The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFI... See more...

Aliases for TAF7 Gene

Aliases for TAF7 Gene

  • TATA-Box Binding Protein Associated Factor 7 2 3 5
  • TAF7 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 55kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, F, 55kD 2 3
  • RNA Polymerase II TBP-Associated Factor Subunit F 3 4
  • Transcription Initiation Factor TFIID Subunit 7 3 4
  • TAF(II)55 3 4
  • TAFII-55 3 4
  • TAFII55 3 4
  • TAF2F 3 4
  • Transcription Initiation Factor TFIID, 55 KDa Subunit 3
  • Transcription Initiation Factor TFIID 55 KDa Subunit 4
  • Transcription Factor IID Subunit TAFII55 3
  • TBP-Associated Factor F 3

External Ids for TAF7 Gene

Previous HGNC Symbols for TAF7 Gene

  • TAF2F

Previous GeneCards Identifiers for TAF7 Gene

  • GC05M140514
  • GC05M141281
  • GC05M140681
  • GC05M140726
  • GC05M140678
  • GC05M135843

Summaries for TAF7 Gene

Entrez Gene Summary for TAF7 Gene

  • The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF7 Gene

TAF7 (TATA-Box Binding Protein Associated Factor 7) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is TAF7L.

UniProtKB/Swiss-Prot Summary for TAF7 Gene

  • Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).

Gene Wiki entry for TAF7 Gene

Additional gene information for TAF7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAF7 Gene

Genomics for TAF7 Gene

GeneHancer (GH) Regulatory Elements for TAF7 Gene

Promoters and enhancers for TAF7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J141318 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.8 783 4.4 ZBTB40 EP300 CTCF NRF1 TCF12 POLR2G SP1 GTF2E2 PHF8 ZFX ENSG00000288095 TAF7 lnc-SLC25A2-1 PCDHB15 PCDHGB4 ENSG00000272108 PCDHB9 PCDHB18P PCDHB6 PCDHGA3
GH05J141506 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 6 -195.7 -195694 20 EP300 ZNF217 CTCF SIN3A TCF12 MYC USF1 SP1 JUND TEAD4 PCDHGC5 PCDHGC4 PCDHGA7 DIAPH1 PCDHGB6 PCDHGA2 PCDHGA11 PCDHB18P RN7SL68P PCDHGC3
GH05J141563 Enhancer 1.2 ENCODE dbSUPER 10.5 -243.6 -243629 1.4 ZNF217 EP300 CTCF TCF12 NCOR1 JUND TEAD4 FOS ZNF639 ZNF10 HARS2 IK PCDHB8 PCDHB3 PCDHA6 PCDHB9 PCDHB7 ENSG00000272108 PCDHB15 PCDHGC3
GH05J141674 Enhancer 1 FANTOM5 Ensembl ENCODE 5.2 -355.5 -355478 3.5 CTCF TEAD4 POLR2A HDAC2 YY1 NANOG TCF12 ZFHX2 ZNF189 PRDM10 PCDH1 RNF14 PCDH12 DELE1 PCDHGB6 PCDHGA8 TAF7 PCDHGC3 ARAP3 HDAC3
GH05J141249 Enhancer 0.3 Ensembl 10 +70.4 70374 1.2 CTCF PCDHB16 PCDHB8 PCDHB7 PCDHB10 PCDHB9 TAF7 PCDHGB4 PCDHGB1 PCDHGA3 PCDHGA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAF7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAF7

Top Transcription factor binding sites by QIAGEN in the TAF7 gene promoter:
  • AP-1
  • AREB6
  • ATF-2
  • c-Jun
  • Sp1

Genomic Locations for TAF7 Gene

Genomic Locations for TAF7 Gene
chr5:141,260,225-141,320,784
(GRCh38/hg38)
Size:
60,560 bases
Orientation:
Minus strand
chr5:140,698,057-140,700,351
(GRCh37/hg19)
Size:
2,295 bases
Orientation:
Minus strand

Genomic View for TAF7 Gene

Genes around TAF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF7 Gene

Proteins for TAF7 Gene

  • Protein details for TAF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15545-TAF7_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 7
    Protein Accession:
    Q15545
    Secondary Accessions:
    • B2RBV9
    • Q13036

    Protein attributes for TAF7 Gene

    Size:
    349 amino acids
    Molecular mass:
    40259 Da
    Quaternary structure:
    • TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs) (PubMed:27007846, PubMed:10438527). Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:27007846). Interacts with TAF1; the interaction is direct (PubMed:25412659). Interacts with TAFII250, TAFII100, TAFII28, TAFII20, and TAFII18, but not with TAFII30 or TBP (PubMed:8702684, PubMed:10438527). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (PubMed:15960975). Binds to CIITA and TAF1 and inhibits their acetyltransferase activity, thereby repressing activated transcription and behaving as a repressor at these promoters.
    Miscellaneous:
    • Overexpression of TAF7 in HeLa cells inhibits cyclin D1 and cyclin A gene transcription and causes the cells to accumulate in early S phase. In contrast, depletion of TAF7 from TFIID complexes by siRNAs increases histone H3 acetylation at both cyclin promoters and stimulates cyclins CCND1 and CCNA gene transcription.

    Three dimensional structures from OCA and Proteopedia for TAF7 Gene

neXtProt entry for TAF7 Gene

Post-translational modifications for TAF7 Gene

  • Phosphorylated by CIITA. Phosphorylation at Ser-264 by TAF1 in early G1 phase disrupts binding to TAF1.
  • Ubiquitination at Lys66 and Lys141
  • Modification sites at PhosphoSitePlus

Other Protein References for TAF7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF7 Gene

Domains & Families for TAF7 Gene

Gene Families for TAF7 Gene

Protein Domains for TAF7 Gene

Blocks:
  • TAFII55 protein conserved region
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAF7 Gene

GenScript: Design optimal peptide antigens:
  • Transcription initiation factor TFIID 55 kDa subunit (TAF7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15545

UniProtKB/Swiss-Prot:

TAF7_HUMAN :
  • The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase, which methylates Lys-5 in vitro.
  • Belongs to the TAF7 family.
Domain:
  • The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase, which methylates Lys-5 in vitro.
Family:
  • Belongs to the TAF7 family.
genes like me logo Genes that share domains with TAF7: view

Function for TAF7 Gene

Molecular function for TAF7 Gene

UniProtKB/Swiss-Prot Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).

Phenotypes From GWAS Catalog for TAF7 Gene

Gene Ontology (GO) - Molecular Function for TAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001097 TFIIH-class transcription factor complex binding IDA 18391197
GO:0003700 contributes_to DNA-binding transcription factor activity IDA 9603525
GO:0003713 transcription coactivator activity IDA,IBA 7824954
GO:0005515 protein binding IPI 7824954
GO:0008134 transcription factor binding IPI 7824954
genes like me logo Genes that share ontologies with TAF7: view
genes like me logo Genes that share phenotypes with TAF7: view

Animal Models for TAF7 Gene

MGI Knock Outs for TAF7:
  • Taf7 Taf7<tm1.1Dss>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAF7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAF7 Gene

Localization for TAF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF7 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IPI 25412659
GO:0005669 transcription factor TFIID complex IEA,TAS 25412659
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TAF7: view

Pathways & Interactions for TAF7 Gene

genes like me logo Genes that share pathways with TAF7: view

Pathways by source for TAF7 Gene

1 BioSystems pathway for TAF7 Gene
1 KEGG pathway for TAF7 Gene
1 GeneGo (Thomson Reuters) pathway for TAF7 Gene
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
7 Qiagen pathways for TAF7 Gene
  • Assembly of RNA Polymerase-II Initiation Complex
  • Crosstalk Between CARM1 and ESRs
  • Estrogen Pathway
  • Glucocorticoid Receptor Signaling
  • Nuclear Receptor Activation by Vitamin-A

Gene Ontology (GO) - Biological Process for TAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 11592977
GO:0000296 spermine transport ISS --
GO:0006352 DNA-templated transcription, initiation IDA 9603525
GO:0006357 regulation of transcription by RNA polymerase II IEA,IBA 21873635
GO:0006366 transcription by RNA polymerase II IEA,TAS --
genes like me logo Genes that share ontologies with TAF7: view

No data available for SIGNOR curated interactions for TAF7 Gene

Drugs & Compounds for TAF7 Gene

No Compound Related Data Available

Transcripts for TAF7 Gene

mRNA/cDNA for TAF7 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAF7

Alternative Splicing Database (ASD) splice patterns (SP) for TAF7 Gene

No ASD Table

Relevant External Links for TAF7 Gene

GeneLoc Exon Structure for
TAF7

Expression for TAF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAF7 Gene

Protein differential expression in normal tissues from HIPED for TAF7 Gene

This gene is overexpressed in Retina (14.1), Fetal Brain (11.5), and Blymphocyte (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAF7 Gene



Protein tissue co-expression partners for TAF7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAF7

SOURCE GeneReport for Unigene cluster for TAF7 Gene:

Hs.438838

mRNA Expression by UniProt/SwissProt for TAF7 Gene:

Q15545-TAF7_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TAF7 Gene

  • Nervous system(4.9)
  • Skin(4.6)
  • Liver(4.5)
  • Kidney(2.4)
  • Heart(2.3)
  • Muscle(2.3)
  • Spleen(2.3)
genes like me logo Genes that share expression patterns with TAF7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF7 Gene

Orthologs for TAF7 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF7 31 30
  • 99.62 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TAF7 31 30
  • 92.74 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TAF7 31 30
  • 90.89 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf7 30
  • 89.44 (n)
mouse
(Mus musculus)
Mammalia Taf7 17 31 30
  • 88.82 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 84 (a)
OneToMany
-- 31
  • 80 (a)
OneToMany
-- 31
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TAF7 31
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAF7 31 30
  • 78.38 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF7 31
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taf7 30
  • 72.9 (n)
Str.11144 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.1684 30
zebrafish
(Danio rerio)
Actinopterygii taf7 31 30 30
  • 70.62 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Taf7 31
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea taf-7.2 31
  • 31 (a)
ManyToMany
taf-7.1 31
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 40 (a)
OneToMany
Species where no ortholog for TAF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF7 Gene

ENSEMBL:
Gene Tree for TAF7 (if available)
TreeFam:
Gene Tree for TAF7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAF7: view image

Paralogs for TAF7 Gene

Paralogs for TAF7 Gene

(1) SIMAP similar genes for TAF7 Gene using alignment to 1 proteins:

  • TAF7_HUMAN
genes like me logo Genes that share paralogs with TAF7: view

Variants for TAF7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAF7 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
VAR_005629 - p.Ser178Arg

Additional dbSNP identifiers (rs#s) for TAF7 Gene

Structural Variations from Database of Genomic Variants (DGV) for TAF7 Gene

Variant ID Type Subtype PubMed ID
esv2759382 CNV gain 17122850
nsv428127 CNV loss 18775914
nsv477099 CNV novel sequence insertion 20440878

Variation tolerance for TAF7 Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAF7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF7 Gene

Disorders for TAF7 Gene

Additional Disease Information for TAF7

No disorders were found for TAF7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF7 Gene

Publications for TAF7 Gene

  1. Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators. (PMID: 7824954) Chiang CM … Roeder RG (Science (New York, N.Y.) 1995) 2 3 4 54
  2. Structure of promoter-bound TFIID and model of human pre-initiation complex assembly. (PMID: 27007846) Louder RK … Nogales E (Nature 2016) 3 4 54
  3. Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module. (PMID: 25412659) Wang H … Zheng N (Cell research 2014) 3 4 54
  4. Genome-wide association study of lung function decline in adults with and without asthma. (PMID: 22424883) Imboden M … Probst-Hensch NM (The Journal of allergy and clinical immunology 2012) 3 41 54
  5. Phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7. (PMID: 22711989) Kloet SL … Wang EH (Molecular and cellular biology 2012) 3 4 54

Products for TAF7 Gene

Sources for TAF7 Gene