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Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008]
TAF6L (TATA-Box Binding Protein Associated Factor 6 Like) is a Protein Coding gene. Among its related pathways are Chromatin organization and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and histone acetyltransferase activity. An important paralog of this gene is TAF6.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | TAS | 9674425 |
GO:0003713 | transcription coactivator activity | IBA,IDA | 11564863 |
GO:0004402 | histone acetyltransferase activity | IBA | -- |
GO:0005515 | protein binding | IPI | 9674425 |
GO:0016251 | contributes_to RNA polymerase II general transcription initiation factor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000118 | histone deacetylase complex | TAS | 9674425 |
GO:0000124 | SAGA complex | IEA,IBA | 21873635 |
GO:0005634 | nucleus | IBA,IDA | 11564863 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005669 | transcription factor TFIID complex | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
Assembly of RNA Polymerase-II Initiation Complex
.91
Transcription of mRNA
.91
|
Protein Acetylation and Deacetylation
.51
Crosstalk Between CARM1 and ESRs
.39
Transcription Ligand-Dependent Transcription of Retinoid-Target genes
.33
|
2 | Chromatin organization | ||
3 | Notch Signaling Pathway (WikiPathways) | ||
4 | GPCR Pathway |
Estrogen Pathway
.55
|
|
5 | PEDF Induced Signaling |
Glucocorticoid Receptor Signaling
.43
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006325 | chromatin organization | IBA | 21873635 |
GO:0006338 | chromatin remodeling | TAS | 9674425 |
GO:0006352 | DNA-templated transcription, initiation | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | ISS | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA,TAS | 9674425 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
C646 | Pharma | HAT p300-CBP inhibitor,cell-permeable | 0 |
Compound | Action | Cas Number |
---|---|---|
C646 | HAT p300-CBP inhibitor,cell-permeable | 328968-36-1 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TAF6L 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TAF6L 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TAF6L 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TAF6L 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Taf6l 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Taf6l 30 |
|
||
Chicken (Gallus gallus) |
Aves | TAF6L 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TAF6L 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | taf6l 30 |
|
||
Str.11073 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.14337 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | taf6l 30 31 |
|
OneToOne | |
wufa05b10 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | mia 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | taf-6.1 31 |
|
OneToMany | |
taf-6.2 31 |
|
OneToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TAF6 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
No disorders were found for TAF6L Gene.