Aliases for TAF5 Gene
- TATA-Box Binding Protein Associated Factor 5 2 3 5
- TAF5 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 100kDa 2 3
- TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, D, 100kD 2 3
- Transcription Initiation Factor TFIID 100 KDa Subunit 3 4
- TAF(II)100 3 4
- TAFII-100 3 4
External Ids for TAF5 Gene
Previous HGNC Symbols for TAF5 Gene
Previous GeneCards Identifiers for TAF5 Gene
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes an integral subunit of TFIID associated with all transcriptionally competent forms of that complex. This subunit interacts strongly with two TFIID subunits that show similarity to histones H3 and H4, and it may participate in forming a nucleosome-like core in the TFIID complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for TAF5 Gene
TAF5 (TATA-Box Binding Protein Associated Factor 5) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is TAF5L.
UniProtKB/Swiss-Prot for TAF5 Gene
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TAFII55, also have been observed.