Aliases for TAF6L Gene
- TATA-Box Binding Protein Associated Factor 6 Like 2 3 5
- TAF6-Like RNA Polymerase II P300/CBP-Associated Factor-Associated Factor 65 KDa Subunit 6L 3 4
- TAF6-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65kDa 2 3
- PCAF-Associated Factor 65-Alpha 3 4
- PAF65-Alpha 3 4
- PAF65A 3 4
- TAF6-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65 KD 2
- P300/CBP-Associated Factor (PCAF)-Associated Factor 65 3
External Ids for TAF6L Gene
Previous GeneCards Identifiers for TAF6L Gene
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008]
GeneCards Summary for TAF6L Gene
TAF6L (TATA-Box Binding Protein Associated Factor 6 Like) is a Protein Coding gene. Among its related pathways are Chromatin organization and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and histone acetyltransferase activity. An important paralog of this gene is TAF6.
UniProtKB/Swiss-Prot Summary for TAF6L Gene
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.