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Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes an integral subunit of TFIID associated with all transcriptionally competent forms of that complex. This subunit interacts strongly with two TFIID subunits that show similarity to histones H3 and H4, and it may participate in forming a nucleosome-like core in the TFIID complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
TAF5 (TATA-Box Binding Protein Associated Factor 5) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is TAF5L.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 17996705 |
GO:0003713 | transcription coactivator activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 9045704 |
GO:0016251 | RNA polymerase II general transcription initiation factor activity | IMP | 9045704 |
GO:0042802 | identical protein binding | IPI | 17227857 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | IDA | 24289924 |
GO:0005634 | nucleus | IEA,IDA | 15637059 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005669 | transcription factor TFIID complex | IDA | 9045704 |
GO:0005730 | NOT nucleolus | IDA | 15637059 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
Assembly of RNA Polymerase-II Initiation Complex
.91
Transcription of mRNA
.91
|
Protein Acetylation and Deacetylation
.51
Crosstalk Between CARM1 and ESRs
.39
Transcription Ligand-Dependent Transcription of Retinoid-Target genes
.33
|
2 | HIV Life Cycle |
.91
.65
|
.45
|
3 | HIV Transcription Elongation | ||
4 | Regulation of TP53 Activity | ||
5 | Gene Expression |
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006352 | DNA-templated transcription, initiation | IDA | 9603525 |
GO:0006366 | transcription by RNA polymerase II | TAS | -- |
GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
GO:0016032 | viral process | IEA | -- |
GO:0042795 | snRNA transcription by RNA polymerase II | TAS | -- |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TAF5 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | TAF5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TAF5 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Taf5 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Taf5 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TAF5 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TAF5 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TAF5 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | taf5 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | taf5 30 31 |
|
OneToOne | |
wufc38g05 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13815 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011678 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Taf5 30 31 32 |
|
OneToOne | |
CG4448 32 |
|
|
|||
can 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | taf-5 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E23453g 30 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AEL246C 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TAF5 30 31 33 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | TAF5 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os06g0649500 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.7323 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2112 31 |
|
OneToOne | |
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | taf5 30 |
|
SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
708795 | Benign: not provided | 103,381,735(+) | G/C | SYNONYMOUS_VARIANT | |
818167 | Not Provided: not provided | 103,379,720(+) | G/A | MISSENSE_VARIANT | |
rs10883859 | - | p.Ser130Ala |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv965n100 | CNV | gain | 25217958 |
dgv966n100 | CNV | gain | 25217958 |
No disorders were found for TAF5 Gene.