Aliases for TAF6L Gene
Aliases for TAF6L Gene
- TATA-Box Binding Protein Associated Factor 6 Like 2 3 5
- TAF6-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65kDa 2 3
- PCAF-Associated Factor 65-Alpha 3 4
- PAF65-Alpha 3 4
- PAF65A 3 4
- TAF6-Like RNA Polymerase II P300/CBP-Associated Factor-Associated Factor 65 KDa Subunit 6L 3
- TAF6-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65 KD 2
- P300/CBP-Associated Factor (PCAF)-Associated Factor 65 3
External Ids for TAF6L Gene
- HGNC: 17305
- Entrez Gene: 10629
- Ensembl: ENSG00000162227
- OMIM: 602946
- UniProtKB: Q9Y6J9
Previous GeneCards Identifiers for TAF6L Gene
- GC11P065051
- GC11P064114
- GC11P062790
- GC11P062314
- GC11P062295
- GC11P062538
- GC11P058868
Summaries for TAF6L Gene
-
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008]
GeneCards Summary for TAF6L Gene
TAF6L (TATA-Box Binding Protein Associated Factor 6 Like) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and histone acetyltransferase activity. An important paralog of this gene is TAF6.
UniProtKB/Swiss-Prot for TAF6L Gene
-
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF6L Gene
Genomics for TAF6L Gene
GeneHancer (GH) Regulatory Elements for TAF6L Gene
Promoters and enhancers for TAF6L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TAF6L on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TAF6L Gene
Genomic Locations for TAF6L Gene
- chr11:62,771,303-62,787,342
- (GRCh38/hg38)
- Size:
- 16,040 bases
- Orientation:
- Plus strand
- chr11:62,538,775-62,554,814
- (GRCh37/hg19)
Genomic View for TAF6L Gene
Genes around TAF6L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.3 by Ensembl
- 11q12.3 by Entrez Gene
- 11q12.3 by HGNC
TAF6L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TAF6L Gene
Proteins for TAF6L Gene
-
Protein details for TAF6L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6J9-TAF6L_HUMAN
- Recommended name:
- TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
- Protein Accession:
- Q9Y6J9
- B2RAT0
- Q96HA6
Protein attributes for TAF6L Gene
- Size:
- 622 amino acids
- Molecular mass:
- 67814 Da
- Quaternary structure:
-
- The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
Protein Expression for TAF6L Gene
Post-translational modifications for TAF6L Gene
Other Protein References for TAF6L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for TAF6L
-
Abcam antibodies for TAF6L
- Invitrogen Antibodies for TAF6L
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Protein Products
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-
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-
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Assay Products
No data available for DME Specific Peptides for TAF6L Gene
Domains & Families for TAF6L Gene
Gene Families for TAF6L Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TAF6L Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TAF6L Gene
Graphical View of Domain Structure for InterPro Entry
Q9Y6J9- Family:
-
- Belongs to the TAF6 family.
Function for TAF6L Gene
Molecular function for TAF6L Gene
- UniProtKB/Swiss-Prot Function:
- Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.
Phenotypes From GWAS Catalog for TAF6L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | TAS | 9674425 |
| GO:0003713 | transcription coactivator activity | IDA | 11564863 |
| GO:0004402 | contributes_to histone acetyltransferase activity | IDA | 11564863 |
| GO:0005515 | protein binding | IPI | 9674425 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for TAF6L Gene
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-
-
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-
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Vectors and viruses for KO, Activation, Repression, and more
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miRNA for TAF6L Gene
- miRTarBase miRNAs that target TAF6L
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-
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- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TAF6L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF6L Gene
Localization for TAF6L Gene
Subcellular locations from UniProtKB/Swiss-Prot for TAF6L Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 2 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000118 | histone deacetylase complex | TAS | 9674425 |
| GO:0005634 | nucleus | IDA | 11564863 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0030914 | STAGA complex | IDA | 11564863 |
| GO:0070062 | extracellular exosome | IDA,HDA | 18570454 |
Pathways & Interactions for TAF6L Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RNA Polymerase II Transcription Initiation And Promoter Clearance | ||
| 2 | Chromatin organization | ||
| 3 | Influenza A | ||
| 4 | Notch signaling pathway (KEGG) | ||
| 5 | GPCR Pathway |
.55
|
|
Pathways by source for TAF6L Gene
3 Reactome pathways for TAF6L Gene
2 KEGG pathways for TAF6L Gene
1 GeneGo (Thomson Reuters) pathway for TAF6L Gene
1 R&D Systems pathway for TAF6L Gene
Interacting Proteins for TAF6L Gene
Selected Interacting proteins:
Q9Y6J9-TAF6L_HUMAN
ENSP00000294168
for TAF6L Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006338 | chromatin remodeling | TAS | 9674425 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006352 | DNA-templated transcription, initiation | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | TAS | 9674425 |
No data available for SIGNOR curated interactions for TAF6L Gene
Drugs & Compounds for TAF6L Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| C646 | Pharma | HAT p300-CBP inhibitor,cell-permeable | 0 |
(1) ApexBio Compounds for TAF6L Gene
| Compound | Action | Cas Number |
|---|---|---|
| C646 | HAT p300-CBP inhibitor,cell-permeable | 328968-36-1 |
Transcripts for TAF6L Gene
mRNA/cDNA for TAF6L Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (200) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TAF6L Gene
CRISPR Products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TAF6L
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miRNA Products
- Search ViGene Biosciences for TAF6L
Inhibitory RNA Products
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TAF6L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||
| SP5: |
Expression for TAF6L Gene
This gene is overexpressed in Plasma (15.7), Liver, secretome (15.5), Pancreas (12.5), and CD8 Tcells (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAF6L Gene
NURSA nuclear receptor signaling pathways regulating expression of TAF6L Gene:
TAF6LSOURCE GeneReport for Unigene cluster for TAF6L Gene:
Hs.714400Evidence on tissue expression from TISSUES for TAF6L Gene
- Nervous system(3.9)
- Lung(3.2)
Primer Products
-
OriGene qPCR primer pairs for TAF6L
- genomics-online: primer clones - Search results for 79 available TAF6L gene related products
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Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF6L Gene
Orthologs for TAF6L Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TAF6L 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TAF6L 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TAF6L 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TAF6L 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Taf6l 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Taf6l 33 |
|
||
| chicken (Gallus gallus) |
Aves | TAF6L 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | TAF6L 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | taf6l 33 |
|
||
| Str.11073 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.14337 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | taf6l 33 34 |
|
||
| wufa05b10 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | mia 34 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | taf-6.1 34 |
|
OneToMany | |
| taf-6.2 34 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TAF6 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for TAF6L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TAF6L Gene
(1) SIMAP similar genes for TAF6L Gene using alignment to 5 proteins:
Variants for TAF6L Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000009827 | -- | 62,780,240(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000011074 | -- | 62,780,484(+) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000067794 | -- | 62,786,746(+) | T/C | coding_sequence_variant, missense_variant | |
| rs1000081793 | -- | 62,786,984(+) | T/C | coding_sequence_variant, synonymous_variant | |
| rs1000506168 | -- | 62,775,232(+) | A/G | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.76;
33.39% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TAF6L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TAF6L
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF6L Gene
Disorders for TAF6L Gene
Additional Disease Information for TAF6L
No disorders were found for TAF6L Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF6L Gene
Publications for TAF6L Gene
- Histone-like TAFs within the PCAF histone acetylase complex. (PMID: 9674425) Ogryzko VV … Nakatani Y (Cell 1998) 2 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis. (PMID: 12601814) Cavusoglu N … Van Dorsselaer A (Proteomics 2003) 3 4 58
- Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. (PMID: 11564863) Martinez E … Roeder RG (Molecular and cellular biology 2001) 3 4 58
- The TAFs in the HAT. (PMID: 9674419) Struhl K … Moqtaderi Z (Cell 1998) 3 4 58
Products for TAF6L Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 56 available TAF6L Antibodies ranked by validation data
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Sources for TAF6L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
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- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
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- (121) MeSH
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- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems