TAF6L Gene (Protein Coding)

TATA-Box Binding Protein Associated Factor 6 Like

GC11P062771
GIFtS:
38
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory sign... See more...

Aliases for TAF6L Gene

Aliases for TAF6L Gene

  • TATA-Box Binding Protein Associated Factor 6 Like 2 3 5
  • PAF65A 2 3 4
  • TAF6-Like RNA Polymerase II P300/CBP-Associated Factor-Associated Factor 65 KDa Subunit 6L 3 4
  • TAF6-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65kDa 2 3
  • PCAF-Associated Factor 65-Alpha 3 4
  • PAF65-Alpha 3 4
  • TAF6-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65 KD 2
  • P300/CBP-Associated Factor (PCAF)-Associated Factor 65 3
  • TAF6L 5

External Ids for TAF6L Gene

Previous GeneCards Identifiers for TAF6L Gene

  • GC11P065051
  • GC11P064114
  • GC11P062790
  • GC11P062314
  • GC11P062295
  • GC11P062538
  • GC11P058868

Summaries for TAF6L Gene

Entrez Gene Summary for TAF6L Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF6L Gene

TAF6L (TATA-Box Binding Protein Associated Factor 6 Like) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and histone acetyltransferase activity. An important paralog of this gene is TAF6.

UniProtKB/Swiss-Prot Summary for TAF6L Gene

  • Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release (By similarity).

Gene Wiki entry for TAF6L Gene

Additional gene information for TAF6L Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAF6L Gene

Genomics for TAF6L Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for TAF6L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAF6L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAF6L

Top Transcription factor binding sites by QIAGEN in the TAF6L gene promoter:
  • E2F
  • E2F-1
  • ER-alpha
  • FOXD1
  • MyoD
  • p300
  • p53
  • RFX1
  • XBP-1
  • ZIC2

Genomic Locations for TAF6L Gene

Latest Assembly
chr11:62,771,357-62,787,342
(GRCh38/hg38)
Size:
15,986 bases
Orientation:
Plus strand

Previous Assembly
chr11:62,538,868-62,554,814
(GRCh37/hg19 by Entrez Gene)
Size:
15,947 bases
Orientation:
Plus strand

chr11:62,538,775-62,554,814
(GRCh37/hg19 by Ensembl)
Size:
16,040 bases
Orientation:
Plus strand

Genomic View for TAF6L Gene

Genes around TAF6L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF6L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF6L Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TAF6L Gene

Proteins for TAF6L Gene

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  • Protein details for TAF6L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6J9-TAF6L_HUMAN
    Recommended name:
    TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
    Protein Accession:
    Q9Y6J9
    Secondary Accessions:
    • B2RAT0
    • Q96HA6

    Protein attributes for TAF6L Gene

    Size:
    622 amino acids
    Molecular mass:
    67814 Da
    Quaternary structure:
    • The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.

neXtProt entry for TAF6L Gene

Protein Expression for TAF6L Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TAF6L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF6L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF6L Gene

Domains & Families for TAF6L Gene

Gene Families for TAF6L Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TAF6L Gene

InterPro:
Blocks:
  • Protein of unknown function DUF1546
ProtoNet:

Suggested Antigen Peptide Sequences for TAF6L Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57614, highly similar to TAF6-like RNA polymerase IIp300/CBP-associated factor-associated factor 65 kDa subunit 6L (B4DVM4_HUMAN)
  • PCAF-associated factor 65-alpha (TAF6L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y6J9

UniProtKB/Swiss-Prot:

TAF6L_HUMAN :
  • Belongs to the TAF6 family.
Family:
  • Belongs to the TAF6 family.
genes like me logo Genes that share domains with TAF6L: view

Function for TAF6L Gene

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Molecular function for TAF6L Gene

UniProtKB/Swiss-Prot Function:
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release (By similarity).

Phenotypes From GWAS Catalog for TAF6L Gene

Gene Ontology (GO) - Molecular Function for TAF6L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 9674425
GO:0003713 transcription coactivator activity IBA,IDA 11564863
GO:0005515 protein binding IPI 9674425
GO:0016251 RNA polymerase II general transcription initiation factor activity IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with TAF6L: view
genes like me logo Genes that share phenotypes with TAF6L: view

Animal Models for research

miRNA for TAF6L Gene

miRTarBase miRNAs that target TAF6L

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAF6L

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF6L Gene

Localization for TAF6L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF6L Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF6L gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAF6L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex TAS 9674425
GO:0000124 SAGA complex IEA --
GO:0005634 nucleus IEA,IDA 11564863
GO:0005654 nucleoplasm IDA --
GO:0005669 transcription factor TFIID complex IEA --
genes like me logo Genes that share ontologies with TAF6L: view

Pathways & Interactions for TAF6L Gene

PathCards logo

SuperPathways for TAF6L Gene

SuperPathway Contained pathways
1 RNA Polymerase II Transcription Initiation And Promoter Clearance
Assembly of RNA Polymerase-II Initiation Complex
.91
Transcription of mRNA
.91
Basal transcription factors
.59
Protein Acetylation and Deacetylation
.51
Crosstalk Between CARM1 and ESRs
.39
Transcription Ligand-Dependent Transcription of Retinoid-Target genes
.32
2 Chromatin organization
Chromatin modifying enzymes
.51
Chromatin organization
.51
HATs acetylate histones
.51
3 Notch Signaling Pathway (WikiPathways)
Notch Signaling Pathways
.31
4 GPCR Pathway
Estrogen Pathway
.55
5 PEDF Induced Signaling
Glucocorticoid Receptor Signaling
.43
genes like me logo Genes that share pathways with TAF6L: view

Pathways by source for TAF6L Gene

1 KEGG pathway for TAF6L Gene
1 GeneGo (Thomson Reuters) pathway for TAF6L Gene
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
1 R&D Systems pathway for TAF6L Gene
7 Qiagen pathways for TAF6L Gene
  • Assembly of RNA Polymerase-II Initiation Complex
  • Crosstalk Between CARM1 and ESRs
  • Estrogen Pathway
  • Glucocorticoid Receptor Signaling
  • Nuclear Receptor Activation by Vitamin-A

Gene Ontology (GO) - Biological Process for TAF6L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling TAS 9674425
GO:0006352 DNA-templated transcription, initiation IEA --
GO:0006355 regulation of transcription, DNA-templated ISS --
GO:0006357 regulation of transcription by RNA polymerase II TAS 9674425
GO:0006367 transcription initiation from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with TAF6L: view

No data available for SIGNOR curated interactions for TAF6L Gene

Drugs & Compounds for TAF6L Gene

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(1) Drugs for TAF6L Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
C646 Pharma HAT p300-CBP inhibitor,cell-permeable 0

(1) ApexBio Compounds for TAF6L Gene

Compound Action Cas Number
C646 HAT p300-CBP inhibitor,cell-permeable 328968-36-1
genes like me logo Genes that share compounds with TAF6L: view

Drug products for research

Transcripts for TAF6L Gene

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mRNA/cDNA for TAF6L Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAF6L

Alternative Splicing Database (ASD) splice patterns (SP) for TAF6L Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10
SP1: - - -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for TAF6L Gene

GeneLoc Exon Structure for
TAF6L

Expression for TAF6L Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAF6L Gene

mRNA expression in normal human tissues for TAF6L Gene
mRNA expression by BioGPS for TAF6L GenemRNA expression by GTEx for TAF6L Gene

Protein differential expression in normal tissues from HIPED for TAF6L Gene

This gene is overexpressed in Plasma (15.7), Liver, secretome (15.5), Pancreas (12.5), and CD8 Tcells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAF6L Gene



Protein tissue co-expression partners for TAF6L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAF6L

SOURCE GeneReport for Unigene cluster for TAF6L Gene:

Hs.714400

Evidence on tissue expression from TISSUES for TAF6L Gene

  • Nervous system(3.9)
  • Lung(3.2)
genes like me logo Genes that share expression patterns with TAF6L: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF6L Gene

Orthologs for TAF6L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF6L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia TAF6L 30 31
  • 99.62 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia TAF6L 30 31
  • 88.75 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia TAF6L 30 31
  • 88.51 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia TAF6L 31
  • 87 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Taf6l 30 17 31
  • 85.66 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Taf6l 30
  • 85.44 (n)
Chicken
(Gallus gallus)
 Aves TAF6L 31
  • 76 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia TAF6L 31
  • 71 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia taf6l 30
  • 62.52 (n)
Str.11073 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.14337 30
Zebrafish
(Danio rerio)
 Actinopterygii taf6l 30 31
  • 64.94 (n)
 OneToOne
wufa05b10 30
Fruit Fly
(Drosophila melanogaster)
 Insecta mia 31
  • 17 (a)
 OneToOne
Worm
(Caenorhabditis elegans)
 Secernentea taf-6.1 31
  • 13 (a)
 OneToMany
taf-6.2 31
  • 11 (a)
 OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes TAF6 31
  • 18 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 31 (a)
 OneToOne
Species where no ortholog for TAF6L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TAF6L Gene

ENSEMBL:
Gene Tree for TAF6L (if available)
TreeFam:
Gene Tree for TAF6L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAF6L: view image

Paralogs for TAF6L Gene

Paralogs for TAF6L Gene

(1) SIMAP similar genes for TAF6L Gene using alignment to 5 proteins:

  • TAF6L_HUMAN
  • B4DVM4_HUMAN
  • E9PK90_HUMAN
  • E9PLV8_HUMAN
  • E9PP94_HUMAN
genes like me logo Genes that share paralogs with TAF6L: view

Variants for TAF6L Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TAF6L Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TAF6L Gene

Variant ID Type Subtype PubMed ID
nsv478847 CNV novel sequence insertion 20440878
nsv508636 CNV deletion 20534489
nsv509416 CNV insertion 20534489
nsv555175 CNV loss 21841781

Variation tolerance for TAF6L Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAF6L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF6L

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAF6L Gene

Disorders for TAF6L Gene

Additional Disease Information for TAF6L

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for TAF6L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF6L Gene

Publications for TAF6L Gene

  1. Histone-like TAFs within the PCAF histone acetylase complex. (PMID: 9674425) Ogryzko VV … Nakatani Y (Cell 1998) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis. (PMID: 12601814) Cavusoglu N … Van Dorsselaer A (Proteomics 2003) 3 4
  4. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. (PMID: 11564863) Martinez E … Roeder RG (Molecular and cellular biology 2001) 3 4
  5. The TAFs in the HAT. (PMID: 9674419) Struhl K … Moqtaderi Z (Cell 1998) 3 4

ExternalLinks

View latest publications for TAF6L gene in Mastermind

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