Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory sign... See more...

Aliases for TAF9B Gene

Aliases for TAF9B Gene

  • TATA-Box Binding Protein Associated Factor 9b 2 3 5
  • DN-7 2 3 4
  • TAF9-Like RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 31kDa 2 3
  • TAF9B RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 31kDa 2 3
  • Transcription Initiation Factor TFIID Subunit 9B 3 4
  • Transcription-Associated Factor TAFII31L 3 4
  • Neuronal Cell Death-Related Protein 7 3 4
  • TAFII31L 2 3
  • TFIID-31 2 3
  • TAF9L 3 4
  • DN7 2 3
  • Transcription Initiation Factor TFIID Subunit 9-Like 4
  • Transcription Initiation Factor IID, 31kD Subunit 3
  • TBP-Associated Factor 9L 3
  • TAF9B 5

External Ids for TAF9B Gene

Previous HGNC Symbols for TAF9B Gene

  • TAF9L

Previous GeneCards Identifiers for TAF9B Gene

  • GC0XP9L0788
  • GC0XM077271
  • GC0XM077385
  • GC0XM070971

Summaries for TAF9B Gene

Entrez Gene Summary for TAF9B Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF9B Gene

TAF9B (TATA-Box Binding Protein Associated Factor 9b) is a Protein Coding gene. Among its related pathways are Regulation of TP53 Activity and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and transcription corepressor activity. An important paralog of this gene is TAF9.

UniProtKB/Swiss-Prot Summary for TAF9B Gene

  • Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.

Gene Wiki entry for TAF9B Gene

Additional gene information for TAF9B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAF9B Gene

Genomics for TAF9B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TAF9B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ078138 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 626.9 +0.3 250 2 TFE3 ZNF692 POLR2A BACH1 ZHX2 ZIC2 RBFOX2 PATZ1 SMAD5 SP1 TAF9B RF00017-8549 PGAM4
GH0XJ078140 Promoter 0.3 EPDnew 600.7 -1.4 -1369 0.1 TAF9B piR-32023-273 CYSLTR1
GH0XJ078160 Promoter 0.3 EPDnew 600.4 -21.2 -21158 0.1 TAF9B piR-57195-271 FNDC3CP lnc-TAF9B-1 CYSLTR1
GH0XJ078102 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 26.3 +33.3 33282 7.3 CEBPG SP1 CREB1 GATAD2A PRDM10 ZNF629 REST IKZF1 NFKBIZ ZNF692 PGK1 TAF9B ATRX CYSLTR1 FGF16 lnc-TAF9B-2 NONHSAG054842.2 PGAM4
GH0XJ078325 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 22.3 -188.5 -188504 6.3 RUNX3 IKZF1 NR2F1 JUNB BATF EBF1 CYSLTR1 TAF9B FGF16 piR-35002-189 RTL3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAF9B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAF9B

Top Transcription factor binding sites by QIAGEN in the TAF9B gene promoter:
  • C/EBPalpha
  • Cdc5
  • CHOP-10
  • FOXF2
  • Pax-2
  • Pax-2a
  • Pax-2b
  • POU2F1
  • POU2F1a
  • YY1

Genomic Locations for TAF9B Gene

Genomic Locations for TAF9B Gene
chrX:78,129,748-78,139,650
(GRCh38/hg38)
Size:
9,903 bases
Orientation:
Minus strand
chrX:77,385,245-77,395,203
(GRCh37/hg19)
Size:
9,959 bases
Orientation:
Minus strand

Genomic View for TAF9B Gene

Genes around TAF9B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF9B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF9B Gene

Proteins for TAF9B Gene

  • Protein details for TAF9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBM6-TAF9B_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 9B
    Protein Accession:
    Q9HBM6
    Secondary Accessions:
    • B2RUZ9
    • Q9Y2S3

    Protein attributes for TAF9B Gene

    Size:
    251 amino acids
    Molecular mass:
    27622 Da
    Quaternary structure:
    • Binds TAF5 and TAF6. Component of TFIID and the TATA-binding protein-free TAF complex (TFTC). TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Binds N-terminal domain of p53/TP53 which is essential for transcription.

neXtProt entry for TAF9B Gene

Post-translational modifications for TAF9B Gene

  • Ubiquitination at Lys24
  • Modification sites at PhosphoSitePlus

Other Protein References for TAF9B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF9B Gene

Domains & Families for TAF9B Gene

Gene Families for TAF9B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TAF9B Gene

InterPro:
Blocks:
  • Transcription factor TAFII-31
ProtoNet:

Suggested Antigen Peptide Sequences for TAF9B Gene

GenScript: Design optimal peptide antigens:
  • Transcription-associated factor TAFII31L (TAF9B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HBM6

UniProtKB/Swiss-Prot:

TAF9B_HUMAN :
  • Belongs to the TAF9 family.
Family:
  • Belongs to the TAF9 family.
genes like me logo Genes that share domains with TAF9B: view

Function for TAF9B Gene

Molecular function for TAF9B Gene

UniProtKB/Swiss-Prot Function:
Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.

Phenotypes From GWAS Catalog for TAF9B Gene

Gene Ontology (GO) - Molecular Function for TAF9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0003714 transcription corepressor activity IC 12837753
GO:0005515 protein binding IPI 15899866
GO:0008134 transcription factor binding IBA 21873635
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with TAF9B: view
genes like me logo Genes that share phenotypes with TAF9B: view

Animal Models for TAF9B Gene

MGI Knock Outs for TAF9B:
  • Taf9b Taf9b<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAF9B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAF9B Gene

Localization for TAF9B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF9B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF9B gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TAF9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IBA 21873635
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 15899866
GO:0033276 transcription factor TFTC complex IDA 15899866
genes like me logo Genes that share ontologies with TAF9B: view

Pathways & Interactions for TAF9B Gene

genes like me logo Genes that share pathways with TAF9B: view

Pathways by source for TAF9B Gene

1 KEGG pathway for TAF9B Gene
1 GeneGo (Thomson Reuters) pathway for TAF9B Gene
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
7 Qiagen pathways for TAF9B Gene
  • Assembly of RNA Polymerase-II Initiation Complex
  • Crosstalk Between CARM1 and ESRs
  • Estrogen Pathway
  • Glucocorticoid Receptor Signaling
  • Nuclear Receptor Activation by Vitamin-A

Gene Ontology (GO) - Biological Process for TAF9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 12837753
GO:0006352 DNA-templated transcription, initiation IEA --
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0016579 protein deubiquitination TAS --
genes like me logo Genes that share ontologies with TAF9B: view

No data available for SIGNOR curated interactions for TAF9B Gene

Drugs & Compounds for TAF9B Gene

No Compound Related Data Available

Transcripts for TAF9B Gene

mRNA/cDNA for TAF9B Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAF9B

Alternative Splicing Database (ASD) splice patterns (SP) for TAF9B Gene

No ASD Table

Relevant External Links for TAF9B Gene

GeneLoc Exon Structure for
TAF9B

Expression for TAF9B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAF9B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TAF9B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (48.2), Placenta (9.8), and Fetal ovary (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAF9B Gene



Protein tissue co-expression partners for TAF9B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAF9B

SOURCE GeneReport for Unigene cluster for TAF9B Gene:

Hs.592248

Evidence on tissue expression from TISSUES for TAF9B Gene

  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with TAF9B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF9B Gene

Orthologs for TAF9B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF9B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TAF9B 30 31
  • 99.47 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TAF9B 30 31
  • 94.38 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TAF9B 30 31
  • 93.89 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Taf9b 30
  • 91.8 (n)
Mouse
(Mus musculus)
Mammalia Taf9b 30 17 31
  • 91.3 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TAF9B 31
  • 72 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 58 (a)
OneToMany
Chicken
(Gallus gallus)
Aves TAF9 31
  • 80 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 76 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii taf9 31
  • 75 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta e(y)1 31
  • 32 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea taf-9 31
  • 29 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF9 31
  • 29 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 45 (a)
OneToMany
Species where no ortholog for TAF9B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for TAF9B Gene

ENSEMBL:
Gene Tree for TAF9B (if available)
TreeFam:
Gene Tree for TAF9B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAF9B: view image

Paralogs for TAF9B Gene

Paralogs for TAF9B Gene

(1) SIMAP similar genes for TAF9B Gene using alignment to 1 proteins:

  • TAF9B_HUMAN

Pseudogenes.org Pseudogenes for TAF9B Gene

genes like me logo Genes that share paralogs with TAF9B: view

Variants for TAF9B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAF9B Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
816843 Uncertain Significance: Intellectual disability 78,138,843(-) G/T MISSENSE_VARIANT
rs875989809 Uncertain Significance: not specified 78,136,913(-) ACCTA/TT SPLICE_DONOR_VARIANT

Additional dbSNP identifiers (rs#s) for TAF9B Gene

Variation tolerance for TAF9B Gene

Residual Variation Intolerance Score: 42.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAF9B Gene

Human Gene Mutation Database (HGMD)
TAF9B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF9B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TAF9B Gene

Disorders for TAF9B Gene

No disorders were found for TAF9B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF9B Gene

Publications for TAF9B Gene

  1. TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9. (PMID: 15899866) Frontini M … Tora L (Molecular and cellular biology 2005) 2 3 4
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. In vivo functional analysis of the histone 3-like TAF9 and a TAF9-related factor, TAF9L. (PMID: 12837753) Chen Z … Manley JL (The Journal of biological chemistry 2003) 3 23
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for TAF9B Gene

Sources for TAF9B Gene