Aliases for TAF9B Gene
- TATA-Box Binding Protein Associated Factor 9b 2 3 5
- DN-7 2 3 4
- TAF9-Like RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 31kDa 2 3
- TAF9B RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 31kDa 2 3
- Transcription Initiation Factor TFIID Subunit 9B 3 4
- Transcription-Associated Factor TAFII31L 3 4
- Neuronal Cell Death-Related Protein 7 3 4
External Ids for TAF9B Gene
Previous HGNC Symbols for TAF9B Gene
Previous GeneCards Identifiers for TAF9B Gene
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process. [provided by RefSeq, Jul 2008]
GeneCards Summary for TAF9B Gene
TAF9B (TATA-Box Binding Protein Associated Factor 9b) is a Protein Coding gene. Among its related pathways are Regulation of TP53 Activity and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and transcription corepressor activity. An important paralog of this gene is TAF9.
UniProtKB/Swiss-Prot Summary for TAF9B Gene
Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.