This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene conta... See more...

Aliases for TAF8 Gene

Aliases for TAF8 Gene

  • TATA-Box Binding Protein Associated Factor 8 2 3 5
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, A, 45/50kDa 2 3
  • TAF8 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 43kDa 2 3
  • Transcription Initiation Factor TFIID 43 KDa Subunit 3 4
  • Transcription Initiation Factor TFIID Subunit 8 3 4
  • TBP-Associated Factor 43 KDa 3 4
  • TBP-Associated Factor 8 3 4
  • Protein Taube Nuss 3 4
  • TAFII-43 3 4
  • HTAFII43 3 4
  • TAFII43 3 4
  • TBN 3 4
  • TBP-Associated Factor, RNA Polymerase II, 43 KD 3
  • TBP-Associated Factor TAFII43 3
  • Taube Nuss Homolog (Mouse) 2
  • Taube Nuss Homolog 3
  • TAF(II)43 3
  • TAF 3
  • II 3

External Ids for TAF8 Gene

Previous HGNC Symbols for TAF8 Gene

  • TBN

Previous GeneCards Identifiers for TAF8 Gene

  • GC00U991138
  • GC06P042127
  • GC06P042018
  • GC06P041736

Summaries for TAF8 Gene

Entrez Gene Summary for TAF8 Gene

  • This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF8 Gene

TAF8 (TATA-Box Binding Protein Associated Factor 8) is a Protein Coding gene. Diseases associated with TAF8 include Corpus Callosum, Partial Agenesis Of, X-Linked and Microcephaly. Among its related pathways are Gene Expression and Formation of HIV-1 elongation complex containing HIV-1 Tat. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot Summary for TAF8 Gene

  • Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity).

Gene Wiki entry for TAF8 Gene

Additional gene information for TAF8 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAF8 Gene

Genomics for TAF8 Gene

GeneHancer (GH) Regulatory Elements for TAF8 Gene

Promoters and enhancers for TAF8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAF8 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAF8

Top Transcription factor binding sites by QIAGEN in the TAF8 gene promoter:
  • AP-1
  • AP-2gamma
  • ATF-2
  • c-Fos
  • c-Jun
  • TBP
  • TFIID

Genomic Locations for TAF8 Gene

Genomic Locations for TAF8 Gene
chr6:42,050,513-42,087,462
(GRCh38/hg38)
Size:
36,950 bases
Orientation:
Plus strand
chr6:42,018,251-42,055,199
(GRCh37/hg19)
Size:
36,949 bases
Orientation:
Plus strand

Genomic View for TAF8 Gene

Genes around TAF8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF8 Gene

Proteins for TAF8 Gene

  • Protein details for TAF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7C8-TAF8_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 8
    Protein Accession:
    Q7Z7C8
    Secondary Accessions:
    • Q5T0K1
    • Q8N4R9
    • Q96M52

    Protein attributes for TAF8 Gene

    Size:
    310 amino acids
    Molecular mass:
    34262 Da
    Quaternary structure:
    • TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TBP, TAF1, TAF6, TAF10, TAF11 and TAF13. Component also of a small TAF complex (SMAT) containing TAF8, TAF10 and SUPT7L. Forms a heterodimer with TAF10. Interaction with TAF10 is mediated mainly via its histone fold domain while interaction with SUPT7L is via its C-terminal region.
    Miscellaneous:
    • 'Taube nuss' means 'empty nut' in German.
    SequenceCaution:
    • Sequence=BAB71460.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAF8 Gene

    Alternative splice isoforms for TAF8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF8 Gene

Post-translational modifications for TAF8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TAF8 Gene

Domains & Families for TAF8 Gene

Gene Families for TAF8 Gene

Protein Domains for TAF8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAF8 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57866, highly similar to Homo sapiens TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, mRNA (B4DZU5_HUMAN)
  • Transcription initiation factor TFIID 43 kDa subunit (TAF8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z7C8

UniProtKB/Swiss-Prot:

TAF8_HUMAN :
  • Ectopic expression of the histone fold domain acts as a dominant-negative mutant resulting in differentiation inhibition.
  • Belongs to the TAF8 family.
Domain:
  • Ectopic expression of the histone fold domain acts as a dominant-negative mutant resulting in differentiation inhibition.
Family:
  • Belongs to the TAF8 family.
genes like me logo Genes that share domains with TAF8: view

Function for TAF8 Gene

Molecular function for TAF8 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity).
UniProtKB/Swiss-Prot Induction:
Induced with triglyceride accumulation.

Phenotypes From GWAS Catalog for TAF8 Gene

Gene Ontology (GO) - Molecular Function for TAF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15870280
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with TAF8: view
genes like me logo Genes that share phenotypes with TAF8: view

Animal Models for TAF8 Gene

MGI Knock Outs for TAF8:
  • Taf8 Taf8<tm2b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for TAF8 Gene

miRTarBase miRNAs that target TAF8

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAF8

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAF8 Gene

Localization for TAF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF8 Gene

Nucleus. Cytoplasm. Note=Localized in the cytoplasm and transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF8 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TAF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15870280
GO:0005654 nucleoplasm IDA,TAS --
GO:0005669 transcription factor TFIID complex IDA,IEA 14580349
GO:0005737 cytoplasm IEA --
GO:0048471 perinuclear region of cytoplasm IDA 15870280
genes like me logo Genes that share ontologies with TAF8: view

Pathways & Interactions for TAF8 Gene

PathCards logo

SuperPathways for TAF8 Gene

genes like me logo Genes that share pathways with TAF8: view

Pathways by source for TAF8 Gene

1 KEGG pathway for TAF8 Gene
1 GeneGo (Thomson Reuters) pathway for TAF8 Gene
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes

Gene Ontology (GO) - Biological Process for TAF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001833 inner cell mass cell proliferation IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0042795 snRNA transcription by RNA polymerase II TAS --
GO:0045598 regulation of fat cell differentiation IDA 14580349
genes like me logo Genes that share ontologies with TAF8: view

No data available for SIGNOR curated interactions for TAF8 Gene

Drugs & Compounds for TAF8 Gene

No Compound Related Data Available

Transcripts for TAF8 Gene

mRNA/cDNA for TAF8 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAF8

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: -
SP7: -
SP8: - -

Relevant External Links for TAF8 Gene

GeneLoc Exon Structure for
TAF8

Expression for TAF8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAF8 Gene

Protein differential expression in normal tissues from HIPED for TAF8 Gene

This gene is overexpressed in Plasma (38.4) and Blymphocyte (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAF8 Gene



Protein tissue co-expression partners for TAF8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAF8

SOURCE GeneReport for Unigene cluster for TAF8 Gene:

Hs.520122

Evidence on tissue expression from TISSUES for TAF8 Gene

  • Bone(2.2)
genes like me logo Genes that share expression patterns with TAF8: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF8 Gene

Orthologs for TAF8 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAF8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF8 31 30
  • 99.57 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 94 (a)
OneToMany
-- 31
  • 87 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TAF8 31 30
  • 92.58 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAF8 31
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF8 31 30
  • 91.72 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Taf8 17 31 30
  • 89.86 (n)
rat
(Rattus norvegicus)
Mammalia Taf8 30
  • 89.19 (n)
chicken
(Gallus gallus)
Aves TAF8 31 30
  • 82.38 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF8 31
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taf8 30
  • 73.14 (n)
Str.5817 30
African clawed frog
(Xenopus laevis)
Amphibia tbn-prov 30
zebrafish
(Danio rerio)
Actinopterygii taf8 31 30
  • 69.05 (n)
OneToOne
zgc56401 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2307 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012105 30
  • 55.45 (n)
fruit fly
(Drosophila melanogaster)
Insecta Taf8 31 30
  • 51.77 (n)
OneToMany
sa 31
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea taf-8 31
  • 13 (a)
OneToOne
Species where no ortholog for TAF8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF8 Gene

ENSEMBL:
Gene Tree for TAF8 (if available)
TreeFam:
Gene Tree for TAF8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAF8: view image

Paralogs for TAF8 Gene

No data available for Paralogs for TAF8 Gene

Variants for TAF8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAF8 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
638647 Pathogenic: Microcephaly; Partial agenesis of the corpus callosum; Severe global developmental delay 42,077,099(+) G/A SPLICE_ACCEPTOR_VARIANT
795892 Likely Benign: not provided 42,051,482(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for TAF8 Gene

Structural Variations from Database of Genomic Variants (DGV) for TAF8 Gene

Variant ID Type Subtype PubMed ID
esv2731983 CNV deletion 23290073
nsv475784 CNV novel sequence insertion 20440878
nsv602989 CNV loss 21841781
nsv830646 CNV loss 17160897
nsv830649 CNV loss 17160897

Variation tolerance for TAF8 Gene

Residual Variation Intolerance Score: 26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAF8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF8 Gene

Disorders for TAF8 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TAF8 Gene - From: ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
corpus callosum, partial agenesis of, x-linked
  • corpus callosum, partial agenesis of
microcephaly
  • microcephalus
poland syndrome
  • poland syndactyly
- elite association - COSMIC cancer census association via MalaCards
Search TAF8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TAF8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TAF8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAF8 Gene

Publications for TAF8 Gene

  1. Identification of a small TAF complex and its role in the assembly of TAF-containing complexes. (PMID: 17375202) Demény MA … Tora L (PloS one 2007) 3 4 23 54
  2. The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. (PMID: 14580349) Guermah M … Roeder RG (Molecular cell 2003) 3 4 23 54
  3. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J … Lambert JC (Molecular psychiatry 2009) 3 41 54
  4. The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners. (PMID: 15870280) Soutoglou E … Tora L (Molecular and cellular biology 2005) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for TAF8 Gene

Sources for TAF8 Gene