAN
    Recommended name:
    Chemokine-like protein TAFA-1
    Protein Accession:
    Q7Z5A9
    Secondary Accessions:
    • A8K0V3
    • Q8TCL8

    Protein attributes for TAFA1 Gene

    Size:
    133 amino acids
    Molecular mass:
    14901 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TAFA1 Gene

Post-translational modifications for TAFA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TAFA1 Gene

Domains & Families for TAFA1 Gene

Gene Families for TAFA1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for TAFA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAFA1 Gene

GenScript: Design optimal peptide antigens:
  • Chemokine-like protein TAFA-1 (F19A1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z5A9

UniProtKB/Swiss-Prot:

TAFA1_HUMAN :
  • Belongs to the TAFA family.
Family:
  • Belongs to the TAFA family.
genes like me logo Genes that share domains with TAFA1: view

Function for TAFA1 Gene

Molecular function for TAFA1 Gene

UniProtKB/Swiss-Prot Function:
Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation.

Phenotypes From GWAS Catalog for TAFA1 Gene

Gene Ontology (GO) - Molecular Function for TAFA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0048018 receptor ligand activity IBA,ISS --
genes like me logo Genes that share ontologies with TAFA1: view
genes like me logo Genes that share phenotypes with TAFA1: view

Animal Models for TAFA1 Gene

MGI Knock Outs for TAFA1:
  • Tafa1 Tafa1<tm1(KOMP)Vlcg>
  • Tafa1 Tafa1<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for TAFA1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAFA1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAFA1 Gene

Localization for TAFA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAFA1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAFA1 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 4
cytoskeleton 1
mitochondrion 1
plasma membrane 0
nucleus 0
cytosol 0
lysosome 0

Gene Ontology (GO) - Cellular Components for TAFA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA,ISS --
GO:0005783 endoplasmic reticulum IDA --
genes like me logo Genes that share ontologies with TAFA1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAFA1 Gene

Pathways & Interactions for TAFA1 Gene

PathCards logo

SuperPathways for TAFA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TAFA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0010469 regulation of signaling receptor activity ISS --
GO:0014016 neuroblast differentiation IBA,ISS --
GO:1902692 regulation of neuroblast proliferation IBA,ISS --
genes like me logo Genes that share ontologies with TAFA1: view

No data available for Pathways by source and SIGNOR curated interactions for TAFA1 Gene

Drugs & Compounds for TAFA1 Gene

No Compound Related Data Available

Transcripts for TAFA1 Gene

mRNA/cDNA for TAFA1 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAFA1

Alternative Splicing Database (ASD) splice patterns (SP) for TAFA1 Gene

No ASD Table

Relevant External Links for TAFA1 Gene

GeneLoc Exon Structure for
TAFA1

Expression for TAFA1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAFA1

SOURCE GeneReport for Unigene cluster for TAFA1 Gene:

Hs.655061

mRNA Expression by UniProt/SwissProt for TAFA1 Gene:

Q7Z5A9-TAFA1_HUMAN
Tissue specificity: Brain-specific.

Evidence on tissue expression from TISSUES for TAFA1 Gene

  • Nervous system(4.5)
  • Kidney(4)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAFA1 Gene

Orthologs for TAFA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAFA1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM19A1 31
  • 100 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FAM19A1 31
  • 94 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia FAM19A1 30 31
  • 93.98 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FAM19A1 30 31
  • 92.73 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FAM19A1 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Fam19a1 30 31
  • 90.98 (n)
OneToOne
Tafa1 17
Chicken
(Gallus gallus)
Aves FAM19A1 30 31
  • 88.72 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FAM19A1 31
  • 98 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fam19a1 30
  • 83.46 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100329998 30
  • 76.9 (n)
fam19a1 31
  • 73 (a)
OneToOne
Species where no ortholog for TAFA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TAFA1 Gene

ENSEMBL:
Gene Tree for TAFA1 (if available)
TreeFam:
Gene Tree for TAFA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAFA1: view image

Paralogs for TAFA1 Gene

Paralogs for TAFA1 Gene

genes like me logo Genes that share paralogs with TAFA1: view

Variants for TAFA1 Gene

Additional dbSNP identifiers (rs#s) for TAFA1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TAFA1 Gene

Variant ID Type Subtype PubMed ID
dgv4770n100 CNV gain 25217958
esv1736654 CNV deletion 17803354
esv22648 CNV loss 19812545
esv2434953 CNV insertion 19546169
esv2667612 CNV deletion 23128226
esv2670431 CNV deletion 23128226
esv2752014 CNV gain 17911159
esv3399066 CNV insertion 20981092
esv3429381 CNV duplication 20981092
esv3568835 CNV loss 25503493
esv3596475 CNV loss 21293372
esv3596476 CNV loss 21293372
esv3596478 CNV loss 21293372
esv3596479 CNV loss 21293372
esv3596480 CNV gain 21293372
esv3596481 CNV loss 21293372
esv999186 CNV insertion 20482838
nsv1003158 CNV loss 25217958
nsv1003779 CNV loss 25217958
nsv1010992 CNV gain 25217958
nsv1013531 CNV gain 25217958
nsv1109520 CNV deletion 24896259
nsv1127965 CNV deletion 24896259
nsv1139122 CNV deletion 24896259
nsv1160944 CNV duplication 26073780
nsv3861 CNV insertion 18451855
nsv437864 CNV loss 16468122
nsv473043 CNV novel sequence insertion 20440878
nsv476547 CNV novel sequence insertion 20440878
nsv478283 CNV novel sequence insertion 20440878
nsv590562 CNV gain 21841781
nsv590563 CNV gain 21841781
nsv822119 CNV loss 20364138
nsv834721 CNV gain 17160897
nsv998582 CNV gain 25217958

Variation tolerance for TAFA1 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 5.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAFA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAFA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAFA1 Gene

Disorders for TAFA1 Gene

No disorders were found for TAFA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAFA1 Gene

Publications for TAFA1 Gene

  1. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. (PMID: 15028294) Tom Tang Y … Rupp F (Genomics 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for TAFA1 Gene

Sources for TAFA1 Gene